Acetyl-CoA: Difference between revisions
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{{MitoPedia | {{MitoPedia | ||
|description=[[File:Acetyl coenzyme A 700.png|left| | |description=[[File:Acetyl coenzyme A 700.png|left|200px|acetyl-CoA]]'''Acetyl-CoA''', C<sub>23</sub>H<sub>38</sub>N<sub>7</sub>O<sub>17</sub>P<sub>3</sub>S, is a central piece in metabolism involved in several biological processes, but its main role is to deliver the acetyl group into the [[TCA cycle]] for its oxidation. It can be synthesized in different pathways: (i) in glycolysis from [[pyruvate]], by pyruvate dehydrogenase, which also forms NADH; (ii) from fatty acids β-oxidation, which releases one acetyl-CoA each round; (iii) in the catabolism of some amino acids such as leucine, lysine, phenylalanine, tyrosine and tryptophan. | ||
<br>In the mitochondrial matrix, acetyl-CoA is condensed with [[oxaloacetate]] to form [[citrate]] through the action of [[citrate synthase]] in the [[tricarboxylic acid cycle]]. Acetyl-CoA cannot cross the mitochondrial inner membrane but citrate can be transported out of the mitochondria. In the cytosol, citrate can be converted to acetyl-CoA and be used in the synthesis of fatty acid, cholesterol, ketone bodies, acetylcholine, and other processes. | |||
|info=[[Gnaiger 2020 BEC MitoPathways]] | |||
}} | |||
Communicated by [[Cecatto Cristiane]] and [[Iglesias-Gonzalez Javier]] last update 2020-10-20 | |||
{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Substrate and metabolite | |mitopedia topic=Substrate and metabolite | ||
}} | |||
{{Labeling | |||
|additional=MitoPedia:FAT4BRAIN | |||
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Latest revision as of 10:17, 17 November 2022
Description
Acetyl-CoA, C23H38N7O17P3S, is a central piece in metabolism involved in several biological processes, but its main role is to deliver the acetyl group into the TCA cycle for its oxidation. It can be synthesized in different pathways: (i) in glycolysis from pyruvate, by pyruvate dehydrogenase, which also forms NADH; (ii) from fatty acids β-oxidation, which releases one acetyl-CoA each round; (iii) in the catabolism of some amino acids such as leucine, lysine, phenylalanine, tyrosine and tryptophan.
In the mitochondrial matrix, acetyl-CoA is condensed with oxaloacetate to form citrate through the action of citrate synthase in the tricarboxylic acid cycle. Acetyl-CoA cannot cross the mitochondrial inner membrane but citrate can be transported out of the mitochondria. In the cytosol, citrate can be converted to acetyl-CoA and be used in the synthesis of fatty acid, cholesterol, ketone bodies, acetylcholine, and other processes.
Reference: Gnaiger 2020 BEC MitoPathways
Communicated by Cecatto Cristiane and Iglesias-Gonzalez Javier last update 2020-10-20
MitoPedia topics:
Substrate and metabolite
Labels:
MitoPedia:FAT4BRAIN