Baines 2018 Cell Calcium

Baines CP, Gutiérrez-Aguilar M (2018) The still uncertain identity of the channel-forming unit(s) of the mitochondrial permeability transition pore. https://doi.org/10.1016/j.ceca.2018.05.003

» Cell Calcium 73:121-30. PMID: 29793100 Open Access

Baines Christopher P, Gutierrez-Aguilar Manuel (2018) Cell Calcium

Abstract: Mitochondria from different organisms can undergo a sudden process of inner membrane unselective leakiness to molecules known as the mitochondrial permeability transition (MPT). This process has been studied for nearly four decades and several proteins have been claimed to constitute, or at least regulate the usually inactive pore responsible for this transition. However, no protein candidate proposed as the actual pore-forming unit has passed rigorous gain- or loss-of-function genetic tests. Here we review evidence for -and against- putative channel-forming components of the MPT pore. We conclude that the structure of the MPT pore still remains largely undefined and suggest that future studies should follow established technical considerations to unambiguously consolidate the channel forming constituent(s) of the MPT pore. • Keywords: ATP synthase, Adenine nucleotide translocase, Bioenergetics, Cell death, Cyclophilin D, Cyclosporin A, Mitochondrial permeability transition pore, Phosphate carrier • Bioblast editor: Plangger M

Labels: MiParea: mt-Membrane