Difference between revisions of "Huetter 2002 Mol Biol Rep"
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|topics=Oxygen kinetics | |topics=Oxygen kinetics | ||
|couplingstates=ROUTINE | |couplingstates=ROUTINE | ||
| | |pathways=ROX | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|discipline=Mitochondrial Physiology | |discipline=Mitochondrial Physiology | ||
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Revision as of 10:38, 8 November 2016
Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Mol Biol Rep 29:83-7. |
Huetter E, Renner K, Jansen-Duerr P, Gnaiger E (2002) Mol Biol Rep
Abstract: Oxygen kinetics in fibroblasts was biphasic. This was quantitatively explained by a major mitochondrial hyperbolic component in the low-oxygen range and a linear increase of rotenone- and antimycin A- inhibited oxygen consumption in the high-oxygen range. This suggest an increased production of reactive oxygen species and oxidative stress at elevated, air-level oxygen concentrations. The high oxygen activity of mitochondrial respiration provides the basis for the maintenance of a high aerobic scope at physiological low-oxygen levels, whereas further pronounced depression induces energetic stress under hypoxia.
• O2k-Network Lab: AT Innsbruck Gnaiger E, AT Innsbruck Jansen-Duerr P, AT Innsbruck OROBOROS
Labels: MiParea: Respiration
Organism: Human
Preparation: Intact cells
Regulation: Oxygen kinetics Coupling state: ROUTINE Pathway: ROX HRR: Oxygraph-2k