Claret 2017 Abstract MITOEAGLE Barcelona
Mitochondrial performance and central regulation of energy balance.
Claret M (2017)
Event: MitoEAGLE Barcelona 2017
The hypothalamus is a key area of the central nervous system implicated in the regulation of whole-body energy homeostasis. The regulation of this biological process is achieved through a complex sensing of hormones and nutrient-related signals, followed by its integration and coordination of precise neurochemical and neurophysiological responses. These effector mechanisms are critically mediated by specific populations of neurons of the arcuate nucleus of the hypothalamus that express the anorexigenic pro-opiomelanocortin (POMC) or orexigenic agouti related protein (AgRP) neuropeptides. These subsets of neurons are able to sense circulating nutrients (glucose, fatty acids, amino acids) informing about the energy status of the organism. However the molecular mechanisms underlying nutrient-sensing in POMC neurons remain incompletely understood.
Mitochondria are key organelles implicated in cellular nutrient/energy management and are able to bioenergetically adjust to different metabolic situations. Therefore these organelles may be nutrient-sensing and signaling entities that orchestrate a global response aimed at maintaining energy balance.
Our laboratory is interested in understanding the role of mitochondria, from different angles, in hypothalamic neurocircuits and their involvement in physiology and pathophysiology in the context of metabolic disorders such as obesity and diabetes. To do so, we use genetic in vivo approaches to manipulate defined populations of neurons in order to correlate the function of a particular protein with specific physiological and behavioral outputs. This approach is further complemented with a wide range of additional techniques from different disciplines, such as physiology, behavior, molecular biology, cellular biology and imaging amongst others.
• Bioblast editor: Kandolf G
Labels: MiParea: mt-Medicine, mt-Awareness Pathology: Diabetes, Obesity
- Neuronal Control Metabolism Lab, Inst d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.