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Difference between revisions of "Huetter 2002 Mol Biol Rep"

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{{Publication
{{Publication
|title=Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Molec. Biol. Rep. 29: 83-87.
|title=Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Mol Biol Rep 29:83-7.
|info=[http://www.ncbi.nlm.nih.gov/pubmed/12241081 PMID: 12241081]
|info=[http://www.ncbi.nlm.nih.gov/pubmed/12241081 PMID: 12241081]
|authors=Huetter E, Renner K, Jansen Duerr P, Gnaiger E
|authors=Huetter E, Renner K, Jansen-Duerr P, Gnaiger Erich
|year=2002
|year=2002
|journal=Molec. Biol. Rep.
|journal=Mol Biol Rep
|abstract=Oxygen kinetics in fibroblasts was biphasic. This was quantitatively explained by a major mitochondrial hyperbolic component in the low-oxygen range and a linear increase of rotenone- and antimycin A- inhibited oxygen consumption in the high-oxygen range. This suggest an i9ncreased production of reactive oxygen species and oxidative stress at elevated, air-level oxygen concentrations. The high oxygen activity of mitochondrial respiration provides the basis for the maintenance of a high aerobic scope at physiological low-oxygen levels, whereas further pronounced depression induces energetic stress under hypoxia.
|abstract=Oxygen kinetics in fibroblasts was biphasic. This was quantitatively explained by a major mitochondrial hyperbolic component in the low-oxygen range and a linear increase of rotenone- and antimycin A- inhibited oxygen consumption in the high-oxygen range. This suggest an increased production of reactive oxygen species and oxidative stress at elevated, air-level oxygen concentrations. The high oxygen activity of mitochondrial respiration provides the basis for the maintenance of a high aerobic scope at physiological low-oxygen levels, whereas further pronounced depression induces energetic stress under hypoxia.
|mipnetlab=AT_Innsbruck_Gnaiger E, AT_Innsbruck_Jansen Duerr P
|mipnetlab=AT Innsbruck Gnaiger E, AT Innsbruck Jansen-Duerr P, AT Innsbruck Oroboros , DE Regensburg Renner-Sattler K
|discipline=Mitochondrial Physiology
}}
}}
== Cited by ==
::* 8 articles in PubMed (2024-01-11) https://pubmed.ncbi.nlm.nih.gov/12241081/
{{Template:Cited by Komlodi 2021 MitoFit AmR}}
{{Labeling
{{Labeling
|instruments=Oxygraph-2k
|area=Respiration
|injuries=Hypoxia
|organism=Human
|organism=Human
|tissues=Fibroblast
|tissues=Fibroblast
|preparations=Intact Cell; Cultured; Primary
|preparations=Intact cells
|kinetics=Oxygen
|topics=Oxygen kinetics
|topics=Respiration; OXPHOS; ETS Capacity
|couplingstates=ROUTINE
|discipline=Mitochondrial Physiology
|pathways=ROX
|instruments=Oxygraph-2k
|additional=MitoFit 2021 AmR
}}
}}

Latest revision as of 08:12, 11 January 2024

Publications in the MiPMap
Hütter E, Renner K, Jansen-Dürr P, Gnaiger E (2002) Biphasic oxygen kinetics of cellular respiration and linear oxygen dependence of antimycin A inhibited oxygen consumption. Mol Biol Rep 29:83-7.

» PMID: 12241081

Huetter E, Renner K, Jansen-Duerr P, Gnaiger Erich (2002) Mol Biol Rep

Abstract: Oxygen kinetics in fibroblasts was biphasic. This was quantitatively explained by a major mitochondrial hyperbolic component in the low-oxygen range and a linear increase of rotenone- and antimycin A- inhibited oxygen consumption in the high-oxygen range. This suggest an increased production of reactive oxygen species and oxidative stress at elevated, air-level oxygen concentrations. The high oxygen activity of mitochondrial respiration provides the basis for the maintenance of a high aerobic scope at physiological low-oxygen levels, whereas further pronounced depression induces energetic stress under hypoxia.


O2k-Network Lab: AT Innsbruck Gnaiger E, AT Innsbruck Jansen-Duerr P, AT Innsbruck Oroboros, DE Regensburg Renner-Sattler K

Cited by

  • Komlódi T, Schmitt S, Zdrazilova L, Donnelly C, Zischka H, Gnaiger E. Oxygen dependence of hydrogen peroxide production in isolated mitochondria and permeabilized cells. MitoFit Preprints (in prep).

Labels: MiParea: Respiration 


Organism: Human  Tissue;cell: Fibroblast  Preparation: Intact cells 

Regulation: Oxygen kinetics  Coupling state: ROUTINE  Pathway: ROX  HRR: Oxygraph-2k 

MitoFit 2021 AmR