Dyscoupled respiration: Difference between revisions
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In addition to intrinsic uncoupling, dyscoupling occurs under pathological and toxicological conditions. Thus a distinction is made between physiological uncoupling and pathologically defective dyscoupling in mitochondrial respiration. | In addition to intrinsic uncoupling, dyscoupling occurs under pathological and toxicological conditions. Thus a distinction is made between physiological uncoupling and pathologically defective dyscoupling in mitochondrial respiration. | ||
|info=[[Gnaiger 2014 MitoPathways]] | |info=[[Gnaiger 2014 MitoPathways]] | ||
}} | }} | ||
{{MitoPedia concepts | {{MitoPedia concepts | ||
|mitopedia concept=Respiratory state | |mitopedia concept=Respiratory state | ||
}} | }} | ||
{{MitoPedia methods | {{MitoPedia methods | ||
|mitopedia method=Respirometry | |mitopedia method=Respirometry | ||
}} | }} | ||
{{MitoPedia O2k and high-resolution respirometry|type=Respiration | {{MitoPedia O2k and high-resolution respirometry|type=Respiration | ||
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{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=EAGLE | |mitopedia topic=EAGLE | ||
}} | }} | ||
Communicated by [[Gnaiger E]] 2010-10-19, edited 2012-10-31. | |||
== Coupling efficiency: from 0 to <1 == | == Coupling efficiency: from 0 to <1 == | ||
* ''More details:'' [[Uncoupler]] ♦ [[ETS coupling efficiency]] | * ''More details:'' [[Uncoupler]] ♦ [[ETS coupling efficiency]] |
Revision as of 18:12, 18 November 2016
Description
Dyscoupled respiration is LEAK respiration distinguished from intrinsically (physiologically) uncoupled and from extrinsic experimentally uncoupled respiration as an indication of extrinsic uncoupling (pathological, toxicological, pharmacological by agents that are not specifically applied to induce uncoupling, but are tested for their potential dyscoupling effect). Dyscoupling indicates a mitochondrial dysfunction.
In addition to intrinsic uncoupling, dyscoupling occurs under pathological and toxicological conditions. Thus a distinction is made between physiological uncoupling and pathologically defective dyscoupling in mitochondrial respiration.
Reference: Gnaiger 2014 MitoPathways
MitoPedia concepts:
Respiratory state
MitoPedia methods:
Respirometry
MitoPedia topics: EAGLE
Communicated by Gnaiger E 2010-10-19, edited 2012-10-31.
Coupling efficiency: from 0 to <1
- More details: Uncoupler ♦ ETS coupling efficiency