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Property "Has-20abstract" (as page type) with input value "-5B-5BImage:MITOEAGLE-2Dlogo.jpg-7Cleft-7C100px-7Clink=http:-2F-2Fwww.mitoglobal.org-2Findex.php-2FMITOEAGLE-7CCOST-20Action-20MitoEAGLE-5D-5D-0AConsiderable-20progress-20in-20understanding-20the-20relationship-20between-20Ca-3Csup-3E2+-3C-2Fsup-3E-20signalling-20cascades-20and-20mitochondrial-20physiology-20has-20been-20accumulated-20over-20the-20last-20few-20years-20due-20to-20the-20development-20of-20more-20advanced-20optical-20techniques-20and-20electrophysiological-20approaches.-0AIn-20summary,-20although-20major-20advances-20in-20understanding-20the-20molecular-20physiology-20of-20myometrium-20have-20been-20achieved,-20there-20is-20a-20pressing-20need-20to-20understand-20human-20uterine-20contractile-20activity-20and-20the-20role-20of-20other-20channels-20and-20receptors-20such-20as-20chloride,-20sodium,-20ryanodine-20and-20the-20role-20of-20nucleotides-20such-20as-20adenosine,-20adenosine-20diphosphate-20(ADP),-20and-20ATP-20in-20human-20myometrium.-20The-20role-20of-20CICR-20is-20still-20unclear-20in-20myometrium-20and-20needs-20further-20elucidation.-20There-20is-20also-20a-20need-20to-20fully-20understand-20the-20role-20of-20mitochondria-20in-20calcium-20homeostasis.-20These-20investigations-20and-20the-20development-20with-20the-20action-20of-20agonists-20and-20antagonists-20on-20uterine-20smooth-20muscle-20will-20add-20more-20to-20our-20understanding-20of-20uterine-20physiology-20and-20lead-20to-20more-20successful-20approaches-20in-20diagnosing-20and-20managing-20the-20reproductive-20disorders-20such-20as-20preterm-20labor,-20dysmenorrhea,-20prolonged-20labor,-20and-20weak-20uterine-20contractions-20(dystocia).-20It-20is-20apparent-20that-20understanding-20the-20normal-20physiology-20of-20uterine-20contractions-20and-20relaxation-20at-20the-20molecular-20and-20cellular-20level-20would-20help-20clinicians-20and-20healthcare-20providers-20to-20modulate-20unnecessary-20uterine-20activity-20if-20problems-20arise-20throughout-20Calcium-20Signaling-20pregnancy-20and-20to-20plan-20a-20suitable-20therapeutic-20target-20according-20to-20each-20problem.-0A-0AThis-20study-20was-20undertaken-20to-20elucidate-20the-20cellular-20coupling-20mechanism-20of-20beta-3Csub-3E3-3C-2Fsub-3E-2Dadrenergic-20receptors-20with-20potassium-20channels-20in-20myometrium-20of-20non-2Dpregnant-20buffaloes.-20In-20materials-20and-20methods-20the-20uteri-20of-20diestrous-20stage-20buffaloes-20were-20collected-20from-20local-20abattoir-20and-20myometrial-20strips-20were-20prepared-20from-20the-20mid-2Dcornual-20region-20of-20uterus-20for-20measurement-20of-20isometric-20tension.-0A-0AResult-20shows-20that-20Both-20BRL-2D37344-20and-20SAR150640,-20two-20specific-20agonists-20of-20β3-2Dadrenoceptors,-20produced-20dose-2Ddependent-20inhibitory-20effect-20on-20myometrial-20spontaneity-20and-20this-20effect-20was-20blocked-20by-20SR-2059230A,-20a-20selective-20β3-20specific-20adrenoceptorantagonist.-20BRL-2D37344-20was-20found-20to-20be-20more-20potent-20than-20SAR-20150640-20as-20the-20respective-20pD2-20values-20were-20found-20to-20be-207.22-20±-200.09-20(n-20=-207)-20and-203.27-20±-202.67-20(n-20=-206).-20Further,-20potassium-20channel-20blockers,-20namely-2Dglybenclamide-20(10-20μM),-20tetraethyl-20ammonium-20(1-20mM)-20and-20iberiotoxin-20(100-20nM)-20significantly-20shifted-20the-20dose-20response-20curve-20of-20BRL-2D37344-20towards-20right-20with-20reduction-20in-20efficacy-20(Rmax).-20However,-204-2Daminopyridine-20(1-20mM)-20failed-20to-20alter-20the-20tocolytic-20effect-20of-20BRL-2D37344.-0A-0AOur-20conclusion-20shows-20that-20results-20suggest-20by-20beta-3Csub-3E3-3C-2Fsub-3E-2Dadrenergic-20receptors-20mediate-20an-20additional-20mechanism-20of-20myometrial-20relaxation-20in-20buffaloes-20and,-20besides-20direct-20involvement-20of-20β3-2Dadrenoceptor,-20their-20tocolytic-20effect-20is-20also-20mediated-20through-20K-3Csub-3EATP-3C-2Fsub-3E-20and-20BK-3Csub-3ECa-3C-2Fsub-3E-20channels-20in-20buffalo-20myometrium.-20Therefore,-20beta-3Csub-3E3-3C-2Fsub-3E-2Dadrenergic-20receptors-20seem-20to-20be-20a-20potential-20alternative-20target-20for-20management-20of-20pre-2Dterm-20labour-3B-20however,-20similar-20studies-20are-20warranted-20on-20uterus-20of-20pregnant-20animals." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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