Difference between revisions of "Desler 2017 Abstract MITOEAGLE Barcelona"
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|title=[[File:MITOEAGLE-representation.jpg|left|60px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]] | |title=[[File:MITOEAGLE-representation.jpg|left|60px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]] | ||
Bioenergetic changes of differentiating human embryonic cells. | Bioenergetic changes of differentiating human embryonic cells. | ||
|info=[[ | |info=[[MitoEAGLE]] | ||
|authors=Desler C, | |authors=Desler C, Hopkinson BM, Kalisz M, Vestentoft PS, Bisgaard HC, Rasmussen LJ | ||
|year=2017 | |year=2017 | ||
|event= | |event=MitoEAGLE Barcelona 2017 | ||
|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]] | |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]] | ||
Mitochondrial dysfunction has been demonstrated to result in premature aging due to its effects on stem cells. Nevertheless, a full understanding of the role of mitochondrial bioenergetics through differentiation is still lacking. We show the bioenergetics profile of human stem cells of embryonic origin differentiating along the hepatic lineage. Our study reveals especially the transition between hepatic specification and hepatic maturation, as dependent of mitochondrial respiration and demonstrates that even though differentiating cells are primarily dependent on glycolysis until induction of hepatocyte maturation, oxidative phosphorylation is essential at all stages of differentiation. | Mitochondrial dysfunction has been demonstrated to result in premature aging due to its effects on stem cells. Nevertheless, a full understanding of the role of mitochondrial bioenergetics through differentiation is still lacking. We show the bioenergetics profile of human stem cells of embryonic origin differentiating along the hepatic lineage. Our study reveals especially the transition between hepatic specification and hepatic maturation, as dependent of mitochondrial respiration and demonstrates that even though differentiating cells are primarily dependent on glycolysis until induction of hepatocyte maturation, oxidative phosphorylation is essential at all stages of differentiation. | ||
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|area=Respiration | |area=Respiration | ||
|diseases=Aging;senescence | |diseases=Aging;senescence | ||
| | |organism=Human | ||
|tissues=Stem cells | |tissues=Liver, Stem cells | ||
|event=A4 | |||
|event= | |||
}} | }} | ||
== Affiliations == | == Affiliations == | ||
:::: Desler(1,2) , | :::: Desler C(1,2), Hopkinson BM(1), Kalisz M(3), Vestentoft PS(1), Bisgaard HC(1), Rasmussen LJ(1,2) | ||
::::# | ::::#Dept Cellular Molecular Med | ||
::::#Center | ::::#Center Healthy Aging | ||
::::# | ::::#Danish Stem Cell Center, Fac Health Sciences; Univ Copenhagen, Denmark | ||
Latest revision as of 14:34, 12 January 2018
 Bioenergetic changes of differentiating human embryonic cells. |
Link: MitoEAGLE
Desler C, Hopkinson BM, Kalisz M, Vestentoft PS, Bisgaard HC, Rasmussen LJ (2017)
Event: MitoEAGLE Barcelona 2017
Mitochondrial dysfunction has been demonstrated to result in premature aging due to its effects on stem cells. Nevertheless, a full understanding of the role of mitochondrial bioenergetics through differentiation is still lacking. We show the bioenergetics profile of human stem cells of embryonic origin differentiating along the hepatic lineage. Our study reveals especially the transition between hepatic specification and hepatic maturation, as dependent of mitochondrial respiration and demonstrates that even though differentiating cells are primarily dependent on glycolysis until induction of hepatocyte maturation, oxidative phosphorylation is essential at all stages of differentiation.
• Bioblast editor: Bitschnaub B
Labels: MiParea: Respiration Pathology: Aging;senescence
Organism: Human Tissue;cell: Liver, Stem cells
Event: A4
Affiliations
- Desler C(1,2), Hopkinson BM(1), Kalisz M(3), Vestentoft PS(1), Bisgaard HC(1), Rasmussen LJ(1,2)
- Dept Cellular Molecular Med
- Center Healthy Aging
- Danish Stem Cell Center, Fac Health Sciences; Univ Copenhagen, Denmark
