Ambiguity crisis: Difference between revisions

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{{MitoPedia
|description=Is the '''ambiguity crisis''' a contemporary crisis comparable to the credibility or [[reproducibility crisis]]? The term 'crisis' is rooted etymologically in the Greek word ''krinein'': meaning to 'separate, decide, judge'. In this sense, science and communication in general are a continuous crisis at the edge of separating clarity or certainty from confusing double meaning, obscure 'alchemical' gibberish, or even fake-news. Reproducibility relates to the condition of repeating and confirming calculations or experiments presented in a published resource. While ambiguity is linked to relevant issues of reproducibility, it extends to the communications space of terminological and graphical representations of concepts. Type 1 ambiguities are the inevitable consequence of conceptual evolution, in the process of which ambiguities are replaced by experimentally and theoretically supported paradigm shifts to clear-cut theorems. In contrast, type 2 ambiguities are traced in publications that reflect merely a disregard and ignorance of established concepts without an attempt to justify the inherent deviations from high-quality science.
|description=Is the '''ambiguity crisis''' a contemporary crisis comparable to the credibility or [[reproducibility crisis]]? The term 'crisis' is rooted etymologically in the Greek word ''krinein'': meaning to 'separate, decide, judge'. In this sense, science and communication in general are a continuous crisis at the edge of separating clarity or certainty from confusing double meaning, obscure 'alchemical' gibberish, or even fake-news. Reproducibility relates to the condition of repeating and confirming calculations or experiments presented in a published resource. While ambiguity is linked to relevant issues of reproducibility, it extends to the communications space of terminological and graphical representations of concepts. Type 1 ambiguities are the inevitable consequence of conceptual evolution, in the process of which ambiguities are replaced by experimentally and theoretically supported paradigm shifts to clear-cut theorems. In contrast, type 2 ambiguities are traced in publications that reflect merely a disregard and ignorance of established concepts without an attempt to justify the inherent deviations from high-quality science. There are many shades of grey between these types of ambiguity.
|info=
|info=Gnaiger E (2023) Complex II ambiguities ― FADH2 in the electron transfer system. https://doi.org/10.26124/mitofit:2023-0003.v5
}}
}}



Revision as of 21:38, 7 June 2023


high-resolution terminology - matching measurements at high-resolution


Ambiguity crisis

Description

Is the ambiguity crisis a contemporary crisis comparable to the credibility or reproducibility crisis? The term 'crisis' is rooted etymologically in the Greek word krinein: meaning to 'separate, decide, judge'. In this sense, science and communication in general are a continuous crisis at the edge of separating clarity or certainty from confusing double meaning, obscure 'alchemical' gibberish, or even fake-news. Reproducibility relates to the condition of repeating and confirming calculations or experiments presented in a published resource. While ambiguity is linked to relevant issues of reproducibility, it extends to the communications space of terminological and graphical representations of concepts. Type 1 ambiguities are the inevitable consequence of conceptual evolution, in the process of which ambiguities are replaced by experimentally and theoretically supported paradigm shifts to clear-cut theorems. In contrast, type 2 ambiguities are traced in publications that reflect merely a disregard and ignorance of established concepts without an attempt to justify the inherent deviations from high-quality science. There are many shades of grey between these types of ambiguity.


Reference: Gnaiger E (2023) Complex II ambiguities ― FADH2 in the electron transfer system. https://doi.org/10.26124/mitofit:2023-0003.v5


References

Bioblast linkReferenceYear
Agarwal A, Ioannidis JPA (2019) PREDIMED trial of Mediterranean diet: retracted, republished, still trusted? BMJ 364:l341. https://doi.org/10.1136/bmj.l3412019
Azzi A (2022) Oxidative stress: What is it? Can it be measured? Where is it located? Can it be good or bad? Can it be prevented? Can it be cured? Antioxidants (Basel) 11:1431. https://doi.org/10.3390/antiox110814312022
Bik EM, Casadevall A, Fang FC (2016) The prevalence of inappropriate image duplication in biomedical research publications. mBio 7:e00809-16. https://doi.org/10.1128/mBio.00809-162016
Chance B, Williams GR (1955) Respiratory enzymes in oxidative phosphorylation: III. The steady state. J Biol Chem 217:409-27.1955
Donnelly C, Schmitt S, Cecatto C, Cardoso LHD, KomlΓ³di T, Place N, Kayser B, Gnaiger E (2022) The ABC of hypoxia – what is the norm. Bioenerg Commun 2022.12.v2. https://doi.org/10.26124/bec:2022-0012.v22022
Einstein A (1905) Über die von der molekularkinetischen Theorie der WÀrme geforderte Bewegung von in ruhenden Flüssigkeiten suspendierten Teilchen. Ann Physik 4, XVII:549-60.1905
Empson W (1930) Seven types of ambiguity. Chatto and Windus, London.1930
Fanelli D (2018) Opinion: Is science really facing a reproducibility crisis, and do we need it to?. Proc Natl Acad Sci U S A 115:2628-31. https://doi.org/10.1073/pnas.17082721142018
Gall T, Ioannidis JPA, Maniadis Z (2017) The credibility crisis in research: Can economics tools help? PLoS Biol 15:e2001846. https://doi.org/10.1371/journal.pbio.20018462017
Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-00022020
Gnaiger E (2023) Complex II ambiguities ― FADH2 in the electron transfer system. MitoFit Preprints 2023.3.v6. https://doi.org/10.26124/mitofit:2023-0003.v6 - Published 2023-11-22 J Biol Chem (2024)2023
Gnaiger E (2024) Addressing the ambiguity crisis in bioenergetics and thermodynamics. MitoFit Preprints 2024.3. https://doi.org/10.26124/mitofit:2024-00032024
Gnaiger E (2024) Complex II ambiguities ― FADH2 in the electron transfer system. J Biol Chem 300:105470. https://doi.org/10.1016/j.jbc.2023.1054702024
Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v12020
Gnaiger E, MΓ©ndez G, Hand SC (2000) High phosphorylation efficiency and depression of uncoupled respiration in mitochondria under hypoxia. Proc Natl Acad Sci U S A 97:11080-5. https://doi.org/10.1073/pnas.97.20.110802000
Grosholz Emily R (2007) Representation and productive ambiguity in mathematics and the sciences. Oxford Univ Press 312 pp.2007
Ioannidis JPA (2005) Why most published research findings are false. PLoS Med 2:e124. https://doi.org/10.1371/journal.pmed.00201242005
Ioannidis JPA (2014) How to make more published research true. PLOS Med 11:e1001747. https://doi.org/10.1371/journal.pmed.10017472014
Kane A, Amin B (2023) Amending the literature through version control. Biol Lett 19:20220463. https://doi.org/10.1098/rsbl.2022.04632023
Mitchell P (1966) Chemiosmotic coupling in oxidative and photosynthetic phosphorylation. Biochim Biophys Acta Bioenergetics 1807 (2011):1507-38. https://doi.org/10.1016/j.bbabio.2011.09.0181966
National Academies of Sciences, Engineering, and Medicine (2023) Navigating infodemics and building trust during public health emergencies: proceedings of a workshop in brief. National Academies Press, Washington, DC. https://doi.org/10.17226/271882023
National Academies of Sciences, Engineering, and Medicine (2017) Fostering integrity in research. National Academies Press, Washington, DC. https://doi.org/10.17226/218962017
Nernst W (1921) Studies in chemical thermodynamics. Nobel Lecture December 12, 1921:353-362.1921
Ossa-Richardson A (2019) A history of ambiguity. Princeton Univ Press https://doi.org/10.2307/j.ctv80cd3c.2019
Oza A (2023) AI beats human sleuth at finding problematic images in research papers. Nature 622:230. https://doi.org/10.1038/d41586-023-02920-y2023
Petersen OH (2019) Reproducibility - again. J Physiol 597:657-8. https://doi.org/10.1113/JP2774862019
Prigogine I (1967) Introduction to thermodynamics of irreversible processes. Interscience, New York, 3rd ed:147pp.1967
Rohrer JM, Tierney W, Uhlmann EL, DeBruine LM, Heyman T, Jones B, Schmukle SC, Silberzahn R, WillΓ©n RM, Carlsson R, Lucas RE, Strand J, Vazire S, Witt JK, Zentall TR, Chabris CF, Yarkoni T (2021) Putting the Self in self-correction: findings from the loss-of-confidence project. Perspect Psychol Sci 16:1255-69. https://doi.org/10.1177/17456916209641062021
Teixeira da Silva JA (2022) A synthesis of the formats for correcting erroneous and fraudulent academic literature, and associated challenges. J Gen Philos Sci 53:583-99. https://doi.org/10.1007/s10838-022-09607-42022
Van't Hoff JH (1901) Osmotic pressure and chemical equilibrium. Nobel Lecture December 13, 1901:5-10. https://www.nobelprize.org/prizes/chemistry/1901/hoff/lecture/1901
Verkhratsky A, Petersen OH (2023) How do we clean up the scientific record? Function (Oxf) 4:zqad055. https://doi.org/10.1093/function/zqad0552023


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