Difference between revisions of "O2k-Publications: Cancer"
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Year | Reference | Tissue and cell | Cell line | Mammal and model | Regulation;kinetics | |
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Torcasio 2024 J Transl Med | 2024 | Torcasio R, Gallo Cantafio ME, Veneziano C, De Marco C, Ganino L, Valentino I, Occhiuzzi MA, Perrotta ID, Mancuso T, Conforti F, Rizzuti B, Martino EA, Gentile M, Neri A, Viglietto G, Grande F, Amodio N (2024) Targeting of mitochondrial fission through natural flavanones elicits anti-myeloma activity. J Transl Med 22:208. https://doi.org/10.1186/s12967-024-05013-0 | Blood cells | Human | ||
Antona 2023 Cell Death Discov | 2023 | Antona A, Leo G, Favero F, Varalda M, Venetucci J, Faletti S, Todaro M, Mazzucco E, Soligo E, Saglietti C, Stassi G, Manfredi M, Pelicci G, CorĂ D, Valente G, Capello D (2023) Targeting lysine-specific demethylase 1 (KDM1A/LSD1) impairs colorectal cancer tumorigenesis by affecting cancer cells stemness, motility, and differentiation. https://doi.org/10.1038/s41420-023-01502-1 | Endothelial;epithelial;mesothelial cell | Human | ||
Yang 2023 Redox Biol | 2023 | Yang X, Gu C, Cai J, Li F, He X, Luo L, Xiao W, Hu B, Hu J, Qian H, Ren S, Zhang L, Zhu X, Yang L, Yang J, Yang Z, Zheng Y, Huang X, Wang Z (2023) Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis. https://doi.org/10.1016/j.redox.2023.103002 | Liver | Human | ||
Ren 2023 Cell Discov | 2023 | Ren X, Yan J, Zhao Q, Bao X, Han X, Zheng C, Zhou Y, Chen L, Wang B, Yang L, Lin X, Liu D, Lin Y, Li M, Fang H, Lu Z, Lyu J (2023) The Fe-S cluster assembly protein IscU2 increases α-ketoglutarate catabolism and DNA 5mC to promote tumor growth. https://doi.org/10.1038/s41421-023-00558-8 | Islet cell;pancreas;thymus | Human | ||
Mendoza-Fuentes 2023 PeerJ | 2023 | Mendoza-Fuentes A, GonzĂĄlez-Burgos E, Aparicio Trejo OE, Delgado-Lamas G, RodrĂguez-ChĂĄvez JL, Pedraza-Chaverri J, GĂłmez-Serranillos MP, Araiza-Olivera D (2023) The cytotoxicity effect of 7-hydroxy-3,4-dihydrocadalene from Heterotheca inuloides and semisynthetic cadalenes derivates towards breast cancer cells: involvement of oxidative stress-mediated apoptosis. https://doi.org/10.7717/peerj.15586 | Human | |||
Yang 2023 Cell Death Discov | 2023 | Yang H, Gao Y, Xu D, Xu K, Liang SQ, Yang Z, Scherz A, Hall SRR, Forster S, Berezowska S, Yao F, Ochsenbein AF, Marti TM, Kocher GJ, Schmid RA, Dorn P, Peng RW (2023) MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma. https://doi.org/10.1038/s41420-023-01307-2 | Lung;gill Endothelial;epithelial;mesothelial cell | Human | ||
Martell 2023 Acta Neuropathol Commun | 2023 | Martell E, Kuzmychova H, Senthil H, Kaul E, Chokshi CR, Venugopal C, Anderson CM, Singh SK, Sharif T (2023) Compensatory cross-talk between autophagy and glycolysis regulates senescence and stemness in heterogeneous glioblastoma tumor subpopulations. https://doi.org/10.1186/s40478-023-01604-y | Nervous system | Human | Aerobic glycolysis | |
Martell 2023 Nat Commun | 2023 | Martell E, Kuzmychova H, Kaul E, Senthil H, Chowdhury SR, Morrison LC, Fresnoza A, Zagozewski J, Venugopal C, Anderson CM, Singh SK, Banerji V, Werbowetski-Ogilvie TE, Sharif T (2023) Metabolism-based targeting of MYC via MPC-SOD2 axis-mediated oxidation promotes cellular differentiation in group 3 medulloblastoma. https://doi.org/10.1038/s41467-023-38049-9 | Nervous system | Human | ||
Mioc 2023 Molecules | 2023 | Mioc M, Mioc A, Racoviceanu R, Ghiulai R, Prodea A, Milan A, Barbu Tudoran L, Oprean C, Ivan V, Èoica C (2023) The antimelanoma biological assessment of triterpenic acid functionalized gold nanoparticles. https://doi.org/10.3390/molecules28010421 | Endothelial;epithelial;mesothelial cell | Human | ||
Boykov 2023 Sci Rep | 2023 | Boykov IN, Montgomery MM, Hagen JT, Aruleba RT, McLaughlin KL, Coalson HS, Nelson MA, Pereyra AS, Ellis JM, Zeczycki TN, Vohra NA, Tan SF, Cabot MC, Fisher-Wellman KH (2023) Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across cancer types. https://doi.org/10.1038/s41598-023-43963-5 | Heart Endothelial;epithelial;mesothelial cell | Mouse | ||
Peixoto 2023 J Physiol Biochem | 2023 | Peixoto ĂS, Moreno MF, Castro Ă, Perandini LA, Belchior T, Oliveira TE, Vieira TS, Gilio GR, Tomazelli CA, Leonardi BF, Ortiz-Silva M, Silva Junior LP, Moretti EH, Steiner AA, Festuccia WT (2023) Hepatocellular carcinoma induced by hepatocyte Pten deletion reduces BAT UCP-1 and thermogenic capacity in mice, despite increasing serum FGF-21 and iWAT browning. https://doi.org/10.1007/s13105-023-00970-4 | Liver Fat | Mouse | ||
Cruz-Gregorio 2023 Phytother Res | 2023 | Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Medina-Campos ON, Sciutto E, Fragoso G, Pedraza-Chaverri J (2023) α-Mangostin induces oxidative damage, mitochondrial dysfunction, and apoptosis in a triple-negative breast cancer model. https://doi.org/10.1002/ptr.7812 | Endothelial;epithelial;mesothelial cell | Mouse | ||
Liu 2023 Pharmacol Res | 2023 | Liu S, Yue S, Guo Y, Han JY, Wang H (2023) Sorafenib induces cardiotoxicity through RBM20-mediated alternative splicing of sarcomeric and mitochondrial genes. https://doi.org/10.1016/j.phrs.2023.107017 | Heart | Rat | ||
Fisher-Wellman 2023 Cancers (Basel) | 2023 | Fisher-Wellman KH, Kassai M, Hagen JT, Neufer PD, Kester M, Loughran TP Jr, Chalfant CE, Feith DJ, Tan SF, Fox TE, Ung J, Fabrias G, Abad JL, Sharma A, Golla U, Claxton DF, Shaw JJP, Bhowmick D, Cabot MC (2023) Simultaneous inhibition of ceramide hydrolysis and glycosylation synergizes to corrupt mitochondrial respiration and signal caspase driven cell death in drug-resistant acute myeloid leukemia. https://doi.org/10.3390/cancers15061883 | Blood cells | Human | ||
Clemente 2023 Commun Biol | 2023 | Clemente N, Baroni S, Fiorilla S, Tasso F, Reano S, Borsotti C, Ruggiero MR, Alchera E, Corrazzari M, Walker G, Follenzi A, Crich SG, Carini R (2023) Boosting intracellular sodium selectively kills hepatocarcinoma cells and induces hepatocellular carcinoma tumor shrinkage in mice. https://doi.org/10.1038/s42003-023-04946-4 | Liver | Human | ||
Mahmoud 2023 Pharmacol Res | 2023 | Mahmoud AM, Kostrzewa M, Marolda V, Cerasuolo M, Maccarinelli F, Coltrini D, Rezzola S, Giacomini A, Mollica MP, Motta A, Paris D, Zorzano A, Marzo VD, Ronca R, Ligresti A (2023) Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer. https://doi.org/10.1016/j.phrs.2023.106683 | Endothelial;epithelial;mesothelial cell | Mouse | ATP production | |
Wang 2023 Cancer Cell Int | 2023 | Wang Y, Wang J, Chen L, Chen Z, Wang T, Xiong S, Zhou T, Wu G, He L, Cao J, Liu M, Li H, Gu H (2023) PRRG4 regulates mitochondrial function and promotes migratory behaviors of breast cancer cells through the Src-STAT3-POLG axis. https://doi.org/10.1186/s12935-023-03178-0 | Endothelial;epithelial;mesothelial cell | Human | ||
Erdem 2022 Nat Commun | 2022 | Erdem A, Marin S, Pereira-Martins DA, Geugien M, Cunningham A, Pruis MG, WeinhÀuser I, Gerding A, Bakker BM, Wierenga ATJ, Rego EM, Huls G, Cascante M, Schuringa JJ (2022) Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability. https://doi.org/10.1038/s41467-022-29639-0 | Other cell lines | Human | ||
Nadeu 2022 Nat Med | 2022 | Nadeu F, Royo R, Massoni-Badosa R, Playa-Albinyana H, Garcia-Torre B, Duran-Ferrer M, Dawson KJ, Kulis M, Diaz-Navarro A, Villamor N, Melero JL, Chapaprieta V, Dueso-Barroso A, Delgado J, Moia R, Ruiz-Gil S, Marchese D, GirĂł A, Verdaguer-Dot N, Romo M, Clot G, Rozman M, Frigola G, Rivas-Delgado A, Baumann T, Alcoceba M, GonzĂĄlez M, Climent F, Abrisqueta P, CastellvĂ J, Bosch F, Aymerich M, Enjuanes A, Ruiz-GaspĂ S, LĂłpez-Guillermo A, Jares P, BeĂ S, Capella-Gutierrez S, GelpĂ JL, LĂłpez-Bigas N, Torrents D, Campbell PJ, Gut I, Rossi D, Gaidano G, Puente XS, Garcia-Roves PM, Colomer D, Heyn H, Maura F, MartĂn-Subero JI, Campo E (2022) Detection of early seeding of Richter transformation in chronic lymphocytic leukemia. https://doi.org/10.1038/s41591-022-01927-8 | Lymphocyte Blood cells | Human | ||
Siow 2022 J Cell Sci | 2022 | Siow WX, Kabiri Y, Tang R, Chao YK, Plesch E, Eberhagen C, Flenkenthaler F, Fröhlich T, Bracher F, Grimm C, Biel M, Zischka H, Vollmar AM, Bartel K (2022) Lysosomal TRPML1 regulates mitochondrial function in hepatocellular carcinoma cells. https://doi.org/10.1242/jcs.259455 | Liver | Mouse | Ion;substrate transport | |
Karavyraki 2022 MitoFit | 2022 | Karavyraki M, Gnaiger E, Porter RK (2022) A comparison of bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. https://doi.org/10.26124/mitofit:2022-0022 â 2022-11-11 published in Bioenerg Commun 2022.11. | Human | Aerobic glycolysis | ||
Antona 2022 Cancers (Basel) | 2022 | Antona A, Varalda M, Roy K, Favero F, Mazzucco E, ZuccalĂ M, Leo G, Soggia G, Bettio V, Tosi M, Gaggianesi M, Riva B, Reano S, Genazzani A, Manfredi M, Stassi G, CorĂ D, D'Alfonso S, Capello D (2022) Dissecting the mechanism of action of spiperone-a candidate for drug repurposing for colorectal cancer. https://doi.org/10.3390/cancers14030776 | Endothelial;epithelial;mesothelial cell | Human | ||
Zhang 2022 Int J Mol Sci | 2022 | Zhang A, Gupte AA, Chatterjee S, Li S, Ayala AG, Miles BJ, Hamilton DJ (2022) Enhanced succinate oxidation with mitochondrial complex II reactive oxygen species generation in human prostate cancer. https://doi.org/10.3390/ijms232012168 | Genital | Human | ||
Deng 2022 Cell Mol Life Sci | 2022 | Deng H, Gao Y, Trappetti V, Hertig D, Karatkevich D, Losmanova T, Urzi C, Ge H, Geest GA, Bruggmann R, Djonov V, Nuoffer JM, Vermathen P, Zamboni N, Riether C, Ochsenbein A, Peng RW, Kocher GJ, Schmid RA, Dorn P, Marti TM (2022) Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage. https://doi.org/10.1007/s00018-022-04453-5 | Endothelial;epithelial;mesothelial cell | Human | ||
Karavyraki 2022 BEC | 2022 | Karavyraki M, Gnaiger E, Porter RK (2022) Bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. Bioenerg Commun 2022.11. https://doi.org/10.26124/bec:2022-0011 | Human | Aerobic glycolysis | ||
Wang 2022 Transl Cancer Res | 2022 | Wang B, Liu B, Luo Q, Sun D, Li H, Zhang J, Jin X, Cheng X, Niu J, Yuan Q, Chen Y (2022) PANK1 associates with cancer metabolism and immune infiltration in clear cell renal cell carcinoma: a retrospective prognostic study based on the TCGA database. https://doi.org/10.21037/tcr-22-1488 | Kidney Endothelial;epithelial;mesothelial cell | Human | ||
Delfinis 2022 JCI Insight | 2022 | Delfinis LJ, Bellissimo CA, Gandhi S, DiBenedetto SN, Garibotti MC, Thuhan AK, Tsitkanou S, Rosa-Caldwell ME, Rahman FA, Cheng AJ, Wiggs MP, Schlattner U, Quadrilatero J, Greene NP, Perry CG (2022) Muscle weakness precedes atrophy during cancer cachexia and is linked to muscle-specific mitochondrial stress. https://doi.org/10.1172/jci.insight.155147 | Skeletal muscle | Mouse | PCr;Cr | |
Torres-Quesada 2022 Cancers (Basel) | 2022 | Torres-Quesada O, Doerrier C, Strich S, Gnaiger E, Stefan E (2022) Physiological cell culture media tune mitochondrial bioenergetics and drug sensitivity in cancer cell models. https://doi.org/10.3390/cancers14163917 | Other cell lines | Human | Coupling efficiency;uncoupling | |
Cruz-Gregorio 2022 Antioxidants (Basel) | 2022 | Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Medina-Campos ON, Sciutto E, Fragoso G, Pedraza-Chaverri J (2022) GK-1 Induces oxidative stress, mitochondrial dysfunction, decreased membrane potential, and impaired autophagy flux in a mouse model of breast cancer. https://doi.org/10.3390/antiox12010056 | Endothelial;epithelial;mesothelial cell | Mouse | ||
Kluckova 2022 Hemasphere | 2022 | Kluckova K, Clear AJ, D'Avola A, Rassenti LZ, Kipps TJ, Gribben JG, Riches JC (2022) B-cell receptor signaling induced metabolic alterations in chronic lymphocytic leukemia can be partially bypassed by TP53 abnormalities. https://doi.org/10.1097/hs9.0000000000000722 | Blood cells | |||
Fialova 2022 Biomed Pharmacother | 2022 | Fialova JL, Hönigova K, Raudenska M, Miksatkova L, Zobalova R, Navratil J, Ć migovĂĄ J, Moturu TR, Vicar T, Balvan J, Vesela K, Abramenko N, Kejik Z, Kaplanek R, Gumulec J, Rosel D, Martasek P, BrĂĄbek J, Jakubek M, Neuzil J, Masarik M (2022) Pentamethinium salts suppress key metastatic processes by regulating mitochondrial function and inhibiting dihydroorotate dehydrogenase respiration. https://doi.org/10.1016/j.biopha.2022.113582 | Endothelial;epithelial;mesothelial cell | Human | ||
Torres-Quesada 2022 MitoFit | 2022 | Torres-Quesada O, Doerrier C, Strich S, Gnaiger E, Stefan E (2022) Human Plasma-Like Media fine-tune mitochondrial function and alter drug sensitivity in cancer cell lines. https://doi.org/10.26124/mitofit:2022-0008 â 2022-08-13 published in https://doi.org/10.3390/cancers14163917 | Other cell lines | Human | Coupling efficiency;uncoupling | |
Zhang 2021 Pharmaceutics | 2021 | Zhang H, Zhang A, Gupte AA, Hamilton DJ (2021) Plumbagin elicits cell-specific cytotoxic effects and metabolic responses in melanoma cells. Pharmaceutics 13:706. | Endothelial;epithelial;mesothelial cell Other cell lines | Human | ||
Schmidt 2021 Cancer Metab | 2021 | Schmidt CA, McLaughlin KL, Boykov IN, Mojalagbe R, Ranganathan A, Buddo KA, Lin CT, Fisher-Wellman KH, Neufer PD (2021) Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells. Cancer Metab 9:3. | Liver | Human | ||
Lelcu 2021 Children (Basel) | 2021 | Lelcu T, BĂźnÄ AM, DÄnilÄ MD, Popoiu CM, Aburel OM, Arghirescu ST, Borza C, Muntean DM (2021) Assessment of platelet mitochondrial respiration in a pediatric population: A pilot study in healthy children and children with acute lymphoblastic leukemia. https://doi.org/10.3390/children8121196 | Platelet | Human | ||
Bastos Sant'Anna Silva 2021 Cancers (Basel) | 2021 | Bastos Sant'Anna Silva AC, Perez Valencia JA, Sciacovelli M, Lalou C, Sarlak S, Tronci L, Nikitopoulou E, Meszaros AT, Frezza C, Rossignol R, Gnaiger E, Klocker H (2021) Succinate anaplerosis has an onco-driving potential in prostate cancer cells. https://doi.org/10.3390/cancers13071727 | Genital | Human | Substrate | |
Wigner 2021 Sci Rep | 2021 | Wigner P, Zielinski K, Labieniec-Watala M, Marczak A, Szwed M (2021) Doxorubicin-transferrin conjugate alters mitochondrial homeostasis and energy metabolism in human breast cancer cells. Sci Rep 11:4544. | Other cell lines | Human | ||
Palacka 2021 Int J Mol Sci | 2021 | Palacka P, GvozdjĂĄkovĂĄ A, RausovĂĄ Z, KucharskĂĄ J, SlopovskĂœ J, ObertovĂĄ J, Furka D, Furka S, Singh KK, SumbalovĂĄ Z (2021) Platelet mitochondrial bioenergetics reprogramming in patients with urothelial carcinoma. https://doi.org/10.3390/ijms23010388 | Platelet | Human | ||
Zunica 2021 Cancer Metab | 2021 | Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP (2021) Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15. Cancer Metab 9:36. | Endothelial;epithelial;mesothelial cell | Human Mouse | ||
Sighel 2021 Cell Rep | 2021 | Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, Soldano A, Adami V, Ambrosini C, Broso F, Rosatti EF, Longhi S, Buccarelli M, D'Alessandris QG, Giannetti S, Pacioni S, Ricci-Vitiani L, Rorbach J, Pallini R, Roulland S, Amunts A, Mancini I, Modelska A, Quattrone A (2021) Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Cell Rep 35:109024. | Nervous system Stem cells | Human | ||
Klepinina 2021 PLoS One | 2021 | Klepinina L, Klepinin A, Truu L, Chekulayev V, Vija H, Kuus K, Teino I, Pook M, Maimets T, Kaambre T (2021) Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLoS One 16:e0245348. | Endothelial;epithelial;mesothelial cell | Human | ||
Brito 2021 BMC Cancer | 2021 | Brito A, Merle C, Lagarde P, Faustin B, Devin A, Lartigue L, Chibon F (2021) Cell fusion enhances energy metabolism of mesenchymal tumor hybrid cells to sustain their proliferation and invasion. BMC Cancer 21:863. | Fibroblast | Human | ||
Meng 2021 FEBS Open Bio | 2021 | Meng L, Chen D, Meng G, Lu L, Han C (2021) Dysregulation of the Sirt5/IDH2 axis contributes to sunitinib resistance in human renal cancer cells. FEBS Open Bio 11:921-31. | Kidney | Human | ||
Kripnerova 2021 J Clin Med | 2021 | KripnerovĂĄ M, Parmar HS, Ć ĂĄna J, KopkovĂĄ A, RadovĂĄ L, Sopper S, Biernacki K, JedliÄka J, KohoutovĂĄ M, KuncovĂĄ J, Peychl J, Rudolf E, Äervinka M, Houdek Z, DvoĆĂĄk P, HoufkovĂĄ K, PeĆĄta M, TĆŻma Z, DolejĆĄovĂĄ M, TichĂĄnek F, BabuĆĄka V, Leba M, SlabĂœ O, Hatina J (2021) Complex interplay of genes underlies invasiveness in fibrosarcoma progression model. J Clin Med 10:2297. | Fibroblast | Mouse | ||
Chowdhury 2021 Cancers (Basel) | 2021 | Chowdhury SR, Peltier C, Hou S, Singh A, Johnston JB, Gibson SB, Marshall A, Banerji V (2021) Ex vivo mitochondrial respiration parallels biochemical response to ibrutinib in CLL cells. Cancers (Basel) 13:E354. | Lymphocyte | Human | ||
Amoedo 2021 J Clin Invest | 2021 | Amoedo ND, Sarlak S, Obre E, Esteves P, Bégueret H, Kieffer Y, Rousseau B, Dupis A, Izotte J, Bellance N, Dard L, Redonnet-Vernhet I, Punzi G, Rodrigues MF, Dumon E, Mafhouf W, Guyonnet-Dupérat V, Gales L, Palama T, Bellvert F, Dugot-Senan N, Claverol S, Baste JM, Lacombe D, Rezvani HR, Pierri CL, Mechta-Grigoriou F, Thumerel M, Rossignol R (2021) Targeting the mitochondrial trifunctional protein restrains tumor growth in oxidative lung carcinomas. J Clin Invest 131:e133081. | Lung;gill | Human | ||
Roy Chowdhury 2020 Cancers (Basel) | 2020 | Roy Chowdhury S, Bouchard EDJ, Saleh R, Nugent Z, Peltier C, Mejia E, Hou S, McFall C, Squires M, Hewitt D, Davidson L, Shen GX, Johnston JB, Doucette C, Hatch GM, Fernyhough P, Marshall A, Gibson SB, Dawe DE, Banerji V (2020) Mitochondrial respiration correlates with prognostic markers in chronic lymphocytic leukemia and is normalized by ibrutinib treatment. Cancers (Basel) 12:E650. | Lymphocyte Blood cells | Human | ||
Messner 2020 Thesis | 2020 | Messner M (2020) Sorafenib resistance of hepatocellular carcinoma. PhD Thesis 130. | Liver | Human | ||
Lara-Marqueza 2020 J Funct Foods | 2020 | Lara-MĂĄrquez M, BĂĄez-Magaña M, Raymundo-Ramos C, Spagnuolo PA, MacĂas-RodrĂguez L, Salgado-Garciglia R, Ochoa-Zarzosa A, LĂłpez-Meza JE (2020) Lipid-rich extract from Mexican avocado (Persea americana var. drymifolia) induces apoptosis and modulates the inflammatory response in Caco-2 human colon cancer cells. J Funct Foods 64:103658. | Endothelial;epithelial;mesothelial cell | Human | ||
Cruz 2020 Cancers (Basel) | 2020 | Cruz B, Oliveira A, Viana LR, Lopes-Aguiar L, Canevarolo R, Colombera MC, Valentim RR, Garcia-FĂłssa F, de Sousa LM, Castelucci BG, Consonni SR, Martins-de-Souza D, de Jesus MB, Russell ST, Gomes-Mardondes MCC (2020) Leucine-tich diet modulates the metabolomic and proteomic profile of skeletal muscle during cancer cachexia. Cancers (Basel) 12:E1880. | Skeletal muscle | Mouse | ||
Coppin 2020 Cell Death Dis | 2020 | Coppin L, Jannin A, Ait Yahya E, Thuillier C, Villenet C, Tardivel M, Bongiovanni A, Gaston C, de Beco S, Barois N, van Seuningen I, Durand E, Bonnefond A, Vienne JC, Vamecq J, Figeac M, Vincent A, Delacour D, Porchet N, Pigny P (2020) Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface. Cell Death Dis 11:360. | Islet cell;pancreas;thymus Endothelial;epithelial;mesothelial cell | Human | ||
Makrecka-Kuka 2020 Sci Rep | 2020 | Makrecka-Kuka M, Dimitrijevs P, Domracheva I, Jaudzems K, Dambrova M, Arsenyan P (2020) Fused isoselenazolium salts suppress breast cancer cell growth by dramatic increase in pyruvate-dependent mitochondrial ROS production. https://doi.org/10.1038/s41598-020-78620-8. | Endothelial;epithelial;mesothelial cell | Mouse | ||
Hayes 2020 Nutrients | 2020 | Hayes P, Fergus C, Ghanim M, Cirzi C, Burtnyak L, McGrenaghan CJ, Tuorto F, Nolan DP, Kelly VP (2020) Queuine micronutrient deficiency promotes Warburg metabolism and reversal of the mitochondrial ATP synthase in HeLa cells. Nutrients 12:E871. | HeLa | Human | ||
Pola 2020 Invest New Drugs | 2020 | Pola M, Kolarova H, Ruzicka J, Zholobenko A, Modriansky M, Mosinger J, Bajgar R (2020) Effects of zinc porphyrin and zinc phthalocyanine derivatives in photodynamic anticancer therapy under different partial pressures of oxygen in vitro. Invest New Drugs 39:89-97. | HeLa | Human | ||
Mayoral-Varo 2020 PLoS One | 2020 | Mayoral-Varo V, Calcabrini A, SĂĄnchez-BailĂłn MP, MartĂnez-Costa ĂH, GonzĂĄlez-PĂĄramos C, Ciordia S, Hardisson D, AragĂłn JJ, FernĂĄndez-Moreno MĂ, MartĂn-PĂ©rez J (2020) c-Src functionality controls self-renewal and glucose metabolism in MCF7 breast cancer stem cells . PLoS One 15:e0235850. | Endothelial;epithelial;mesothelial cell | Human | ||
D'Onofrio 2020 Sci Rep | 2020 | D'Onofrio N, Cacciola NA, Martino E, Borrelli F, Fiorino F, Lombardi A, Neglia G, Balestrieri ML, Campanile G (2020) ROS-mediated apoptotic cell death of human colon cancer LoVo cells by milk ÎŽ-valerobetaine. Sci Rep 10:8978. | Endothelial;epithelial;mesothelial cell | Human | Cyt c | |
Robledo-Cadena 2020 Pharmaceuticals (Basel) | 2020 | Robledo-Cadena DX, Gallardo-PĂ©rez JC, DĂĄvila-Borja V, Pacheco-VelĂĄzquez SC, Belmont-DĂaz JA, Ralph SJ, Blanco-Carpintero BA, Moreno-SĂĄnchez R, RodrĂguez-EnrĂquez S (2020) Non-steroidal anti-inflammatory drugs increase cisplatin, paclitaxel, and doxorubicin efficacy against human cervix cancer cells. Pharmaceuticals (Basel) 13:463. | Endothelial;epithelial;mesothelial cell HeLa Fibroblast | Human | ||
Rebane-Klemm 2020 Cancers (Basel) | 2020 | Rebane-Klemm E, Truu L, Reinsalu L, Puurand M, Shevchuk I, Chekulayev V, Timohhina N, Tepp K, Bogovskaja J, Afanasjev V, Suurmaa K, Valvere V, Kaambre T (2020) Mitochondrial respiration in KRAS and BRAF mutated colorectal tumors and polyps. Cancers (Basel) 12:E815. | Endothelial;epithelial;mesothelial cell | Human | ||
Vulczak 2020 Cells | 2020 | Vulczak A, Souza AO, Ferrari GD, Azzolini AECS, Pereira-da-Silva G, Alberici LC (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:E628. | Endothelial;epithelial;mesothelial cell | Mouse | ||
Bianchi 2020 IUBMB Life | 2020 | Bianchi SE, Pegues MA, Dias CK, Mascia F, Doneda E, Pittol V, Rao A, Klamt F, Bassani VL (2020) Achyrocline satureioides compounds, achyrobichalcone and 3-O-methylquercetin, induce mitochondrial dysfunction and apoptosis in human breast cancer cell lines. IUBMB Life 72:2133-45. | Endothelial;epithelial;mesothelial cell | Human | ||
Li 2020 Cells | 2020 | Li M, Wang L, Wang Y, Zhang S, Zhou G, Lieshout R, Ma B, Liu J, Qu C, Verstegen MMA, Sprengers D, Kwekkeboom J, van der Laan LJW, Cao W, Peppelenbosch MP, Pan Q (2020) Mitochondrial fusion via OPA1 and MFN1 supports liver tumor cell metabolism and growth. Cells 9:E121. | Liver | Human | ||
Sharma 2020 Integr Cancer Ther | 2020 | Sharma P, Singh S (2020) Combinatorial effect of DCA and let-7a on triple-negative MDA-MB-231 cells: A metabolic approach of treatment. Integr Cancer Ther 19:1534735420911437. | Endothelial;epithelial;mesothelial cell | Human | ||
Parri 2020 Curr Opin Biotechnol | 2020 | Parri M, Ippolito L, Cirri P, Ramazzotti M, Chiarugi P (2020) Metabolic cell communication within tumour microenvironment: models, methods and perspectives. Curr Opin Biotechnol 63:210-19. | ||||
Schoepf 2020 Nat Commun | 2020 | Schöpf Bernd, Weissensteiner Hansi, SchĂ€fer Georg, Fazzini Federica, Charoentong Pornpimol, Naschberger Andreas, Rupp Bernhard, Fendt Liane, Bukur Valesca, Giese Irina, Sorn Patrick, SantâAnna-Silva Ana Carolina, Iglesias-Gonzalez Javier, Sahin Ugur, Kronenberg Florian, Gnaiger Erich, Klocker Helmut (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. https://doi.org/10.1038/s41467-020-15237-5 | Genital Other cell lines | Human | Coupling efficiency;uncoupling Flux control Inhibitor | |
Visavadiya 2020 Mol Cell Biochem | 2020 | Visavadiya NP, Pena GS, Khamoui AV (2020) Mitochondrial dynamics and quality control are altered in a hepatic cell culture model of cancer cachexia. Mol Cell Biochem 476:23-34. | Liver | Mouse | ||
Mann 2020 Sci Rep | 2020 | Mann J, Yang N, Montpetit R, Kirschenman R, Lemieux H, Goping IS (2020) BAD sensitizes breast cancer cells to docetaxel with increased mitotic arrest and necroptosis. https://doi.org/10.1038/s41598-019-57282-1 | Other cell lines | Human | ||
Silva Ferraz 2020 Biochem Pharmacol | 2020 | Silva Ferraz L, Torres da Costa R, Alves da Costa C, Augusto JoĂŁo Ribeiro C, Costa Arruda D, Stuchi Maria-Engler S, Rodrigues T (2020) Targeting mitochondria in melanoma: interplay between MAPK signaling pathway and mitochondrial dynamics . Biochem Pharmacol 178:114104. | Endothelial;epithelial;mesothelial cell | Human | ||
Jian 2020 Cell Metab | 2020 | Jian C, Fu J, Cheng X, Shen LJ, Ji YX, Wang X, Pan S, Tian H, Tian S, Liao R, Song K, Wang HP, Zhang X, Wang Y, Huang Z, She ZG, Zhang XJ, Zhu L, Li H (2020) Low-dose sorafenib acts as a mitochondrial uncoupler and ameliorates nonalcoholic steatohepatitis. Cell Metab 31:892-908. https://doi.org/10.1016/j.cmet.2020.04.011 | Liver | Mouse | ||
Contreras Mostazo 2020 Cancers (Basel) | 2020 | Mostazo MGC, Kurrle N, Casado M, Fuhrmann D, Alshamleh I, HĂ€upl B, MartĂn-Sanz P, BrĂŒne B, Serve H, Schwalbe H, SchnĂŒtgen F, Marin S, Cascante M (2020) Metabolic plasticity is an essential requirement of acquired tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Cancers (Basel) 12:E3443. | Blood cells | Human | ||
Khamoui 2020 Physiol Genomics | 2020 | Khamoui AV, Tokmina-Roszyk D, Rossiter HB, Fields GB, Visavadiya NP (2020) Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia. Physiol Genomics 52:203-16. | Liver | Mouse | ||
Macasoi 2020 Oncol Rep | 2020 | MacaÈoi I, Pavel IZ, MoacÄ AE, Avram S, David LV, Coricovac D, Mioc A, Spandidos DA, Tsatsakis A, Èoica C, DumitraÈcu V, Dehelean C (2020) Mechanistic investigations of antitumor activity of a Rhodamine Bâoleanolic acid derivative bioconjugate. Oncol Rep 44:1169-83. | Endothelial;epithelial;mesothelial cell | Human | ||
De Souza 2020 Heliyon | 2020 | De Souza CEA, Andrade Pires AR, Cardoso CR, Carlos RM, Cadena SMSC, Acco A (2020) Antineoplastic activity of a novel ruthenium complex against human hepatocellular carcinoma (HepG2) and human cervical adenocarcinoma (HeLa) cells. Heliyon 6:e03862. | Liver HeLa | Human | ||
Kunz 2020 J Biol Chem | 2020 | Kunz HE, Dorschner JM, Berent TE, Meyer T, Wang X, Jatoi A, Kumar R, Lanza IR (2020) Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting. J Biol Chem 295:17441-59. | Skeletal muscle | Mouse | ||
Cruz-Gregorio 2019 Biomolecules | 2019 | Cruz-Gregorio A, Aranda-Rivera AK, Aparicio-Trejo OE, Coronado-Martinez I, Pedraza-Chaverri J, Lizano M (2019) E6 oncoproteins from high-risk human papillomavirus induce mitochondrial metabolism in a head and neck squamous cell carcinoma model. Biomolecules 9:E351. | Endothelial;epithelial;mesothelial cell | Human | ||
Neyroud 2019 J Muscle Res Cell Motil | 2019 | Neyroud D, Nosacka RL, Judge AR, Hepple RT (2019) Colon 26 adenocarcinoma (C26)-induced cancer cachexia impairs skeletal muscle mitochondrial function and content. J Muscle Res Cell Motil 40:59-65. | Skeletal muscle | Mouse | ||
Teh 2019 Mol Cancer Ther | 2019 | Teh JT, Zhu WL, Newgard CB, Casey PJ, Wang M (2019) Respiratory capacity and reserve predict cell sensitivity to mitochondria inhibitors: mechanism-based markers to identify metformin-responsive cancers. Mol Cancer Ther 18:693-705. | Other cell lines | Human Mouse | ||
Scatena 2019 Curr Med Chem | 2019 | Scatena R, Bottoni P (2019) The tangled mitochondrial metabolism in cancer: An innovative pharmacological approach. Curr Med Chem 27:2106-17. | ||||
Mann 2019 Oncogene | 2019 | Mann J, Githaka JM, Buckland TW, Yang N, Montpetit R, Patel N, Li L, Baksh S, Godbout R, Lemieux H, Goping IS (2019) Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism. Oncogene 38:3325-39. | Endothelial;epithelial;mesothelial cell | Human | ||
Viana 2019 Sci Rep | 2019 | Viana LR, Tobar N, Busanello ENB, Marques AC, de Oliveira AG, Lima TI, Machado G, Castelucci BG, Ramos CD, Brunetto SQ, Silveira LR, Vercesi AE, Consonni SR, Gomes-Marcondes MCC (2019) Leucine-rich diet induces a shift in tumour metabolism from glycolytic towards oxidative phosphorylation, reducing glucose consumption and metastasis in Walker-256 tumour-bearing rats. Sci Rep 9:15529. | Endothelial;epithelial;mesothelial cell | Rat | ||
Aubin 2019 Thesis | 2019 | Aubin M (2019) Glucocorticoids and acute lymphoid leukemia: a proteomic approach. Doctoral Dissertation 99. | Lymphocyte | Human | ||
Reda 2019 Sci Rep | 2019 | Reda A, Refaat A, Abd-Rabou AA, Mahmoud AM, Adel M, Sabet S, Ali SS (2019) Role of mitochondria in rescuing glycolytically inhibited subpopulation of triple negative but not hormone-responsive breast cancer cells. Sci Rep 9:13748. | Endothelial;epithelial;mesothelial cell | Human | ||
Altinok 2019 J Cell Physiol | 2019 | Altinok O, Poggio JL, Stein DE, Bowne WB, Shieh AC, Snyder NW, Orynbayeva Z (2019) Malate-aspartate shuttle promotes l-lactate oxidation in mitochondria. J Cell Physiol 235:2569-81. | Other cell lines | Human | ||
Gao 2019 Cancer Cell Int | 2019 | Gao Y, Dorn P, Liu S, Deng H, Hall SRR, Peng RW, Schmid RA, Marti TM (2019) Cisplatin-resistant A549 non-small cell lung cancer cells can be identified by increased mitochondrial mass and are sensitive to pemetrexed treatment. Cancer Cell Int 19:317. | Lung;gill Endothelial;epithelial;mesothelial cell | Human | ||
Wang 2019 Free Radic Biol Med | 2019 | Wang SQ, Yang XY, Cui SX, Gao ZH, Qu XJ (2019) Heterozygous knockout insulin-like growth factor-1 receptor (IGF-1R) regulates mitochondrial functions and prevents colitis and colorectal cancer. Free Radic Biol Med 134:87-98. | Heart Liver Endothelial;epithelial;mesothelial cell | Mouse | ||
Aguilar 2019 Cell Rep | 2019 | Aguilar E, Esteves P, Sancerni T, Lenoir V, Aparicio T, Bouillaud F, Dentin R, Prip-Buus C, Ricquier D, Pecqueur C, Guilmeau S, Alves-Guerra MC (2019) UCP2 deficiency increases colon tumorigenesis by promoting lipid synthesis and depleting NADPH for antioxidant defenses. Cell Rep 28:2306-16. | Endothelial;epithelial;mesothelial cell | Mouse | ||
Kulkarni 2019 Haematologica | 2019 | Kulkarni PP, Tiwari A, Singh N, Gautam D, Sonkar VK, Agarwal V, Dash D (2019) Aerobic glycolysis fuels platelet activation: small-molecule modulators of platelet metabolism as anti-thrombotic agents. Haematologica 104:806-18. | Blood cells Platelet | Human | ||
Sundstroem 2019 Acta Neuropathol Commun | 2019 | SundstrĂžm T, Prestegarden L, Azuaje F, Aasen SN, RĂžsland GV, Varughese JK, Bahador M, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Ingham ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Beschorner R, Bjerkvig R, Thorsen F (2019) Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Commun 7:55. | Endothelial;epithelial;mesothelial cell | Human | ||
Esteves 2019 Oncogene | 2019 | Esteves P, Dard L, Brillac A, Hubert C, Sarlak S, Rousseau B, Dumon E, Izotte J, Bonneu M, Lacombe D, Dupuy JW, Amoedo N, Rossignol R (2019) Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F. Oncogene 39:617-36. | Endothelial;epithelial;mesothelial cell | Human | ||
Bousseau 2019 FASEB J | 2019 | Bousseau S, Marchand M, Soleti R, Vergori L, Hilairet G, Recoquillon S, Le Mao M, Gueguen N, Khiati S, Clarion L, Bakalara N, Martinez MC, Germain S, Lenaers G, Andriantsitohaina R (2019) Phostine 3.1a as a pharmacological compound with antiangiogenic properties against diseases with excess vascularization. FASEB J 33:5864-75. | Endothelial;epithelial;mesothelial cell | Human | ||
Ruzickova 2019 Thesis | 2019 | Ruzickova A (2019) Horizontal transfer of mitochondria and its role in carcinogenesis. Master's Thesis 85. | Mouse | |||
Majiene 2019 Nutrients | 2019 | Majiene D, Kuseliauskyte J, Stimbirys A, Jekabsone A (2019) Comparison of the effect of native 1,4-naphthoquinones plumbagin, menadione, and lawsone on viability, redox status, and mitochondrial functions of C6 glioblastoma cells. Nutrients 11:E1294. | Nervous system | Rat | ||
Moscheni 2019 Cancers (Basel) | 2019 | Moscheni C, Malucelli E, Castiglioni S, Procopio A, De Palma C, Sorrentino A, Sartori P, Locatelli L, Pereiro E, Maier JA, Iotti S (2019) 3D quantitative and ultrastructural analysis of mitochondria in a model of doxorubicin sensitive and resistant human colon carcinoma cells. Cancers (Basel) 11:E1254. | Endothelial;epithelial;mesothelial cell | Human | ||
Halle 2019 Am J Physiol Regul Integr Comp Physiol | 2019 | Halle JL, Pena GS, Paez HG, Castro AJ, Rossiter HB, Visavadiya NP, Whitehurst MA, Khamoui AV (2019) Tissue-specific dysregulation of mitochondrial respiratory capacity and coupling control in colon-26 tumor-induced cachexia. Am J Physiol Regul Integr Comp Physiol 317:R68-R82. | Skeletal muscle Liver Fat | Mouse | ||
De Moura Escobar 2019 Toxicol In Vitro | 2019 | de Moura Escobar SJ, Simone M, de Oliveira Ribeiro CA, Martinez GR, Winnischofer SMB, Witting PK, Rocha MEM (2019) Cytotoxic effects of 4'-hydroxychalcone on human neuroblastoma cells (SH-SY5Y). Toxicol In Vitro 61:104640. | Neuroblastoma | Human | ||
Gaiser 2019 Adv Ther (Weinh) | 2019 | Gaiser A, Hafner S, Schmiech M, BĂŒchele B, SchĂ€fer P, Arnim CA, Calzia, E, FeuringâBuske M, Buske C, Vick B, Jeremias I, Syrovets T, Simmet T (2019) Gold nanoparticles with selective antileukemic activity in vitro and in vivo target mitochondrial respiration. Adv Ther (Weinh) doi:10.1002/adtp.201800149. | Blood cells | Human | ||
Malagrino 2019 Oxid Med Cell Longev | 2019 | MalagrinĂČ F, Zuhra K, Mascolo L, Mastronicola D, Vicente JB, Forte E, GiuffrĂš A (2019) Hydrogen sulfide oxidation: adaptive changes in mitochondria of SW480 colorectal cancer cells upon exposure to hypoxia. Oxid Med Cell Longev 2019:8102936. | Endothelial;epithelial;mesothelial cell | Human | Inhibitor | |
Grauso 2019 Sci Rep | 2019 | Grauso M, Lan A, Andriamihaja M, Bouillaud F, Blachier F (2019) Hyperosmolar environment and intestinal epithelial cells: impact on mitochondrial oxygen consumption, proliferation, and barrier function in vitro. Sci Rep 9:11360. | Endothelial;epithelial;mesothelial cell Other cell lines | Human | ||
Ramkumar 2019 Mitochondrion | 2019 | Ramkumar B, Dharaskar SP, Mounika G, Paithankar K, Sreedhar AS (2019) Mitochondrial chaperone, TRAP1 as a potential pharmacological target to combat cancer metabolism. Mitochondrion 50:42-50. | Lung;gill HEK Neuroblastoma | Human | ||
Bajzikova 2019 Cell Metab | 2019 | Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman Werner JH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab 29:399-416. 10.1016/j.cmet.2018.10.014 | Endothelial;epithelial;mesothelial cell Genital Other cell lines | Mouse | ||
Sukovas 2019 J Bioenerg Biomembr | 2019 | Sukovas A, Silkuniene G, Trumbeckaite S, Jasukaitiene A, Degutyte-Fomins L, Mildaziene V, Gulbinas A, Baniene R, Dambrauskas Z, Paskauskas S (2019) Hyperthermia potentiates cisplatin cytotoxicity and negative effects on mitochondrial functions in OVCAR-3 cells. J Bioenerg Biomembr 51:301-10. | Genital | Human | Temperature | |
Turnbull 2019 Am J Physiol Cell Physiol | 2019 | Turnbull PC, Hughes MC, Perry CGR (2019) The fatty acid derivative palmitoylcarnitine abrogates colorectal cancer cell survival by depleting glutathione. Am J Physiol Cell Physiol 317:C1278-88. | Endothelial;epithelial;mesothelial cell | Human | Fatty acid | |
Rodriguez-Enriquez 2019 Toxicol Appl Pharmacol | 2019 | RodrĂguez-EnrĂquez S, Pacheco-VelĂĄzquez SC, MarĂn-HernĂĄndez Ă, Gallardo-PĂ©rez JC, Robledo-Cadena DX, HernĂĄndez-ResĂ©ndiz I, GarcĂa-GarcĂa JD, Belmont-DĂaz J, LĂłpez-Marure R, HernĂĄndez-Esquivel L, SĂĄnchez-Thomas R, Moreno-SĂĄnchez R (2019) Resveratrol inhibits cancer cell proliferation by impairing oxidative phosphorylation and inducing oxidative stress. Toxicol Appl Pharmacol 370:65-77. | Heart Liver | Rat | ||
Djeungoue-Petga 2019 Cell Death Dis | 2019 | Djeungoue-Petga MA, Lurette O, Jean S, Hamel-CĂŽtĂ© G, MartĂn-JimĂ©nez R, Bou M, Cannich A, Roy P, Hebert-Chatelain E (2019) Intramitochondrial Src kinase links mitochondrial dysfunctions and aggressiveness of breast cancer cells. Cell Death Dis 10:940. | Endothelial;epithelial;mesothelial cell | Human | ||
Alvarez 2019 Chem Biol Interact | 2019 | Ălvarez Santos MR, Duarte YB, GĂŒiza FM, Romero BohĂłrquez AR, Mendez-Sanchez SC (2019) Effects of new tetrahydroquinoline-isoxazole hybrides on bioenergetics of hepatocarcinoma Hep-G2 cells and rat liver mitochondria. Chem Biol Interact 302:164-71. | Liver | Human | ||
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Baaten 2018 Haematologica | 2018 | Baaten CCFMJ, Moenen FCJI, Henskens YMC, Swieringa F, Wetzels RJH, van Oerle R, Heijnen HFG, Ten Cate H, Holloway GP, Beckers EAM, Heemskerk JWM, van der Meijden PEJ (2018) Impaired mitochondrial activity explains platelet dysfunction in thrombocytopenic cancer patients undergoing chemotherapy. Haematologica 103:1557-67. | Blood cells Platelet | Human | ||
De Sales 2018 Molecules | 2018 | de Sales NFF, Silva da Costa L, Carneiro TIA, Minuzzo DA, Oliveira FL, Cabral LMC, Torres AG, El-Bacha T (2018) Anthocyanin-rich grape pomace extract (Vitis vinifera L.) from wine industry affects mitochondrial bioenergetics and glucose metabolism in human hepatocarcinoma HepG2 cells. Molecules 23. | Liver Other cell lines | Human | ||
Song 2018 J Cell Physiol | 2018 | Song Y, Gao L, Tang Z, Li H, Sun B, Chu P, Qaed E, Ma X, Peng J, Wang S, Hu M, Tang Z (2018) Anticancer effect of SZC015 on pancreatic cancer via mitochondria-dependent apoptosis and the constitutive suppression of activated nuclear factor ÎșB and STAT3 in vitro and in vivo. J Cell Physiol 234:777-88. | Islet cell;pancreas;thymus | Human | ||
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Tillmans 2018 Thesis | 2018 | Tillmans F (2018) Effect of normobaric hypoxia on leukemic vell lines in vitro. Dissertation p92. | Other cell lines Lymphocyte | Human | ||
Touat 2018 J Clin Invest | 2018 | Touat M, Sourisseau T, Dorvault N, Chabanon RM, Garrido M, Morel D, Krastev DB, Bigot L, Adam J, Frankum JR, Durand S, Pontoizeau C, SouquĂšre S, Kuo MS, Sauvaigo S, Mardakheh F, Sarasin A, Olaussen KA, Friboulet L, Bouillaud F, Pierron G, Ashworth A, LombĂšs A, Lord CJ, Soria JC, Postel-Vinay S (2018) DNA repair deficiency sensitizes lung cancer cells to NAD+ biosynthesis blockade. J Clin Invest 128:1671-87. | Lung;gill Other cell lines | Human | ||
Ounpuu 2018 Biochem Cell Biol | 2018 | Ounpuu L, Truu L, Shevchuk I, Chekulayev V, Klepinin A, Koit A, Tepp K, Puurand M, Rebane-Klemm E, KÀÀmbre T (2018) Comparative analysis of the bioenergetics of human adenocarcinoma Caco-2 cell line and postoperative tissue samples from colorectal cancer patients. Biochem Cell Biol [Epub ahead of print]. | Endothelial;epithelial;mesothelial cell Other cell lines | Human | ||
Kriel 2018 Sci Rep | 2018 | Kriel J, Mueller-Nedebock K, Maarman G, Mbizana S, Ojuka E, Klumperman B, Loos B (2018) Coordinated autophagy modulation overcomes glioblastoma chemoresistance through disruption of mitochondrial bioenergetics. Sci Rep 8:10348. | Nervous system Other cell lines | Human | ||
Zhou 2018 Free Radic Biol Med | 2018 | Zhou L, Yi Y, Yuan Q, Zhang J, Li Y, Wang P, Xu M, Xie S (2018) VAOS, a novel vanadyl complexes of alginate saccharides, inducing apoptosis via activation of AKT-dependent ROS production in NSCLC. Free Radic Biol Med 129:177-85. | Lung;gill | Human | ||
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Fuhrmann 2018 Cell Mol Life Sci | 2018 | Fuhrmann DC, Wittig I, Dröse S, Schmid T, Dehne N, BrĂŒne B (2018) Degradation of the mitochondrial complex I assembly factor TMEM126B under chronic hypoxia. Cell Mol Life Sci 75:3051-67. | Human | |||
Ramil 2018 Thesis | 2018 | Ramil LR, Gulbinas A, Cesna V (2018) âHIPECâ hyperthermic intraperitoneal chemotherapy. Evaluation of intraperitoneal free cancer cells. Master's Thesis. | Endothelial;epithelial;mesothelial cell | Human | ||
Fox 2018 Thesis | 2018 | Fox JC (2018) FROST450, a novel microtubule targeting agent: resistance and cross-resistance in an ovarian cancer cell line. Bachelor's Thesis 27. | Genital | Human | ||
Lim 2018 Sci Rep | 2018 | Lim SC, Tajika M, Shimura M, Carey KT, Stroud DA, Murayama K, Ohtake A, McKenzie M (2018) Loss of the mitochondrial fatty acid ÎČ-oxidation protein medium-chain acyl-Coenzyme A dehydrogenase disrupts oxidative phosphorylation protein complex stability and function. Sci Rep 8:153. | Other cell lines | Human | ||
Goswami 2018 Biophys J | 2018 | Goswami I, Perry JB, Allen ME, Brown DA, von Spakovsky MR, Verbridge SS (2018) Influence of pulsed electric fields and mitochondria-cytoskeleton interactions on cell respiration. Biophys J 114:2951-64. | Other cell lines | Mouse | ||
Cronin 2018 Nature | 2018 | Cronin SJF, Seehus C, Weidinger A, Talbot S, Reissig S, Seifert M, Pierson Y, McNeill E, Longhi MS, Turnes BL, Kreslavsky T, Kogler M, Hoffmann D, Ticevic M, da Luz Scheffer D, Tortola L, Cikes D, Jais A, Rangachari M, Rao S, Paolino M, Novatchkova M, Aichinger M, Barrett L, Latremoliere A, Wirnsberger G, Lametschwandtner G, Busslinger M, Zicha S, Latini A, Robson SC, Waisman A, Andrews N, Costigan M, Channon KM, Weiss G, Kozlov AV, Tebbe M, Johnsson K, Woolf CJ, Penninger JM (2018) The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature 563:564-68. | Lymphocyte | Mouse | ||
Ziegler 2018 Cell | 2018 | Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ă, De Oliveira T, Diamanti MA, MĂŒller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Ăner MG, MĂŒller S, MĂŒller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR (2018) Mitophagy in intestinal epithelial cells triggers adaptive immunity during tumorigenesis. Cell 174:88-101. | Endothelial;epithelial;mesothelial cell | Mouse | ||
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Trumbeckaite 2018 J Bioenerg Biomembr | 2018 | Trumbeckaite S, Cesna V, Jasukaitiene A, Baniene R, Gulbinas A (2018) Different mitochondrial response to cisplatin and hyperthermia treatment in human AGS, Caco-2 and T3M4 cancer cell lines. J Bioenerg Biomembr 50:329-38. | Other cell lines | Human | ||
Zhou 2018 Cell Death Dis | 2018 | Zhou C, Sun H, Zheng C, Gao J, Fu Q, Hu N, Shao X, Zhou Y, Xiong J, Nie K, Zhou H, Shen L, Fang H, Lyu J (2018) Oncogenic HSP60 regulates mitochondrial oxidative phosphorylation to support Erk1/2 activation during pancreatic cancer cell growth. Cell Death Dis 9:161. | Islet cell;pancreas;thymus Other cell lines | Human | ||
Weber 2018 Int J Mol Sci | 2018 | Weber A, Klocker H, Oberacher H, Gnaiger E, Neuwirt H, Sampson N, Eder IE (2018) Succinate accumulation is associated with a shift of mitochondrial respiratory control and HIF-1α upregulation in PTEN negative prostate cancer cells. Int J Mol Sci 19:2129. | Genital | Human | ||
Temelie 2018 Oxid Med Cell Longev | 2018 | Temelie M, Savu DI, Moisoi N (2018) Intracellular and intercellular signalling mechanisms following DNA damage are modulated by PINK1. Oxid Med Cell Longev 1391387. | Nervous system Other cell lines Fibroblast | Human Mouse | ||
Machado-Neto 2018 Cell Death Dis | 2018 | Machado-Neto JA, Fenerich BA, Scopim-Ribeiro R, Eide CA, Coelho-Silva JL, Dechandt CRP, Fernandes JC, Rodrigues Alves APN, Scheucher PS, SimÔes BP, Alberici LC, de Figueiredo Pontes LL, Tognon CE, Druker BJ, Rego EM, Traina F (2018) Metformin exerts multitarget antileukemia activity in JAK2V617F-positive myeloproliferative neoplasms. Cell Death Dis 9:311. | Other cell lines | Human Mouse | ||
Fuhr 2018 EBioMedicine | 2018 | Fuhr L, El-Athman R, Scrima R, Cela O, Carbone A, Knoop H, Li Y, Hoffmann K, Laukkanen MO, Corcione F, Steuer R, Meyer TF, Mazzoccoli G, Capitanio N, RelĂłgio A (2018) The circadian clock regulates metabolic phenotype rewiring via HKDC1 and modulates tumor progression and drug response in colorectal cancer. EBioMedicine 33:105-121. | Other cell lines | Human | ||
Lica 2018 Stem Cells Dev | 2018 | Lica JJ, Grabe GJ, Heldt M, Misiak M, Bloch P, Serocki M, Switalska M, Wietrzyk J, Baginski M, Hellmann A, Borowski E, Skladanowski A (2018) Cell density-dependent cytological stage profile and its application for a screen of cytostatic agents active towards Leukemic Stem Cells. Stem Cells Dev 27:488-513. | Heart Blood cells Other cell lines | Human Mouse | ||
Kuehn 2018 Biochem Pharmacol | 2018 | KĂŒhn B, Brat C, Fettel J, Hellmuth N, Maucher IV, Bulut U, Hock KJ, Grimmer J, Manolikakes G, RĂŒhl M, KĂŒhn A, Zacharowski K, Matrone C, Urbschat A, Roos J, Steinhilber D, Maier TJ (2018) Anti-inflammatory nitro-fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells. Biochem Pharmacol 155:48-60. | Endothelial;epithelial;mesothelial cell Other cell lines | Human | Fatty acid | |
Ruas 2018 Sci Rep | 2018 | Ruas JS, Siqueira-Santos ES, Rodrigues-Silva E, Castilho RF (2018) High glycolytic activity of tumor cells leads to underestimation of electron transport system capacity when mitochondrial ATP synthase is inhibited. https://doi.org/10.1038/s41598-018-35679-8 | Nervous system Other cell lines | Human | ADP ATP Uncoupler | |
Sidlauskas 2017 Neurosci Lett | 2017 | Sidlauskas K, Sidlauskiene R, Li N, Liobikas J (2017) 5-Hydroxy-1,4-naphthalenedione exerts anticancer effects on glioma cells through interaction with the mitochondrial electron transport chain. Neurosci Lett 639:207-14. | Nervous system Other cell lines | Rat | Inhibitor | |
Jang 2017 Biol Open | 2017 | Jang DH, Seeger SC, Grady ME, Shofer FC, Eckmann DM (2017) Mitochondrial dynamics and respiration within cells with increased open pore cytoskeletal meshes. Biol Open 6:1831-9. | Endothelial;epithelial;mesothelial cell Fibroblast | Human | ||
Ounpuu 2017 Biochim Biophys Acta | 2017 | Ounpuu L, Klepinin A, Pook M, Teino I, Peet N, Paju K, Tepp K, Chekulayev V, Shevchuk I, Koks S, Maimets T, Kaambre T (2017) 2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells. Biochim Biophys Acta 1861:2146-54. | Stem cells | Human | ||
Cunha 2017 Int J Biol Macromol | 2017 | Cunha de Padua MM, Suter Correia Cadena SM, de Oliveira Petkowicz CL, Martinez GR, Rodrigues Noleto G (2017) Galactomannan from Schizolobium amazonicum seed and its sulfated derivatives impair metabolism in HepG2 cells. Int J Biol Macromol 101:64-473. | Liver | Human | ||
Favero 2017 Thesis | 2017 | Favero BC (2017) Efeitos da leucina sobre a via da mTOR e da miostatina em cultura celular de miotĂșbulos. Dissertation p55. | Skeletal muscle | Mouse | ||
Dolezal 2017 J Biol Chem | 2017 | Dolezal JM, Wang H, Kulkarni S, Jackson L, Lu J, Ranganathan S, Goetzman ES, Bharathi SS, Beezhold K, Byersdorfer CA, Prochownik EV (2017) Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma. J Biol Chem 292:10068-86. | Liver | Mouse | ||
Phillips 2017 Cancer Res | 2017 | Phillips CM, Zatarain JR, Nicholls ME, Porter C, Widen SG, Thanki K, Johnson P, Jawad MU, Moyer MP, Randall JW, Hellmich JL, Maskey M, Qiu S, Wood TG, Druzhyna N, Szczesny B, MĂłdis K1, Szabo C, Chao C, Hellmich MR. (2017) Upregulation of Cystathionine-ÎČ-Synthase in Colonic Epithelia Reprograms Metabolism and Promotes Carcinogenesis.. Cancer Res. 77(21):5741-5754. | Endothelial;epithelial;mesothelial cell | Human | ||
Crouch 2017 PLOS ONE | 2017 | Crouch ML, Knowels G, Stuppard R, Ericson NG, Bielas JH, Marcinek DJ, Syrjala KL (2017) Cyclophosphamide leads to persistent deficits in physical performance and in vivo mitochondria function in a mouse model of chemotherapy late effects. PLOS ONE 12:e0181086. | Skeletal muscle | Mouse | ||
Rohde 2017 Cell Death Differ | 2017 | Rohde K, Kleinesudeik L, Roesler S, Löwe O, Heidler J, Schröder K, Wittig I, Dröse S, Fulda S (2017) A Bak-dependent mitochondrial amplification step contributes to Smac mimetic/glucocorticoid-induced necroptosis. Cell Death Differ 24:83-97. | Fibroblast | Mouse | ||
Cunha de Padua 2017 Carbohydr Polym | 2017 | Cunha de Padua MM, Suter Correia Cadena SM, de Oliveira Petkowicz CL, Martinez GR, Rodrigues Noleto G (2017) Toxicity of native and oxovanadium (IV/V) galactomannan complexes on HepG2 cells is related to impairment of mitochondrial functions. Carbohydr Polym 173:665-75. | Liver | Human | ||
Rouet 2017 US Patent | 2017 | Rouet P, Smih F (2017) ApoO for use in method for treating cancer and various pathophysiological situations. US Patent US20170035842 A1. | Heart Liver | Human Mouse | ||
Cockova 2017 Thesis | 2017 | ÄoÄkovĂĄ Z (2017) Modulation of RNA demethylase FTO function in SH-SY5Y cells: the effect on insulin signaling and mitochondrial respiration. Diploma Thesis p70. | Nervous system | Human | Inhibitor | |
Cunha-de 2017 Thesis | 2017 | Cunha-de Padua MM (2017) Mecanismos citotĂłxicos da galactomanana de sementes de Schizolobium amazonicum e seus complexos com oxovanĂĄdio em cĂ©lulas de hepatocarcinoma humano (HepG2) e efeito do silenciamento da enzima glucose-6-fosfato isomerase (GPI) na sobrevivĂȘncia de cĂ©lulas de adenocarcinoma de cĂłlon humano (LS174T). Doctoral Thesis p160. | Liver Other cell lines | Human | ||
Yang 2017 Cell Death Dis | 2017 | Yang N, Weinfeld M, Lemieux H, Montpetit B, Goping IS (2017) Photo-activation of the delocalized lipophilic cation D112 potentiates cancer selective ROS production and apoptosis. Cell Death Dis 8:e2587. | Lymphocyte | Saccharomyces cerevisiae Human | ||
Blecha 2017 Free Radic Biol Med | 2017 | Blecha J, Novais SM, Rohlenova K, Novotna E, Lettlova S, Schmitt S, Zischka H, Neuzil J, Rohlena J (2017) Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death. Free Radic Biol Med 112:253-66. | Endothelial;epithelial;mesothelial cell | |||
Huang 2017 Sci Rep | 2017 | Huang L, Zhang K, Guo Y, Huang F, Yang K, Chen L, Huang K, Zhang F, Long Q, Yang Q (2017) Honokiol protects against doxorubicin cardiotoxicity via improving mitochondrial function in mouse hearts. Sci Rep 7:11989. | Heart | Mouse | ||
Asiri 2017 Thesis | 2017 | Asiri A (2017) Effects of asiatic acid on neurite outgrowth in Neuro-2a cells. Master's Thesis p42. | Nervous system | Mouse | ||
Comelli 2017 J Bioenerg Biomembr | 2017 | Comelli M, Pretis I, Buso A, Mavelli I (2017) Mitochondrial energy metabolism and signalling in human glioblastoma cell lines with different PTEN gene status. J Bioenerg Biomembr 50:33-52. | Nervous system | Human | ||
Koit 2017 Oxid Med Cell Longev | 2017 | Koit A, Shevchuk I, Ounpuu L, Klepinin A, Chekulayev V, Timohhina N, Tepp K, Puurand M,Truu L, Heck K, Valvere V, Guzun R, Kaambre T (2017) Mitochondrial respiration in human colorectal and breast cancer clinical material is regulated differently. Oxid Med Cell Longev 2017:1372640. | Endothelial;epithelial;mesothelial cell | Human | ADP | |
Geoghegan 2017 Oncol Lett | 2017 | Geoghegan F, Chadderton N, Farrar GJ, Zisterer DM1, Porter RK (2017) Direct effects of phenformin on metabolism/bioenergetics and viability of SH-SY5Y neuroblastoma cells. Oncol Lett 14:6298-306. | Nervous system | Human | ||
Saintas 2017 PLOS ONE | 2017 | Saintas E, Abrahams L, Ahmad GT, Ajakaiye AM, AlHumaidi AS, Ashmore-Harris C, Clark I, Dura UK, Fixmer CN, Ike-Morris C, Mato Prado M, Mccullough D, Mishra S, Schöler KM, Timur H, Williamson MD, Alatsatianos M, Bahsoun B, Blackburn E, Hogwood CE, Lithgow PE, Rowe M, Yiangou L, Rothweiler F, Cinatl J Jr, Zehner R, Baines AJ, Garrett MD, Gourlay CW, Griffin DK, Gullick WJ, Hargreaves E, Howard MJ, Lloyd DR, Rossman JS, Smales CM, Tsaousis AD, von der Haar T, Wass MN, Michaelis M (2017) Acquired resistance to oxaliplatin is not directly associated with increased resistance to DNA damage in SK-N-ASrOXALI4000, a newly established oxaliplatin-resistant sub-line of the neuroblastoma cell line SK-N-AS. PLOS ONE 12:e0172140. | Nervous system Other cell lines | Human | ||
Zhou 2017 Oxid Med Cell Longev | 2017 | Zhou H, Nie K, Qiu R, Xiong J, Shao X, Wang B, Shen L, Lyu J, Fang H (2017) Generation and bioenergetic profiles of cybrids with east Asian mtDNA haplogroups. Oxid Med Cell Longev 2017:1062314. | Human | |||
Alves 2017 Free Radic Biol Med | 2017 | Alves de Souza CE, Alves de Souza HM, Stipp MC, Corso CR, Galindo CM, Cardoso CR, Dittrich RL, de Souza Ramos EA, Klassen G, Carlos RM, Correia Cadena SMS, Acco A (2017) Ruthenium complex exerts antineoplastic effects that are mediated by oxidative stress without inducing toxicity in Walker-256 tumor-bearing rats. Free Radic Biol Med 110:228-39. | Rat | |||
Balcaitis 2017 Thesis | 2017 | Balcaitis D (2017) The investigation of derivates of the 1,4-naphthoquinone effects to mitochondrial oxygen consumption in glioblastoma cells. Diploma Thesis p43. | Nervous system Other cell lines | Rat | ||
Xhani 2017 Thesis | 2017 | Xhani M (2017) Cellular redox homeostasis and environmental toxicity. Dissertation p110. | Liver Other cell lines | Human | ||
Greenall 2017 Oncogenesis | 2017 | Greenall SA, Lim YC, Mitchell CB, Ensbey KS, Stringer BW, Wilding AL, O'Neill GM, McDonald KL, Gough DJ, Day BW, Johns TG (2017) Cyclin-dependent kinase 7 is a therapeutic target in high-grade glioma. Oncogenesis 6:e336. | Nervous system | Human | ||
Ren 2017 Front Pharmacol | 2017 | Ren YJ, Wang XH, Ji C, Guan YD, Lu XJ, Liu XR, Zhang HH, Guo LC, Xu QH, Zhu WD, Ming ZJ, Yang JM, Cheng Y, Zhang Y (2017) Silencing of NAC1 expression induces cancer cells oxidative stress in hypoxia and potentiates the therapeutic activity of elesclomol. Front Pharmacol 8:804. | HeLa Other cell lines | Human | ||
Lopez 2017 Sci Rep | 2017 | Lopez Sanchez MIG, Waugh HS, Tsatsanis A, Wong BX, Crowston JG, Duce JA, Trounce IA (2017) Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta. Sci Rep 7:9835. | Human | |||
Ma 2017 Int J Cancer | 2017 | Ma L, Fu Q, Xu B, Zhou H, Gao J, Shao X, Xiong J, Gu Q, Wen S, Li F, Shen L, Chen G, Fang H, Lyu J (2017) Breast cancer-associated mitochondrial DNA haplogroup promotes neoplastic growth via ROS-mediated AKT activation. Int J Cancer 142:1786-96. | Human | |||
Canevarolo 2017 Thesis | 2017 | Canevarolo RR (2017) ResistĂȘncia ao metotrexato estĂĄ diretamente associada Ă concentração de glutationa em linhagens de leucemia linfoide aguda. Dissertation p159. | Macrophage-derived | Human | ||
Rodrigues-Silva 2017 J Neurooncol | 2017 | Rodrigues-Silva E, Siqueira-Santos ES, Ruas JS, Ignarro RS, Figueira TR, Rogério F, Castilho RF (2017) Evaluation of mitochondrial respiratory function in highly glycolytic glioma cells reveals low ADP phosphorylation in relation to oxidative capacity. 10.1007/s11060-017-2482-0 | Nervous system | Rat | Inhibitor | |
Valis 2017 Oncotarget | 2017 | ValiĆĄ K, GrobĂĄrovĂĄ V, HernychovĂĄ L, BugĂĄĆovĂĄ M4, Kavan D, Kalous M, ÄernĂœ J, StodĆŻlkovĂĄ E, Kuzma M, Flieger M, ÄernĂœ J, NovĂĄk P (2017) Reprogramming of leukemic cell metabolism through the naphthoquinonic compound Quambalarine B. Oncotarget 8:103137-53. | Liver | Rat | ||
Welker 2017 Thesis | 2017 | Welker L (2017) Metabolic and morphologic shifts in Neuro2a cells cultured in galactose medium. Master's Thesis p26. | Mouse | |||
Jackson 2017 Cancer Res | 2017 | Jackson LE, Kulkarni S, Wang H, Lu J, Dolezal JM, Bharathi SS, Ranganathan S, Patel MS, Deshpande R, Alencastro F, Wendell SG, Goetzman ES, Duncan AW, Prochownik EV (2017) Genetic dissociation of glycolysis and the TCA cycle affects neither normal nor neoplastic proliferation. Cancer Res 77:5795-807. | Liver | Mouse | ||
Rohlenova 2016 Antioxid Redox Signal | 2016 | Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2high breast cancer. Antioxid Redox Signal 26:84-103. | Liver Genital Other cell lines | Human Mouse | ||
Raesaenen 2016 Proc Natl Acad Sci U S A | 2016 | RÀsÀnen M, Degerman J, Nissinen TA, Miinalainen I, KerkelÀ R, Siltanen A, Backman JT, Mervaala E, Hulmi JJ, KivelÀ R, Alitalo K (2016) VEGF-B gene therapy inhibits doxorubicin-induced cardiotoxicity by endothelial protection. Proc Natl Acad Sci U S A 113:13144-49. | Heart | Mouse | ||
Ruas 2016 PLOS ONE | 2016 | Ruas JS, Siqueira-Santos ES, Amigo I, Rodrigues-Silva E, Kowaltowski AJ, Castilho RF (2016) Underestimation of the maximal capacity of the mitochondrial electron transport system in oligomycin-treated cells. PLOS ONE 11:e0150967. | Nervous system Genital Other cell lines | Human Rat | Inhibitor Substrate | |
Liu 2016 Apoptosis | 2016 | Liu X, Gao RW, Li M, Si CF, He YP, Wang M, Yang Y, Zheng QY, Wang CY (2016) The ROS derived mitochondrial respiration not from NADPH oxidase plays key role in Celastrol against angiotensin II-mediated HepG2 cell proliferation. Apoptosis 21:1315-26. | Liver Other cell lines | Human | ||
Villani 2016 Mol Metab | 2016 | Villani LA, Smith BK, Marcinko K, Ford RJ, Broadfield LA, Green AE, Houde VP, Muti P, Tsakiridis T, Steinberg GR (2016) The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration. Mol Metab 5:1048-56. | Genital | Human | Inhibitor | |
Zhunussova 2016 PLOS ONE | 2016 | Zhunussova A, Vitol EA, Polyak B, Tuleukhanov S, Brooks AD, Sensenig R, Friedman G, Orynbayeva Z (2016) Mitochondria-mediated anticancer effects of non-thermal atmospheric plasma. PLOS ONE 11:e0156818. | Genital Other cell lines | Human | ||
Bueno 2016 Thesis | 2016 | Bueno e Silva MM (2016) AlteraçÔes mitocondriais e reprogramação metabólica em células de glioblastoma após tratamento com temozolomida. Dissertation p71. | Nervous system Other cell lines | Human | Inhibitor | |
Gdynia 2016 Nat Commun | 2016 | Gdynia G, Sauer SW, Kopitz J, Fuchs D, Duglova K, Ruppert T, Miller M, Pahl J, Cerwenka A, Enders M, MairbĂ€url H, KamiĆski MM, Penzel R, Zhang C, Fuller JC, Wade RC, Benner A, Chang-Claude J, Brenner H, Hoffmeister M, Zentgraf H, Schirmacher P, Roth W (2016) The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration. Nat Commun 7:10764. | Endothelial;epithelial;mesothelial cell Other cell lines | Human | ||
Bastian 2016 Cancer Lett | 2016 | Bastian A, Matsuzaki S, Humphries KM, Pharaoh GA, Doshi A, Zaware N, Gangjee A, Ihnat MA (2016) AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization. Cancer Lett pii: S0304-3835(16)30745-5. | Mouse | Inhibitor | ||
Breitenbach 2016 Biomolecules | 2016 | Breitenbach M, Eckl P (Ed.) (2016) Oxidative stress in health and disease. Biomolecules p512. | ||||
Gilliam 2016 Am J Physiol Endocrinol Metab | 2016 | Gilliam LA, Lark DS, Reese LR, Torres MJ, Ryan TE, Lin CT, Cathey BL, Neufer PD (2016) Targeted overexpression of mitochondrial catalase protects against cancer chemotherapy-induced skeletal muscle dysfunction. Am J Physiol Endocrinol Metab 311:E293-301. | Skeletal muscle | Mouse | ||
Birkenmeier 2016 Int J Cancer | 2016 | Birkenmeier Katrin, Droese Stefan, Wittig Ilka, Winkelmann Ria, Kaefer Viktoria, Doering Claudia, Hartmann Sylvia, Wenz Tina, Reichert Andreas S, Brandt Ulrich, Hansmann MartinâLeo (2016) Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation. Int J Cancer 138:2231-46. | Other cell lines HeLa Macrophage-derived | Human | ||
Kalinina 2016 J Biophotonics | 2016 | Kalinina S, Breymayer J, SchĂ€fer P, Calzia E, Shcheslavskiy V, Becker W, RĂŒck A (2016) Correlative NAD(P)H-FLIM and oxygen sensing-PLIM for metabolic mapping. J Biophotonics 9:800-11. | Endothelial;epithelial;mesothelial cell Other cell lines | Human | ||
Brecht 2016 Toxicol In Vitro | 2016 | Brecht K, Riebel V, Couttet P, Paech F, Wolf A, Chibout SD, Pognan F, KrĂ€henbĂŒhl S, Uteng M (2016) Mechanistic insights into selective killing of OXPHOS-dependent cancer cells by arctigenin. Toxicol In Vitro 40:55-65. | Islet cell;pancreas;thymus | Human | ||
Leucci 2016 Nature | 2016 | Leucci E, Vendramin R, Spinazzi M, Laurette P, Fiers M, Wouters J, Radaelli E, Eyckerman S, Leonelli C, Vanderheyden K, Rogiers A, Hermans E, Baatsen P, Aerts S, Amant F, Van Aelst S, van den Oord J, de Strooper B, Davidson I, Lafontaine DL, Gevaert K, Vandesompele J, Mestdagh P, Marine JC (2016) Melanoma addiction to the long non-coding RNA SAMMSON. Nature 531:518-22. | Endothelial;epithelial;mesothelial cell Other cell lines | Human | ||
Nissinen 2016 Sci Rep | 2016 | Nissinen TA, Degerman J, RÀsÀnen M, Poikonen AR, Koskinen S, Mervaala E, Pasternack A, Ritvos O, KivelÀ R, Hulmi JJ (2016) Systemic blockade of ACVR2B ligands prevents chemotherapy-induced muscle wasting by restoring muscle protein synthesis without affecting oxidative capacity or atrogenes. Sci Rep 6:32695. | Skeletal muscle | Mouse | ||
Schoenenberger 2016 Cancer Res | 2016 | Schönenberger D, Harlander S, Rajski M, Jacobs RA, Lundby AK, Adlesic M, Hejhal T, Wild PJ, Lundby C, Frew IJ (2016) Formation of renal cysts and tumors in Vhl/Trp53-deficient mice requires HIF1α and HIF2α. Cancer Res 76:2025-36. | Nervous system | Mouse | ATP production | |
Morad 2016 J Lipid Res | 2016 | Morad SA, Ryan TE, Neufer PD, Zeczycki TN, Davis TS, MacDougall MR, Fox TE, Tan SF, Feith DJ, Loughran TP Jr, Kester M, Claxton DF, Barth BM, Deering TG, Cabot MC (2016) Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia. J Lipid Res 57:1231-42. | Blood cells Other cell lines | Human | ||
Klepinin 2016 J Bioenerg Biomembr | 2016 | Klepinin A, Ounpuu L, Guzun R, Chekulayev V, Timohhina N, Tepp K, Shevchuk I, Schlattner U, Kaambre T (2016) Simple oxygraphic analysis for the presence of adenylate kinase 1 and 2 in normal and tumor cells. J Bioenerg Biomembr 48:531-48. | Heart Nervous system Endothelial;epithelial;mesothelial cell Genital | Human Rat Mouse | ATP AMP | |
Lim 2016 FASEB J | 2016 | Lim SC, HroudovĂĄ J, Van Bergen NJ, Lopez Sanchez MI, Trounce IA, McKenzie M (2016) Loss of mitochondrial DNA-encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly. FASEB J 30:2236-48. | Other cell lines | Human | ||
Cerwenka 2016 Mol Cell Oncol | 2016 | Cerwenka A, Kopitz J, Schirmacher P, Roth W, Gdynia G (2016) HMGB1: The metabolic weapon in the arsenal of NK cells. Mol Cell Oncol 3:e1175538. | Endothelial;epithelial;mesothelial cell Other cell lines | Human | ||
Peruzzo 2016 Cell Cycle | 2016 | Peruzzo P, Comelli M, Di Giorgio E, Franforte E, Mavelli I, Brancolini C (2016) Transformation by different oncogenes relies on specific metabolic adaptations. Cell Cycle 15:2656-68. | Fibroblast | Mouse | ||
Jardim-Messeder 2016 Anticancer Res | 2016 | Jardim-Messeder D, Moreira-Pacheco F (2016) 3-Bromopyruvic acid inhibits tricarboxylic acid cycle and glutaminolysis in HepG2 cells. Anticancer Res 36:2233-41. | Liver Kidney | Mouse | ||
Holandino 2016 Bioelectrochemistry | 2016 | Holandino C, Teixeira CA, de Oliveira FA, Barbosa GM, Siqueira CM, Messeder DJ, de Aguiar FS, da Veiga VF, Girard-Dias W, Miranda K, Galina A, Capella MA, Morales MM (2016) Direct electric current treatment modifies mitochondrial function and lipid body content in the A549 cancer cell line. Bioelectrochemistry 111:83-92. | Lung;gill Other cell lines | Human | ||
Casinelli 2016 Cell Death Discov | 2016 | Casinelli G, LaRosa J, Sharma M, Cherok E, Banerjee S, Branca M, Edmunds L, Wang Y, Sims-Lucas S, Churley L, Kelly S, Sun M, Stolz D, Graves JA (2016) N-Myc overexpression increases cisplatin resistance in neuroblastoma via deregulation of mitochondrial dynamics. Cell Death Discov 2:16082. | Nervous system Other cell lines | Human | ||
Coelho 2016 Oncol Rep | 2016 | Coelho RG, Cazarin JM, Cavalcanti de Albuquerque JP, de Andrade BM, Carvalho DP (2016) Differential glycolytic profile and Warburg effect in papillary thyroid carcinoma cell lines. Oncol Rep 36:3673-81. | Other cell lines | Human | Aerobic glycolysis | |
Schoepf 2016 FEBS J | 2016 | Schöpf B, SchÀfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. https://doi.org/10.1111/febs.13733 | Endothelial;epithelial;mesothelial cell Genital Other cell lines Fibroblast | Human | ||
Wang 2016 J Biol Chem | 2016 | Wang H, Lu J, Edmunds LR, Kulkarni S, Dolezal J, Tao J, Ranganathan S, Jackson L, Fromherz M, Stolz DB, Uppala R, Bharathi S, Monga SP, Goetzman ES, Prochownik EV (2016) Coordinated activities of multiple Myc-dependent and Myc-independent biosynthetic pathways in Hepatoblastoma. J Biol Chem 291:26241-51. | Liver | Mouse | ||
Brandt 2016 Chem Biol Interact | 2016 | Brandt AP, Gozzi GJ, Pires Ado R, Martinez GR, Dos Santos Canuto AV, Echevarria A, Di Pietro A, Cadena SM (2016) Impairment of oxidative phosphorylation increases the toxicity of SYD-1 on hepatocarcinoma cells (HepG2). Chem Biol Interact 256:154-60. | Liver Other cell lines | Human | ||
Tan 2015 Cell Metab | 2015 | Tan AS, Baty JW, Dong L, Bezawork-Geleta A, Endaya B, Goodwin J, Bajzikova M, Kovarova J, Peterka M, Yan B, Pesdar EA, Sobol M, Filimonenko A, Stuart S, Vondrusova M, Kluckova K, Sachaphibulkij K, Rohlena J, Hozak P, Truksa J, Eccles D, Haupt LM, Griffiths LR, Neuzil J, Berridge MV (2015) Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. Cell Metab 21:81-94. | Endothelial;epithelial;mesothelial cell Genital Other cell lines | Human Mouse | ||
Garama 2015 Mol Cell Biol | 2015 | Garama DJ, Harris TJ, White CL, Rossello FJ, Abdul-Hay M, Gough DJ, Levy DE (2015) A synthetic lethal interaction between glutathione synthesis and mitochondrial reactive oxygen species provides a tumor-specific vulnerability dependent on STAT3. Mol Cell Biol 35:3646-56. | Endothelial;epithelial;mesothelial cell Fibroblast | Mouse | ||
Singh 2015 Free Radic Biol Med | 2015 | Singh P, Sharma R, McElhanon K, Allen CD, Megyesi JK, BeneĆĄ H, Singh SP (2015) Sulforaphane protects the heart from doxorubicin-induced toxicity. Free Radic Biol Med 86:90-101. | Heart Other cell lines | Mouse | ||
Rodrigues 2016 Biochem J | 2015 | Rodrigues MF, Obre E, Melo FH, Santos-Jr GC, Galina A, Jasiulionis MG, Rossignol R, Rumjanek FD, Amoedo ND (2016) Enhanced OXPHOS, glutaminolysis and beta-oxidation constitute the metastatic phenotype of melanoma cells. https://doi.org/10.1042/BJ20150645 | Endothelial;epithelial;mesothelial cell Other cell lines | Mouse | ATP production | |
Lim 2015 Am J Cancer Res | 2015 | Lim SC, Carey KT, McKenzie M (2015) Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I). Am J Cancer Res 5:689-701. | Kidney Other cell lines HEK HeLa Fibroblast | Human | ||
Ruiz-Perez 2015 J Biol Chem | 2015 | Ruiz-PĂ©rez MV, Medina MĂ, Urdiales JL, KeinĂ€nen TA, SĂĄnchez-JimĂ©nez F (2015) Polyamine metabolism is sensitive to glycolysis inhibition in human neuroblastoma cells. J Biol Chem 290:6106-19. | Nervous system Other cell lines Neuroblastoma | Human | ||
Ofer 2015 Mol Endocrinol | 2015 | Ofer P, Heidegger I, Eder IE, Schöpf B, Neuwirt H, Geley S, Klocker H, Massoner P (2015) Both IGF1R and INSR knockdown exert anti-tumorigenic effects in prostate cancer in vitro and in vivo. Mol Endocrinol 29:1694-707. | Genital Other cell lines | Human | ||
Teh 2015 Oncogene | 2015 | Teh JT, Zhu WL, Ilkayeva OR, Li Y, Gooding J, Casey PJ, Summers SA, Newgard CB, Wang M (2015) Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism. Oncogene 34:3296-304. | Other cell lines | Human | ||
Zhunussova 2015 Am J Cancer Res | 2015 | Zhunussova A, Sen B, Friedman L, Tuleukhanov S, Brooks AD, Sensenig R, Orynbayeva Z (2015) Tumor microenvironment promotes dicarboxylic acid carrier-mediated transport of succinate to fuel prostate cancer mitochondria. Am J Cancer Res 5:1665-79. | Endothelial;epithelial;mesothelial cell Genital Other cell lines | Human Rat | pH Substrate | |
Tesori 2015 Sci Rep | 2015 | Tesori V, Piscaglia AC, Samengo D, Barba M, Bernardini C, Scatena R, Pontoglio A, Castellini L, Spelbrink JN, Maulucci G, Puglisi MA, Pani G, Gasbarrini A (2015) The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing. Sci Rep 5:9149. | Liver Other cell lines Stem cells | Rat | ||
Park 2015 Proc Natl Acad Sci USA | 2015 | Park JH, Kang HJ, Lee YK, Kang H, Kim J, Chung JH, Chang JS, McPherron AC, Lee SB (2015) Inactivation of EWS reduces PGC-1α protein stability and mitochondrial homeostasis. Proc Natl Acad Sci USA 112:6074-9. | Fat | Mouse | ||
Tomsik 2015 J Organomet Chem | 2015 | TomsĂk P, Muthna D, Rezacova M, Micuda S, Cmielova J, Hroch M, Endlicher R, Cervinkova Z, Rudolf E, Hann S, StĂbal D, Therrien B, SĂŒss-Fink G (2015) [(p-MeC6H4Pri)2Ru2(SC6H4-p-But)3]Cl (diruthenium-1), a dinuclear arene ruthenium compound with very high anticancer activity: An in vitro and in vivo study. J Organomet Chem 782:42-51. | Liver | Rat | ||
Peyta 2015 Biochim Biophys Acta | 2015 | Peyta L, Jarnouen K, Pinault M, Coulouarn C, Guimaraes C, Goupille C, de Barros JP, Chevalier S, Dumas JF, Maillot F, Hatch GM, Loyer P, Servais S (2015) Regulation of hepatic cardiolipin metabolism by TNFα: Implication in cancer cachexia. Biochim Biophys Acta 1851:1490-500. | Liver Other cell lines | Rat | ||
Truksa 2015 Antioxid Redox Signal | 2015 | Truksa J, Dong L, Rohlena J, Stursa J, Vondrusova M, Goodwin J, Nguyen M, Kluckova K, Rychtarcikova Z, Lettlova S, Spacilova J, Stapelberg M, Zoratti M, Neuzil J (2015) Mitochondrially targeted vitamin E succinate modulates expression of mitochondrial DNA transcripts and mitochondrial biogenesis. Antioxid Redox Signal 22:883-900. | Genital Other cell lines | Human Mouse | ||
Dueregger 2015 PLoS One | 2015 | Dueregger A, Schöpf B, Eder T, Höfer J, Gnaiger E, Aufinger A, Kenner L, Perktold B, Ramoner R, Klocker H, Eder IE (2015) Differential utilization of dietary fatty acids in benign and malignant cells of the prostate. PLoS One 10(8):e0135704. | Genital Other cell lines | Human | ||
Smolkova 2015 Int J Biochem Cell Biol | 2015 | SmolkovĂĄ K, DvoĆĂĄk A, Zelenka J, VĂtek L, JeĆŸek P (2015) Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells. Int J Biochem Cell Biol 65:125-33. | Endothelial;epithelial;mesothelial cell Other cell lines | Human | ||
Plecita-Hlavata 2015 J Bioenerg Biomembr | 2015 | PlecitĂĄ-HlavatĂĄ L, JeĆŸek J, JeĆŸek P (2015) Aglycemia keeps mitochondrial oxidative phosphorylation under hypoxic conditions in HepG2 cells. J Bioenerg Biomembr 47(6):467-76. | Liver | Human | ||
Kluckova 2015 Methods Mol Biol | 2015 | Kluckova K, Dong L, Bajzikova M, Rohlena J, Neuzil J (2015) Evaluation of respiration of mitochondria in cancer cells exposed to mitochondria-targeted agents. Methods Mol Biol 1265:181-94. | Endothelial;epithelial;mesothelial cell Genital Other cell lines | Mouse | ||
Gouspillou 2015 Sci Rep | 2015 | Gouspillou G, Scheede-Bergdahl C, Spendiff S, Vuda M, Meehan B, Mlynarski H, Archer-Lahlou E, Sgarioto N, Purves-Smith FM, Konokhova Y, Rak J, Chevalier S, Taivassalo T, Hepple RT, Jagoe RT (2015) Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle. Sci Rep 5:8717. | Mouse | |||
Sundstroem 2015 PhD Thesis | 2015 | SundstrĂžm T (2015) Experimental modeling and novel therapeutic strategies in melanoma brain metastasis. PhD Thesis 1-146. | Nervous system | Mouse | ||
Pasdar 2015 PLoS One | 2015 | Pasdar EA, Smits M, Stapelberg M, Bajzikova M, Stantic M, Goodwin J, Yan B, Stursa J, Kovarova J, Sachaphibulkij K, Bezawork-Geleta A, Sobol M, Filimonenko A, Tomasetti M, Zobalova R, Hozak P, Dong LF, Neuzil J (2015) Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents. PLoS One 10:e0119549. | Endothelial;epithelial;mesothelial cell Other cell lines | Human Mouse | ||
Schoeckel 2015 Cancer Metab | 2015 | Schöckel L, Glasauer A, Basit F, Bitschar K, Truong H, Erdmann G, Algire C, HÀgebarth A, Willems PH, Kopitz C, Koopman WJ, Héroult M (2015) Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth. Cancer Metab 3:11. | Endothelial;epithelial;mesothelial cell Other cell lines | Human Mouse | ||
Rodrigues 2015 J Cell Biochem | 2015 | Rodrigues MF, Carvalho Ă, Pezzuto P, Rumjanek FD, AmoĂȘdo ND (2015) Reciprocal modulation of histone deacetylase inhibitors sodium butyrate and trichostatin a on the energy metabolism of breast cancer cells. Int J Biochem Cell Biol 116:797-808. | Endothelial;epithelial;mesothelial cell Other cell lines | Human | ||
Chekulayev 2015 Biochem Biophys Rep | 2015 | Chekulayev V, Mado K, Shevchuk I, Koit A, Kaldma A, Klepinin A, Timohhina N, Tepp K, Kandashvili M, Ounpuu L, Heck K, Truu L, Planken A, Valvere V, Kaambre T (2015) Metabolic remodeling in human colorectal cancer and surrounding tissues: alterations in regulation of mitochondrial respiration and metabolic fluxes. Biochem Biophys Rep 4:111-25. | Endothelial;epithelial;mesothelial cell | Human | ADP | |
Yan 2015 BMC Cancer | 2015 | Yan B, Stantic M, Zobalova R, Bezawork-Geleta A, Stapelberg M, Stursa J, Prokopova K, Dong L, Neuzil J (2015) Mitochondrially targeted vitamin E succinate efficiently kills breast tumour-initiating cells in a complex II-dependent manner. BMC Cancer 15:401. | Genital Other cell lines | Human Mouse | ||
Victorino 2015 Tumour Biol | 2015 | Victorino VJ, Barroso WA, Assunção AK, Cury V, Jeremias IC, Petroni R, Chausse B, Ariga SK, Herrera AC, Panis C, Lima TM, Souza HP (2015) PGC-1ÎČ regulates HER2-overexpressing breast cancer cells proliferation by metabolic and redox pathways. Tumour Biol 37:6035-44. | Genital Other cell lines | Human | ||
Amoedo 2014 Int J Biochem Cell Biol | 2014 | Amoedo ND, Rodrigues MF, Rumjanek FD (2014) Mitochondria: are mitochondria accessory to metastasis? Int J Biochem Cell Biol 51: 53-7. | ||||
Petruzzelli 2014 Cell Metab | 2014 | Petruzzelli M, Schweiger M, Schreiber R, Campos-Olivas R, Tsoli M, Allen J, Swarbrick M, Rose-John S, Rincon M, Robertson G, Zechner R, Wagner EF (2014) A switch from white to brown fat increases energy expenditure in cancer-associated cachexia. Cell Metab 20:433-47. | Fat | Mouse | ||
Rossato 2014 PLoS One | 2014 | Rossato FA, Zecchin KG, La Guardia PG, Ortega RM, Alberici LC, Costa RA, Catharino RR, Graner E, Castilho RF, Vercesi AE (2014) Fatty acid synthase inhibitors induce apoptosis in non-tumorigenic Melan-A cells associated with inhibition of mitochondrial respiration. PLoS One 9:e101060. | Endothelial;epithelial;mesothelial cell Other cell lines | Mouse | ||
Stokich 2014 Cryobiology | 2014 | Stokich B, Osgood Q, Grimm D, Moorthy S, Chakraborty N, Menze MA (2014) Cryopreservation of hepatocyte (HepG2) cell monolayers: Impact of trehalose. Cryobiology 69:281-90. | Liver | Human | ||
Kaldma 2014 Int J Biochem Cell Biol | 2014 | Kaldma A, Klepinin A, Chekulayev V, Mado K, Shevchuk I, Timohhina N, Tepp K, Kandashvili M, Varikmaa M, Koit A, Planken M, Heck K, Truu L, Planken A, Valvere V, Rebane E, Kaambre T (2014) An in situ study of bioenergetic properties of human colorectal cancer: The regulation of mitochondrial respiration and distribution of flux control among the components of ATP synthasome. Int J Biochem Cell Biol 55C:171-86. | Genital | Human | ADP Inhibitor PCr;Cr | |
Galina 2014 Int J Biochem Cell Biol | 2014 | Galina A (2014) Mitochondria: 3-Bromopyruvate vs. mitochondria? A small molecule that attacks tumors by targeting their bioenergetic diversity. Insect Biochem Mol Biol S1357-2725. | ||||
Chini 2014 Clin Cancer Res | 2014 | Chini CC, Gonzalez Guerrico A, Nin V, Camacho-Pereira J, Escande C, Barbosa M, Chini EN (2014) Targeting of NAD metabolism in pancreatic cancer cells: potential novel therapy for pancreatic tumors. Clin Cancer Res 20:120-30. | Islet cell;pancreas;thymus Other cell lines | Human | ||
Hunter 2014 PhD Thesis | 2014 | Hunter FW (2014) Old target; new paradigm: Determinants of sensitivity to hypoxia-directed anticancer prodrugs. PhD Thesis:1-353. | CHO | Other mammals | ||
Kaambre 2013 Front Physiol | 2013 | Kaambre T, Chekulayev V, Shevchuk I, Tepp K, Timohhina N, Varikmaa M, Bagur R, Klepinin A, Anmann T, Koit A, Kaldma A, Guzun R, Valvere V, Saks V (2013) Metabolic control analysis of respiration in human cancer tissue. Front Physiol 4:151. | Endothelial;epithelial;mesothelial cell | Human | ADP Flux control Inhibitor PCr;Cr | |
Bhattacharyya 2013 PLoS One | 2013 | Bhattacharyya S, Saha S, Giri K, Lanza IR, Nair KS, Jennings NB, Rodriguez-Aguayo C, Lopez-Berestein G, Basal E, Weaver AL, Visscher DW, Cliby W, Sood AK, Bhattacharya R, Mukherjee P (2013) Cystathionine Beta-Synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance. PLoS One 8:e79167. | Genital Other cell lines | Human | ||
Vielhaber 2013 Acta Neuropathol | 2013 | Vielhaber S, Debska-Vielhaber G, Peeva V, Schoeler S, Kudin AP, Minin I, Schreiber S, Dengler R, Kollewe K, Zuschratter W, Kornblum C, Zsurka G, Kunz WS (2013) Mitofusin 2 mutations affect mitochondrial function by mitochondrial DNA depletion. Acta Neuropathol 125:245-56. | Skeletal muscle | Human | Inhibitor Threshold;excess capacity | |
Teixeira 2013 Thesis Universidade Federal do Rio de Janeiro - Brazil | 2013 | Teixeira CAA (2013) Mechanisms of antitumoral effects of direct electric current: an in vitro study in lung adenocarcinoma. Thesis Universidade Federal do Rio de Janeiro - Brazil 345pp. | Lung;gill Other cell lines | Human | ||
Felser 2013 Toxicol Sci | 2013 | Felser A, Blum K, Lindinger PW, Bouitbir J, Kraehenbuehl S (2013) Mechanisms of hepatocellular toxicity associated with dronedarone - a comparison to amiodarone. Toxicol Sci 131:480-90. | Liver | Human Rat | Inhibitor mt-Membrane potential Fatty acid | |
Gilliam 2013 Free Radic Biol Med | 2013 | Gilliam LA, Fisher-Wellman KH, Lin CT, Maples JM, Cathey BL, Neufer PD (2013) The anticancer agent doxorubicin disrupts mitochondrial energy metabolism and redox balance in skeletal muscle. Free Radic Biol Med 65:988-96. | Skeletal muscle | Rat | ||
Dickinson 2013 Cell Death Differ | 2013 | Dickinson A, Yeung KY, Donoghue J, Baker MJ, Kelly RDW, McKenzie M, Johns TG, St. John JC (2013) The regulation of mitochondrial DNA copy number in glioblastoma cells. Cell Death Differ 20:1644â53. | Nervous system Other cell lines | Human | ||
Santidrian 2013 J Clin Invest | 2013 | Santidrian AF, Matsuno-Yagi A, Ritland M, Seo BB, Leboeuf SE, Gay LJ, Yagi T, Felding-Habermann B (2013) Mitochondrial complex I activity and NAD+/NADH balance regulate breast cancer progression. J Clin Invest 123:1068-81. | Genital | Human | ||
Dickinson 2013 Thesis University of Warwick - Great Britain | 2013 | Dickinson A (2013) The role of mitochondrial DNA in tumorigenesis. Thesis University of Warwick - Great Britain 292pp. | Other cell lines | Human | ||
Mathieu 2013 J Med Chem | 2013 | Mathieu V, Van Den Berge E, Ceusters Justine D, Konopka T, Cops A, BruyĂšre C, Pirker C, Berger W, Trieu-Van T, Serteyn D, Kiss R, Robiette R (2013) New 5-Aryl-1H-imidazoles display in vitro antitumor activity against apoptosis-resistant cancer models, including melanomas, through mitochondrial targeting. J Med Chem 56:6626-37. | Endothelial;epithelial;mesothelial cell Other cell lines | Human | ||
Gottfried 2013 PLoS One | 2013 | Gottfried E, Lang SA, Renner K, Bosserhoff A, Gronwald W, Rehli M, Einhell S, Gedig I, Singer K, Seilbeck A, Mackensen A, Grauer O, Hau P, Dettmer K, Andreesen R, Oefner PJ, Kreutz M (2013) New aspects of an old drug - Diclofenac targets MYC and glucose metabolism in tumor cells. PLoS One 8:e66987. | Endothelial;epithelial;mesothelial cell Blood cells Other cell lines Lymphocyte | Human Mouse | ||
Lee 2012 Invest Ophthalmol Vis Sci | 2012 | Lee S, Sheck L, Crowston JG, Van Bergen NJ, O'Neill EC, O'Hare F, Kong YX, Chrysostomou V, Vincent AL, Trounce IA (2012) Impaired complex-I-linked respiration and ATP synthesis in primary open-angle glaucoma patient lymphoblasts. Invest Ophthalmol Vis Sci 53:2431-7. | Blood cells Lymphocyte | Human | ATP Substrate | |
Rodrigues-Ferreira 2012 J Bioenerg Biomembr | 2012 | Rodrigues-Ferreira C, Pereira da Silva AP, Galina A (2012) Effect of the antitumoral alkylating agent 3-bromopyruvate on mitochondrial respiration: role of mitochondrially bound hexokinase. J Bioenerg Biomembr 44:39-49. | Nervous system Liver Other cell lines | Human Mouse | ||
Halsne 2012 DNA Repair (Amst) | 2012 | Halsne R, Esbensen Y, Wang W, Scheffler K, Suganthan R, Bjoeraas M, Eide L (2012) Lack of the DNA glycosylases MYH and OGG1 in the cancer prone double mutant mouse does not increase mitochondrial DNA mutagenesis. DNA Repair (Amst) 11:278-85. | Nervous system | Mouse | ||
Domenis 2012 Int J Mol Sci | 2012 | Domenis R, Bisetto E, Rossi D, Comelli M, Mavelli I (2012) Glucose-modulated mitochondria adaptation in tumor cells: a focus on ATP synthase and inhibitor factor 1. Int J Mol Sci 13:1933-50. | Liver | Human | ||
Hirsch 2012 PloS One | 2012 | Hirsch A, Hahn D, KempnĂĄ P, Hofer G, Mullis PE, Nuoffer JM, FlĂŒck CE (2012) Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells. PLoS One 7:e30956. | Other cell lines | Human Pig | Substrate | |
Kaambre 2012 J Bioenerg Biomembr | 2012 | Kaambre T, Chekulayev V, Shevchuk I, Karu-Varikmaa M, Timohhina N, Tepp K, Bogovskaja J, KĂŒtner R, Valvere V, Saks V (2012) Metabolic control analysis of cellular respiration in situ in intraoperational samples of human breast cancer. J Bioenerg Biomembr 44:539-58. | Heart Endothelial;epithelial;mesothelial cell | Human Rat | ADP Flux control Inhibitor PCr;Cr | |
Jardim-Messeder 2012 Int J Biochem Cell Biol | 2012 | Jardim-Messeder D, Camacho-Pereira J, Galina A (2012) 3-Bromopyruvate inhibits calcium uptake by sarcoplasmic reticulum vesicles but not SERCA ATP hydrolysis activity. Int J Biochem Cell Biol 44:801-7. | Skeletal muscle | Rabbit | ADP Inhibitor | |
Chiusa 2012 J Mol Cell Cardiol | 2012 | Chiusa M, Hool SL, Truetsch P, Djafarzadeh S, Jakob SM, Seifriz F, Scherer SJ, Suter TM, Zuppinger C, Zbinden S (2012) Cancer therapy modulates VEGF signaling and viability in adult rat cardiac microvascular endothelial cells and cardiomyocytes. J Mol Cell Cardiol 52:1164-75. | Heart | Rat | ||
Hebert-Chatelain 2012 Biochim Biophys Acta | 2012 | Hebert-Chatelain E, Jose C, Gutierrez Cortes N, Dupuy JW, Rocher C, Dachary-Prigent J, Letellier T (2012) Preservation of NADH ubiquinone-oxidoreductase activity by Src kinase-mediated phosphorylation of NDUFB10. Biochim Biophys Acta 1817:718-725. | Human | ATP ATP production | ||
Jose 2012 Thesis | 2012 | Jose C (2012) RÎle des mitochondries dans la tumorigénÚse: implications pour le traitement du cancer. PhD Thesis 272. | Other cell lines HeLa | Human | ||
Piccoli 2012 Free Radic Biol Med | 2012 | Piccoli C, D'Aprile A, Scrima R, Ambrosi L, Zefferino R, Capitanio N (2012) Subcytotoxic mercury chloride inhibits gap junction intercellular communication by a redox- and phosphorylation-mediated mechanism. Free Radic Biol Med 52: 916-927. | Nervous system | Human | ||
Oliva 2011 PloS One | 2011 | Oliva CR, Moellering DR, Gillespie GY, Griguer CE (2011) Acquisition of chemoresistance in gliomas is associated with increased mitochondrial coupling and decreased ROS production. PloS One 6:e24665. | Nervous system | Human | ||
Eberhart 2011 Biochim Biophys Acta | 2011 | Eberhart K, Rainer J, Bindreither D, Ritter I, Gnaiger E, Kofler R, Oefner PJ, Renner K (2011) Glucocorticoid-induced alterations in mitochondrial membrane properties and respiration in childhood acute lymphoblastic leukemia. Biochim Biophys Acta 1807:719-25. | Blood cells | Human | ||
Kristiansen 2011 J Biol Chem | 2011 | Kristiansen G, Hu J, Wichmann D, Stiehl DP, Rose M, Gerhardt J, Bohnert A, ten Haaf A, Moch H, Raleigh J, Varia MA, Subarsky P, Scandurra FM, Gnaiger E, Gleixner E, Bicker A, Gassmann M, Hankeln T, Dahl E, Gorr TA (2011) Endogenous myoglobin in breast cancer is hypoxia-inducible by alternate transcription and functions to impair mitochondrial activity: a role in tumor suppression? https://doi.org/10.1074/jbc.M111.227553 | Genital Other cell lines | Human | Aerobic glycolysis Oxygen kinetics Substrate | |
Wang 2011 Mol Oncol | 2011 | Wang X, Moraes CT (2011) Increases in mitochondrial biogenesis impair carcinogenesis at multiple levels. Mol Oncol 5: 399-409. | ||||
Domenis 2011 J Bioenerg Biomembr | 2011 | Domenis R, Comelli M, Bisetto E, Mavelli I (2011) Mitochondrial bioenergetic profile and responses to metabolic inhibition in human hepatocarcinoma cell lines with distinct differentiation characteristics. J Bioenerg Biomembr 43: 493-505. | Liver | Human | ||
Amoedo 2011 PLoS One | 2011 | Amoedo ND, Rodrigues MF, Pezzuto P, Galina A, da Costa RM, de Almeida FC, El-Bacha T, Rumjanek FD (2011) Energy metabolism in h460 lung cancer cells: effects of histone deacetylase inhibitors. PLoS One 6:e22264. | Lung;gill | Human | Aerobic glycolysis ADP | |
Kluza 2011 PLoS One | 2011 | Kluza J, Jendoubi M, Ballot C, Dammak A, Jonneaux A, Idziorek T, Joha S, Dauphin V, Malet-Martino M, Balayssac S, Maboudou P, Briand G, Formstecher P, Quesnel B, Marchetti P (2011) Exploiting mitochondrial dysfunction for effective elimination of imatinib-resistant leukemic cells. PLoS One 6:e21924 | Blood cells | Human Mouse | Substrate | |
Namgaladze 2010 Atherosclerosis | 2010 | Namgaladze D, Preiss S, Dröse S, Brandt U, BrĂŒne B (2010) Phospholipase A2-modified low density lipoprotein induces mitochondrial uncoupling and lowers reactive oxygen species in phagocytes. Atherosclerosis 208:142-7. | Blood cells | Human | ||
Smolkova 2010 J Bioenerg Biomembr | 2010 | SmolkovĂĄ K, Bellance N, Scandurra F, GĂ©not E, Gnaiger E, PlecitĂĄ-HlavatĂĄ L, JeĆŸek P, Rossignol R (2010) Mitochondrial bioenergetic adaptations of breast cancer cells to aglycemia and hypoxia. https://doi.org/10.1007/s10863-009-9267-x | Fibroblast | Human | Oxygen kinetics | |
Yang 2010 Cancer Biol Ther | 2010 | Yang D, Wang MT, Tang Yong, Chen Y, Jiang H, Jones TT, Rao K, Brewer GJ, Singh KK, Nie D (2010) Impairment of mitochondrial respiration in mouse fibroblasts by oncogenic H-RAS(Q61L). Canc Biol Ther 9:122-33. | Fibroblast | Mouse | Aerobic glycolysis ADP Inhibitor Substrate | |
Verschoor 2010 PLoS One | 2010 | Verschoor ML, Wilson LA, Verschoor CP, Singh G (2010) Ets-1 regulates energy metabolism in cancer cells. PLoS One 5: e13565. | Human | |||
Fang 2010 Cell | 2010 | Fang M, Shen Z, Huang S, Zhao L, Chen S, Mak TW, Wang X (2010) The ER UDPase ENTPD5 promotes protein N-glycosylation, the Warburg effect, and proliferation in the PTEN pathway. Cell 143:711-24. | Aerobic glycolysis | |||
Mirebeau-Prunier 2010 FEBS J | 2010 | Mirebeau-Prunier D, Le Pennec S, Jacques C, Gueguen N, Poirier J, Malthiery Y, Savagner F (2010) Estrogen-related receptor alpha and PGC-1-related coactivator constitute a novel complex mediating the biogenesis of functional mitochondria. FEBS J 277:713-25. | Human | |||
Eberhart 2009 Leukemia | 2009 | Eberhart K, Renner K, Ritter I, Kastenberger M, Singer K, Hellerbrand C, Kreutz M, Kofler R, Oefner PJ (2009) Low doses of 2-deoxy-glucose sensitize acute lymphoblastic leukemia cells to glucocorticoid-induced apoptosis. Leukemia 23:2167-70. | Blood cells Lymphocyte | Human | ||
Pereira 2009 Biochem J | 2009 | Pereira da Silva AP, El-Bacha T, Kyaw N, dos Santos RS, Da Silva WS, Almeida FC, Da Poian AT, Galina A (2009) Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate. Biochem J 417:717-26. | Liver | Human | ||
Haendeler 2009 Arterioscler Thromb Vasc Biol | 2009 | Haendeler J, Dröse S, BĂŒchner N, Jakob S, Altschmied J, Goy C, Spyridopoulos I, Zeiher AM, Brandt U, Dimmeler S (2009) Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arterioscler Thromb Vasc Biol 29:929-35. | Heart Endothelial;epithelial;mesothelial cell Fibroblast | Human Mouse | Substrate | |
Mufazalov 2009 Mol Biol (Mosk) | 2009 | Mufazalov IA, Pen'kov DN, Cherniak BV, Pletiushkina OIu, Vysokikh MIu, Kirpichnikov MP, Dolgikh DA, Kruglov AA, Kuprash DV, Skulachev VP, Nedospasov SA (2009) Preparation and characterization of mouse embryonic fibroblasts with K72W mutation in somatic cytochrome c gene. Mol Biol (Mosk) 43:648-56. | Fibroblast | Mouse | Cyt c | |
Bellance 2009 Int J Biochem Cell Biol | 2009 | Bellance N, Benard G, Furt F, Begueret H, SmolkovĂĄ K, Passerieux E, Delage JP, Baste JM, Moreau P, Rossignol R (2009) Bioenergetics of lung tumors: Alteration of mitochondrial biogenesis and respiratory capacity. Int J Biochem Cell Biol 41:2566-77. | Fibroblast | Human | ADP Substrate | |
Garedew 2009 Respir Physiol Neurobiol | 2009 | Garedew A, KĂ€mmerer U, Singer D (2009) Respiratory response of malignant and placental cells to changes in oxygen concentration. Respir Physiol Neurobiol 165:154-60. | Blood cells | Human | ||
Samper 2009 Free Radic Biol Med | 2009 | Samper E, Morgado L, Estrada JC, Bernad A, Hubbard A, Cadenas S, Melov S (2009) Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas. Free Radic Biol Med 46:387-96. | Aerobic glycolysis | |||
Bredholt T 2009 Mol Cancer | 2009 | Bredholt T, Dimba EA, Hagland HR, Wergeland L, Skavland J, Fossan KO, Tronstad KJ, Johannessen AC, Vintermyr OK, Gjertsen BT (2009) Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines. Mol Cancer 8:101. | Blood cells | Human | ADP Inhibitor | |
Hervouet 2008 Carcinogenesis | 2008 | Hervouet E, CĂzkovĂĄ A, Demont J, VojtĂskovĂĄ A, Pecina P, Franssen-van Hal NL, Keijer J, Simonnet H, IvĂĄnek R, Kmoch S, Godinot C, Houstek J (2008) HIF and reactive oxygen species regulate oxidative phosphorylation in cancer. Carcinogenesis 29:1528-37. | ||||
Kuhnt 2007 Neurochem Res | 2007 | Kuhnt T, Pelz T, Qu X, Haensgen G, Dunst J, Gellerich FN (2007) Mitochondrial OXPHOS functions in R1H rhabdomyosarcoma and skeletal muscles of the rat. Neurochem Res 32:973â80. | Skeletal muscle | Rat | Substrate | |
Soller 2007 Mol Pharmacol | 2007 | Soller M, Dröse S, Brandt U, BrĂŒne B, von Knethen A (2007) Mechanism of Thiazolidinedione-dependent cell death in Jurkat T cells. Mol Pharmacol 71:1535-44. | Heart Other cell lines | Inhibitor mt-Membrane potential | ||
Labajova 2006 Anal Biochem | 2006 | Labajova A, Vojtiskova A, Krivakova P, Kofranek J, Drahota Z, Houstek J (2006) Evaluation of mitochondrial membrane potential using a computerized device with a tetraphenylphosphonium-selective electrode. Anal Biochem 353:37-42. | Liver | Rat | mt-Membrane potential | |
Pye 2006 Nucleic Acids Research | 2006 | Pye D, Kyriakouli DS, Taylor GA, Johnson R, Elstner M, Meunier B, Chrzanowska-Lightowlers ZMA, Taylor RW, Turnbull DM, Lightowlers RN (2006) Production of transmitochondrial cybrids containing naturally occurring pathogenic mtDNA variants. Nucleic Acids Research 34:e95 | Human | |||
Hervouet 2006 Biochem Biophys Res Commun | 2006 | Hervouet E, Pecina P, Demont J, VojtĂĆĄkovĂĄ A, Simonnet H, HouĆĄtek J, Godinot C (2006) Inhibition of cytochrome c oxidase subunit 4 precursor processing by the hypoxia mimic cobalt chloride. Biochem Biophys Res Commun 344:1086-93. | Human Saccharomyces cerevisiae Fungi | Inhibitor | ||
Chowdhury 2005 Biochem Biophys Res Comm | 2005 | Chowdhury SK, Gemin A, Singh G (2005) High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS production in prostate cancer cell lines. Biochem Biophys Res Comm 333:1139-45. | Genital | Human | Substrate | |
Hervouet 2005 Carcinogenesis | 2005 | Hervouet E, Demont J, Pecina P, VojtĂskovĂĄ A, Houstek J, Simonnet H, Godinot C (2005) A new role for the von Hippel-Lindau tumor suppressor protein: Stimulation of mitochondrial oxidative phosphorylation complex biogenesis. Carcinogenesis 26:531-9. | ||||
Renner 2003 Biochim Biophys Acta | 2003 | Renner K, Amberger A, Konwalinka G, Gnaiger E (2003) Changes of mitochondrial respiration, mitochondrial content and cell size after induction of apoptosis in leukemia cells. Biochim Biophys Acta 1642:115-23. | Blood cells | Human | Coupling efficiency;uncoupling Cyt c | |
Pasdois 2003 J Bioenerg Biomembr | 2003 | Pasdois P, Deveaud C, Voisin P, Bouchaud V, Rigoulet M, Beauvoit B (2003) Contribution of the phosphorylable complex I in the growth phase-dependent respiration of C6 glioma cells in vitro. J Bioenerg Biomembr 35:439-50. | Neuroblastoma | Rat | ||
Opalka 2002 Biochem Pharmacol | 2002 | Opalka JR, Gellerich FN, Kling L, MĂŒller-Beckmann B, Zierz S (2002) Effect of the new matrix metalloproteinase inhibitor RO-28-2653 on mitochondrial function. Biochem Pharmacol 63:725-32. | Heart | Rat | ||
Renner 2002 Mol Biol Rep | 2002 | Renner K, Kofler R, Gnaiger E (2002) Mitochondrial function in glucocorticoid triggered T-ALL cells with transgenic Bcl-2 expression. Mol Biol Rep 29:97-101. | Blood cells | Human | ||
Perrin 2002 Biochimie | 2002 | Perrin A, Roudier E , Duborjal H, Bachelet C, Riva-Lavieille C, Leverve X, Massarelli R (2002) Pyruvate reverses metabolic effects produced by hypoxia in glioma and hepatoma cell cultures. Biochimie 84:1003-11. | Nervous system Liver | Human Rat | ||
Savagner 2001 J Clin Endocrinol Metabol | 2001 | Savagner F, Franc B, Guyetant S, Rodien P, Reynier P, Malthiery Y (2001) Defective mitochondrial ATP synthesis in oxyphilic thyroid tumors. J Clin Endocrinol Metabol 86:4920-25. | Human | Coupling efficiency;uncoupling | ||
Knoblechner 1994 BTK-294 | 1994 | Knoblechner A, Steinlechner R, Schirmer M, Gellerich FN, Margreiter R, Konwalinka G, Gnaiger E (1994) The effect of 2-chlorodeoxy-adenosine on endogenous respiration of a human lymphoma cell line (U-937). In: What is Controlling Life? (Gnaiger E, Gellerich FN, Wyss M, eds) Modern Trends in BioThermoKinetics 3. Innsbruck Univ Press:294-6. | Blood cells | Human |
O2k-Publications: Cancer - Abstracts
Sort in ascending/descending order by a click on one of the small symbols in squares below.
Year | Reference | Tissue and cell | Cell line | Mammal and model | Regulation;kinetics | |
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Strich 2023 MiPschool Obergurgl | 2023 | Bioenergetic profiling of kinase inhibitors reveals drug off-targer effects in colon cancer cell models | ||||
Porter 2022 Abstract Bioblast | 2022 | 6.3. «10+5» Karavyraki M, Gnaiger E, Porter Richard K (2022) A comparison of bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. Bioblast 2022: BEC Inaugural Conference. In: https://doi.org/10.26124/bec:2022-0001 »MitoFit Preprint« | Human | Aerobic glycolysis | ||
Bastos Sant'Anna Silva 2019 Life Sciences Meeting 2019 Innsbruck AT | 2019 | Cellular succinate transport and mitochondrial respiratory function in prostate cancer. | Genital | Human | Ion;substrate transport | |
Van der Ende 2019 MiPschool Coimbra | 2019 | Mitochondrial respiration in muscle tissue of colon cancer patients. | Skeletal muscle | Human | ||
Lelcu 2019 MiP2019 | 2019 | Assessment of platelet respiration in blood malignancies: a pilot study in children and adults. | Platelet | Human | ||
Timohhina 2019 MiP2019 | 2019 | Metabolic effects of mitochondria-targeted antioxidant peptides in colorectal cancer cells. | Endothelial;epithelial;mesothelial cell | Human | ||
Ounpuu 2018 MiP2018 | 2018 | Metabolic plasticity of cancer stem-like cells. | Stem cells | Human | ||
Bastos Sant'Anna Silva 2018 MiPschool Tromso C4 | 2018 | Role of succinate in prostate cancer cells: uptake and mitochondrial respiratory function. | Genital | Human | ||
Pereira da Silva Grilo da Silva 2018 MiP2018 | 2018 | The unspecific effect of etomoxir on mitochondrial respiration. | Nervous system Liver Other cell lines | Human Mouse | Inhibitor Substrate Uncoupler | |
Garipi 2018 MiPschool Tromso E2 | 2018 | Phenotyping mitochondrial metabolism in Barrettâs metaplasia-dysplasia-adenocarcinoma sequence: respiratory capacity, extracelular proton flux and ROS production | Endothelial;epithelial;mesothelial cell Other cell lines | Human | ||
Escames 2018 MiP2018 | 2018 | Suppression of AKT/mTOR pathway and activation of mitophagy by melatonin via mitocondrial regulation in head and neck cancer. Escames_Presentation | Other cell lines | Human Mouse | ||
Bastos Sant'Anna Silva 2018 Life Sciences Meeting 2018 Innsbruck AT | 2018 | Effect of cell-permeable succinate and malonate prodrugs on mitochondrial respiration in prostate cancer cells. | Kidney Other cell lines HEK | Calcium Substrate | ||
Evinova 2018 MiP2018 | 2018 | High-resolution respirometry of neuroblastoma SH-SY 5Y cell line. | Other cell lines Neuroblastoma | Human | Threshold;excess capacity | |
Chang 2018 Life Sciences Meeting 2018 Innsbruck AT | 2018 | pH dependence of mitochondrial respiration and H2O2 production in oral cancer cells â a pilot study. | HEK Kidney | Human | ||
Rodriguez-Hernandez 2018 Free Radic Biol Med | 2018 | Rodriguez-HernĂĄndez A, StaĆkovĂĄ P, GonzĂĄlez R, De la Rosa AJ, Ălamo-Martinez JM, Marin-GĂłmez LM, Sobotka O, KuÄera O, Padillo FJ, ÄervinkovĂĄ Z, MuntanĂ© J (2018) The alteration of mitochondrial function is associated with the induction of endoplasmic reticulum stress autophagy and apoptosis by Sorafenib in liver cancer cells. Free Radic Biol Med. | Liver | |||
Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna IT | 2018 | Cellular succinate transport and mitochondrial respiratory function in prostate cancer. | HEK Genital | Human | Substrate Ion;substrate transport | |
Schoepf 2018 33rd Annual EAU Congress Copenhagen | 2018 | Shift of mitochondrial oxidative phosphorylation is associated with mtDNA mutational load in primary prostate cancer tissue. | Genital | Human | ||
Roy Chowdhury 2018 J Thorac Oncol | 2018 | Roy Chowdhury S, Saleh R, Girard C, Peltier C, Desautels D, Dawe D, Banerji V, Banerji S (2018) Targeting mitochondrial metabolism as a selective therapeutic approach in small cell lung cancer (SCLC). J Thorac Oncol. | Lung;gill | Human | ||
Malagrino 2018 Free Radic Biol Med | 2018 | MalagrinĂČ F, Zuhra K, Mastronicola D, Mascolo L, Vicente JB, Forte E, GiuffrĂš A (2018) H2S metabolism in colon cancer cells: Effect of hypoxia. Free Radic Biol Med. | ||||
Klepinin 2017 MiP2017 | 2017 | Novel method to study the role of the adenylate kinase network in health and disease. | Heart Stem cells | Human Rat | ||
Karavyraki 2017 Abstract IOC122 | 2017 | Mitochondrial function and morphology linked to metabolic differences in normal, dysplastic and cancerous oral cells. | Endothelial;epithelial;mesothelial cell | Human | ||
Scatena 2017 Abstract MITOEAGLE Barcelona | 2017 | Mitochondria and cancer stem cells in hepatocarcinoma. An illustrative example of a tangled methodological approach. | Liver | |||
Ounpuu 2017 MiP2017 | 2017 | The role of dietary fibers in the energy metabolism of human colon cancer cells. | Human | |||
Truu 2017 Abstract IOC122 | 2017 | Bioenergetics of colorectal cancer. | Endothelial;epithelial;mesothelial cell | |||
Gnaiger 2017 Abstract MitoEAGLE Barcelona | 2017 | Quality first: a paradigm shift in mt-respiratory control towards global connection. | Heart Genital | Human Mouse | ||
Truu 2017 MiP2017 | 2017 | Bioenergetic comparison of human colorectal and breast cancer clinical patients. | Human | |||
Phillips 2017 Cancer Research | 2017 | Abstract 3548: Hypoxia-induced Cystathionine-ÎČ-synthase (CBS) expression: impact on colonic epithelial cells metabolism, proliferation and migration. | Endothelial;epithelial;mesothelial cell | |||
Bufe 2017 TRACT PhD project abstract | 2017 | Metabolic profiles in normal, dysplastic and cancerous oral cells. | Other cell lines | Human | ||
Karavyraki 2017 MiPschool Obergurgl | 2017 | Mitochondrial function and morphology linked to metabolic differences in normal, dysplastic and cancerous oral cells. | Human | |||
Gnaiger 2017 Abstract EUROMIT2017 Cologne | 2017 | Again not a Warburg effect - mitochondrial function in primary prostate cancer. | Endothelial;epithelial;mesothelial cell Genital Fibroblast | Human | ||
Labieniec-Watala 2017 MiP2017 | 2017 | Lack of the effect of low metformin concentrations on the response of breast cancer cell mitochondria to radiotherapy under conditions of the in vitro experimental hyperglycemia. Labieniec-Watala_Presentation | Genital | Human | ||
Skolik 2017 Abstract IOC122 | 2017 | What can we learn from different sugars as substrates for cancer cells? | Liver | Human | ||
Weber 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | Loss of PTEN in prostate cancer cells leads to a switch to succinate-mediated mitochondrial respiration associated with increased expression of NaDC3 and HIF-1alpha. | Genital | Human Mouse | Substrate | |
Schoepf 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | Mitochondrial function in primary prostate cancer. | Human | Flux control | ||
Zatarain 2016 Abstract Cancer Research | 2016 | Abstract 4276: Cystathionine-ÎČ-synthase overexpression increases cell proliferation, migration, bioenergetics and tumorigenesis in a non-tumorigenic colorectal cancer (CRC) cell line. | Endothelial;epithelial;mesothelial cell | Human Mouse | ||
Schoepf 2016 Abstract Androgens 2016 | 2016 | Mitochondrial function and mitochondrial heteroplasmy levels differ between benign and malignant prostate tissue. | Genital | |||
Coelho 2015 Abstract Thyroid Cancer | 2015 | AMPK overactivation in BCPAP tumor cells induces cell death through increased reactive oxygen species (ROS). | ||||
Amoedo 2015 Abstract MiP2015 | 2015 | The energy requirement of metastatic cells. | Other cell lines | Mouse Rat | ||
Kaambre 2015 Abstract MiP2015 | 2015 | Quantitative characterization of respiratory parameters of human colorectal and breast cancer clinical material. | Endothelial;epithelial;mesothelial cell | Human | ||
Shevchuk 2015 Abstract MiP2015 | 2015 | Analysis of energy fluxes in colorectal cancer saponin skinned tissues and Caco-2 cells. | Endothelial;epithelial;mesothelial cell | Human | ||
Kluckova 2014 Abstract MiP2014 | 2014 | Proximal ubiquinone binding site in mitochondrial respiratory Complex II is a target for vitamin E analog MitoVES, an experimental anti-cancer agent. Mitochondr Physiol Network 19.13. | Other cell lines | |||
Maedo 2014 Abstract IOC 2014-04 Schroecken | 2014 | Maedo K, Kaldma A, Planken A, Klepinin A, Chekulayev V, Varikmaa M, Tepp K, Chevchuk I, Kaambre T (2014) Regulation of mitochondrial respiration in human colorectal cancer cells in situ: the possible role of beta-tubulins. Mitochondr Physiol Network 19.02. | Endothelial;epithelial;mesothelial cell | Human | ADP | |
Amoedo 2014 Abstract MiP2014 | 2014 | The metabolic panorama during tumor progression towards malignancy. | Other cell lines | Aerobic glycolysis ATP production Fatty acid | ||
Bristot 2014 Abstract MiP2014 | 2014 | High-resolution respirometry and bioenergetics evaluation in fibroblasts derived from patients with TP53 germline mutations. | Fibroblast | Human | ||
El-Bacha 2014 Abstract MiP2014 | 2014 | Cytotoxicity of grape pomace extract (Vitis vinifera L.) from Brazilian wine industry in human hepatocarcinoma HepG2 cells. | Liver | Human | Aerobic glycolysis ATP production | |
Rodrigues 2014 Abstract MiP2014 | 2014 | Bioenergeticsâ traits of tongue cancer metastatic cells. | Lymphocyte | Mouse | ||
Kandashvili 2014 Abstract MiP2014 | 2014 | Regulation of energy metabolism in human colorectal cancer cells in situ. | Endothelial;epithelial;mesothelial cell | Human | ADP | |
Schoepf 2014 Abstract MiP2014 | 2014 | OXPHOS analysis in small prostate biopsies. | Genital | Human | ||
Skulachev 2013 Abstract MiP2013 | 2013 | Skulachev VP (2013) SkQ1, the first mitochondria-targeted medicine available in drugstores. Mitochondr Physiol Network 18.08. | Heart Skeletal muscle Nervous system Kidney Islet cell;pancreas;thymus Other cell lines HeLa Fibroblast Stem cells | Human Mouse Horse Dog Rabbit Fishes Other invertebrates Fungi Plants | mt-Membrane potential Threshold;excess capacity Uncoupler | |
Beach 2013 Abstract MiP2013 | 2013 | Beach A, Richard VR, Leonov A, Burstein MT, Feldman R, Gentile C, Titorenko VI (2013) Lithocholic acid delays aging in yeast and exhibits an anti-tumor effect in human cells by altering mitochondrial composition, structure and function. Mitochondr Physiol Network 18.08. | Other cell lines Neuroblastoma | Human Saccharomyces cerevisiae | mt-Membrane potential | |
Rodrigues 2013 Abstract MiP2013 | 2013 | Rodrigues MF, Amoedo ND, Rumjanek FD (2013) Studies of bioenergetics alterations in breast cancer lines induced by histone desacetylase inhibitors. Mitochondr Physiol Network 18.08. | Genital | Aerobic glycolysis | ||
Zelenka 2013 Abstract MiP2013 | 2013 | Zelenka J, Smolkova K, Dvorak A, Vitek L, Jezek P (2013) Reverse carboxylation glutaminolysis in breast cancer cells. Mitochondr Physiol Network 18.08. | Other cell lines HeLa | Human | ||
Zelenka J 2013 Abstract MiP2013 | 2013 | Zelenka J, Alan L, Jezek P(2013) Response of cancer cells to mitochondrial DNA damage. Mitochondr Physiol Network 18.08. | Other cell lines | Aerobic glycolysis ATP Coupling efficiency;uncoupling Ion;substrate transport | ||
Bajzikova 2013 Abstract IOC79 | 2013 | Bajzikova M (2013) Mitochondrially targeted vitamin E succinate and its effects on mitochondrial oxidative phosphorylation system. Mitochondr Physiol Network 18.07. | Other cell lines | Human | ||
Galina 2013 Abstract MiP2013 | 2013 | Galina A, Messeder DJM, Camacho-Pereira J, Pereira da Silva AP, Rodrigues-Ferreira C (2013) Effects of antitumor alkylating agent 3-bromopyruvate on energy transducing pathways in hepatoma HepG2, liver mitochondria and SERCA: Is there any role for mitochondrial hexokinase activity? Mitochondr Physiol Network 18.08. | Skeletal muscle Nervous system Liver Other cell lines | Rat | Calcium Flux control mt-Membrane potential Redox state Threshold;excess capacity | |
Amoedo 2013 Abstract MiP2013 | 2013 | AmoĂȘdo ND, Rodrigues MF, Pereira S, Melo F, Jasiulionis M, Galina A, Rumjanek FD(2013) Comparative biochemistry of tumorigenesis: role of mitochondria in the metastatic process. Mitochondr Physiol Network 18.08. | Endothelial;epithelial;mesothelial cell Other cell lines | Mouse | Aerobic glycolysis | |
Acuna-Castroviejo 2012 Abstract Bioblast | 2012 | Acuna-Castroviejo D (2012) Melatonin and the quality of life: the melatonin-mitochondrion connection. Mitochondr Physiol Network 17.12. | Heart Skeletal muscle Nervous system Liver | Mouse Rat | ATP production Ion;substrate transport mt-Membrane potential Redox state | |
Amoedo 2012 Abstract Bioblast | 2012 | Amoedo ND, Rodrigues MF, Pereira SAS, Melo FH, Jasiulionis MG, Galina A, Rumjanek FD (2012) Mitochondrial function and bioenergetics during malignant transformation and metastasis. Mitochondr Physiol Network 17.12. | Other cell lines | Mouse | Aerobic glycolysis Substrate | |
Tronstad 2012 Abstract Bioblast | 2012 | Nikolaisen J, Nilsson LIH, Hagland HR, Koopman WJ, Tronstad KJ (2012) Mitochondrial morphology and biogenesis in cellular stress. Mitochondr Physiol Network 17.12. | Liver Endothelial;epithelial;mesothelial cell Blood cells | Human Rat | ||
Silva MiP 2011 | 2011 | Silva da Costa L, Pereira da Silva AP, Da Poian AT, El-Bacha T (2011) Mitochondrial bioenergetic alterations in mouse neuroblastoma cells infected with Sindbis Virus: Implications to viral replication and neuronal death. MiP2011. | Neuroblastoma | ATP production Inhibitor Substrate | ||
El-Bacha MiP2010 | 2010 | Amoedo ND, Rodrigues MF, Pezutto P, Lourenco MVC, Madeiro da Costa RF, Oliveira MF, Galina A, Rumjanek FD, El-Bacha T (2010) Metabolic reprogramming of lung cancer cell induced by sodium butyrate: studies on mitochondrial physiology and bioenergetics. | Other cell lines | |||
Amoedo 2010 Abstract MiP2010 | 2010 | AmoĂȘdo ND, Rodrigues MF, Pezutto P, Lourenço MVC, Madeiro da Costa RF, Oliveira MF, Galina A, Rumjanek FD, El-Bacha T (2010) Metabolic reprogramming of lung cancer cell induced by sodium butyrate: Studies on mitochondrial physiology and bioenergetics. Mitochondr Physiol Network 15.06. | Endothelial;epithelial;mesothelial cell Fibroblast | Human | Aerobic glycolysis ADP Substrate Amino acid |