Carriere 2019 Academic Press

Carrière A, Casteilla L (2019) Role of mitochondria in adipose tissues metabolism and plasticity. Academic Press In: Mitochondria in obesity and type 2 diabetes. Morio B, Pénicaud L, Rigoulet M (eds) Academic Press. https://doi.org/10.1016/B978-0-12-811752-1.00007-9

» https://doi.org/10.1016/B978-0-12-811752-1.00007-9

Carriere A, Casteilla L (2019) Academic Press

Abstract: White and brown adipose tissues together control whole body energetic homeostasis through metabolic and endocrine activities. While white fat represents the main energy store of the organism, brown fat is specialized in nonshivering thermogenesis thanks to the expression of the mitochondrial uncoupling protein-1 (UCP1) in brown adipocytes. One key feature of adipose tissues is their extraordinary plasticity and their capacity to adapt their size, phenotype, and function to changing environmental, metabolic, and stresses conditions; the so-called browning process illustrates well such a great plasticity. Mitochondria number, morphology, activity, cellular distribution, and turnover as well as their impact on the overall cellular redox state are determinant for the cellular processes underlying adipose tissues metabolism, biology, and plasticity. After a brief description of the different adipose tissues and their specific role in metabolic homeostasis, the critical role of mitochondria and how they support adipose tissue physiology will be described.

• Bioblast editor: Gnaiger E

Correction: FADH₂ and Complex II

FADH₂ is shown as the substrate feeding electrons into Complex II (CII). This is wrong and requires correction - for details see Gnaiger (2024).

Gnaiger E (2024) Complex II ambiguities ― FADH₂ in the electron transfer system. J Biol Chem 300:105470. https://doi.org/10.1016/j.jbc.2023.105470 - »Bioblast link«

Labels:

Enzyme: Complex II;succinate dehydrogenase