Liu 2017 MiP2017

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Jiankang Liu
Targeting mitochondria for preventing and treating diabetes with natural compounds from food and nutrition.

Link: MiP2017

Liu J (2017)

Event: MiP2017

COST Action MITOEAGLE
Metabolic syndrome, such as type 2 diabetes and obesity, has become a worldwide health problem. The underlying mechanisms of metabolic syndrome are still unclear. Mitochondrial dysfunction, including loss of mitochondrial homeostasis and over-production of reactive oxygen species, has been suggested to be involved in metabolic syndrome. Increasing evidence suggests that targeting mitochondria to protect mitochondria function could prevent and ameliorate various diseases associated with mitochondrial dysfunction and this has formed a unique medicine, i.e., mitochondrial medicine. In this presentation, I will summarize our recent studies with natural compounds from food and nutrition to target mitochondria by regulating mitochondrial homeostasis to improve mitochondrial function and mediate redox balance for preventing and ameliorating obesity and diabetes. We have focused on natural compounds from food and nutrition including olive, bitter gourd and pomegranate to in cellular systems and in animal models. The in vitro and in vivo studies may help us to understand the importance and mechanisms of mitochondrial metabolism, and to develop mitochondria-targeting agents for preventing and treating metabolic syndrome.


Bioblast editor: Kandolf G


Labels: MiParea: Exercise physiology;nutrition;life style, mt-Medicine  Pathology: Diabetes, Obesity 







Affiliations

Center Mitochondrial Biol Medicine, School Life Science Technology, Frontier Inst Science Technology, Xi’an Jiaotong Univ, Xi’an, China; School of Pharmacy, Univ Southern California, Los Angeles, CA, USA. - j.liu@mail.xjtu.edu.cn