Description
Complex I, NADH:ubiquinone oxidoreductase (EC 1.6.5.3), is an enzyme complex of the Electron transfer pathway, a proton pump across the inner mt-membrane, responsible for electron transfer to ubiquinone from NADH formed in the mt-matrix. CI forms a supercomplex with Complex III. There is a widespread ambiguity on the 'lonely H+ (the lonely hydron)' surrounding Complex I: CI ambiguities.
Abbreviation: CI
Reference: MiPNet08.15, Gnaiger 2020 BEC MitoPathways
N versus CI
- In the 2007-2014 editions of Gnaiger 2020 BEC MitoPathways, the abbreviation CI refers alternatively to a Complex I-linked substrate state (N-pathway control state).
Proton pump
- Kampjut D, Sazanov LA (2022) Structure of respiratory complex I - An emerging blueprint for the mechanism. Curr Opin Struct Biol 74:102350. doi: 10.1016/j.sbi.2022.102350
- 2010 - Structural biology: Piston drives a proton pump
List of publications: Complex I
Year | Reference | Mammal and model | Tissue and cell | Stress | Diseases | |
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Devin 2024 MitoFit | 2024 | Devin A, Rigoulet M (2024) Tribute to Mårten Wikström – A proton pump: a new and rich paradigm in bioenergetics. MitoFit Preprints 2024.6. https://doi.org/10.26124/mitofit:2024-0006 | ||||
Jiang 2024 Nat Metab | 2024 | Jiang S, Yuan T, Rosenberger FA, Mourier A, Dragano NRV, Kremer LS, Rubalcava-Gracia D, Hansen FM, Borg M, Mennuni M, Filograna R, Alsina D, Misic J, Koolmeister C, Papadea P, de Angelis MH, Ren L, Andersson O, Unger A, Bergbrede T, Di Lucrezia R, Wibom R, Zierath JR, Krook A, Giavalisco P, Mann M, Larsson NG (2024) Inhibition of mammalian mtDNA transcription acts paradoxically to reverse diet-induced hepatosteatosis and obesity. Nat Metab [Epub ahead of print]. https://doi.org/10.1038/s42255-024-01038-3 | Mouse | Liver | Obesity Other | |
Balmaceda 2024 Biochim Biophys Acta Mol Basis Dis | 2024 | Balmaceda V, Komlodi T, Szibor M, Gnaiger E, Moore AL, Fernandez-Vizarra E, Viscomi C (2024) The striking differences in the bioenergetics of brain and liver mitochondria are enhanced in mitochondrial disease. Biochim Biophys Acta Mol Basis Dis 1870:167033. https://doi.org/10.1016/j.bbadis.2024.167033 | Mouse | Nervous system Liver | Oxidative stress;RONS | |
Luptak 2023 Antioxidants (Basel) | 2023 | Ľupták M, Fišar Z, Hroudová J (2023) Different effects of SSRIs, Bupropion, and Trazodone on mitochondrial functions and monoamine oxidase isoform activity. Antioxidants (Basel) 12:1208. https://doi.org/10.3390/antiox12061208 | Pig | Nervous system | Neurodegenerative | |
Koizumi 2023 Front Cardiovasc Med | 2023 | Koizumi T, Watanabe M, Yokota T, Tsuda M, Handa H, Koya J, Nishino K, Tatsuta D, Natsui H, Kadosaka T, Koya T, Nakao M, Hagiwara H, Kamada R, Temma T, Tanaka S, Anzai T (2023) Empagliflozin suppresses mitochondrial reactive oxygen species generation and mitigates the inducibility of atrial fibrillation in diabetic rats. Front Cardiovasc Med 10: 1005408. | Rat | Heart | Cardiovascular Diabetes | |
Martell 2023 Nat Commun | 2023 | Martell E, Kuzmychova H, Kaul E, Senthil H, Chowdhury SR, Morrison LC, Fresnoza A, Zagozewski J, Venugopal C, Anderson CM, Singh SK, Banerji V, Werbowetski-Ogilvie TE, Sharif T (2023) Metabolism-based targeting of MYC via MPC-SOD2 axis-mediated oxidation promotes cellular differentiation in group 3 medulloblastoma. https://doi.org/10.1038/s41467-023-38049-9 | Human | Nervous system | Cancer | |
Fletcher 2023 Transl Res | 2023 | Fletcher E, Miserlis D, Sorokolet K, Wilburn D, Bradley C, Papoutsi E, Wilkinson T, Ring A, Ferrer L, Haynatzki G, Smith RS, Bohannon WT, Koutakis P (2023) Diet-induced obesity augments ischemic myopathy and functional decline in a murine model of peripheral artery disease. https://doi.org/10.1016/j.trsl.2023.05.002 | Mouse | Skeletal muscle | Myopathy Obesity | |
Sazanov 2023 Biochem J | 2023 | Sazanov LA (2023) From the 'black box' to 'domino effect' mechanism: what have we learned from the structures of respiratory complex I. Biochem J 480:319-33. https://doi.org/10.1042/BCJ20210285 | ||||
Curtabbi 2023 Redox Biol | 2023 | Curtabbi A, Guarás A, Cabrera-Alarcón JL, Rivero M, Calvo E, Rosa-Moreno M, Vázquez J, Medina M, Enríquez JA (2023) Regulation of respiratory complex I assembly by FMN cofactor targeting. https://doi.org/10.1016/j.redox.2023.103001 | Mouse | Fibroblast Kidney | ||
Wikstroem 2023 Enzymes | 2023 | Wikström M, Pecorilla C, Sharma V (2023) The mitochondrial respiratory chain. Enzymes 54:15-36. https://doi.org/10.1016/bs.enz.2023.05.001 | ||||
Wikstroem 2023 FEBS Lett | 2023 | Wikström M, Djurabekova A, Sharma V (2023) On the role of ubiquinone in the proton translocation mechanism of respiratory complex I. FEBS Lett 597:224-36. https://doi.org/10.1002/1873-3468.14506 | ||||
Schiller 2022 Sci Adv | 2022 | Schiller J, Laube E, Wittig I, Kühlbrandt W, Vonck J, Zickermann V (2022) Insights into complex I assembly: Function of NDUFAF1 and a link with cardiolipin remodeling. https://doi.org/10.1126/sciadv.add3855 | ||||
Lee 2022 Nat Commun | 2022 | Lee Y, Haapanen O, Altmeyer A, Kühlbrandt W, Sharma V, Zickermann V (2022) Ion transfer mechanisms in Mrp-type antiporters from high resolution cryoEM and molecular dynamics simulations. https://doi.org/10.1038/s41467-022-33640-y | ||||
Schiller 2022 Pharmaceuticals (Basel) | 2022 | Schiller J, Zickermann V (2022) Binding of natural inhibitors to respiratory complex I. https://doi.org/10.3390/ph15091088 | ||||
Vercellino 2022 Nat Rev Mol Cell Biol | 2022 | Vercellino I, Sazanov LA (2022) The assembly, regulation and function of the mitochondrial respiratory chain. Nat Rev Mol Cell Biol 23:141-161. doi: 10.1038/s41580-021-00415-0 | ||||
Kampjut 2022 Curr Opin Struct Biol | 2022 | Kampjut D, Sazanov LA (2022) Structure of respiratory complex I - An emerging blueprint for the mechanism. Curr Opin Struct Biol 74:102350. doi: 10.1016/j.sbi.2022.102350 | ||||
Molina-Granada 2022 Commun Biol | 2022 | Molina-Granada D, González-Vioque E, Dibley MG, Cabrera-Pérez R, Vallbona-Garcia A, Torres-Torronteras J, Sazanov LA, Ryan MT, Cámara Y, Martí R (2022) Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit. Commun Biol 5:620. doi: 10.1038/s42003-022-03568-6 | HEK | |||
Zhou 2022 J Hum Genet | 2022 | Zhou X, Lou X, Zhou Y, Xie Y, Han X, Dong Q, Ying X, Laurentinah MR, Zhang L, Chen Z, Li D, Fang H, Lyu J, Yang Y, Wang Y (2022) Novel biallelic mutations in TMEM126B cause splicing defects and lead to Leigh-like syndrome with severe complex I deficiency. https://doi.org/10.1038/s10038-022-01102-4 | Human | Lymphocyte | Mitochondrial disease | |
Karavyraki 2022 MitoFit | 2022 | Karavyraki M, Gnaiger E, Porter RK (2022) A comparison of bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. https://doi.org/10.26124/mitofit:2022-0022 — 2022-11-11 published in Bioenerg Commun 2022.11. | Human | Cancer | ||
Yamauchi 2022 Sci Rep | 2022 | Yamauchi Y, Nakamura A, Yokota T, Takahashi K, Kawata S, Tsuchida K, Omori K, Nomoto H, Kameda H, Cho KY, Anzai T, Tanaka S, Terauchi Y, Miyoshi H, Atsumi T (2022) Luseogliflozin preserves the pancreatic beta-cell mass and function in db/db mice by improving mitochondrial function. Sci Rep 12: 9740. | Mouse | Islet cell;pancreas;thymus | Diabetes | |
Zhang 2022 Mol Med Rep | 2022 | Zhang J, Sun B, Yang J, Chen Z, Li Z, Zhang N, Li H, Shen L (2022) Comparison of the effect of rotenone and 1‑methyl‑4‑phenyl‑1,2,3,6‑tetrahydropyridine on inducing chronic Parkinson's disease in mouse models. https://doi.org/10.3892/mmr.2022.12607 | Mouse | Nervous system | Parkinson's | |
Yoval-Sanchez 2022 Redox Biol | 2022 | Yoval-Sánchez B, Ansari F, James J, Niatsetskaya Z, Sosunov S, Filipenko P, Tikhonova IG, Ten V, Wittig I, Rafikov R, Galkin A (2022) Redox-dependent loss of flavin by mitochondria complex I is different in brain and heart. https://doi.org/10.1016/j.redox.2022.102258 | Mouse | Heart Nervous system | Ischemia-reperfusion | |
Hamann 2022 J Fungi (Basel) | 2022 | Hamann A, Osiewacz HD, Teichert I (2022) Sordaria macrospora sterile mutant pro34 is impaired in respiratory complex I assembly. https://doi.org/10.3390/jof8101015 | Fungi | |||
Ganguly 2022 MitoFit | 2022 | Ganguly U, Bir A, Chakrabarti S (2022) Cytotoxicity of mitochondrial Complex I inhibitor rotenone: a complex interplay of cell death pathways. https://doi.org/10.26124/mitofit:2022-0013.v2 — 2022-11-22 published in Bioenerg Commun 2022.14. | Nervous system Neuroblastoma | Cell death Oxidative stress;RONS | Parkinson's | |
Ganguly 2022 BEC | 2022 | Ganguly U, Bir A, Chakrabarti S (2022) Cytotoxicity of mitochondrial Complex I inhibitor rotenone: a complex interplay of cell death pathways. Bioenerg Commun 2022.14. https://doi.org/10.26124/bec:2022-0014 | Nervous system Neuroblastoma | Cell death Oxidative stress;RONS | Parkinson's | |
Karavyraki 2022 BEC | 2022 | Karavyraki M, Gnaiger E, Porter RK (2022) Bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. Bioenerg Commun 2022.11. https://doi.org/10.26124/bec:2022-0011 | Human | Cancer | ||
Takada 2022 Proc Natl Acad Sci U S A | 2022 | Takada S, Maekawa S, Furihata T, Kakutani N, Setoyama D, Ueda K, Nambu H, Hagiwara H, Handa H, Fumoto Y, Hata S, Masunaga T, Fukushima A, Yokota T, Kang D, Kinugawa S, Sabe H (2022) Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure. Proc Natl Acad Sci U S A 119: e2203628119. | Mouse | Heart | Cardiovascular | |
Aya 2022 Eur J Pharmacol | 2022 | Shiraki A, Oyama J, Shimizu T, Nakajima T, Yokota T, Node K (2022) Empagliflozin improves cardiac mitochondrial function and survival through energy regulation in a murine model of heart failure. Eur J Pharmacol 931: 175194. | Mouse | Heart | Cardiovascular | |
Kravchuk 2022 Nature | 2022 | Kravchuk V, Petrova O, Kampjut D, Wojciechowska-Bason A, Breese Z, Sazanov L (2022) A universal coupling mechanism of respiratory complex I. Nature 609:808-14. https://doi.org/10.1038/s41586-022-05199-7. Erratum in: Nature. 2022;611:E9. | Eubacteria | |||
Meyer 2022 New Phytol | 2022 | Meyer EH, Letts JA, Maldonado M (2022) Structural insights into the assembly and the function of the plant oxidative phosphorylation system. New Phytol 235:1315-29. https://doi.org/10.1111/nph.18259 | ||||
Curtabbi 2022 IUBMB Life | 2022 | Curtabbi A, Enríquez JA (2022) The ins and outs of the flavin mononucleotide cofactor of respiratory complex I. IUBMB Life 74:629-44. https://doi.org/10.1002/iub.2600 | ||||
Sighel 2021 Cell Rep | 2021 | Sighel D, Notarangelo M, Aibara S, Re A, Ricci G, Guida M, Soldano A, Adami V, Ambrosini C, Broso F, Rosatti EF, Longhi S, Buccarelli M, D'Alessandris QG, Giannetti S, Pacioni S, Ricci-Vitiani L, Rorbach J, Pallini R, Roulland S, Amunts A, Mancini I, Modelska A, Quattrone A (2021) Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Cell Rep 35:109024. | Human | Nervous system Stem cells | Cancer | |
Szczerbinski 2021 Cells | 2021 | Szczerbinski L, Taylor MA, Puchta U, Konopka P, Paszko A, Citko A, Szczerbinski K, Goscik J, Gorska M, Larsen S, Kretowski A (2021) The response of mitochondrial respiration and quantity in skeletal muscle and adipose tissue to exercise in humans with prediabetes. Cells 10:3013. | Human | Skeletal muscle Fat | Diabetes | |
Oemer 2021 J Lipid Res | 2021 | Oemer G, Edenhofer ML, Wohlfarter Y, Lackner K, Leman G, Koch J, Cardoso LHD, Lindner HH, Gnaiger E, Dubrac S, Zschocke J, Keller MA (2021) Fatty acyl availability modulates cardiolipin composition and alters mitochondrial function in HeLa cells. https://doi.org/10.1016/j.jlr.2021.100111 | Human | HeLa | ||
Dubinin 2021 Membranes (Basel) | 2021 | Dubinin MV, Semenova AA, Nedopekina DA, Davletshin EV, Spivak AY, Belosludtsev KN (2021) Effect of F16-betulin conjugate on mitochondrial membranes and its role in cell death initiation. Membranes (Basel) 11:352. | Rat | Liver | ||
Peruzzotti-Jametti 2021 PLoS Biol | 2021 | Peruzzotti-Jametti L, Bernstock JD, Willis CM, Manferrari G, Rogall R, Fernandez-Vizarra E, Williamson JC, Braga A, van den Bosch A, Leonardi T, Krzak G, Kittel A, Beninca C, Vicario N, Tan S, Bastos C, Bicci I, Iraci N, Smith JA, Peacock B, Muller KH, Lehner PJ, Buzas EI, Faria N, Zeviani M, Frezza C, Brisson A, Matheson NJ, Viscomi C, Pluchino S (2021) Neural stem cells traffic functional mitochondria via extracellular vesicles. PLoS Biol 19:3001166. | Mouse | Nervous system Stem cells | Neurodegenerative | |
Friedman 2021 Quantum Reports | 2021 | Friedman J, Mourokh L, Vittadello M (2021) Mechanism of proton pumping in Complex I of the mitochondrial respiratory chain. Quantum Reports 3:425-34. https://doi.org/10.3390/quantum3030027 | ||||
Brzezinski 2021 Chem Rev | 2021 | Brzezinski P, Moe A, Ädelroth P (2021) Structure and mechanism of respiratory III-IV supercomplexes in bioenergetic membranes. Chem Rev 121:9644-73. https://doi.org/10.1021/acs.chemrev.1c00140 | Saccharomyces cerevisiae Eubacteria | |||
Giachin 2021 Angew Chem Int Ed Engl | 2021 | Giachin G, Jessop M, Bouverot R, Acajjaoui S, Saïdi M, Chretien A, Bacia-Verloop M, Signor L, Mas PJ, Favier A, Borel Meneroud E, Hons M, Hart DJ, Kandiah E, Boeri Erba E, Buisson A, Leonard G, Gutsche I, Soler-Lopez M (2021) Assembly of the mitochondrial Complex I assembly complex suggests a regulatory role for deflavination. Angew Chem Int Ed Engl 60:4689-97. doi: 10.1002/anie.202011548 | ||||
Read 2021 Redox Biol | 2021 | Read AD, Bentley RE, Archer SL, Dunham-Snary KJ (2021) Mitochondrial iron-sulfur clusters: Structure, function, and an emerging role in vascular biology. Redox Biol 47:102164. doi:10.1016/j.redox.2021.102164 | ||||
Davies 2021 FASEB J | 2021 | Davies KL, Smith DJ, El-Bacha T, Stewart ME, Easwaran A, Wooding PFP, Forhead AJ, Murray AJ, Fowden AL, Camm EJ (2021) Development of cerebral mitochondrial respiratory function is impaired by thyroid hormone deficiency before birth in a region-specific manner. FASEB J 35:21591. | Other mammals | Nervous system | ||
Chambers 2021 JCI Insight | 2021 | Chambers KT, Cooper MA, Swearingen AR, Brookheart RT, Schweitzer GG, Weinheimer CJ, Kovacs A, Koves TR, Muoio DM, McCommis KS, Finck BN (2021) Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations. JCI Insight 6:134340. | Mouse | Heart | Cardiovascular | |
Bandara 2021 Mitochondrion | 2021 | Bandara AB, Drake JC, James CC, Smyth JW, Brown DA (2021) Complex I protein NDUFS2 is vital for growth, ROS generation, membrane integrity, apoptosis, and mitochondrial energetics. Mitochondrion 58:160-68. | Human | HEK | ||
Vercellino 2021 Nature | 2021 | Vercellino I, Sazanov LA (2021) Structure and assembly of the mammalian mitochondrial supercomplex CIII2CIV. Nature 598:364-367. doi: 10.1038/s41586-021-03927-z | Mouse | |||
Burska 2021 Biochim Biophys Acta Mol Basis Dis | 2021 | Burska D, Stiburek L, Krizova J, Vanisova M, Martinek V, Sladkova J, Zamecnik J, Honzik T, Zeman J, Hansikova H, Tesarova M (2021) Homozygous missense mutation in UQCRC2 associated with severe encephalomyopathy, mitochondrial complex III assembly defect and activation of mitochondrial protein quality control. Biochim Biophys Acta Mol Basis Dis 1867:166147. | Human | Fibroblast | Myopathy | |
Acin-Perez 2021 Life (Basel) | 2021 | Acin-Perez R, Benincá C, Shabane B, Shirihai OS, Stiles L (2021) Utilization of human samples for assessment of mitochondrial bioenergetics: gold standards, limitations, and future perspectives. Life (Basel) 11:949. doi: 10.3390/life11090949 | Human | Skeletal muscle Blood cells Fibroblast Platelet | Cryopreservation Mitochondrial disease | |
Ko 2021 Biomolecules | 2021 | Ko HJ, Tsai CY, Chiou SJ, Lai YL, Wang CH, Cheng JT, Chuang TH, Huang CF, Kwan AL, Loh JK, Hong YR (2021) The phosphorylation status of Drp1-Ser637 by PKA in mitochondrial fission modulates mitophagy via PINK1/Parkin to exert multipolar spindles assembly during mitosis. Biomolecules 11:424. | Human | HeLa | ||
Parey 2021 Sci Adv | 2021 | Parey K, Lasham J, Mills DJ, Djurabekova A, Haapanen O, Yoga EG, Xie H, Kühlbrandt W, Sharma V, Vonck J, Zickermann V (2021) High-resolution structure and dynamics of mitochondrial complex I-Insights into the proton pumping mechanism. https://doi.org/10.1126/sciadv.abj3221 | ||||
Vidimce 2021 Front Pharmacol | 2021 | Vidimce J, Pillay J, Shrestha N, Dong LF, Neuzil J, Wagner KH, Holland OJ, Bulmer AC (2021) Mitochondrial function, fatty acid metabolism, and body composition in the hyperbilirubinemic gunn rat. Front Pharmacol 12:586715. | Rat | Skeletal muscle Liver | ||
Latina 2021 Acta Neuropathol Commun | 2021 | Latina V, Giacovazzo G, Cordella F, Balzamino BO, Micera A, Varano M, Marchetti C, Malerba F, Florio R, Ercole BB, La Regina F, Atlante A, Coccurello R, Di Angelantonio S, Calissano P, Amadoro G (2021) Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer's Disease. Acta Neuropathol Commun 9:38. | Mouse | Nervous system | Alzheimer's | |
Terwilliger 2021 Vasc Med | 2021 | Terwilliger ZS, Ryan TE, Goldberg EJ, Schmidt CA, Yamaguchi DJ, Karnekar R, Brophy P, Green TD, Zeczycki TN, Mac Gabhann F, Annex BH, McClung JM (2021) Racial differences in the limb skeletal muscle transcriptional programs of patients with critical limb ischemia. Vasc Med 26:247-58. | Human | Skeletal muscle | Cardiovascular | |
Galemou Yoga 2021 Front Chem | 2021 | Galemou Yoga E, Schiller J, Zickermann V (2021) Ubiquinone binding and reduction by complex I-open questions and mechanistic implications. https://doi.org/10.3389/fchem.2021.672851 | ||||
Davis 2021 J Appl Physiol | 2021 | Davis MS, Barrett MR (2021) Effect of conditioning and physiology hyperthermia on canine skeletal muscle mitochondrial oxygen consumption. J Appl Physiol. 130:1317-1325 | Dog | Skeletal muscle | Temperature | |
Briones-Herrera 2020 Free Radic Biol Med | 2020 | Briones-Herrera A, Ramírez-Camacho I, Zazueta C, Tapia E, Pedraza-Chaverri J (2020) Altered proximal tubule fatty acid utilization, mitophagy, fission and supercomplexes arrangement in experimental Fanconi syndrome are ameliorated by sulforaphane-induced mitochondrial biogenesis. Free Radic Biol Med 153:54-70. | Rat | Kidney | ||
Silva-Rodrigues 2020 Free Radic Biol Med | 2020 | Silva-Rodrigues T, De-Souza-Ferreira E, Machado CM, Cabral-Braga B, Rodrigues-Ferreira C, Galina A (2020) Hyperglycemia in a Type 1 Diabetes Mellitus model causes a shift in mitochondria coupled-glucose phosphorylation and redox metabolism in rat brain. Free Radic Biol Med 160:796-806. | Rat | Nervous system | Oxidative stress;RONS | Diabetes |
Alahmad 2020 EMBO Mol Med | 2020 | Alahmad A, Nasca A, Heidler J, Thompson K, Oláhová M, Legati A, Lamantea E, Meisterknecht J, Spagnolo M, He L, Alameer S, Hakami F, Almehdar A, Ardissone A, Alston CL, McFarland R, Wittig I, Ghezzi D, Taylor RW (2020) Bi-allelic pathogenic variants in NDUFC2 cause early-onset Leigh syndrome and stalled biogenesis of complex I. EMBO Mol Med 12:e12619. | Human | Fibroblast | Neurodegenerative | |
Bundgaard 2020 J Exp Biol | 2020 | Bundgaard A, Qvortrup K, Rasmussen LJ, Fago A (2020) Turtles maintain mitochondrial integrity but reduce mitochondrial respiratory capacity in the heart after cold acclimation and anoxia. J Exp Biol 222:jeb200410. | Amphibians | Heart | ||
Marrocco 2020 Thesis | 2020 | Marrocco A (2020) Alterations of CCSP expression and macrophages metabolism in the development of silica-induced pulmonary inflammation and fibrosis. PhD Thesis 108. | Mouse | Macrophage-derived | Other | |
Miotto 2020 Am J Physiol Endocrinol Metab | 2020 | Miotto PM, Petrick HL, Holloway GP (2020) Acute insulin deprivation results in altered mitochondrial substrate sensitivity conducive to greater fatty acid transport. Am J Physiol Endocrinol Metab 319:E345-53. | Rat | Skeletal muscle | Diabetes | |
Galemou Yoga 2020 Nat Commun | 2020 | Galemou Yoga E, Parey K, Djurabekova A, Haapanen O, Siegmund K, Zwicker K, Sharma V, Zickermann V, Angerer H (2020) Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I. https://doi.org/10.1038/s41467-020-19778-7 | ||||
Venediktova 2020 Mitochondrion | 2020 | Venediktova NI, Mashchenko OV, Talanov EY, Belosludtseva NV, Mironova GD (2020) Energy metabolism and oxidative status of rat liver mitochondria in conditions of experimentally induced hyperthyroidism. Mitochondrion 52:190-96. | Rat | Liver | Other | |
Szczepanowska 2020 Nat Commun | 2020 | Szczepanowska K, Senft K, Heidler J, Herholz M, Kukat A, Höhne MN, Hofsetz E, Becker C, Kaspar S, Giese H, Zwicker K, Guerrero-Castillo S, Baumann L, Kauppila J, Rumyantseva A, Müller S, Frese CK, Brandt U, Riemer J, Wittig I, Trifunovic A (2020) A salvage pathway maintains highly functional respiratory complex I. Nat Commun 11:1643. | Caenorhabditis elegans | |||
Schoepf 2020 Nat Commun | 2020 | Schöpf B, Weissensteiner H, Schäfer G, Fazzini F, Charoentong P, Naschberger A, Rupp B, Fendt L, Bukur V, Giese I, Sorn P, Sant’Anna-Silva AC, Iglesias-Gonzalez J, Sahin U, Kronenberg F, Gnaiger E, Klocker H (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. Nat Commun 11:1487. https://doi.org/10.1038/s41467-020-15237-5 | Human | Genital Other cell lines | Cancer | |
Brand 2020 J Clin Med | 2020 | Brand S, Ebner K, Mikoteit T, Lejri I, Gerber M, Beck J, Holsboer-Trachsler E, Eckert A (2020) Influence of regular physical activity on mitochondrial activity and symptoms of burnout-an interventional pilot study. J Clin Med 9:E667. | Human | Lymphocyte | Other | |
Mohsin 2020 Arch Biochem Biophys | 2020 | Mohsin AA, Thompson J, Hu Y, Hollander J, Lesnefsky EJ, Chen Q (2020) Endoplasmic reticulum stress-induced complex I defect: Central role of calcium overload. Arch Biochem Biophys 683:108299. | Rat | Skeletal muscle | Oxidative stress;RONS | |
Frambach 2020 Biochim Biophys Acta Mol Basis Dis | 2020 | Frambach SJCM, van de Wal MAE, van den Broek PHH, Smeitink JAM, Russel FGM, de Haas R, Schirris TJJ (2020) Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis 1866:165727. | Mouse | Skeletal muscle | Mitochondrial disease | |
Ajime 2020 Nicotine Tob Res | 2020 | Ajime TT, Serré J, Wüst RCI, Messa GAM, Poffé C, Swaminathan A, Maes K, Janssens W, Troosters T, Degens H, Gayan-Ramirez G (2020) Two weeks smoking cessation reverses cigarette smoke-induced skeletal muscle atrophy and mitochondrial dysfunction in mice. Nicotine Tob Res 23:143-51. | Mouse | Skeletal muscle | ||
Wei 2020 Hum Mutat | 2020 | Wei X, Du M, Li D, Wen S, Xie J, Li Y, Chen A, Zhang K, Xu P, Jia M, Wen C, Zhou H, Lyu J, Yang Y, Fang H (2020) Mutations in FASTKD2 are associated with mitochondrial disease with multi-OXPHOS deficiency. Hum Mutat 41:961-72. | Human | Lymphocyte | Mitochondrial disease | |
Protasoni 2020 EMBO J | 2020 | Protasoni M, Pérez-Pérez R, Lobo-Jarne T, Harbour ME, Ding S, Peñas A, Diaz F, Moraes CT, Fearnley IM, Zeviani M, Ugalde C, Fernández-Vizarra E (2020) Respiratory supercomplexes act as a platform for complex III-mediated maturation of human mitochondrial complexes I and IV. EMBO J 39:e102817. | Human | Other cell lines | ||
Monaco 2020 Am J Physiol Endocrinol Metab | 2020 | Monaco CMF, Bellissimo CA, Hughes MC, Ramos SV, Laham R, Perry CGR, Hawke TJ (2020) Sexual dimorphism in human skeletal muscle mitochondrial bioenergetics in response to type 1 diabetes. Am J Physiol Endocrinol Metab 318:E44-E51. | Human | Skeletal muscle | Diabetes | |
Wang 2020 J Mol Med (Berl) | 2020 | Wang SY, Zhu Siyu, Wu Jian, Zhang Maomao, Xu Yousheng, Xu Wei, Cui Jinjin, Yu Bo, Cao Wei, Liu Jingjin (2020) Exercise enhances cardiac function by improving mitochondrial dysfunction and maintaining energy homoeostasis in the development of diabetic cardiomyopathy. J Mol Med (Berl) 98:245-61. | Mouse | Heart | Oxidative stress;RONS | Diabetes Cardiovascular Obesity |
Alston 2020 Am J Hum Genet | 2020 | Alston CL, Veling MT, Heidler J, Taylor LS, Alaimo JT, Sung AY, He L, Hopton S, Broomfield A, Pavaine J, Diaz J, Leon E, Wolf P, McFarland R, Prokisch H, Wortmann SB, Bonnen PE, Wittig I, Pagliarini DJ, Taylor RW (2020) Pathogenic bi-allelic mutations in NDUFAF8 cause Leigh syndrome with an isolated complex I deficiency. Am J Hum Genet 106:92-101. | Human | Fibroblast | ||
Woessner 2020 Thesis | 2020 | Woessner MN (2020) BEET-HF: The effects of dietary inorganic nitrate supplementation on aerobic exercise performance, vascular function, cardiac performance and mitochondrial respiration in patients with heart failure with reduced ejection fraction. PhD Thesis 198. | Human | Skeletal muscle | Cardiovascular | |
Madeo 2020 US Patent | 2020 | Madeo F, Eisenberg T, Stekovic S (2020) Use of spermidine for the enhancement of mitochondrial respiration. US Patent US20200054579 A1. | Mouse | Heart | ||
Hroudova 2020 Mol Neurobiol | 2020 | Hroudová J, Nováková T, Korábečný J, Maliňák D, Górecki L, Fišar Z (2020) Effects of novel tacrine derivatives on mitochondrial energy metabolism and monoamine oxidase activity-in vitro study. Mol Neurobiol 58:1102-13. | Pig | Nervous system | ||
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Lim 2018 Sci Rep | 2018 | Lim SC, Tajika M, Shimura M, Carey KT, Stroud DA, Murayama K, Ohtake A, McKenzie M (2018) Loss of the mitochondrial fatty acid β-oxidation protein medium-chain acyl-Coenzyme A dehydrogenase disrupts oxidative phosphorylation protein complex stability and function. Sci Rep 8:153. | Human | Other cell lines | Cancer | |
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Shen 2018 Biosci Rep | 2018 | Shen NY, Ng SY, Toepp SL, Ljubicic V (2018) Protein arginine methyltransferase expression and activity during myogenesis. Biosci Rep 38. pii: BSR20171533. | Mouse | Skeletal muscle | ||
De Paula Martins 2018 Free Radic Biol Med | 2018 | de Paula Martins R, Ghisoni K, Lim CK, Aguiar AS Jr, Guillemin GJ, Latini A (2018) Neopterin preconditioning prevents inflammasome activation in mammalian astrocytes. Free Radic Biol Med 115:371-82. | Rat | Nervous system | ||
Monaco 2018 Diabetologia | 2018 | Monaco CMF, Proudfoot R, Miotto PM, Herbst EAF, MacPherson REK, Holloway GP (2018) α-linolenic acid supplementation prevents exercise-induced improvements in white adipose tissue mitochondrial bioenergetics and whole-body glucose homeostasis in obese Zucker rats. Diabetologia 61:433-44. | Rat | Skeletal muscle Fat | Obesity | |
Geffroy 2018 Biochim Biophys Acta | 2018 | Geffroy G, Benyahia R, Frey S, Desquiret-Dumas V, Gueguen N, Bris C, Belal S, Inisan A, Renaud A, Chevrollier A, Henrion D, Bonneau D, Letournel F, Lenaers G, Reynier P, Procaccio V (2018) The accumulation of assembly intermediates of the mitochondrial complex I matrix arm is reduced by limiting glucose uptake in a neuronal-like model of MELAS syndrome. Biochim Biophys Acta 1864:1596-1608. | Human | Nervous system Other cell lines | ||
Allard 2018 J Clin Endocrinol Metab | 2018 | Allard NAE, Schirris TJJ, Verheggen RJ, Russel FGM, Rodenburg RJ, Smeitink JAM, Thompson PD, Hopman MTE, Timmers S (2018) Statins affect skeletal muscle performance: evidence for disturbances in energy metabolism. J Clin Endocrinol Metab 103:75-84. | Human | Skeletal muscle | Myopathy | |
Fouret 2018 Br J Nutr | 2018 | Fouret G, Gaillet S, Lecomte J, Bonafos B, Djohan F, Barea B, Badia E, Coudray C, Feillet-Coudray C (2018) 20-Week follow-up of hepatic steatosis installation and liver mitochondrial structure and activity and their interrelation in rats fed a high-fat-high-fructose diet. Br J Nutr 119:368-80. | Rat | Liver | Diabetes Obesity | |
Zimin 2018 Br J Anaesth | 2018 | Zimin PI, Woods CB, Kayser EB, Ramirez JM, Morgan PG, Sedensky MM (2018) Isoflurane disrupts excitatory neurotransmitter dynamics via inhibition of mitochondrial complex I. Br J Anaesth 120:1019-32. | Mouse | Nervous system | ||
Seite 2018 Sci Rep | 2018 | Seite S, Mourier A, Camougrand N, Salin B, Figueiredo-Silva AC, Fontagne-Dicharry S, Panserat S, Seiliez I (2018) Dietary methionine deficiency affects oxidative status, mitochondrial integrity and mitophagy in the liver of rainbow trout (Oncorhynchus mykiss). Sci Rep 8:10151. | Fishes | Liver | ||
Perks 2018 Cell Rep | 2018 | Perks KL, Rossetti G, Kuznetsova I, Hughes LA, Ermer JA, Ferreira N, Busch JD, Rudler DL, Spahr H, Schöndorf T, Shearwood AJ, Viola HM, Siira SJ, Hool LC, Milenkovic D, Larsson NG, Rackham O, Filipovska A (2018) PTCD1 is required for 16S rRNA maturation complex stability and mitochondrial ribosome assembly. Cell Rep 23:127-42. | Mouse | Heart | ||
Cree-Green 2018 Diabetes | 2018 | Cree-Green M, Scalzo RL, Harrall K, Newcomer BR, Schauer IE, Huebschmann AG, McMillin S, Brown MS, Orlicky D, Knaub L, Nadeau KJ, Mcclatchey PM, Bauer TA, Regensteiner JG, Reusch JEB (2018) Supplemental oxygen improves in-vivo mitochondrial oxidative phosphorylation flux in sedentary obese adults with type 2 diabetes. Diabetes 67:1369-79. | Human | Skeletal muscle | Diabetes Obesity | |
Boutoual 2018 Scientific Reports | 2018 | Boutoual, R., Meseguer, S., Villarroya, M., Martin-Hernandez, E., Errami, M., Martin, M. A., Casado, M., and Armengod, M. E. (2018) Defects in the mitochondrial-tRNA modification enzymes MTO1 and GTPBP3 promote different metabolic reprogramming through a HIF-PPARgamma-UCP2-AMPK axis. Scientific reports 8, 1163 | Human | Other cell lines Fibroblast | Mitochondrial disease | Cardiovascular |
JanssenDuijghuijsen 2018 Thesis | 2018 | JanssenDuijghuijsen LM (2018) Good, Bad, or Risky? Intestinal permeability to protein: Human and in vitro studies. Doctoral Thesis p154. | Human | Endothelial;epithelial;mesothelial cell | ||
Monzio Compagnoni 2018 Biochim Biophys Acta Mol Basis Dis | 2018 | Monzio Compagnoni G, Kleiner G, Bordoni A, Fortunato F, Ronchi D, Salani S, Guida M, Corti C, Pichler I, Bergamini C, Fato R, Pellecchia MT, Vallelunga A, Del Sorbo F, Elia A, Reale C, Garavaglia B, Mora G, Albanese A, Cogiamanian F, Ardolino G, Bresolin N, Corti S, Comi GP, Quinzii CM, Di Fonzo A (2018) Mitochondrial dysfunction in fibroblasts of multiple system atrophy. Biochim Biophys Acta Mol Basis Dis 1864:3588-97. | Human | Fibroblast | Neurodegenerative | |
Kauppila 2018 Nucleic Acids Res | 2018 | Kauppila JHK, Bonekamp NA, Mourier A, Isokallio MA, Just A, Kauppila TES, Stewart JB, Larsson NG (2018) Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice. Nucleic Acids Res 46:6642-69. | Mouse | Aging;senescence | ||
Juarez-Flores 2018 J Transl Med | 2018 | Juárez-Flores DL, González-Casacuberta I, Ezquerra M, Bañó M, Carmona-Pontaque F, Catalán-García M, Guitart-Mampel M, Rivero JJ, Tobias E, Milisenda JC, Tolosa E, Marti MJ, Fernández-Santiago R, Cardellach F, Morén C, Garrabou G (2018) Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2G2019S -Parkinson's disease. J Transl Med 16:160. | Human | Fibroblast | Parkinson's | |
Stein 2018 Cell Rep | 2018 | Stein CS, Jadiya P, Zhang X, McLendon JM, Abouassaly GM, Witmer NH, Anderson EJ, Elrod JW, Boudreau RL (2018) Mitoregulin: A lncRNA-encoded microprotein that supports mitochondrial supercomplexes and respiratory efficiency. Cell Rep 23:3710-20. | Human | Heart Skeletal muscle | ||
Keller 2018 Oxid Med Cell Longev | 2018 | Keller AC, Knaub LA, Scalzo RL, Hull SE, Johnston AE, Walker LA, Reusch JEB (2018) Sepiapterin improves vascular reactivity and insulin-stimulated glucose in wistar rats. Oxid Med Cell Longev 2018:7363485. | Rat | Endothelial;epithelial;mesothelial cell | Cardiovascular | |
Paech 2018b Toxicology | 2018 | Paech F, Abegg VF, Duthaler U, Terracciano L, Bouitbir J, Krähenbühl S (2018) Sunitinib induces hepatocyte mitochondrial damage and apoptosis in mice. Toxicology 409:13-23. | Mouse | Liver | Cell death Cryopreservation | |
Giacco 2018 FASEB J | 2018 | Giacco A, Delli Paoli G, Senese R, Cioffi F, Silvestri E, Moreno M, Ruoppolo M, Caterino M, Costanzo M, Lombardi A, Goglia F, Lanni A, de Lange P (2018) The saturation degree of fatty acids and their derived acylcarnitines determines the direct effect of metabolically active thyroid hormones on insulin sensitivity in skeletal muscle cells. FASEB J 33:1811-23. | Rat | Skeletal muscle | ||
Rekuviene 2018 Thesis | 2018 | Rekuvienė E (2018) Effect of respiratory complex I inhibitors on mitochondrial permeability transition and cell viability during brain ischemia. Doctoral Dissertation 138. | Rat | Nervous system | Ischemia-reperfusion Permeability transition | |
Hayward 2018 Thesis | 2018 | Hayward L (2018) The effect of anoxia on mitochondrial function in a hibernator (Ictidomys tridecemlineatus). Master's Thesis 57. | Other mammals | Liver | Ischemia-reperfusion | |
Parey 2018 Elife | 2018 | Parey K, Brandt U, Xie H, Mills DJ, Siegmund K, Vonck J, Kühlbrandt W, Zickermann V (2018) Cryo-EM structure of respiratory complex I at work. https://doi.org/10.7554/elife.39213 | ||||
McLaughlin 2018 Biochem Biophys Res Commun | 2018 | McLaughlin KL, McClung JM, Fisher-Wellman KH (2018) Bioenergetic consequences of compromised mitochondrial DNA repair in the mouse heart. Biochem Biophys Res Commun 504:742-48. | Mouse | Heart | ||
Eimre 2018 Oxid Med Cell Longev | 2018 | Eimre M, Paju K, Peet N, Kadaja L, Tarrend M, Kasvandik S, Seppet J, Ivask M, Orlova E, Kõks S (2018) Increased mitochondrial protein levels and bioenergetics in the musculus rectus femoris of Wfs1-deficient mice. Oxid Med Cell Longev 2018:3175313. | Mouse | Skeletal muscle | Diabetes Inherited | |
Hedges 2018 J Appl Physiol (1985) | 2018 | Hedges CP, Woodhead JST, Wang HW, Mitchell CJ, Cameron-Smith D, Hickey AJR, Merry TL (2018) Peripheral blood mononuclear cells do not reflect skeletal muscle mitochondrial function or adaptation to high-intensity interval training in healthy young men. J Appl Physiol (1985) 126:454-61. | Human | Skeletal muscle Blood cells | ||
Pape 2018 Nutrients | 2018 | Pape JA, Newey CR, Burrell HR, Workman A, Perry K, Bikman BT, Bridgewater LC, Grose JH (2018) Per-Arnt-Sim kinase (PASK) deficiency increases cellular respiration on a standard diet and decreases liver triglyceride accumulation on a western high-fat high-sugar diet. Nutrients 10:1990. | Mouse | Skeletal muscle Liver | ||
Walczak 2018 FASEB J | 2018 | Walczak J, Dębska-Vielhaber G, Vielhaber S, Szymański J, Charzyńska A, Duszyński J, Szczepanowska J (2018) Distinction of sporadic and familial forms of ALS based on mitochondrial characteristics. FASEB J 33:4388-403. | Human | Fibroblast | Neurodegenerative | |
Thompson 2018 EMBO Mol Med | 2018 | Thompson K, Mai N, Oláhová M, Scialó F, Formosa LE, Stroud DA, Garrett M, Lax NZ, Robertson FM, Jou C, Nascimento A, Ortez C, Jimenez-Mallebrera C, Hardy SA, He L, Brown GK, Marttinen P, McFarland R, Sanz A, Battersby BJ, Bonnen PE, Ryan MT, Chrzanowska-Lightowlers ZM, Lightowlers RN, Taylor RW (2018) OXA1L mutations cause mitochondrial encephalopathy and a combined oxidative phosphorylation defect. EMBO Mol Med 10:e9060. | Drosophila | |||
Pamenter 2018 PLoS One | 2018 | Pamenter ME, Lau GY, Richards JG (2018) Effects of cold on murine brain mitochondrial function. PLoS One 13:e0208453. | Mouse | Nervous system | ||
Souza 2018 Sci Rep | 2018 | Souza RWA, Alves CRR, Medeiros A, Rolim N, Silva GJJ, Moreira JBN, Alves MN, Wohlwend M, Gebriel M, Hagen L, Sharma A, Koch LG, Britton SL, Slupphaug G, Wisløff U, Brum PC (2018) Differential regulation of cysteine oxidative post-translational modifications in high and low aerobic capacity. Sci Rep 8:17772. | Rat | Heart Skeletal muscle | ||
Tyagi 2018 Sci Rep | 2018 | Tyagi A, Nguyen CU, Chong T, Michel CR, Fritz KS, Reisdorph N, Knaub L, Reusch JEB, Pugazhenthi S (2018) SIRT3 deficiency-induced mitochondrial dysfunction and inflammasome formation in the brain. Sci Rep 8:17547. | Mouse | Nervous system | ||
Wang 2018 Cell Physiol Biochem | 2018 | Wang P, Hu Y, Yao D, Li Y (2018) Omi/HtrA2 regulates a aitochondria-dependent apoptotic pathway in a murine model of septic encephalopathy. Cell Physiol Biochem 49:2163-73. | Rat | Nervous system | Oxidative stress;RONS Cell death | Neurodegenerative Sepsis |
Lobo-Jarne 2018 Cell Rep | 2018 | Lobo-Jarne T, Nývltová E, Pérez-Pérez R, Timón-Gómez A, Molinié T, Choi A, Mourier A, Fontanesi F, Ugalde C, Barrientos A (2018) Human COX7A2L regulates complex III biogenesis and promotes supercomplex organization remodeling without affecting mitochondrial bioenergetics. Cell Rep 25:1786-99. | Human | HEK Other cell lines | ||
Aparicio-Trejo 2018 Free Radic Biol Med | 2018 | Aparicio-Trejo OE, Reyes-Fermín LM, Briones-Herrera A, Tapia E, León-Contreras JC, Hernández-Pando R, Sánchez-Lozada LG, Pedraza-Chaverri J (2018) Protective effects of N-acetyl-cysteine in mitochondria bioenergetics, oxidative stress, dynamics and S-glutathionylation alterations in acute kidney damage induced by folic acid. Free Radic Biol Med 130:379-96. | Rat | Kidney | Oxidative stress;RONS | Other |
Warnau 2018 Proc Natl Acad Sci U S A | 2018 | Warnau J, Sharma V, Gamiz-Hernandez AP, Di Luca A, Haapanen O, Vattulainen I, Wikström M, Hummer G, Kaila VRI (2018) Redox-coupled quinone dynamics in the respiratory complex I. Proc Natl Acad Sci U S A 115:E8413-20. https://doi.org/10.1073/pnas.1805468115 | ||||
Ryan 2018 JCI Insight | 2018 | Ryan TE, Yamaguchi DJ, Schmidt CA, Zeczycki TN, Shaikh SR, Brophy P, Green TD, Tarpey MD, Karnekar R, Goldberg EJ, Sparagna GC, Torres MJ, Annex BH, Neufer PD, Spangenburg EE, McClung JM (2018) Extensive skeletal muscle cell mitochondriopathy distinguishes critical limb ischemia patients from claudicants. JCI Insight 3:123235. | Human | Skeletal muscle | Cardiovascular | |
Laouafa 2018 Adv Exp Med Biol | 2018 | Laouafa S, Roussel D, Marcouiller F, Soliz J, Bairam A, Joseph V (2018) Role of estradiol receptor beta (ERβ) on arterial pressure, respiratory chemoreflex and mitochondrial function in young and aged female mice. Adv Exp Med Biol 1071:115-27. | Mouse | Nervous system | Hypoxia | Aging;senescence |
Rocha 2018 J Physiol Biochem | 2018 | Rocha C, Koury OH, Scheede-Bergdahl C, Bergdahl A (2018) Cardiac mitochondrial respiration following a low-carbohydrate, high-fat diet in apolipoprotein E-deficient mice. J Physiol Biochem 75:65-72. | Mouse | Heart | ||
Angebault 2018 Sci Signal | 2018 | Angebault C, Fauconnier J, Patergnani S, Rieusset J, Danese A, Affortit CA, Jagodzinska J, Mégy C, Quiles M, Cazevieille C, Korchagina J, Bonnet-Wersinger D, Milea D, Hamel C, Pinton P, Thiry M, Lacampagne A, Delprat B, Delettre C (2018) ER-mitochondria cross-talk is regulated by the Ca2+ sensor NCS1 and is impaired in Wolfram syndrome. Sci Signal 11:eaaq1380. | Human | Fibroblast | Neurodegenerative Inherited | |
Alston 2018 Am J Hum Genet | 2018 | Alston CL, Heidler J, Dibley MG, Kremer LS, Taylor LS, Fratter C, French CE, Glasgow RIC, Feichtinger RG, Delon I, Pagnamenta AT, Dolling H, Lemonde H, Aiton N, Bjørnstad A, Henneke L, Gärtner J, Thiele H, Tauchmannova K, Quaghebeur G, Houstek J, Sperl W, Raymond FL, Prokisch H, Mayr JA, McFarland R, Poulton J, Ryan MT, Wittig I, Henneke M, Taylor RW (2018) Bi-allelic mutations in NDUFA6 establish its role in early-onset isolated mitochondrial complex I deficiency. Am J Hum Genet 103:592-601. | Human | Fibroblast | Mitochondrial disease | |
Friederich 2018 Nat Commun | 2018 | Friederich MW, Timal S, Powell CA, Dallabona C, Kurolap A, Palacios-Zambrano S, Bratkovic D, Derks TGJ, Bick D, Bouman K, Chatfield KC, Damouny-Naoum N, Dishop MK, Falik-Zaccai TC, Fares F, Fedida A, Ferrero I, Gallagher RC, Garesse R, Gilberti M, González C, Gowan K, Habib C, Halligan RK, Kalfon L, Knight K, Lefeber D, Mamblona L, Mandel H, Mory A, Ottoson J, Paperna T, Pruijn GJM, Rebelo-Guiomar PF, Saada A, Sainz B Jr, Salvemini H, Schoots MH, Smeitink JA, Szukszto MJ, Ter Horst HJ, van den Brandt F, van Spronsen FJ, Veltman JA, Wartchow E, Wintjes LT, Zohar Y, Fernández-Moreno MA, Baris HN, Donnini C, Minczuk M, Rodenburg RJ, Van Hove JLK (2018) Pathogenic variants in glutamyl-tRNAGln amidotransferase subunits cause a lethal mitochondrial cardiomyopathy disorder. Nat Commun 9:4065. | Human Fungi | Fibroblast | Myopathy | |
JanssenDuijghuijsen 2017 Front Physiol | 2017 | JanssenDuijghuijsen LM, Grefte S, de Boer VCJ, Zeper L, van Dartel DAM, van der Stelt I, Bekkenkamp-Grovenstein M, van Norren K, Wichers HJ, Keijer J (2017) Mitochondrial ATP depletion disrupts Caco-2 monolayer integrity and internalizes Claudin 7. Front Physiol 8:794. | Human | Endothelial;epithelial;mesothelial cell Other cell lines | ||
Scheede-Bergdahl 2017 Can J Physiol Pharmacol | 2017 | Scheede-Bergdahl C, Bergdahl A (2017) Adaptation of mitochondrial expression and ATP production in dedifferentiating vascular smooth muscle cells. Can J Physiol Pharmacol 95:1473-9. | Mouse | Endothelial;epithelial;mesothelial cell | Cardiovascular | |
Dechandt 2017 J Bioenerg Biomembr | 2017 | Dechandt CRP, Zuccolotto-Dos-Reis FH, Teodoro BG, Fernandes AMAP, Eberlin MN, Kettelhut IC, Curti C, Alberici LC (2017) Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes. J Bioenerg Biomembr 49:399-411. | Rat | Liver | Other | |
Takahashi 2017 Exp Gerontol | 2017 | Takahashi K, Ohsawa I, Shirasawa T, Takahashi M (2017) Optic atrophy 1 mediates coenzyme Q-responsive regulation of respiratory complex IV activity in brain mitochondria. Exp Gerontol 98:217-223. | Mouse | Nervous system | Aging;senescence | |
Welker 2017 Thesis | 2017 | Welker L (2017) Metabolic and morphologic shifts in Neuro2a cells cultured in galactose medium. Master's Thesis p26. | Mouse | Cancer | ||
Mueller 2017 Orphanet J Rare Dis | 2017 | Mueller SM, Gehrig SM, Petersen JA, Frese S, Mihaylova V, Ligon-Auer M, Khmara N, Nuoffer JM, Schaller A, Lundby C, Toigo M, Jung HH (2017) Effects of endurance training on skeletal muscle mitochondrial function in Huntington disease patients. Orphanet J Rare Dis 12:184. | Human | Skeletal muscle | Neurodegenerative | |
Ruiz 2017 Brain Pathol | 2017 | Ruiz M, Bégou M, Launay N, Ranea-Robles P, Bianchi P, López-Erauskin J, Morató L, Guilera C, Petit B, Vaurs-Barriere C, Guéret-Gonthier C, Bonnet-Dupeyron MN, Fourcade S, Auwerx J, Boespflug-Tanguy O, Pujol A (2017) Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease. Brain Pathol 28:611-30. | Human Mouse | Nervous system Fibroblast | Oxidative stress;RONS | Inherited Neurodegenerative |
Mahalingam 2017 J Physiol | 2017 | Mahalingam S, McClelland GB, Scott GR (2017) Evolved changes in the intracellular distribution and physiology of muscle mitochondria in high-altitude native deer mice. J Physiol 595:4785-801. | Mouse | Skeletal muscle | Hypoxia | |
Xu 2017 J Hum Genet | 2017 | Xu B, Li X, Du M, Zhou C, Fang H, Lyu J, Yang Y (2017) Novel mutation of ND4 gene identified by targeted next-generation sequencing in patient with Leigh syndrome. J Hum Genet 62:291-7. | Human | Blood cells Platelet | Neurodegenerative | |
Stepanova 2017 J Cereb Blood Flow Metab | 2017 | Stepanova A, Kahl A, Konrad C, Ten V, Starkov AS, Galkin A (2017) Reverse electron transfer results in a loss of flavin from mitochondrial complex I: Potential mechanism for brain ischemia-reperfusion injury. J Cereb Blood Flow Metab 37:3649-58. | Mouse | Nervous system | Ischemia-reperfusion | |
Blecha 2017 Free Radic Biol Med | 2017 | Blecha J, Novais SM, Rohlenova K, Novotna E, Lettlova S, Schmitt S, Zischka H, Neuzil J, Rohlena J (2017) Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death. Free Radic Biol Med 112:253-66. | Endothelial;epithelial;mesothelial cell | Oxidative stress;RONS | Cancer | |
Schatton 2017 J Cell Biol | 2017 | Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI (2017) CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol 216:675-93. | Mouse | Liver | ||
Koit 2017 Oxid Med Cell Longev | 2017 | Koit A, Shevchuk I, Ounpuu L, Klepinin A, Chekulayev V, Timohhina N, Tepp K, Puurand M,Truu L, Heck K, Valvere V, Guzun R, Kaambre T (2017) Mitochondrial respiration in human colorectal and breast cancer clinical material is regulated differently. Oxid Med Cell Longev 2017:1372640. | Human | Endothelial;epithelial;mesothelial cell | Cancer | |
Derungs 2017 Mol Psychiatry | 2017 | Derungs R, Camici GG, Spescha RD, Welt T, Tackenberg C, Späni C, Wirth F, Grimm A, Eckert A, Nitsch RM, Kulic L (2017) Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer's disease. Mol Psychiatry 22:605-14. | Mouse | Nervous system | Aging;senescence Alzheimer's | |
Rekuviene 2017 Data Brief | 2017 | Rekuviene E, Ivanoviene L, Borutaite V, Morkuniene R (2017) Data on effects of rotenone on calcium retention capacity, respiration and activities of respiratory chain complexes I and II in isolated rat brain mitochondria. Data Brief 13:707-12. | Rat | Nervous system | Cryopreservation Ischemia-reperfusion | |
Greggio 2017 Cell Metab | 2017 | Greggio C, Jha P, Kulkarni SS, Lagarrigue S, Broskey NT, Boutant M, Wang X, Alonso SC, Ofori E, Auwerx J, Cantó C, Amati F (2017) Enhanced respiratory chain supercomplex formation in response to exercise in human skeletal muscle. Cell Metab 25:301-11. | Human | Skeletal muscle | ||
Asiri 2017 Thesis | 2017 | Asiri A (2017) Effects of asiatic acid on neurite outgrowth in Neuro-2a cells. Master's Thesis p42. | Mouse | Nervous system | Cancer | |
Newsom 2017 Am J Physiol Endocrinol Metab | 2017 | Newsom SA, Miller BF, Hamilton KL, Ehrlicher SE, Stierwalt HD, Robinson MM (2017) Long-term rates of mitochondrial protein synthesis are increased in mouse skeletal muscle with high fat feeding regardless of insulin sensitizing treatment. Am J Physiol Endocrinol Metab 313:552-62. | Mouse | Skeletal muscle | Diabetes Obesity | |
Zhang 2017 J Biol Chem | 2017 | Zhang Y, Bharathi SS, Rardin MJ, Lu J, Maringer KV, Sims-Lucas S, Prochownik EV, Gibson BW, Goetzman ES (2017) Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain. J Biol Chem 292:10239-49. | Human | Liver HEK | ||
Gruenig 2017 Toxicol In Vitro | 2017 | Grünig D, Felser A, Bouitbir J, Krähenbühl S (2017) The catechol-O-methyltransferase inhibitors tolcapone and entacapone uncouple and inhibit the mitochondrial respiratory chain in HepaRG cells. Toxicol In Vitro 42:337-47. | Human Mouse | Liver Other cell lines | ||
Mathers 2017 J Comp Physiol B | 2017 | Mathers KE, McFarlane SV, Zhao L, Staples JF (2017) Regulation of mitochondrial metabolism during hibernation by reversible suppression of electron transport system enzymes. J Comp Physiol B 187:227-34. | Other mammals | Liver | Temperature | |
Van den Berg 2017 Am J Respir Crit Care Med | 2017 | van den Berg M, Hooijman PE, Beishuizen A, de Waard MC, Paul MA, Hartemink KJ, van Hees HWH, Lawlor MW, Brocca L, Bottinelli R, Pellegrino MA, Stienen GJM, Heunks LMA, Wüst RCI, Ottenheijm CAC (2017) Diaphragm atrophy and weakness in the absence of mitochondrial dysfunction in the critically ill. Am J Respir Crit Care Med 196:1544-58. | Human | Skeletal muscle | Other | |
Friederich 2017 Hum Mol Genet | 2017 | Friederich MW, Erdogan AJ, Coughlin CR 2nd, Elos MT, Jiang H, O'Rourke CP, Lovell MA, Wartchow E, Gowan K, Chatfield KC, Chick WS, Spector EB, Van Hove JLK, Riemer J (2017) Mutations in the accessory subunit NDUFB10 result in isolated complex I deficiency and illustrate the critical role of intermembrane space import for complex I holoenzyme assembly. Hum Mol Genet 26:702-16. | Human | Fibroblast | Myopathy | |
Kahlhoefer 2017 Biochim Biophys Acta Bioenerg | 2017 | Kahlhöfer F, Kmita K, Wittig I, Zwicker K, Zickermann V (2017) Accessory subunit NUYM (NDUFS4) is required for stability of the electron input module and activity of mitochondrial complex I. https://doi.org/10.1016/j.bbabio.2016.11.010 | ||||
Angerer 2017 Biochim Biophys Acta Mol Cell Res | 2017 | Angerer H, Schönborn S, Gorka J, Bahr U, Karas M, Wittig I, Heidler J, Hoffmann J, Morgner N, Zickermann V (2017) Acyl modification and binding of mitochondrial ACP to multiprotein complexes. https://doi.org/10.1016/j.bbamcr.2017.08.006 | ||||
Kenny 2017 Diabetologia | 2017 | Kenny HC, Rudwill F, Breen L, Salanova M, Blottner D, Heise T, Heer M, Blanc S, O'Gorman DJ (2017) Bed rest and resistive vibration exercise unveil novel links between skeletal muscle mitochondrial function and insulin resistance. Diabetologia 60:1491-501. | Human | Skeletal muscle | Diabetes | |
Buso 2017 Thesis | 2017 | Buso A (2017) Mitochondrial oxidative phosphorylation plasticity/adaptation triggered by disturbances and stresses and targeted by therapies. PhD Thesis p110. | Mouse | Skeletal muscle | Aging;senescence | |
Rekuviene 2017 Neurosci Lett | 2017 | Rekuviene E, Ivanoviene L, Borutaite V, Morkuniene R (2017) Rotenone decreases ischemia-induced injury by inhibiting mitochondrial permeability transition in mature brains. Neurosci Lett 653:45-50. | Rat | Nervous system | Ischemia-reperfusion Permeability transition | |
Profilo 2017 Biochim Biophys Acta | 2017 | Profilo E, Peña-Altamira LE, Corricelli M, Castegna A, Danese A, Agrimi G, Petralla S, Giannuzzi G, Porcelli V, Sbano L, Viscomi C, Massenzio F, Palmieri EM, Giorgi C, Fiermonte G, Virgili M, Palmieri L, Zeviani M, Pinton P, Monti B, Palmieri F, Lasorsa FM (2017) Down-regulation of the mitochondrial aspartate-glutamate carrier isoform 1 AGC1 inhibits proliferation and N-acetylaspartate synthesis in Neuro2A cells. Biochim Biophys Acta 1863:1422-35. | Mouse | Nervous system Other cell lines Neuroblastoma | ||
Lin 2017 Dis Model Mech | 2017 | Lin H, Magrane J, Rattelle A, Stepanova A, Galkin A, Clark EM, Dong YN, Halawani SM, Lynch DR (2017) Early cerebellar deficits in mitochondrial biogenesis and respiratory chain complexes in the KIKO mouse model of Friedreich ataxia. Dis Model Mech 10(11):1343-52. | Mouse | Nervous system | Inherited | |
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Zhou 2017 Biochim Biophys Acta | 2017 | Zhou L, Wang W, Hoppel C, Liu J, Zhu X (2017) Parkinson's disease-associated pathogenic VPS35 mutation causes complex I deficits. Biochim Biophys Acta 1863:2791-5. | Human | Fibroblast | Parkinson's | |
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Linden 2016 Am J Physiol Gastrointest Liver Physiol | 2017 | Linden MA, Fletcher JA, Meers GM, Thyfault JP, Laughlin MH, Rector RS (2017) A return to ad libitum feeding following caloric restriction promotes hepatic steatosis in hyperphagic OLETF rats. Am J Physiol Gastrointest Liver Physiol 311:G387-95. | Rat | Liver | Obesity | |
Lores-Arnaiz 2017 J Neurochem | 2017 | Lores-Arnaiz S, Karadayian AG, Gutnisky A, Rodríguez de Lores Arnaiz G (2017) The low affinity neurotensin receptor antagonist levocabastine impairs brain nitric oxide synthesis and mitochondrial function by independent mechanisms. J Neurochem 143:684-96. | Rat | Nervous system | ||
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Hals 2017 Physiol Rep | 2017 | Hals I, Ohki T, Singh R, Ma Z, Björklund A, Balasuriya C, Scholz H, Grill V (2017) Hyperoxia reduces insulin release and induces mitochondrial dysfunction with possible implications for hyperoxic treatment of neonates. Physiol Rep 5. pii: e13447. | Human Mouse | Islet cell;pancreas;thymus | Hypoxia | |
Ferens 2017 Biochem Cell Biol | 2017 | Ferens FG, Spicer V, Krokhin OV, Motnenko A, Summers WA, Court DA (2017) A deletion variant partially complements a porin-less strain of Neurospora crassa. Biochem Cell Biol 95:318-27. | Fungi | |||
Boutant 2017 EMBO J | 2017 | Boutant M, Kulkarni SS, Joffraud M, Ratajczak J, Valera-Alberni M, Combe R, Zorzano A, Cantó C (2017) Mfn2 is critical for brown adipose tissue thermogenic function. EMBO J 36:1543-58. | Mouse | Fat Fibroblast | ||
Haegler 2017 PLOS ONE | 2017 | Haegler P, Grünig D, Berger B, Terracciano L, Krähenbühl S, Bouitbir J (2017) Hepatic effects of pharmacological doses of hydroxy-cobalamin[c-lactam] in mice. PLOS ONE 12:e0171026. | Mouse | Liver | ||
McFarlane 2017 Am J Physiol Regul Integr Comp Physiol | 2017 | McFarlane SV, Mathers KE, Staples JF (2017) Reversible temperature-dependent differences in brown adipose tissue respiration during torpor in a mammalian hibernator. Am J Physiol Regul Integr Comp Physiol 312:R434-42. | Other mammals | Fat | Temperature | |
Schmidt 2017 J Vasc Surg | 2017 | Schmidt CA, Ryan TE, Lin CT, Inigo MM, Green TD, Brault JJ, Spangenburg EE, McClung JM (2017) Diminished force production and mitochondrial respiratory deficits are strain-dependent myopathies of subacute limb ischemia. J Vasc Surg 65:1504-1514. | Mouse | Skeletal muscle | Hypoxia | Myopathy Other |
Gusdon 2017 Exp Gerontol | 2017 | Gusdon AM, Callio J, Distefano G, O'Doherty RM, Goodpaster BH, Coen PM, Chu CT (2017) Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice. Exp Gerontol 90:1-13. | Mouse | Nervous system | Oxidative stress;RONS | Aging;senescence |
Seiferling 2016 EMBO Rep | 2016 | Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, König T, Kukat A, Trifunovic A (2016) Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep 17:953-64. | Mouse | Heart | Cardiovascular | |
Oliveira 2016 PLOS ONE | 2016 | Oliveira MP, Correa Soares JB, Oliveira MF (2016) Sexual preferences in nutrient utilization regulate oxygen consumption and reactive oxygen species generation in Schistosoma mansoni: potential implications for parasite redox biology. PLOS ONE 11:e0158429. | Other invertebrates | Oxidative stress;RONS | ||
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Bratic 2016 PLoS Genet | 2016 | Bratic A, Clemente P, Calvo-Garrido J, Maffezzini C, Felser A, Wibom R, Wedell A, Freyer C, Wredenberg A (2016) Mitochondrial polyadenylation is a one-step process required for mRNA integrity and tRNA maturation. PLoS Genet 12:e1006028. | Drosophila | |||
Iglesias-Gonzalez 2016 Mol Neurobiol | 2016 | Iglesias-González J, Sánchez-Iglesias S, Beiras-Iglesias A, Méndez-Álvarez E, Soto-Otero R (2016) Effects of aluminium on rat brain mitochondria bioenergetics: an in vitro and in vivo study. Mol Neurobiol 54:563-70. | Rat | Nervous system | Alzheimer's Neurodegenerative Parkinson's | |
Rohlenova 2016 Antioxid Redox Signal | 2016 | Rohlenova K, Sachaphibulkij K, Stursa J, Bezawork-Geleta A, Blecha J, Endaya B, Werner L, Cerny J, Zobalova R, Goodwin J, Spacek T, Alisadeh E, Yan B, Nguyen M, Vondrusova M, Sobol M, Jezek P, Hozak P, Truksa J, Rohlena J, Dong L, Neuzil J (2016) Selective disruption of respiratory supercomplexes as a new strategy to suppress Her2high breast cancer. Antioxid Redox Signal 26:84-103. | Human Mouse | Liver Genital Other cell lines | Oxidative stress;RONS | Cancer |
Milerova 2016 Mol Cell Biochem | 2016 | Milerová M, Drahota Z, Chytilová A, Tauchmannová K, Houštěk J, Ošťádal B (2016) Sex difference in the sensitivity of cardiac mitochondrial permeability transition pore to calcium load. Mol Cell Biochem 412:147-54. | Rat | Heart | Ischemia-reperfusion | |
Wuest 2016 Cardiovasc Res | 2016 | Wüst RC, de Vries HJ, Wintjes LT, Rodenburg RJ, Niessen HW, Stienen GJ (2016) Mitochondrial complex I dysfunction and altered NAD(P)H kinetics in rat myocardium in cardiac right ventricular hypertrophy and failure. Cardiovasc Res 111:362-72. | Rat | Heart | Cardiovascular | |
Stepanova 2016 Biochim Biophys Acta | 2016 | Stepanova A, Shurubor Y, Valsecchi F, Manfredi G, Galkin A (2016) Differential susceptibility of mitochondrial complex II to inhibition by oxaloacetate in brain and heart. Biochim Biophys Acta 1857:1561-8. | Mouse | Heart Nervous system | ||
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Van Zutphen 2016 J Hepatol | 2016 | van Zutphen T, Ciapaite J, Bloks VW, Ackereley C, Gerding A, Jurdzinski A, Allgayer de Moraes R, Zhang L, Wolters JC, Bischoff R, Wanders RJA, Houten SM, Bronte-Tinkew D, Shatseva T, Lewis GF, Groen AK, Reijngoud DJ, Bakker BM, Jonker JW, Kim PK, Bandsma RH (2016) Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction. J Hepatol 65:1198-1208. | Rat | Liver | ||
Saben 2016 Cell Rep | 2016 | Saben JL, Boudoures AL, Asghar Z, Thompson A, Drury A, Zhang W, Chi M, Cusumano A, Scheaffer S, Moley KH (2016) Maternal metabolic syndrome programs mitochondrial dysfunction via germline changes across three generations. Cell Rep 16:1-8. | Mouse | Skeletal muscle | Obesity | |
Richman 2016 Nat Commun | 2016 | Richman TR, Spåhr H, Ermer JA, Davies SM, Viola HM, Bates KA, Papadimitriou J, Hool LC, Rodger J, Larsson NG, Rackham O, Filipovska A (2016) Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice. Nat Commun 7:11884. | Mouse | Heart Liver | Mitochondrial disease | |
Gomez 2016 Thesis | 2016 | Gomez CR (2016) Mitochondrial responses to anoxia exposure in red eared sliders (Trachemys scripta). Master's Thesis p102. | Reptiles | Heart Nervous system | Oxidative stress;RONS | |
Thomas 2016 Neurodegeneration Therapeutics | 2016 | Thomas RR, Keeney PM, Berr SB, Khan SM, Portell FR, Shakenov MZ, Antkowiak PF, Kundu B, Tustison N, Brohawn DG, Bennett JP (2016) Recombinant human TFAM stimulates rat brain, rat cervical spinal cord and human neural stem cell mitochondrial bioenergetics. Neurodegeneration Therapeutics p41. | Rat | Nervous system | Mitochondrial disease | |
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Gerber 2016 J Med Genet | 2016 | Gerber S, Ding MG, Gérard X, Zwicker K, Zanlonghi X, Rio M, Serre V, Hanein S, Munnich A, Rotig A, Bianchi L, Amati-Bonneau P, Elpeleg O, Kaplan J, Brandt U, Rozet JM (2016) Compound heterozygosity for severe and hypomorphic NDUFS2 mutations cause non-syndromic LHON-like optic neuropathy. J Med Genet 54:346-56. | Human | Endothelial;epithelial;mesothelial cell Fibroblast | ||
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Johnson 2016 Stem Cells Dev | 2016 | Johnson J, Lee W, Frazier AE, Vaghjiani V, Laskowski A, Rodriguez AL, Cagnone GL, McKenzie M, White SJ, Nisbet DR, Thorburn DR, St John JC (2016) Deletion of the complex I subunit NDUFS4 adversely modulates cellular differentiation. Stem Cells Dev 25:239-50. | Mouse | Stem cells | ||
Cacabelos 2016 Acta Neuropathol Commun | 2016 | Cacabelos D, Ramírez-Núñez O, Granado-Serrano AB, Torres P, Ayala V, Moiseeva V, Povedano M, Ferrer I, Pamplona R, Portero-Otin M, Boada J (2016) Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS. Acta Neuropathol Commun 4:3. | Mouse | Nervous system Other cell lines | Neurodegenerative | |
Schinagl 2016 PLoS One | 2016 | Schinagl CW, Vrabl P, Burgstaller W (2016) Adapting high-resolution respirometry to glucose-limited steady state mycelium of the filamentous fungus Penicillium ochrochloron: method development and standardisation. PLoS One 11:e0146878. | Fungi | |||
Volt 2016 J Pineal Res | 2016 | Volt H, García JA, Doerrier C, Díaz-Casado ME, Guerra-Librero A, López LC, Escames G, Tresguerres JA, Acuña-Castroviejo D (2016) Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin. J Pineal Res 60:193-205. | Mouse | Heart | Aging;senescence Sepsis | |
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Lores-Arnaiz 2016 Neurochem Res | 2016 | Lores-Arnaiz S, Lombardi P, Karadayian AG, Orgambide F, Cicerchia D, Bustamante J (2016) Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging. Neurochem Res 41:353-63. | Mouse | Nervous system | Aging;senescence | |
Morad 2016 J Lipid Res | 2016 | Morad SA, Ryan TE, Neufer PD, Zeczycki TN, Davis TS, MacDougall MR, Fox TE, Tan SF, Feith DJ, Loughran TP Jr, Kester M, Claxton DF, Barth BM, Deering TG, Cabot MC (2016) Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia. J Lipid Res 57:1231-42. | Human | Blood cells Other cell lines | Cell death | Cancer |
Reijne 2016 PLOS ONE | 2016 | Reijne AC, Ciapaite J, van Dijk TH, Havinga R, van der Zee EA, Groen AK, Reijngoud DJ, Bakker BM, van Dijk G (2016) Whole-body vibration partially reverses aging-induced increases in visceral adiposity and hepatic lipid storage in mice. PLOS ONE 11:e0149419. | Mouse | Skeletal muscle Liver | Aging;senescence | |
Letts 2016 Nature | 2016 | Letts JA, Fiedorczuk K, Sazanov LA (2016) The architecture of respiratory supercomplexes. Nature 537:644-8. https://doi.org/10.1038/nature19774 | Bovines | Oxidative stress;RONS | ||
Leucci 2016 Nature | 2016 | Leucci E, Vendramin R, Spinazzi M, Laurette P, Fiers M, Wouters J, Radaelli E, Eyckerman S, Leonelli C, Vanderheyden K, Rogiers A, Hermans E, Baatsen P, Aerts S, Amant F, Van Aelst S, van den Oord J, de Strooper B, Davidson I, Lafontaine DL, Gevaert K, Vandesompele J, Mestdagh P, Marine JC (2016) Melanoma addiction to the long non-coding RNA SAMMSON. Nature 531:518-22. | Human | Endothelial;epithelial;mesothelial cell Other cell lines | Cancer | |
Magdalon 2016 Biochim Biophys Acta | 2016 | Magdalon J, Chimin P, Belchior T, Neves RX, Vieira-Lara MA, Andrade ML, Farias TS, Bolsoni-Lopes A, Paschoal VA, Yamashita AS, Kowaltowski AJ, Festuccia WT (2016) Constitutive adipocyte mTORC1 activation enhances mitochondrial activity and reduces visceral adiposity in mice. Biochim Biophys Acta 1861:430-8. | Mouse | Fat | Obesity Other | |
Keller 2016 Oxid Med Cell Longev | 2016 | Keller AC, Knaub LA, McClatchey PM, Connon CA, Bouchard R, Miller MW, Geary KE, Walker LA, Klemm DJ, Reusch JE (2016) Differential mitochondrial adaptation in primary vascular smooth muscle cells from a diabetic rat model. Oxid Med Cell Longev 2016:8524267. | Rat | Endothelial;epithelial;mesothelial cell | Oxidative stress;RONS | Diabetes |
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Melenovsky 2016 Eur J Heart Fail | 2016 | Melenovsky V, Petrak J, Mracek T, Benes J, Borlaug BA, Nuskova H, Pluhacek T, Spatenka J, Kovalcikova J, Drahota Z, Kautzner J, Pirk J, Houstek J (2016) Myocardial iron content and mitochondrial function in human heart failure: a direct tissue analysis. Eur J Heart Fail 19:522-30. | Human | Heart | Cardiovascular | |
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Amigo 2016 Aging Cell | 2016 | Amigo I, Menezes-Filho SL, Luévano-Martínez LA, Chausse B, Kowaltowski AJ (2016) Caloric restriction increases brain mitochondrial calcium retention capacity and protects against excitotoxicity. Aging Cell 16:73-81. | Mouse | Nervous system | ||
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Davuluri 2016 J Physiol | 2016 | Davuluri G, Allawy A, Thapaliya S, Rennison JH, Singh D, Kumar A, Sandlers Y, Van Wagoner DR, Flask CA, Hoppel C, Kasumov T, Dasarathy S (2016) Hyperammonaemia-induced skeletal muscle mitochondrial dysfunction results in cataplerosis and oxidative stress. J Physiol 594:7341-60. | Mouse | Skeletal muscle Other cell lines | Oxidative stress;RONS | |
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McFarlane 2016 Thesis | 2016 | McFarlane SV (2016) Temperature-dependent alterations of brown adipose tissue metabolism during hibernation in the thirteen-lined ground squirrel, Ictidomys tridecemlineatus. Dissertation p74. | Other mammals | Fat | Temperature | |
King 2016 Redox Biol | 2016 | King AL, Mantena SK, Andringa KK, Millender-Swain T, Dunham-Snary KJ, Oliva CR, Griguer CE, Bailey SM (2016) The methyl donor S-adenosylmethionine prevents liver hypoxia and dysregulation of mitochondrial bioenergetic function in a rat model of alcohol-induced fatty liver disease. Redox Biol 9:188-97. | Rat | Liver | Oxidative stress;RONS | Other |
Rackham 2016 Cell Rep | 2016 | Rackham O, Busch JD, Matic S, Siira SJ, Kuznetsova I, Atanassov I, Ermer JA, Shearwood AM, Richman TR, Stewart JB, Mourier A, Milenkovic D, Larsson NG, Filipovska A (2016) Hierarchical RNA processing is required for mitochondrial ribosome assembly. Cell Rep 16:1874-90. | Mouse | Heart | ||
Hummer 2016 Biochim Biophys Acta | 2016 | Hummer G, Wikström M (2016) Molecular simulation and modeling of complex I. Biochim Biophys Acta 1857:915-21. https://doi.org/10.1016/j.bbabio.2016.01.005 | ||||
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Ludzki 2015 Diabetes | 2015 | Ludzki A, Paglialunga S, Smith BK, Herbst EA, Allison MK, Heigenhauser GJ, Neufer PD, Holloway GP (2015) Rapid repression of ADP transport by palmitoyl-CoA is attenuated by exercise training in humans; a potential mechanism to decrease oxidative stress and improve skeletal muscle insulin signaling. Diabetes 64:2769-79. | Human Mouse | Skeletal muscle | Diabetes | |
Lantier 2015 Diabetes | 2015 | Lantier L, Williams AS, Williams IM, Yang KK, Bracy DP, Goelzer M, James FD, Gius D, Wasserman DH (2015) SIRT3 is crucial for maintaining skeletal muscle insulin action and protects against severe insulin resistance in high fat fed mice. Diabetes 64:3081-92. | Mouse | Skeletal muscle | Diabetes | |
Skemiene 2015 FEBS J | 2015 | Skemiene K, Liobikas J, Borutaite V (2015) Anthocyanins as substrates for mitochondrial complex I - protective effect against heart ischemic injury. FEBS J 282:963-71. | Rat | Heart | Ischemia-reperfusion | |
Leman 2015 Int J Biochem Cell Biol | 2015 | Leman G, Gueguen N, Desquiret-Dumas V, Kane MS, Wettervald C, Chupin S, Chevrollier A, Lebre AS, Bonnefont JP, Barth M, Amati-Bonneau P, Verny C, Henrion D, Bonneau D, Reynier P, Procaccio V (2015) Assembly defects induce oxidative stress in inherited mitochondrial complex I deficiency. Int J Biochem Cell Biol 65:91-103. | Human | Endothelial;epithelial;mesothelial cell Fibroblast | Oxidative stress;RONS Mitochondrial disease | |
Karadayian 2015 Neuroscience | 2015 | Karadayian AG, Bustamante J, Czerniczyniec A, Lombardi P, Cutrera RA, Lores-Arnaiz S (2015) Alcohol hangover induces mitochondrial dysfunction and free radical production in mouse cerebellum. Neuroscience 304:47-59. | Mouse | Nervous system | ||
Wang 2015 Nat Commun | 2015 | Wang Y, Oxer D, Hekimi S (2015) Mitochondrial function and lifespan of mice with controlled ubiquinone biosynthesis. Nat Commun 6:6393. | Mouse | Heart Skeletal muscle Kidney | Aging;senescence | |
Mourier 2015 J Cell Biol | 2015 | Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG (2015) Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels. J Cell Biol 208:429-42. | Mouse | Heart Fibroblast | ||
Ikaga 2015 Biochem Biophys Rep | 2015 | Ikaga R, Namekatac I, Kotiadisd VN, Ogawab H, Duchend MR, Tanakac H, Iida-Tanakab N (2015) Knockdown of aquaporin-8 induces mitochondrial dysfunction in 3T3-L1 cells. Biochem Biophys Rep 4:187–95. | Mouse | Fat Other cell lines | ||
Martinez 2015 Thesis | 2015 | Martínez Gasca B (2015) Generacion de modelos celulares para el estudio del efecto fenotipico de la variacion genetica en el mtDNA. Thesis 1-35. | Human | Liver Other cell lines | ||
Farrar 2015 US Patent | 2015 | Farrar GJ, Millington-Ward S, Chadderton N (2015) Variants of yeast ndi1 gene, and uses thereof in the treatment of disease associated with mitochondrial dysfunction. US Patent WO 2013093029 A3. | Human | HeLa | Neurodegenerative | |
Whitfield 2015 J Physiol | 2015 | Whitfield J, Ludzki A, Heigenhauser GJ, Senden JM, Verdijk LB, van Loon LJ, Spriet LL, Holloway GP (2015) Beetroot juice supplementation reduces whole body oxygen consumption but does not improve indices of mitochondrial efficiency in human skeletal muscle. J Physiol 594:421-35. | Human | Skeletal muscle | Oxidative stress;RONS | |
Schoeckel 2015 Cancer Metab | 2015 | Schöckel L, Glasauer A, Basit F, Bitschar K, Truong H, Erdmann G, Algire C, Hägebarth A, Willems PH, Kopitz C, Koopman WJ, Héroult M (2015) Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth. Cancer Metab 3:11. | Human Mouse | Endothelial;epithelial;mesothelial cell Other cell lines | Cancer | |
Agil 2015 J Pineal Res | 2015 | Agil A, El-Hammadi M, Jiménez-Aranda A, Tassi M, Abdo W, Fernández-Vázquez G, Reiter RJ (2015) Melatonin reduces hepatic mitochondrial dysfunction in diabetic obese rats. J Pineal Res 59:70-9. | Rat | Liver | Diabetes Obesity | |
Beauchamp 2015 Biosci Rep | 2015 | Beauchamp B, Thrush AB, Quizi J, Antoun G, McIntosh N, Al-Dirbashi OY, Patti ME, Harper ME (2015) Undernutrition during pregnancy in mice leads to dysfunctional cardiac muscle respiration in adult offspring. Biosci Rep 35. pii:e00200. | Mouse | Heart Liver | Cardiovascular Diabetes Obesity | |
Chu 2015 Liver Transpl | 2015 | Chu MJ, Hickey AJ, Jiang Y, Petzer A, Bartlett AS, Phillips AR (2015) Mitochondrial dysfunction in steatotic rat livers occurs because a defect in complex I makes the liver susceptible to prolonged cold ischemia. Liver Transpl 21:396-407. | Rat | Liver | Ischemia-reperfusion | |
Flatters 2015 Prog Mol Biol Transl Sci | 2015 | Flatters SJ (2015) The contribution of mitochondria to sensory processing and pain. Prog Mol Biol Transl Sci 131:119-46. | Rat | Nervous system | Diabetes Other | |
Paglialunga 2015 Diabetologia | 2015 | Paglialunga S, Ludzki A, Root-McCaig J, Holloway GP (2015) In adipose tissue, increased mitochondrial emission of reactive oxygen species is important for short-term high-fat diet-induced insulin resistance in mice. Diabetologia 58:1071-80. | Mouse | Fat | Oxidative stress;RONS | Diabetes |
Richman 2015 PLoS Genet | 2015 | Richman TR, Ermer JA, Davies SM, Perks KL, Viola HM, Shearwood AM, Hool LC, Rackham O, Filipovska A (2015) Mutation in MRPS34 compromises protein synthesis and causes mitochondrial dysfunction. PLoS Genet 11:e1005089. | Mouse | Heart Liver | Mitochondrial disease | Aging;senescence Cardiovascular Other |
Van Rahden 2015 Am J Hum Genet | 2015 | van Rahden VA, Fernandez-Vizarra E, Alawi M, Brand K, Fellmann F, Horn D, Zeviani M, Kutsche K (2015) Mutations in NDUFB11, encoding a complex I component of the mitochondrial respiratory chain, cause microphthalmia with linear skin defects syndrome. Am J Hum Genet 96:640-50. | Human | HeLa | Cell death | Other |
Yuan 2015 BMC Cancer | 2015 | Yuan Y, Wang W, Li H, Yu Y, Tao J, Huang S, Zeng Z (2015) Nonsense and missense mutation of mitochondrial ND6 gene promotes cell migration and invasion in human lung adenocarcinoma. BMC Cancer 15:346. | Human | Lung;gill Other cell lines | Cancer | |
Caito 2015 Antioxid Redox Signal | 2015 | Caito SW, Aschner M (2015) Mitochondrial redox dysfunction and environmental exposures. Antioxid Redox Signal 23:578-95. | Human Mouse Rat Bovines Drosophila Fishes Hexapods | Heart Nervous system Liver Kidney Lung;gill Endothelial;epithelial;mesothelial cell | Cell death Ischemia-reperfusion Oxidative stress;RONS | COPD |
Teh 2015 Oncogene | 2015 | Teh JT, Zhu WL, Ilkayeva OR, Li Y, Gooding J, Casey PJ, Summers SA, Newgard CB, Wang M (2015) Isoprenylcysteine carboxylmethyltransferase regulates mitochondrial respiration and cancer cell metabolism. Oncogene 34:3296-304. | Human | Other cell lines | Cancer | |
Schrauwen-Hinderling 2015 Antioxid Redox Signal | 2015 | Schrauwen-Hinderling VB, Kooi ME, Schrauwen P (2015) Mitochondrial function and diabetes; consequences for skeletal and cardiac muscle metabolism. Antioxid Redox Signal 24:39-51. | Human | Heart Skeletal muscle | Diabetes Other | |
Soares 2015 PLoS One | 2015 | Soares JB, Gaviraghi A, Oliveira MF (2015) Mitochondrial physiology in the major arbovirus vector Aedes aegypti: substrate preferences and sexual differences define respiratory capacity and superoxide production. PLoS One 10:e0120600. | Hexapods | Skeletal muscle | Oxidative stress;RONS | |
Lim 2015 Am J Cancer Res | 2015 | Lim SC, Carey KT, McKenzie M (2015) Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I). Am J Cancer Res 5:689-701. | Human | Kidney Other cell lines HEK HeLa Fibroblast | Cancer | |
Kruse 2015 Aging Cell | 2015 | Kruse SE, Karunadharma PP, Basisty N, Johnson R, Beyer RP, MacCoss MJ, Rabinovitch PS, Marcinek DJ (2015) Age modifies respiratory complex I and protein homeostasis in a muscle type-specific manner. Aging Cell 15:89-99. | Mouse | Skeletal muscle | Oxidative stress;RONS | Aging;senescence |
Kmita 2015 Proc Natl Acad Sci U S A | 2015 | Kmita K, Wirth C, Warnau J, Guerrero-Castillo S, Hunte C, Hummer G, Kaila VR, Zwicker K, Brandt U, Zickermann V (2015) Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I. https://doi.org/10.1073/pnas.1424353112 | ||||
Zickermann 2015 Science | 2015 | Zickermann V, Wirth C, Nasiri H, Siegmund K, Schwalbe H, Hunte C, Brandt U (2015) Mechanistic insight from the crystal structure of mitochondrial complex I. https://doi.org/10.1126/science.1259859 | ||||
Blanchet 2015 Sci Rep | 2015 | Blanchet L, Smeitink JA, van Emst-de Vries SE, Vogels C, Pellegrini M, Jonckheere AI, Rodenburg RJ, Buydens LM, Beyrath J, Willems PH, Koopman WJ (2015) Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning. Sci Rep 5:8035. | Human | Endothelial;epithelial;mesothelial cell Fibroblast | Mitochondrial disease | |
Kucera 2015 Oxid Med Cell Longev | 2015 | Kucera O, Mezera V, Moravcova A, Endlicher R, Lotkova H, Drahota Z, Cervinkova Z (2015) In vitro toxicity of epigallocatechin gallate in rat liver mitochondria and hepatocytes. Oxid Med Cell Longev 2015:476180. | Rat | Liver | Oxidative stress;RONS | |
Van Hoose 2015 Thesis | 2015 | Van Hoose P (2015) Co-treatment with conjugated linoleic acid and nitrite modulates mitochondrial respiration and electron transport chain activity in vivo and attenuates mitochondrial dysfunction during cardiac injury. Dissertations p128. | Mouse | Heart | Ischemia-reperfusion | Cardiovascular |
Patil 2015 J Nutr Biochem | 2015 | Patil YN, Dille KN, Burk DH, Cortez CC, Gettys TW (2015) Cellular and molecular remodeling of inguinal adipose tissue mitochondria by dietary methionine restriction. J Nutr Biochem 26:1235-47. | Mouse | Skeletal muscle Liver Fat | ||
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Harris 2015 Diabetes | 2015 | Harris LA, Skinner JR, Shew TM, Pietka TA, Abumrad NA, Wolins NE (2015) Perilipin 5-driven lipid droplet accumulation in skeletal muscle stimulates the expression of fibroblast growth factor 21. Diabetes 64:2757-68. | Mouse | Skeletal muscle | ||
Kishita 2015 Am J Hum Genet | 2015 | Kishita Y, Pajak A, Bolar NA, Marobbio CM, Maffezzini C, Miniero DV, Monné M, Kohda M, Stranneheim H, Murayama K, Naess K, Lesko N, Bruhn H, Mourier A, Wibom R, Nennesmo I, Jespers A, Govaert P, Ohtake A, Van Laer L, Loeys BL, Freyer C, Palmieri F, Wredenberg A, Okazaki Y, Wedell A (2015) Intra-mitochondrial methylation deficiency due to mutations in SLC25A26. Am J Hum Genet 97:761-8. | Human | Skeletal muscle Fibroblast | Inherited Other | |
Herbst 2015 Neuroscience | 2015 | Herbst EA, Holloway GP (2015) Exercise training normalizes mitochondrial respiratory capacity within the striatum of the R6/1 model of Huntington's disease. Neuroscience 303:515-23. | Mouse | Nervous system | Neurodegenerative | |
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Czerniczyniec 2015 J Bioenerg Biomembr | 2015 | Czerniczyniec A, Lanza EM, Karadayian AG, Bustamante J, Lores-Arnaiz S (2015) Impairment of striatal mitochondrial function by acute paraquat poisoning. J Bioenerg Biomembr 47:395-408. | Rat | Nervous system | ||
Angebault 2015 Am J Hum Genet | 2015 | Angebault C, Guichet PO, Talmat-Amar Y, Charif M, Gerber S, Fares-Taie L, Gueguen N, Halloy F, Moore D, Amati-Bonneau P, Manes G, Hebrard M, Bocquet B, Quiles M, Piro-Mégy C, Teigell M, Delettre C, Rossel M, Meunier I, Preising M, Lorenz B, Carelli V, Chinnery PF, Yu-Wai-Man P, Kaplan J, Roubertie A, Barakat A, Bonneau D, Reynier P, Rozet JM, Bomont P, Hamel CP, Lenaers G (2015) Recessive mutations in RTN4IP1 cause isolated and syndromic optic neuropathies. Am J Hum Genet 97:754-60. | Human | Endothelial;epithelial;mesothelial cell Fibroblast | Other | |
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Worth 2014 J Biol Chem | 2014 | Worth AJ, Basu SS, Snyder NW, Mesaros C, Blair IA (2014) Inhibition of neuronal cell mitochondrial complex I with rotenone increases lipid β-oxidation, supporting acetyl-coenzyme A levels. J Biol Chem 289:26895-903. doi: 10.1074/jbc.M114.591354 | Nervous system | Neurodegenerative Parkinson's | ||
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Lauritzen 2010 Mol Cell Biol | 2010 | Lauritzen KH, Moldestad O, Eide L, Carlsen H, Nesse G, Storm JF, Mansuy IM, Bergersen LH, Klungland A (2010) Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior. Mol Cell Biol 30:1357-67. | Mouse | Nervous system | Mitochondrial disease | |
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Stankova 2010 Toxicol In Vitro | 2010 | Staňková P, Kučera O, Lotková H, Roušar T, Endlicher R, Cervinková Z (2010) The toxic effect of thioacetamide on rat liver in vitro. Toxicol In Vitro 24:2097-2103. | Liver | Oxidative stress;RONS | ||
Schoenfeld 2010 Biochim Biophys Acta | 2010 | Schönfeld P, Wieckowski MR, Lebiedzinska M, Wojtczak L (2010) Mitochondrial fatty acid oxidation and oxidative stress: Lack of reverse electron transfer-associated production of reactive oxygen species. Biochim Biophys Acta 1797:929-38. | Rat | Heart | Oxidative stress;RONS | |
Chowdhury 2010 Am J Physiol Endocrinol Metab | 2010 | Chowdhury SK, Sangle GV, Xie X, Stelmack GL, Halayko AJ, Shen GX (2010) Effects of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells. Am J Physiol Endocrinol Metab 298:E89-98. | Pig | Endothelial;epithelial;mesothelial cell | Oxidative stress;RONS Mitochondrial disease | |
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Nilsson 2010 Thesis | 2010 | Nilsson I (2010) Hypothalmic regulation of food intake – focus on the anx/anx mouse. Thesis Karolinska Institute Stockholm, Department of Molecular Medicine and Sugery, 62 pp. | Mouse | Nervous system | Oxidative stress;RONS | |
Barksdale 2010 FASEB J | 2010 | Barksdale KA, Perez-Costas E, Gandy JC, Melendez-Ferro M, Roberts RC, Bijur GN (2010) Mitochondrial viability in mouse and human postmortem brain. FASEB J 24:3590-9. | Human Mouse | Nervous system | Cryopreservation Ischemia-reperfusion | |
Iftikar 2010 JEMBE | 2010 | Iftikar F, MacDonald JR, Hickey AJ (2010) Thermal limits of portunid crab heart mitochondria: Could more thermo-stable mitochondria advantage invasive species? JEMBE 395:232-9. | Crustaceans | Heart | ||
Groeger 2010 Crit Care | 2010 | Groeger M, Wagner F, Baumgart K, Huber-Lang M, Knoeferl M, Georgieff M, Radermacher P, Szabo C, Calzia E (2010) Mitochondrial respiration and cytochrome c inhibition by sulfide in peritoneal macrophages in vitro: Effects of temperature and pH. Crit Care 14:P6. | Macrophage-derived | |||
Korsten 2010 Biochim Biophys Acta | 2010 | Korsten A, de Coo IF, Spruijt L, de Wit LE, Smeets HJ, Sluiter W (2010) Patients with Leber hereditary optic neuropathy fail to compensate impaired oxidative phosphorylation. Biochim Biophys Acta 1797:197-203. | Human | Nervous system Blood cells Lymphocyte | Inherited Neurodegenerative | |
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Larsen 2009 Diabetologia | 2009 | Larsen S, Ara I, Rabøl R, Andersen JL, Boushel RC, Dela F, Helge JW (2009) Are substrate use during exercise and mitochondrial respiratory capacity decreased in arm and leg muscle in type 2 diabetes? Diabetologia 52:1400-8. | Human | Skeletal muscle | Diabetes | |
Trimmer 2009 Mol Neurodegener | 2009 | Trimmer PA, Schwartz KM, Borland MK, De Taboada L, Streeter J, Oron U (2009) Reduced axonal transport in Parkinson's disease cybrid neurites is restored by light therapy. Mol Neurodegener 4:26. | Human | Nervous system | Parkinson's | |
Rhein 2009 Cell Mol Neurobiol | 2009 | Rhein V, Baysang G, Rao S, Meier F, Bonert A, Müller-Spahn F, Eckert A (2009) Amyloid-beta leads to impaired cellular respiration, energy production and mitochondrial electron chain complex activities in human neuroblastoma cells. Cell Mol Neurobiol 29:1063-71. | Human | Nervous system Neuroblastoma | Alzheimer's Neurodegenerative | |
Raboel 2009 J Clin Endocrinol Metabol | 2009 | Rabøl R, Højberg PM, Almdal T, Boushel R, Haugaard SB, Madsbad S, Dela F (2009) Effect of hyperglycemia on mitochondrial respiration in type 2 diabetes. J Clin Endocrinol Metabol 94:1372-78. | Human | Skeletal muscle | Diabetes | |
Lim 2009 PlosOne | 2009 | Lim S, Ahn SY, Song IC, Chung MH, Jang HC, Park KS, Lee KU, Pak YK, Lee HK (2009) Chronic exposure to the herbicide, atrazine, causes mitochondrial dysfunction and insulin resistance. PLoS One 4:e5186. | Rat | Skeletal muscle Liver | Mitochondrial disease | |
Nouette-Gaulain 2009 Anesthesiology | 2009 | Nouette-Gaulain K, Bellance N, Prévost B, Passerieux E, Pertuiset C, Galbes O, Smolkova K, Masson F, Miraux S, Delage JP, Letellier T, Rossignol R, Capdevila X, Sztark F (2009) Erythropoietin protects against local anesthetic myotoxicity during continuous regional analgesia. Anesthesiology 110:648-59. | Human Rat | Skeletal muscle Nervous system | ||
Osenbroch 2009 FEBS J | 2009 | Osenbroch Poe, Auk-Emblem P, Halsne R, Strand J, Forstroem RJ, van der Pluijm I, Eide L (2009) Accumulation of mitochondrial DNA damage and bioenergetic dysfunction in CSB defective cells. FEBS J 276:2811-21. | Mouse | Aging;senescence Neurodegenerative | ||
Borland 2009 Biochim Biophys Acta | 2009 | Borland MK, Mohanakumar KP, Rubinstein JD, Keeney PM, Xie J, Capaldi R, Dunham LD, Trimmer PA, Bennett JP Jr (2009) Relationships among molecular genetic and respiratory properties of Parkinson's disease cybrid cells show similarities to Parkinson's brain tissues. Biochim Biophys Acta 792: 68-74. | Human | Nervous system | Neurodegenerative Parkinson's | |
Cassereau 2009 Neurogenetics | 2009 | Cassereau J, Chevrollier A, Gueguen N, Malinge MC, Letournel F, Nicolas G, Richard L, Ferre M, Verny C, Dubas F, Procaccio V, Amati-Bonneau P, Bonneau D, Reynier P (2009) Mitochondrial Complex I deficiency in GDAP1-related autosomal dominant Charcot-Marie-Tooth disease (CMT2K). Neurogenetics 10:145-50. | Human | Nervous system | Inherited Neurodegenerative | |
King 2009 Biochemistry | 2009 | King MS, Sharpley MS, Hirst J (2009) Reduction of hydrophilic ubiquinones by the flavin in mitochondrial NADH:ubiquinone oxidoreductase (Complex I) and production of reactive oxygen species. Biochemistry 48:2053-62. https://doi.org/10.1021/bi802282h | ||||
Droese 2009 Biochim Biophys Acta | 2009 | Dröse S, Hanley PJ, Brandt U (2009) Ambivalent effects of diazoxide on mitochondrial ROS production at respiratory chain Complexes I and III. Biochim Biophys Acta 1790:558-65. | Rat | Heart | Oxidative stress;RONS | |
Anderson 2009 J Clin Invest | 2009 | Anderson EJ, Lustig ME, Boyle KE, Woodlief TL, Kane DA, Lin C-T, Price JW, Kang L, Rabinovitch PS, Szeto HH, Houmard JA, Cortright RN, Wasserman DH, Neufer PD (2009) Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest 119:573-81. | Human Mouse Rat | Skeletal muscle | Oxidative stress;RONS | Diabetes |
Iyer 2009 Mitochondrion | 2009 | Iyer S, Thomas R, Portell F, Dunham L, Quigley C, Bennett JP (2009) Recombinant mitochondrial transcription factor A with N-terminal mitochondrial transduction domain increases respiration and mitochondrial gene expression. Mitochondrion 9:196-203. | Human | Skeletal muscle Nervous system | Inherited | |
Keeney 2009 Exp Neurol | 2009 | Keeney PM, Dunham LD, Quigley CK, Morton SL, Bergquist KE, Bennett JP (2009) Cybrid models of Parkinson's disease show variable mitochondrial biogenesis and genotype-respiration relationships. Exp Neurol 220:374-82. | Human | Blood cells Platelet | Mitochondrial disease | Parkinson's |
Hoffman 2009 J Biol Chem | 2009 | Hoffman DL, Brookes PS (2009) Oxygen sensitivity of mitochondrial reactive oxygen species generation depends on metabolic conditions. J Biol Chem 284:16236-45. | Rat | Oxidative stress;RONS | ||
Kulawiak 2008 Exp Neurol | 2008 | Kulawiak B, Kudin AP, Szewczyk A, Kunz WS (2008) BK channel openers inhibit ROS production of isolated rat brain mitochondria. Exp Neurol 212:543-7. | Rat | Nervous system | ||
Cervinkova 2008 Physiol Res | 2008 | Cervinková Z, Rauchová H, Kriváková P, Drahota Z (2008) Inhibition of palmityl carnitine oxidation in rat liver mitochondria by tert-butyl hydroperoxide. Physiol Res 57:133-6. | Liver | Oxidative stress;RONS | ||
Gruno 2008 J Gastroenterol | 2008 | Gruno M, Peet N, Tein A, Salupere R, Sirotkina M, Valle J, Peetsalu A, Seppet EK (2008) Atrophic gastritis: deficient complex I of the respiratory chain in the mitochondria of corpus mucosal cells. J Gastroenterol 43:780-8. | Human | Endothelial;epithelial;mesothelial cell | Mitochondrial disease | |
Aragones 2008 Nat Genet | 2008 | Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, K Harten S, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger Erich, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P (2008) Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 40:170-80. | Mouse | Skeletal muscle | Ischemia-reperfusion Oxidative stress;RONS | |
Juellig 2008 Proteomics | 2008 | Jüllig M, Hickey AJ, Chai CC, Skea GL, Middleditch MJ, Costa S, Choong SY, Philips AR, Cooper GJ (2008) Is the failing heart out of fuel or a worn engine running rich? A study of mitochondria in old spontaneously hypertensive rats. Proteomics 8:2556-72. | Rat | Heart | Mitochondrial disease | |
De Cavanagh 2008 Exp Gerontol | 2008 | de Cavanagh EM, Flores I, Ferder M, Inserra F, Ferder L (2008) Renin-angiotensin system inhibitors protect against age-related changes in rat liver mitochondrial DNA content and gene expression. Exp Gerontol 43:919-28. | Rat | Liver | Oxidative stress;RONS | Aging;senescence |
Mortiboys 2008 Ann Neurol | 2008 | Mortiboys H, Thomas KJ, Koopman WJ, Klaffke S, Abou-Sleiman P, Olpin S, Wood NW, Willems PH, Smeitink JA, Cookson MR, Bandmann O (2008) Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts. Ann Neurol 64:555-65. | Human | Fibroblast | Parkinson's | |
Regueira 2008 Crit Care Med | 2008 | Regueira T, Baenziger B, Djafarzadeh S, Brandt S, Gorrasi J, Takala J, Lepper PM, Jakob SM (2008) Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration. Crit Care Med 12:R88 | Pig | Liver | ||
Eimre 2008 Biochim Biophys Acta | 2008 | Eimre M, Paju K, Pelloux S, Beraud N, Roosimaa M, Kadaja L, Gruno M, Peet N, Orlova E, Remmelkoor R, Piirsoo A, Saks V, Seppet E (2008) Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes. Biochim Biophys Acta 1777:514-24. | Rat | Heart | ||
Soller 2007 Mol Pharmacol | 2007 | Soller M, Dröse S, Brandt U, Brüne B, von Knethen A (2007) Mechanism of Thiazolidinedione-dependent cell death in Jurkat T cells. Mol Pharmacol 71:1535-44. | Heart Other cell lines | Oxidative stress;RONS | Cancer | |
Gillardon 2007 Proteomics | 2007 | Gillardon F, Rist W, Kussmaul L, Vogel J, Berg M, Danzer K, Kraut N, Hengerer B (2007) Proteomic and functional alterations in brain mitochondria from Tg2576 mice occur before amyloid plaque deposition. Proteomics 7:605-16. | Mouse | Nervous system | Alzheimer's Neurodegenerative | |
Hoepken 2007 Neurobiol Dis | 2007 | Hoepken HH, Gispert S, Morales B, Wingerter O, Del Turco D, Mülsch A, Nussbaum RL, Müller K, Dröse S, Brandt U, Deller T, Wirth B, Kudin AP, Kunz WS, Auburger G (2007) Mitochondrial dysfunction, peroxidation damage and changes in glutathione metabolism in PARK6. Neurobiol Dis 25:401-11. | Human | Fibroblast | Oxidative stress;RONS | Neurodegenerative Parkinson's |
McKenzie 2006 J Mol Biol | 2006 | McKenzie M, Lazarou M, Thorburn DR, Ryan MT (2006) Mitochondrial respiratory chain supercomplexes are destabilized in Barth Syndrome patients. J Mol Biol 361:462-9. | Lymphocyte | Cardiovascular Other | ||
Sharpley 2006 J Biol Chem | 2006 | Sharpley MS, Hirst J (2006) The inhibition of mitochondrial complex I (NADH:ubiquinone oxidoreductase) by Zn2+. J Biol Chem 281:34803-9. https://doi.org/10.1074/jbc.M607389200 | ||||
Blakely 2006 Pediatr Res | 2006 | Blakely EL, Rennie KJ, Jones L, Elstner M, Chrzanowska-Lightowlers ZMA, White CB, Shield JPH, Pilz DT, Turnbull DM, Poulton J, Taylor RW (2006) Sporadic intragenic inversion of the mitochondrial DNA MTND1 gene causing fatal infantile lactic acidosis. Pediatr Res 59:440-4. | Human | Fibroblast | Mitochondrial disease | |
Galkin 2006 Biochim Biophys Acta | 2006 | Galkin A, Dröse S, Brandt U (2006) The proton pumping stoichiometry of purified mitochondrial Complex I reconstituted into proteoliposomes. Biochim Biophys Acta 1757:1575-81. | Fungi | |||
Safiulina 2006 Toxicol Sci | 2006 | Safiulina D, Peet N, Seppet E, Zharkovsky A, Kaasik A (2006) Dehydroepiandrosterone inhibits Complex I of the mitochondrial respiratory chain and is neurotoxic in vitro and in vivo at high concentrations. Toxicol Sci 93:348-56. | Rat | Nervous system | Neurodegenerative | |
Maneiro 2005 Ann Rheum Dis | 2005 | Maneiro E, López-Armada MJ, de Andres MC, Caramés B, Martín MA, Bonilla A, Del Hoyo P, Galdo F, Arenas J, Blanco FJ (2005) Effect of nitric oxide on mitochondrial respiratory activity of human articular chondrocyte. Ann Rheum Dis 64:388-95. | Human | Oxidative stress;RONS | ||
Winkler-Stuck 2005 J Neural Transm | 2005 | Winkler-Stuck K, Kirches E, Mawrin C, Dietzmann K, Lins H, Wallesch CW, Kunz WS, Wiedemann FR (2005) Re-evaluation of the dysfunction of mitochondrial respiratory chain in skeletal muscle of patients with Parkinson's disease. J Neural Transm 112:499-518. | Human | Skeletal muscle | Mitochondrial disease | Parkinson's |
... further results |
References
Bioblast link | Reference | Year |
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BEC 2020.1 doi10.26124bec2020-0001.v1 | Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1 | 2020 |
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