Laner 2017 Abstract EUROMIT2017 Cologne

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EUROMIT2017

K-Regio MitoFit and MitoEAGLE – towards a global data bank on mitochondrial physiology.

Link: EUROMIT2017

Beno M, Doerrier C, Drinnan M, Garcia-Souza LF, Gnaiger E, Krumschnabel G, Laner V, Sumbalova Z, Cizmarova B (2017)

Event: EUROMIT2017 Cologne DE

A lack of physical activity associates with decreased mitochondrial capacity and is a major cause underlying metabolic dysregulation and preventable diseases in modern societies. In contrast, an active lifestyle supports enhanced mitochondrial capacities and reduces the risk of degenerative diseases. Despite this well-known relation between health and mitochondrial function, there is no regimented, quantitative system, or database organised to routinely test, compare and monitor mitochondrial capacities within individuals or populations. Every study of mitochondrial (mt) function and disease in human tissues and cells is faced with Evolution, Age, Gender, Lifestyle and Environment (EAGLE) as essential background conditions characterizing the individual patient, subject, study group, species, tissue or – to some extent - cell line. Only a large and well-coordinated network can manage to generate the necessary number of consistent data to address the complexity of EAGLE. Using high-resolution respirometry, the K-Regio MitoFit and MitoEAGLE initiatives develop novel lab standards and diagnostic methods for monitoring of a mitochondrial fitness score. SOPs are elaborated for sample preparation, respiratory evaluation and data documentation. Fresh and cryopreserved cells obtained non-invasively from blood samples broaden the scope for respirometric mitochondrial diagnosis.


Bioblast editor: Kandolf G O2k-Network Lab: AT Innsbruck Gnaiger E, AT Innsbruck Oroboros


Labels: MiParea: Respiration, Comparative MiP;environmental MiP, Gender, Exercise physiology;nutrition;life style, mt-Medicine, mt-Awareness  Pathology: Aging;senescence  Stress:Mitochondrial disease  Organism: Human 




HRR: Oxygraph-2k 

MitoEAGLE 

Affiliations

Beno M(1), Doerrier C(1), Drinnan M(2), Garcia-Souza LF(3), Gnaiger E(1,2), Krumschnabel G(1), Laner V(1), Sumbalova Z(2), Cizmarova B(2,4)
  1. Oroboros Instruments, Innsbruck, Austria. - verena.laner@oroboros.at
  2. Medical Univ Innsbruck, Austria
  3. Leopold-Franzens Univ Innsbruck, Austria
  4. Pavol Jozef Šafárik Univ Kosice, Slovakia


Support

Contribution to: K-Regio project MitoFit, funded by the Land Tirol, Austria, and to European Union Framework Programme Horizon 2020 COST Action CA15203 MitoEAGLE.