Gnaiger 2015 Scand J Med Sci Sports
Gnaiger E, Boushel R, Sรธndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Dรญez-Sรกnchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JAL, Christiansen M, Helge JW, Saltin B (2015) Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and caucasians in the arctic winter. Scand J Med Sci Sports 25 (Suppl 4):126โ34. |
Gnaiger E, Boushel R, Sรธndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Dรญez-Sรกnchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet JA, Christiansen M, Helge JW, Saltin B (2015) Scand J Med Sci Sports
Abstract: During evolution, mtDNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fibre type and uncoupling protein-3 content. Mitochondrial phenotype displayed plasticity in relation to lifestyle and environment. Untrained Inuit and Danes had identical capacities to oxidize fat substrate in arm muscle, which increased in Danes during the 42 days of acclimation to exercise, approaching the higher level of the Inuit hunters. A common pattern emerges of mitochondrial acclimatization and evolutionary adaptation in humans at high latitude and high altitude where economy of locomotion may be optimized by preservation of biochemical coupling efficiency at modest mitochondrial density, when submaximum performance is uncoupled from VO2 and maximum capacities of oxidative phosphorylation.
โข O2k-Network Lab: AT Innsbruck Gnaiger E, AT Innsbruck OROBOROS, CA Vancouver Boushel RC, NL Maastricht Schrauwen P
Labels: MiParea: Respiration, mt-Biogenesis;mt-density, mtDNA;mt-genetics, Comparative MiP;environmental MiP, Gender, Exercise physiology;nutrition;life style
Stress:Temperature Organism: Human Tissue;cell: Skeletal muscle Preparation: Permeabilized tissue Enzyme: Marker enzyme, TCA cycle and matrix dehydrogenases Regulation: Coupling efficiency;uncoupling, Cyt c Coupling state: LEAK, OXPHOS, ETS"ETS" is not in the list (LEAK, ROUTINE, OXPHOS, ET) of allowed values for the "Coupling states" property.
HRR: Oxygraph-2k
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