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• Bradshaw 2019 Nutrients
  |title=Bradshaw PC (2019) Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging. Nutrients 11:504. ...pro-longevity therapies should aim to maintain the levels of both NAD⁺ and NADPH in aging tissues.
  2 KB (245 words) - 10:56, 4 February 2022
• Dutton 1989 Arch Biochem Biophys
  ...nson A (1989) Redox cycling of resorufin catalyzed by rat liver microsomal NADPH-cytochrome P450 reductase. Arch Biochem Biophys 268:605-16. ...tive than molecular O2 in this regard. Overall, these results suggest that NADPH-cytochrome P450 reductase catalyzes the one-electron reduction of resorufin
  3 KB (422 words) - 21:45, 24 September 2021
• Mishin 2010 Free Radical Biol Med
  ...H-cytochrome P450 reductase (0.31nmol of hydrogen peroxide/min/100Units of NADPH-cytochrome P450 reductase). This was independent of the addition of any exo
  2 KB (261 words) - 16:40, 23 February 2015
• Mishin 2010 Free Radic Biol Med
  ...H-cytochrome P450 reductase (0.31nmol of hydrogen peroxide/min/100Units of NADPH-cytochrome P450 reductase). This was independent of the addition of any exo
  2 KB (256 words) - 21:41, 24 September 2021
• Kynurenine hydroxylase
  ...ne. Kynurenine hydroxylase catalyzes the chemical reaction: L-kynurenine + NADPH + H⁺ + O₂ ↔ 3-hydroxy-L-kynurenine + NADP<sup>+</s ...gen incorporated need not be derived from O₂ with [[NADH]] or [[NADPH]] as one donor, and incorporation of one atom of oxygen into the other dono
  871 bytes (118 words) - 05:13, 12 February 2016
• Ying 2008 Antioxid Redox Signal
  |title=Ying W (2008) NAD⁺/NADH and NADP⁺/NADPH in cellular functions and cell death: regulation and biological consequence ...H-dependent reactive oxygen species (ROS) generation from mitochondria and NADPH oxidase-dependent ROS generation are two critical mechanisms of ROS generat
  2 KB (254 words) - 17:54, 1 February 2022
• Angiulli 2015 Biochim Biophys Acta
  ...nia infantum trypanothione'' reductase is a promiscuous enzyme carrying an NADPH:O₂ oxidoreductase activity shared by glutathione reductase. Bioc ...rmation of C(4a)-(hydro)peroxyflavin and sulfenic acid intermediates. This NADPH:O₂ oxidoreductase activity is shared by ''Saccharomyces cerevisi
  2 KB (348 words) - 08:26, 21 February 2020
• Marshall 1996 Am J Respir Cell Mol Biol
  ...e=Marshall C, Mamary AJ, Verhoeven AJ, Marshall BE (1996) Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction. Am J Respir Cel ...se superoxide by hypoxic conditions. It is concluded that a trans-membrane NADPH-oxidase is the most likely and that activation of this system may be involv
  3 KB (377 words) - 17:48, 20 April 2022
• Blacker 2016 Free Radic Biol Med
  ...S, Duchen MR (2016) Investigating mitochondrial redox state using NADH and NADPH autofluorescence. Free Radic Biol Med 100:53-65. ...te in complex tissue preparations. As the fluorescence spectra of NADH and NADPH are indistinguishable, interpreting the signals resulting from their combin
  2 KB (292 words) - 17:11, 1 February 2022
• Hoejeberg 1977 Biochem Biophys Res Commun
  ...of lipophilic anions, whereas the rate of reduction of NAD⁺ by NADPH is enhanced about 13 fold by uncouplers. Polyacrylamide gel electrophoresis
  1 KB (148 words) - 12:45, 24 February 2015
• Koziel 2013 Biochem J
  ...Duerr P (2013) Mitochondrial respiratory chain complex I is inactivated by NADPH oxidase Nox4. Biochem J 452:231-9. ...duction regulating cell proliferation, survival and differentiation. Nox4 (NADPH oxidase 4) induces cellular senescence in human endothelial cells; however,
  2 KB (224 words) - 12:26, 28 April 2015
• Thioredoxin reductase
  ...TrxR2 (mitochondrial) and TrxR3 (testis-specific). All of them contains an NADPH and FAD-binding domain, being the net reaction the same but differing in th
  1 KB (201 words) - 16:00, 10 May 2019
• Wei 2020 Cell Rep
  ...Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z (2020) Reducing NADPH synthesis counteracts diabetic nephropathy through restoration of AMPK acti ...ion of AMPK in podocytes. Therefore, this study demonstrates that reducing NADPH production is critical for renal AMPK activation in response to RYGB surger
  2 KB (300 words) - 04:55, 21 November 2023
• Vásquez-Vivar 1997 FEBS Letters
  ...eiodonium and is abolished by superoxide dismutase. It is likely that eNOS/NADPH can reduce lucigenin to LC.+ which reduces oxygen to superoxide. Consequent
  1 KB (164 words) - 17:41, 13 April 2022
• Figueira 2021 Arch Biochem Biophys
  ...o A, Ronchi JA, Dos Santos GRRM, Santos WD, Treberg JR, Castilho RF (2021) NADPH supply and the contribution of NAD(P)⁺ transhydrogenase (NNT) to ...act SMM. Nonetheless, if the available substrates favor non-NNT sources of NADPH, the H₂O₂ removal by SMM is maintained in Nnt<sup>-/-
  3 KB (434 words) - 17:42, 18 August 2021
• Favia 2021 Int J Mol Sci
  ...erse reaction, at the expense of its antioxidant potential, thus consuming NADPH to support NADH production. At the same time, the reduced NNT activity prev |keywords=NADPH, antioxidant, cystic fibrosis, glucose-6-phosphate dehydrogenase, mitochond
  2 KB (302 words) - 17:34, 22 February 2022
• Abdel-Rahman 2015 Abstract MiPschool Cape Town 2015
  |title=Assessment of NADPH-dependent oxygen consumption and hydrogen peroxide production by high-resol ...vels in biological specimens. Thus, the development of a method to measure NADPH oxidase-derived ROS generation would be a valuable research tool to underst
  4 KB (519 words) - 13:14, 23 January 2019
• Liu 2016 Apoptosis
  ...heng QY, Wang CY (2016) The ROS derived mitochondrial respiration not from NADPH oxidase plays key role in Celastrol against angiotensin II-mediated HepG2 c ...ssion levels of AngII type 2 (AT₂) receptor without influencing NADPH oxidase activity. PD123319 as a special inhibitor of AT2R was able to effec
  3 KB (356 words) - 22:54, 7 March 2020
• Francisco 2018 J Neurochem
  ...but peroxide detoxification can be partially counterbalanced by concurrent NADPH sources depending on substrate availability. Notably, only brain mitochondr
  3 KB (405 words) - 13:20, 17 April 2019
• Maddalena 2017 Biochem Biophys Res Commun
  ...experienced by cells in culture influence hydrogen peroxide production via NADPH oxidase 1/4, highlighting the importance of regulating oxygen levels in cul
  2 KB (315 words) - 14:31, 11 February 2022

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