Desler 2017 Abstract MITOEAGLE Barcelona: Difference between revisions
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Bioenergetic changes of differentiating human embryonic cells. | Bioenergetic changes of differentiating human embryonic cells. | ||
|info=[[MITOEAGLE]] | |info=[[MITOEAGLE]] | ||
|authors=Desler C, M. Hopkinson B, Kalisz M , Siig Vestentoft P, Bisgaard HC, Juel Rasmussen L | |authors=Desler C, M. Hopkinson B, Kalisz M , Siig Vestentoft P, Bisgaard HC, Juel Rasmussen L | ||
|year=2017 | |year=2017 | ||
|event=MITOEAGLE Barcelona 2017 | |event=MITOEAGLE Barcelona 2017 | ||
|abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]] | |abstract=[[Image:MITOEAGLE-logo.jpg|left|100px|link=http://www.mitoglobal.org/index.php/MITOEAGLE|COST Action MITOEAGLE]] | ||
Mitochondrial dysfunction has been demonstrated to result in premature aging due to its effects on stem cells. Nevertheless, a full understanding of the role of mitochondrial bioenergetics through differentiation is still lacking. We show the bioenergetics profile of human stem cells of embryonic origin differentiating along the hepatic lineage. Our study reveals especially the transition between hepatic specification and hepatic maturation, as dependent of mitochondrial respiration and demonstrates that even though differentiating cells are primarily dependent on glycolysis until induction of hepatocyte maturation, oxidative phosphorylation is essential at all stages of differentiation. | Mitochondrial dysfunction has been demonstrated to result in premature aging due to its effects on stem cells. Nevertheless, a full understanding of the role of mitochondrial bioenergetics through differentiation is still lacking. We show the bioenergetics profile of human stem cells of embryonic origin differentiating along the hepatic lineage. Our study reveals especially the transition between hepatic specification and hepatic maturation, as dependent of mitochondrial respiration and demonstrates that even though differentiating cells are primarily dependent on glycolysis until induction of hepatocyte maturation, oxidative phosphorylation is essential at all stages of differentiation. | ||
|editor=[[Bitschnaub B]], | |editor=[[Bitschnaub B]], | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|area= | |area=Respiration | ||
|diseases=Aging;senescence | |diseases=Aging;senescence | ||
|injuries=Oxidative stress;RONS | |injuries=Oxidative stress;RONS | ||
|tissues=Stem cells | |||
|tissues= | |topics=Aerobic glycolysis | ||
| | |||
|event=A3 | |event=A3 | ||
}} | }} | ||
== Affiliations == | == Affiliations == | ||
:::: Desler(1,2) , M. Hopkinson(1), Kalisz(3) , Siig Vestentoft(1) , Bisgaard(1), Juel Rasmussen(1,2) | :::: Desler(1,2) , M. Hopkinson(1), Kalisz(3) , Siig Vestentoft(1) , Bisgaard(1), Juel Rasmussen(1,2) | ||
Revision as of 11:05, 6 March 2017
 Bioenergetic changes of differentiating human embryonic cells. |
Link: MITOEAGLE
Desler C, M. Hopkinson B, Kalisz M, Siig Vestentoft P, Bisgaard HC, Juel Rasmussen L (2017)
Event: MITOEAGLE Barcelona 2017
Mitochondrial dysfunction has been demonstrated to result in premature aging due to its effects on stem cells. Nevertheless, a full understanding of the role of mitochondrial bioenergetics through differentiation is still lacking. We show the bioenergetics profile of human stem cells of embryonic origin differentiating along the hepatic lineage. Our study reveals especially the transition between hepatic specification and hepatic maturation, as dependent of mitochondrial respiration and demonstrates that even though differentiating cells are primarily dependent on glycolysis until induction of hepatocyte maturation, oxidative phosphorylation is essential at all stages of differentiation.
• Bioblast editor: Bitschnaub B
Labels: MiParea: Respiration Pathology: Aging;senescence Stress:Oxidative stress;RONS
Tissue;cell: Stem cells
Regulation: Aerobic glycolysis
Event: A3
Affiliations
- Desler(1,2) , M. Hopkinson(1), Kalisz(3) , Siig Vestentoft(1) , Bisgaard(1), Juel Rasmussen(1,2)
- Department of Cellular and Molecular Medicine, University of Copenhagen, Denmark
- Center for Healthy Aging, University of Copenhagen, Denmark
- The Danish Stem Cell Center, Faculty of Health Sciences, University of Copenhagen, Denmark
