Gnaiger 2018 MiPschool Tromso A2
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Link: MitoEAGLE
Gnaiger E (2018)
Event: MiPschool Tromso-Bergen 2018
Peter Mitchell's protonmotive force is one of the most fundamental concepts in biology [1]. The catabolic reactions of mitochondrial electron transfer (ET) are coupled to vectorial translocation of protons at three coupling sites, which are the proton pumps of the ET system, the respiratory Complexes CI, CIII, and CIV. The driving force of the ET system in the catabolic (k) reaction expressed as OO2 consumption is the Gibbs force of reaction, ΔkFO2, which is typically in the range of -460 to -480 kJ/mol (1.2 V). This is an isomorphic force, also known as a generalized force (the negative affinity of chemical reactions) in nonequilibrium thermodynamics. Confusion is caused by the failure of terminological distinction between Gibbs energy change of reaction, ΔrG [J], and Gibbs force equal to the partial Gibbs energy change per advancement of reaction [2]. For the protonmotive force the proton is the motive entity, which can be expressed in a variety of formats with different motive units, MU.
Work in progress
• Keywords: Force, Protonmotive force • Bioblast editor: Gnaiger E
Labels: MiParea: Respiration
Regulation: mt-Membrane potential
HRR: Theory
Event: A4, Oral
Affiliations and support
- D. Swarovski Research Lab, Dept. Visceral, Transplant Thoracic Surgery, Medical Univ Innsbruck
- Oroboros Instruments, Innsbruck, Austria
- Contribution to COST Action CA15203 MitoEAGLE, supported by COST (European Cooperation in Science and Technology), and K-Regio project MitoFit.
References
- MitoEAGLE preprint 2018-09-04(41) Mitochondrial respiratory states and rates: Building blocks of mitochondrial physiology Part 1. - www.mitoeagle.org/index.php/MitoEAGLE_preprint_2018-02-08
- Gnaiger E (2018) Gibbs energy or Gibbs force? Mitochondr Physiol Network 2018-08-07. - »Bioblast link«
