MiPschool Obergurgl 2017

MiPschool Obergurgl 2017

Obergurgl AT, 2017 Jul 23-30. 10th MiPschool 2017 MITOEAGLE Science Camp

Mitochondrial Physiology Society (2017-07-23) MitoGlobal

Abstract: 2017 Jul 23-30, Obergurgl, AT.

Date, venue, organization

• 2017 July 23-30
• University Centre Obergurgl, Tyrol, Austria
• Training School jointly organized by the Mitochondrial Physiology Society and COST Action MITOEAGLE

Programme

Programme structure

• 2017-07-23, Day 1: Arrival MiPschool
• 2017-07-24 to 26, Day 2-4: Training school MiPsociety and MITOEAGLE
  • Day 2-3: Intoductory lectures on the mitochondrial electron transfer system (ETS), coupling of electron transfer to proton translocation and phosphorylation (OXPHOS), mitochondrial pathways, respiratory protocols for diagnosis of mitochondrial function, mitochondrial respiratory control in health and disease.
  • Day 4: Scientific lectures and student presentations
• 2017-07-27, Day 5: Departure MiPschool, arrival MITOEAGLE workshop, relaxing day for overall-participants
• 2017-07-28 to 29, Day 6-7: MITOEAGLE Workshop: WG1-4
  • WG1: Harmonization of nomenclature on mitochondrial respiratory states and control parameters: Status of the consensus paper on a consistent terminology on mitochondrial physiology and bioenergetics; recommendations for the use of a common terminology in mitochondrial physiological research as a milestone towards unification of concepts and nomenclature.
  • WG1: Respirometric reference protocols: (i) Standard format for presenting substrate-uncoupler-inhibitor titration (SUIT) protocols for a ‘library of protocols’ applied in mitochondrial respiratory physiology; (ii) criteria for selecting and recommending reference protocols; (iii) documentation of the state-of-the-art standards in designing, conducting, reporting, interpreting, and validating SUIT protocols (compare: Maelstrom Research program).
  • WG2-4: Data repositories
• 2017-07-30, Day 8: Departure MITOEAGLE

Preliminary programme MiPschool

This MiPschool will focus on basic concepts on mitochondrial respiratory states and applications of substrate-uncoupler-inhibitor titration (SUIT) protocols.

• • • • 2017-07-24

Session A (morning) Introduction: coupling control in oxidative phosphorylation

• A1. The electron transfer system – mitochondrial pathways from fuel substrates to oxygen.
• A2. Coupling of the phosphorylation system to electron transfer and respiratory coupling control.
• A3. From Einstein's diffusion equation to Mitchell’s chemiosmotic equation: rates and states in the bioenergetics of oxidative phosphorylation.
• A4. Measurement of coupling in intact cells and mitochondrial preparations: biochemical coupling efficiency and ATP/O2 ratios.

Session B (afternoon) Posters and selected abstracts

• B1. Poster session.
• B2: Selected abstracts: measurement of coupling control in intact cells and mitochondrial preparations - open discussion.
• B3. Towards a data base on coupling control in intact cells.

• • • • 2017-07-25

Session C (morning) Introduction: from experimental design to data analysis

• C1. Respiratory pathway control in mitochondrial preparations.
• C2. Substrate-uncoupler-inhibitor titration (SUIT) protocols – fundamental principles.
• C3. Normalization of respiratory flux and flow.
• C4. Respiratory control ratios and control factors.

Session D (afternoon) Posters and selected abstracts

• D1. Selected abstracts: applications of SUIT protocols – open discussion.
• D2. SUIT protocols: design and limitations.
• D3. Towards a data base on mitochondrial respiratory control: diagnostic approaches and comparative mitochondrial physiology.

• • • • 2017-07-26

Session E (morning) Mitochondrial physiology: biomedical applications (possible titles, depending on keynote lecturers/selected abstracts)

• E1. The challenges of functional mitochondrial diagnosis.
• E2. Mitochondrial fitness in human skeletal muscle.
• E3. Scope and limitations of functional mitochondrial diagnosis in blood cells.
• E4. Mitochondrial respiratory function and neuromuscular disease.
• E5. Mitochondrial function and dysfunction in cancer.
• E6. Ischemia-reperfusion injury.
• E7. The metabolic syndrome.

Session F (afternoon) Comparative mitochondrial physiology (possible titles, depending on keynote lecturers/selected abstracts)

• F1. Mitochondrial physiology in cell models versus primary tissue.
• F2. Mitochondrial physiology studies in mouse models.
• F3. Mitochondrial vertrebrate physiology – extreme performers.
• F5. Mitochondrial physiology of and beyond established animal models.
• F6. Mitochondrial physiology in plants and microbes.
• F7. Mitochondrial physiology and evolution.

Session G (evening) MITOEAGLE Early Career Investigators forum

• MITOEAGLE Early Career Investigators

Abstracts

• Categories: Early career investigators (ECI) and students are invited to submit abstracts in four alternative categories:

1. SUIT protocols: basic concepts. - » MitoPedia: SUIT
2. SUIT protocols: various applications with intact cells and mt-preparations.
3. Discuss definitions and controversies for a selected term on respiratory states and respiratory control ratios. - » MitoPedia: Respiratory states, MitoPedia: Respiratory control ratios
4. Present your abstract as a definition of a term in the context of mitochondrial physiology that is missing in MitoPedia. - » MitoPedia

• Format

Doerrier 2017 Abstract MITOEAGLE Barcelona

Template 2017 Abstract MiPschool Obergurgl

• Abstract submission and review

1. Proposed submission deadline: 2017-May-15.
2. Eligibility: Early career investigatrs and students from all COST countries and International Partner Countries can apply - MITOEAGLE network.
3. Check the MITOEAGLE member website (MITOEAGLE network), and select a 'Mentor'. Click on the highlighted name of the mentor for further details.
4. Check the section MITOEAGLE mentor. There may be information that the mentor is fully booked.
5. If the mentor has open slots, add the name of your selected mentor as a final section of your abstract.
6. Send an Email with the word file of your abstract in the attachment to your mentor. Mention MITOEAGLE mentor in the subject line of your Email. Provide a brief explanation to your selected mentor in the form of a cover letter.
7. Send your Email in Cc to [email protected]
8. Your mentor will act as the contact to review your abstract and recommend you as a recepient of the MITOEAGLE scholarship.
9. Experimental abstracts will be reviewed and accepted entirely independent of the experimental platform used in the study, and a wide variety of experimental approaches is highly welcome.

Support

MITOEAGLE scholarships for Early Career Investigators and students

• Submitted abstracts provide the basis for allocation of MITOEAGLE scholarships.
• Proposed deadline: 2017-May-15.
• 42 basic scholarships will cover the local costs (accommodation, meals and registration).
• Students from Inclusiveness Target Countries are eligible for extended scholarships covering travel costs in addition to the basic scholarship.
• Abstracts submitted with data suitable for the data bases or Working Groups 2, 3 and 4 are selected as a basis of additional support for joining the Working Group meeting.
• MITOEAGLE Working Group participants are supported (as far as possible) to join the MiPschool to be better prepared for the collaboration in the WG meeting, particularly the group working on the terminology review on respiratory states.

» For further questions, please contact the MITOEAGLE representatives of the training schools:

Uwe Schlattner

Ayse Basak Engin

» Further details on mentorship: consult MITOEAGLE Early Career Investigators

» List of MITOEAGLE mentors

Funding

• COST Action CA15203 Mitochondrial fitness mapping - MITOEAGLE

The project MitoFit is funded by the Land Tirol within the program K-Regio of Standortagentur Tirol.

Listed under MitoGlobal Events.

Labels:

2017, ORO, MitoFit, MITOEAGLE, Next