Inoue 2023 Sci Rep: Difference between revisions
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|year=2023 | |year=2023 | ||
|journal=Sci Rep | |journal=Sci Rep | ||
|abstract=Physiological aging causes motor function decline and anatomical and biochemical changes in the motor cortex. We confirmed that middle-aged mice at 15-18 months old show motor function decline, which can be restored to the young adult level by supplementing with mitochondrial electron transporter coenzyme | |abstract=Physiological aging causes motor function decline and anatomical and biochemical changes in the motor cortex. We confirmed that middle-aged mice at 15-18 months old show motor function decline, which can be restored to the young adult level by supplementing with mitochondrial electron transporter coenzyme Q<sub>10</sub> (CoQ<sub>10</sub>) as a water-soluble nanoformula by drinking water for 1 week. CoQ<sub>10</sub> supplementation concurrently improved brain mitochondrial respiration but not muscle strength. Notably, we identified an age-related decline in field excitatory postsynaptic potential (fEPSP) amplitude in the pathway from layers II/III to V of the primary motor area of middle-aged mice, which was restored to the young adult level by supplementing with CoQ<sub>10</sub> for 1 week but not by administering CoQ<sub>10</sub> acutely to brain slices. Interestingly, CoQ<sub>10</sub> with high-frequency stimulation induced NMDA receptor-dependent long-term potentiation (LTP) in layer V of the primary motor cortex of middle-aged mice. Importantly, the fEPSP amplitude showed a larger inputβoutput relationship after CoQ<sub>10</sub>-dependent LTP expression. These data suggest that CoQ<sub>10</sub> restores the motor function of middle-aged mice by improving brain mitochondrial function and the basal fEPSP level of the motor cortex, potentially by enhancing synaptic plasticity efficacy. Thus, CoQ<sub>10</sub> supplementation may ameliorate the age-related decline in motor function in humans. | ||
|editor=[[Plangger M]] | |editor=[[Plangger M]] | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|area=Respiration | |area=Respiration, Pharmacology;toxicology | ||
|diseases=Aging;senescence | |||
|tissues=Nervous system | |||
|preparations=Isolated mitochondria | |||
|couplingstates=OXPHOS | |||
|pathways=N | |||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional=2023-03 | |additional=2023-03 | ||
}} | }} |
Latest revision as of 17:06, 21 March 2023
Inoue R, Miura M, Yanai S, Nishimune H (2023) Coenzyme Q10 supplementation improves the motor function of middle-aged mice by restoring the neuronal activity of the motor cortex. https://doi.org/10.1038/s41598-023-31510-1 |
Β» Sci Rep 13:4323. PMID: 36922562 Open Access
Inoue Ritsuko, Miura Masami, Yanai Shuichi, Nishimune Hiroshi (2023) Sci Rep
Abstract: Physiological aging causes motor function decline and anatomical and biochemical changes in the motor cortex. We confirmed that middle-aged mice at 15-18 months old show motor function decline, which can be restored to the young adult level by supplementing with mitochondrial electron transporter coenzyme Q10 (CoQ10) as a water-soluble nanoformula by drinking water for 1 week. CoQ10 supplementation concurrently improved brain mitochondrial respiration but not muscle strength. Notably, we identified an age-related decline in field excitatory postsynaptic potential (fEPSP) amplitude in the pathway from layers II/III to V of the primary motor area of middle-aged mice, which was restored to the young adult level by supplementing with CoQ10 for 1 week but not by administering CoQ10 acutely to brain slices. Interestingly, CoQ10 with high-frequency stimulation induced NMDA receptor-dependent long-term potentiation (LTP) in layer V of the primary motor cortex of middle-aged mice. Importantly, the fEPSP amplitude showed a larger inputβoutput relationship after CoQ10-dependent LTP expression. These data suggest that CoQ10 restores the motor function of middle-aged mice by improving brain mitochondrial function and the basal fEPSP level of the motor cortex, potentially by enhancing synaptic plasticity efficacy. Thus, CoQ10 supplementation may ameliorate the age-related decline in motor function in humans.
β’ Bioblast editor: Plangger M
Labels: MiParea: Respiration, Pharmacology;toxicology
Pathology: Aging;senescence
Tissue;cell: Nervous system
Preparation: Isolated mitochondria
Coupling state: OXPHOS
Pathway: N
HRR: Oxygraph-2k
2023-03