Khan 2015 Abstract MiPschool Cape Town 2015

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Bioenergetic Health Index profiling: step towards personalized medicine.

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Khan N, van der Westhuizen FH (2015)

Event: MiPschool Cape Town 2015

Bioenergetic health index (BHI) profiling is an emerging concept in the field of mitochondrial research [1]. In general, bioenergetics is the study of balance between energy intake and energy utilization for life sustaining processes. Mitochondrion serves as an early warning signal of bioenergetics crisis in patient populations. Any changes in bioenergetics are the first signal to determine the progression of mitochondrial disorders that are complex and multifactorial. In order to achieve the above, the platelets from the patient’s blood samples were extracted and subjected to high throughput assays such as XF Extracellular Flux Analyzer, BHI can be calculated to represent the patient’s composite mitochondrial profile by monitoring the bioenergetic health of immune cells such as monocytes, lymphocytes, neutrophils and platelets from blood [2]. This approach can be a step towards personalized cell based measurements to quantify bioenergetic health index. The study will be discussed in detail later.


Labels: MiParea: Patients 

Stress:Mitochondrial disease  Organism: Human  Tissue;cell: Blood cells 




BHI 

Affiliations

Dept Biochem, North West Univ, South Africa. - Naaz.27khan@gmail.com

References

  1. Chacko BK, Kramer PA, Ravi S, Benavides GA, Mitchell T, Dranka BP, Ferrick D, Singal AK, Ballinger SW, Bailey SM, Hardy RW, Zhang J, Zhi D, Darley-Usmar VM (2014) The Bioenergetic Health Index: a new concept in mitochondrial translational research. Clin Sci 127:367-73.
  2. Kramer PA, Ravi S, Chacko B, Johnson MS, Darley-Usmar VM (2014) A review of the mitochondrial and glycolytic metabolism in human platelets and leukocytes: Implications for their use as bioenergetic biomarkers. Redox Biol 10:206-10.