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Oroboros Instruments

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US PA Philadelphia Wallace DC

Oroboros O2k-Network

O2k-Network Lab Center for Mitochondrial and Epigenomic Medicine (CMEM)

The Children's Hospital of Philadelphia - Research Institute

Colket Translational Research Building

Vision and Mission >> PDF

Doug Wallace and Erich Gnaiger at IOC91, Philadelphia 2014 IOC91 Angelin Potluri.JPG Team Wallace.JPG

Address 3501 Civic Center Blvd, 6th Floor, Office 6060, 19104
City Philadelphia
State/Prov Pennsylvania (PA)
Country USA
Contact Wallace Douglas C, Angelin Alessia
Team Colas Carman, Haroon Suraiya, Holczbauer Agnes, Kopinski Piotr, Lvova Masha, McCormack Shana, McManus Meagan, Morrow Ryan, Ortiz-Gonzales Xilma, Peng Min, Potluri Prasanth, Simon Mariela, Tintos Alonso, Towheed Atif, Vermulst Mark, Wang Ting
Team previous Alves Leonardo S, Hancock Saege, Jang David, Lin Chun Shi
Status O2k 2010-
Oroboros Events MitoFit Science Camp 2016, IOC106, MiP2015, IOC104, IOC91, IOC85, IOC72, IOC61


McManus 2019 Cell Metab2019McManus MJ, Picard M, Chen HW, De Haas HJ, Potluri P, Leipzig J, Towheed A, Angelin A, Sengupta P, Morrow RM, Kauffman BA, Vermulst M, Narula J, Wallace DC (2019) Mitochondrial DNA variation dictates expressivity and progression of nuclear DNA mutations causing cardiomyopathy. Cell Metab 29:78-90.
Weisz 2018 Hum Mol Genet2018Weisz ED, Towheed A, Monyak RE, Toth MS, Wallace DC, Jongens TA (2018) Loss of Drosophila FMRP leads to alterations in energy metabolism and mitochondrial function. Hum Mol Genet 27:95-106.
Jang 2018 Intensive Care Med Exp2018Jang DH, MD, Khatri UG, Shortal BP, Kelly M, Lambert DS, Hardy K, Eckmann DM (2018) Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive Care Med Exp 6:4.
Barca 2018 Hum Mol Genet2018Barca E, Ganetzky RD, Potluri P, Juanola-Falgarona M, Gai X, Li D, Jalas C, Hirsch Y, Emmanuele V, Tadesse S, Ziosi M, Akman HO, Chung WK, Tanji K, McCormick E, Place E, Consugar M, Pierce EA, Hakonarson H, Wallace DC, Hirano M, Falk MJ (2018) USMG5 Ashkenazi Jewish founder mutation impairs mitochondrial complex V dimerization and ATP synthesis. Hum Mol Genet 27:3305-12.
Morrow 2017 Proc Natl Acad Sci U S A2017Morrow RM, Picard M, Derbeneva O, Leipzig J, McManus MJ, Gouspillou G, Barbat-Artigas S, Dos Santos C, Hepple RT, Murdock DG, Wallace DC (2017) Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity. Proc Natl Acad Sci U S A 114:2705-10.
Jang 2016 Clin Toxicol (Phila)2016Jang DH, Shofer FS, Weiss SL, Becker LB (2016) Impairment of mitochondrial respiration following ex vivo cyanide exposure in peripheral blood mononuclear cells. Clin Toxicol (Phila) 54:303-7.
Jang 2016 J Intensive Care Med2016Jang DH, Greenwood JC, Spyres MB, Eckmann D (2016) Measurement of mitochondrial respiration and motility in acute care: sepsis, trauma, and poisoning. J Intensive Care Med 32:86-94.
Kilbaugh 2015 PLoS One2015Kilbaugh TJ, Lvova M, Karlsson M, Zhang Z, Leipzig J, Wallace DC, Margulies SS (2015) Peripheral blood mitochondrial DNA as a biomarker of cerebral mitochondrial dysfunction following traumatic brain injury in a porcine model. PLoS One 10:e0130927.
MiPNet19.06 IOC91 Philadelphia US2014-06-02
Philadelphia US, 2014 Jun 02-03. Oroboros O2k-Workshop on HRR and O2k-Fluorometry, IOC91. O2k-Network Lab »US PA Philadelphia Wallace DC.
Zhang 2013 PLoS One2013Zhang Z, Tsukikawa M, Peng M, Polyak E, Nakamaru-Ogiso E, Ostrovsky J, McCormack S, Place E, Clarke C, Reiner G, McCormick E, Rappaport E, Haas R, Baur JA, Falk MJ (2013) Primary respiratory chain disease causes tissue-specific dysregulation of the global transcriptome and nutrient-sensing signaling network. PLoS One 8:e69282.


update please

O2k-Workshop 2014 Philadelphia

O2k-Workshop IOC91
91st Workshop on High-Resolution Respirometry & O2k-Fluorometry
2014 June 2-3
Center for Mitochondrial and Epigenomic Medicine (CMEM)
The Children's Hospital of Philadelphia - Research Institute
Colket Translational Research Building
* More details: IOC91 Philadelphia

Visiting scientist in the Oroboros MitoFit Laboratory

David Jang: Visiting scientist at the Oroboros MitoFit Laboratory from June 15 to July 15 2016.
Meagan McManus: Visiting scientist at the Oroboros MitoFit Laboratory from September 14 to October 11 2015.