Suravajhala 2017 MiP2017

From Bioblast
Jump to: navigation, search
Prashanth Suravajhala
Can dynamic simulations explain the time course in stressed mitochondrial conditions?

Link: MiP2017

Suravajhala P (2017)

Event: MiP2017

COST Action MITOEAGLE
Human body has quadrillion mitochondria with an average 2000 of them per cell. The physical exercises including breathing, forearm fistula exercises, clapping hands, meditation, mindfulness and perhaps yoga could determine the molecular mechanisms [1] further explaining the effect of stress in certain disorders, viz. aging, hypertension, generalized anxiety disorders (GAD) to name a few.

We hypothesize that there could be spatio-temporal changes that the genome might undergo during such stress conditions which could possibly explain systems biological reasons that links metabolism to mitochondrial quality control. Furthermore the reactive oxygen species (ROS) and antioxidant systems can be evaluated from the time course using complex pathway simulator (COPASI). To assess this, we have taken a dataset constituting the changes in cardiac transcription profiles brought about by heart failure [2].

Integrating these components, we could identify a positive feedback loop demonstrating the role of steady state oscillations. The computed values further give a cascade with changes in gene expression associated with stress related pathways and energy metabolism. Distinct hubs specific to the pathways have been identified from this dataset which subtly explains the arterial resiliency and mitochondrial health. A network of reactions with various parameters was constructuted to augment this.

In summary, we provide a model of mitochondrial metabolism that could possibly explain the role of molecular factors with specific focus on whether or not energy reserves help the body counter oxidative stress. And the question still remains from our preliminary findings: can we establish our hypothesis from experimental data alone?


Bioblast editor: Kandolf G


Labels: MiParea: Exercise physiology;nutrition;life style 







Affiliations

Dept Biotechnol Bioinformatics, Birla Inst Scientific Research, Jaipur, India. - prash@bisr.res.in

References

  1. Bhasin MK, Dusek JA, Chang BH, Joseph MG, Denninger JW, Fricchione GL, Benson H, Libermann TA (2013) Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. PLOS ONE 8:e62817.
  2. [www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GPL570 GEO reference]