Difference between revisions of "Proton slip"
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|description='''Proton slip''' is a property of the proton pumps (Complexes CI, CIII, and CIV) when the proton slips back to the matrix side within the proton pumping process. Slip is different from the [[proton leak]], which depends on ฮ''p'' and is a property of the inner mt-membrane (including the boundaries between membrane-spanning proteins and the lipid phase). Slip is an uncoupling process that depends mainly on flux and contributes to a reduction in the [[biochemical coupling efficiency]] of ATP production and oxygen consumption. Together with proton leak and cation cycling, proton slip is compensated for by [[LEAK respiration]] or LEAK oxygen flux, ''L''. | |description='''Proton slip''' is a property of the proton pumps (Complexes CI, CIII, and CIV) when the [[proton]] slips back to the matrix side within the proton pumping process. Slip is different from the [[proton leak]], which depends on ฮ''p'' and is a property of the inner mt-membrane (including the boundaries between membrane-spanning proteins and the lipid phase). Slip is an uncoupling process that depends mainly on flux and contributes to a reduction in the [[biochemical coupling efficiency]] of ATP production and oxygen consumption. Together with proton leak and cation cycling, proton slip is compensated for by [[LEAK respiration]] or LEAK oxygen flux, ''L''. Compare: [[Proton leak]]. | ||
|info=[[Gnaiger | |info=[[BEC 2020.1]], [[Gnaiger 2020 BEC MitoPathways]] | ||
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{{ | {{Keywords: Uncoupling}} | ||
{{Keywords: pH}} | |||
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{{MitoPedia methods | {{MitoPedia methods | ||
|mitopedia method=Respirometry | |mitopedia method=Respirometry | ||
}} | }} | ||
{{MitoPedia topics | {{MitoPedia topics | ||
|mitopedia topic=Uncoupler | |mitopedia topic=Uncoupler | ||
}} | }} |
Latest revision as of 18:31, 1 January 2021
Description
Proton slip is a property of the proton pumps (Complexes CI, CIII, and CIV) when the proton slips back to the matrix side within the proton pumping process. Slip is different from the proton leak, which depends on ฮp and is a property of the inner mt-membrane (including the boundaries between membrane-spanning proteins and the lipid phase). Slip is an uncoupling process that depends mainly on flux and contributes to a reduction in the biochemical coupling efficiency of ATP production and oxygen consumption. Together with proton leak and cation cycling, proton slip is compensated for by LEAK respiration or LEAK oxygen flux, L. Compare: Proton leak.
Reference: BEC 2020.1, Gnaiger 2020 BEC MitoPathways
- Bioblast links: Uncoupling - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
- Specific
- ยป Artefacts by single dose uncoupling
- ยป ATP synthase
- ยป CCCP
- ยป Coupling-control protocol
- ยป DNP
- ยป Dyscoupled respiration
- ยป FCCP
- ยป Is respiration uncoupled - noncoupled - dyscoupled?
- ยป Noncoupled respiration: Discussion
- ยป Uncoupler
- ยป Uncoupled respiration - see ยป Noncoupled respiration
- ยป Uncoupling proteins
- ยป Uncoupling protein 1
- ยป Uncoupler titrations - Optimum uncoupler concentration
- Specific
- Respiratory states and control ratios
- ยป Biochemical coupling efficiency
- ยป Coupling-control state
- ยป Electron-transfer-pathway state
- ยป Electron-transfer pathway
- ET capacity
- ยป E-L coupling efficiency
- ยป Flux control efficiency
- ยป Flux control ratio
- ยป LEAK-control ratio
- ยป LEAK respiration
- ยป Noncoupled respiration
- ยป OXPHOS
- ยป OXPHOS capacity; ยป State 3
- ยป OXPHOS-control ratio, P/E ratio
- ยป Respiratory acceptor control ratio
- ยป ROUTINE-control ratio
- ยป ROUTINE respiration
- ยป ROUTINE state
- ยป State 3u
- ยป State 4
- ยป Uncoupling-control ratio UCR
- Respiratory states and control ratios
- Gnaiger E et al โ MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1
- Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002
- General (alphabetical order)
- Other keyword lists
- Bioblast links: pH and protons - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
- pH and protons
- ยป pH
- ยป hydrogen ion H+
- ยป hydron H+
- ยป hydronium ion H3O+
- ยป hydride H-
- ยป proton p+
- ยป pH buffering capacity
- ยป proton flux
- ยป proton pump versus hydrogen ion pump
- ยป proton leak
- ยป proton slip
- ยป protonmotive force
- pH and protons
- O2k-pH
- ยป O2k-Catalogue: O2k-pH ISE-Module
- ยป O2k-Manual pH electrode: MiPNet23.15 O2k-pH ISE-Module
- ยป O2k-SOP: MiPNet08.16 pH calibration
- ยป File:PH-Calibration-List.xls
- ยป NextGen-O2k, ratiometric: Carboxy SNARF 1
- ยป NextGen-O2k, ratiometric: HPTS
- ยป pH calibration buffers
- O2k-pH
- O2k-Publications
- HRFR - general
- ยป O2k-Manual: MiPNet22.11 O2k-FluoRespirometer manual
- ยป O2k signals and output
- ยป O2k-SOP: MiPNet14.06 Instrumental O2 background
- ยป MiPNet19.18A O2k-Series G: Start
- ยป ESD
- ยป O2k configuration
- ยป O2k control
- ยป O2k-FluoRespirometer
- ยป O2k-Main Unit#O2k-Series
- ยป Titration-Injection microPump
- ยป Compare: O2k-TPP+_ISE-Module
- HRFR - general
- DatLab
MitoPedia methods:
Respirometry
MitoPedia topics:
Uncoupler