Difference between revisions of "Huetter 2002 Mol Biol Rep"
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|area=Respiration | |area=Respiration | ||
|organism=Human | |organism=Human | ||
| | |tissues=Fibroblast | ||
|preparations=Intact cells | |preparations=Intact cells | ||
|topics=Oxygen kinetics | |topics=Oxygen kinetics | ||
Revision as of 15:35, 9 November 2016
| Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Mol Biol Rep 29:83-7. |
Huetter E, Renner K, Jansen-Duerr P, Gnaiger E (2002) Mol Biol Rep
Abstract: Oxygen kinetics in fibroblasts was biphasic. This was quantitatively explained by a major mitochondrial hyperbolic component in the low-oxygen range and a linear increase of rotenone- and antimycin A- inhibited oxygen consumption in the high-oxygen range. This suggest an increased production of reactive oxygen species and oxidative stress at elevated, air-level oxygen concentrations. The high oxygen activity of mitochondrial respiration provides the basis for the maintenance of a high aerobic scope at physiological low-oxygen levels, whereas further pronounced depression induces energetic stress under hypoxia.
• O2k-Network Lab: AT Innsbruck Gnaiger E, AT Innsbruck Jansen-Duerr P, AT Innsbruck OROBOROS
Labels: MiParea: Respiration
Organism: Human
Tissue;cell: Fibroblast
Preparation: Intact cells
Regulation: Oxygen kinetics Coupling state: ROUTINE Pathway: ROX HRR: Oxygraph-2k
