Talk:NextGen-O2k

The revolutionary all-in-one device to conquer mitochondrial disease

NextGen-O2k H2020-SMEInst

• Horizon 2020 Framework Programme Proposal: 859770 — NextGen-O2k
• EIC-SMEInst-2018-2020 — SME instrument phase 2
• The project Next-Gen-O2k ist supported by the Standortagentur Tyrol and the FFG (Österreichische Forschungsförderungsgesellschaft)
• Duration of the action: 24 months
• Partners: About Oroboros, WGT Elektronik, SHTech, software security networks.
• Application: date ? ; Granted: date? (total budget € 2.35Mil)

Form the O2k to the Next-Gen O2k

O2k

High-resolution respirometry (HRR) and unique combinations of the O2k with

• Fluorometry: the O2k-FluoRespirometer
• Potentiometry: the O2k-pH ISE-Module and O2k-TPP+ ISE-Module
• Amperometric measurement of nitric oxide: the O2k-NO Amp-Module

NextGen-O2k

extend high-resolution respirometry (HRR) to the all-in-one device

• (+1) Cyclic voltammetry: the Q-redox sensor
• (+2) Controlled wavelengths and light intensity: PhotoBiology module

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The NextGen-O2k project

Building the highway to medical discoveries

Mitochondrial research experiences a renaissance driven by its key role in pathological states. It is now established that mitochondria play a major role in cellular homeostasis and their dysfunction is key towards disease onset and progression. The figure below shows a variety of diseases where mitochondrial dysfunction has been detected and highlights its central role regulating cellular health and disease. To develop diagnostic and therapeutic strategies based on mitochondria, researchers need to understand mitochondrial function, morphology and dynamics, and its connections with key cellular pathways.

Why Oroboros

The vision

• Be the scientific driving force in mitochondrial physiology
• Equip each biomedical lab world-wide with the NextGen instruments for research and diagnostic screening
• Support key developments in mitochondrial medicine

• Expand the business to biotechnology and ecology

The mission

Enterprise and science

• Cooperation and feedback in science
• World-wide scientific network and collaborations
• Open-access resources and expert user support

Corporate social responsibility

• QC to solve the reproducibility crisis with the O2k
• Mitochondrial fitness and benefits for health system
• Train our future inventors and start-ups
• New challenge: advance the bio-economy

Impact

Commercialisation

Next-Gen project news

MitoEAGLE Q-workshop

• Electron supply to the Q-junction: assessment of mitochondrial respiration, H2O2 flux and the redox state of the Q-pool. COST Action MitoEAGLE, Innsbruck, Nov 2018.