- high-resolution terminology - matching measurements at high-resolution
ET capacity
Description
T capacity is the respiratory electron-transfer-pathway capacity E of mitochondria measured as oxygen consumption in the noncoupled state at optimum uncoupler concentration. This optimum concentration is obtained by stepwise titration of an established protonophore to induce maximum oxygen flux as the determinant of ET capacity. The experimentally induced noncoupled state at optimum uncoupler concentration is thus distinguished from (1) a wide range of uncoupled states at any experimental uncoupler concentration, (2) physiological uncoupled states controlled by intrinsic uncoupling (e.g. UCP1 in brown fat), and (3) pathological dyscoupled states indicative of mitochondrial injuries or toxic effects of pharmacological or environmental substances. ET capacity in mitochondrial preparations requires the addition of defined fuel substrates to establish an ET-pathway competent state.
» MiPNet article
Abbreviation: E
Reference: BEC 2020.1, Gnaiger 2020 BEC MitoPathways, Gnaiger 2009 Int J Biochem Cell Biol
Noncoupled respiration with a shortcircuit of the proton cycle across the inner mt-membrane at optimum uncoupler (protonophore) concentration stimulating maximum oxygen flux. 2[H] indicates the reduced hydrogen equivalents of CHO substrates and electron transfer to oxygen. H+out are protons pumped out of the matrix phase. Proton leaks dissipate the energy of translocated protons. ET capacity is not limited by the capacity of the phosphorylation system (uncontrolled state). Measurement of ET capacity is possible by uncoupler titrations in living cells and in mt-preparations supported by an ET-pathway competent state, exemplified as the NS-electron transfer pathway state (CI&II-linked substrate supply). Modified after Gnaiger 2020 BEC MitoPathways).
Why ET capacity, why not State 3u?
| Gnaiger E (2017) Why ET capacity, why not State 3u? Mitochondr Physiol Network (2014-07-06) last update 2020-11-10. |
Abstract: Measurement of ET capacity in the noncoupled state at optimum uncoupler concentration does not represent a general substitute for determination of OXPHOS-capacity (compare State 3). If the ratio of OXPHOS/ET capacity (OXPHOS-control ratio or P/E ratio) is less than one, noncoupled respiration overestimates the apparent reserve capacity for oxidative phosphorylation with respect to ROUTINE-respiration of living cells. The conditions for measurement and expression of respiration E vary (oxygen flux, JO2E, or oxygen flow, IO2E). If these conditions are defined and remain consistent within a given context, then the simple symbol E is used to substitute the more explicit expression for respiratory capacity. In the ET state, the mt-membrane potential is almost fully collapsed and provides a reference state for flux control ratios.
• O2k-Network Lab: AT Innsbruck Gnaiger E
The important difference between rates P and E
- The abbreviation State 3u is used frequently in bioenergetics, to indicate the noncoupled state of maximum respiration with the rate E,[1] without sufficient emphasis on the fundamental difference between P (OXPHOS-capacity; coupled, with an uncoupled component) and E (ET capacity, noncoupled) (Gnaiger 2009, 2020).
- P=E: The specific case of equal OXPHOS- and ET capacity (P/E=1) yields the important information that the capacity of the phosphorylation system matches or is in potential excess of the ET capacity, such that OXPHOS-capacity is not limited by the phosphorylation system in a specific electron transfer pathway state. This varies with species and tissues, and changes as a result of pathologies due to defects in the phosphorylation system. An example for P/E=1 is mouse skeletal muscle mitochondria (Aragones et al 2008).
- P<E: When OXPHOS capacity is less than ET capacity, the phosphorylation system limits OXPHOS-capacity, and there is an apparent E-P excess capacity. For example, this is the case in healthy human skeletal muscle mitochondria (Pesta et al 2011) and even more pronounced in human cardiac mitochondria (Lemieux et al 2011).
- P>E: If ET capacity is less than OXPHOS capacity in living cells, or in mitochondrial preparations with defined substrate(s), then you have encountered an experimental artefact, and the apparent ET capacity is too low. Artificially low ET capacity may be obtained due to over-titration of uncoupler, which inhibits the ET pathway. Inhibitors of ATP synthase (oligomycin) may suppress ET capacity in living cells, particularly in stressed cells (Doerrier 2018 Methods Mol Biol).
Consequences for evaluation of coupling
- In some textbooks on Bioenergetics, the respiratory acceptor control ratio RCR is defined as either the State 3/State 4 ratio or the State 3u/State 4 ratio. This reflects lack of conceptual distinction between State 3 (compare P) and 3u (E), and clarification is best achieved by avoiding ambiguous terminology. RCR as defined originally is the 'acceptor control ratio' or 'adenylate control ratio', State 3/State 4 (compare LEAK-control ratio, L/E; biochemical coupling efficiency). The UCR may be defined as the E/L or E/R coupling-control ratio. ET capacity but not OXPHOS capacity provides a generally valid reference for an index of uncoupling.
References
- ↑ Gnaiger E. Electron transfer pathway versus electron transport chain. Mitochondr Physiol Network. »Electron transfer pathway«
- Aragonés J, Schneider M, Van Geyte K, Fraisl P, Dresselaers T, Mazzone M, Dirkx R, Zacchigna S, Lemieux H, Jeoung NH, Lambrechts D, Bishop T, Lafuste P, Diez-Juan A, K Harten S, Van Noten P, De Bock K, Willam C, Tjwa M, Grosfeld A, Navet R, Moons L, Vandendriessche T, Deroose C, Wijeyekoon B, Nuyts J, Jordan B, Silasi-Mansat R, Lupu F, Dewerchin M, Pugh C, Salmon P, Mortelmans L, Gallez B, Gorus F, Buyse J, Sluse F, Harris RA, Gnaiger E, Hespel P, Van Hecke P, Schuit F, Van Veldhoven P, Ratcliffe P, Baes M, Maxwell P, Carmeliet P (2008) Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 40:170-80. »Bioblast link«
- Gnaiger E. Biochemical coupling efficiency: from 0 to <1. Mitochondr Physiol Network. - »Biochemical coupling efficiency«
- Gnaiger E (2009) Capacity of oxidative phosphorylation in human skeletal muscle. New perspectives of mitochondrial physiology. Int J Biochem Cell Biol 41:1837-45. - »Bioblast link«
- Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002
- Gnaiger Erich et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1
- Hatefi Y, Haavik AG, Fowler LR, Griffiths DE (1962) Studies on the Electron transfer pathway XLII. Reconstitution of the Electron transfer pathway. J Biol Chem 237:2661-9. - »Bioblast link«
- International Union of Biochemistry (1991) Nomenclature of electron-transfer proteins. Biochim Biophys Acta 1060. »Open Access«
- International Union of Biochemistry and Molecular Biology. Recommendations for terminology and databases for biochemical thermodynamics - The IUPAC Green Book. »Open Access«
- Lemieux H, Semsroth S, Antretter H, Höfer D, Gnaiger E (2011) Mitochondrial respiratory control and early defects of oxidative phosphorylation in the failing human heart. Int J Biochem Cell Biol 43:1729–38. - »Bioblast link«
- Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Similar qualitative and quantitative changes of mitochondrial respiration following strength and endurance training in normoxia and hypoxia in sedentary humans. Am J Physiol Regul Integr Comp Physiol 301:R1078–87. »Bioblast link«
- Bioblast alert 2014(04)
- Bioblast alert 2013(02): CCCP versus FCCP for high-resultion respirometry (HRR).
Keywords
The Blue Book 2020
OXPHOS-, ROUTINE-, ET-, and LEAK states; respiratory capacities (P, R, E, L) corrected for residual oxygen consumption Rox.
4-compartmental OXPHOS model. (1) ET capacity E of the noncoupled electron transfer system ETS. OXPHOS capacity P is partitioned into (2) the dissipative LEAK component L, and (3) ADP-stimulated P-L net OXPHOS capacity. (4) If P-L is kinetically limited by a low capacity of the phosphorylation system to utilize the protonmotive force pmF, then the apparent E-P excess capacity is available to drive coupled processes other than phosphorylation P» (ADP to ATP) without competing with P».
(P-L)/P is the OXPHOS P-L control efficiency. The biochemical coupling efficiency is independent of kinetic control by the phosphorylation system when expressed as the E-L coupling efficiency, (E-L)/E. (E-P)/E is the kinetic E-P control efficiency.
- Bioblast links: Coupling control - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
1. Mitochondrial and cellular respiratory rates in coupling-control states
| Respiratory rate | Defining relations | Icon | |
|---|---|---|---|
| OXPHOS capacity | P = P´-Rox |  |
mt-preparations |
| ROUTINE respiration | R = R´-Rox |  |
living cells |
| ET capacity | E = E´-Rox |  |
» Level flow |
| » Noncoupled respiration - Uncoupler | |||
| LEAK respiration | L = L´-Rox |  |
» Static head |
| » LEAK state with ATP | |||
| » LEAK state with oligomycin | |||
| » LEAK state without adenylates | |||
| Residual oxygen consumption Rox | L = L´-Rox | 
|
2. Flux control ratios related to coupling in mt-preparations and living cells
| FCR | Definition | Icon | |
|---|---|---|---|
| L/P coupling-control ratio | L/P |  |
» Respiratory acceptor control ratio, RCR = P/L |
| L/R coupling-control ratio | L/R | 
| |
| L/E coupling-control ratio | L/E |  |
» Uncoupling-control ratio, UCR = E/L (ambiguous) |
| P/E control ratio | P/E | 
| |
| R/E control ratio | R/E |  |
» Uncoupling-control ratio, UCR = E/L |
| net P/E control ratio | (P-L)/E | 
| |
| net R/E control ratio | (R-L)/E | 
|
3. Net, excess, and reserve capacities of respiration
| Respiratory net rate | Definition | Icon |
|---|---|---|
| P-L net OXPHOS capacity | P-L | 
|
| R-L net ROUTINE capacity | R-L | 
|
| E-L net ET capacity | E-L | 
|
| E-P excess capacity | E-P | 
|
| E-R reserve capacity | E-R | 
|
4. Flux control efficiencies related to coupling-control ratios
| Coupling-control efficiency | Definition | Icon | Canonical term | ||
|---|---|---|---|---|---|
| P-L control efficiency | jP-L | = (P-L)/P | = 1-L/P |  |
P-L OXPHOS-flux control efficiency |
| R-L control efficiency | jR-L | = (R-L)/R | = 1-L/R |  |
R-L ROUTINE-flux control efficiency |
| E-L coupling efficiency | jE-L | = (E-L)/E | = 1-L/E |  |
E-L ET-coupling efficiency » Biochemical coupling efficiency |
| E-P control efficiency | jE-P | = (E-P)/E | = 1-P/E |  |
E-P ET-excess flux control efficiency |
| E-R control efficiency | jE-R | = (E-R)/E | = 1-R/E |  |
E-R ET-reserve flux control efficiency |
5. General
- » Basal respiration
- » Cell ergometry
- » Dyscoupled respiration
- » Dyscoupling
- » Electron leak
- » Electron-transfer-pathway state
- » Hyphenation
- » Oxidative phosphorylation
- » Oxygen flow
- » Oxygen flux
- » Permeabilized cells
- » Phosphorylation system
- » Proton leak
- » Proton slip
- » Respiratory state
- » Uncoupling
- Bioblast links: Uncoupling - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
- Specific
- » Artefacts by single dose uncoupling
- » ATP synthase
- » CCCP
- » Coupling-control protocol
- » DNP
- » Dyscoupled respiration
- » FCCP
- » Is respiration uncoupled - noncoupled - dyscoupled?
- » Noncoupled respiration: Discussion
- » Uncoupler
- » Uncoupled respiration - see » Noncoupled respiration
- » Uncoupling proteins
- » Uncoupling protein 1
- » Uncoupler titrations - Optimum uncoupler concentration
- Specific
- Respiratory states and control ratios
- » Biochemical coupling efficiency
- » Coupling-control state
- » Electron-transfer-pathway state
- » Electron-transfer pathway
- ET capacity
- » E-L coupling efficiency
- » Flux control efficiency
- » Flux control ratio
- » LEAK-control ratio
- » LEAK respiration
- » Noncoupled respiration
- » OXPHOS
- » OXPHOS capacity; » State 3
- » OXPHOS-control ratio, P/E ratio
- » Respiratory acceptor control ratio
- » ROUTINE-control ratio
- » ROUTINE respiration
- » ROUTINE state
- » State 3u
- » State 4
- » Uncoupling-control ratio UCR
- Respiratory states and control ratios
- Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1
- Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. Bioenerg Commun 2020.2. https://doi.org/10.26124/bec:2020-0002
- General (alphabetical order)
- Other keyword lists
- » List of publications: ET pathway
Sort in ascending/descending order by a click on one of the small symbols in squares below. Default sorting: chronological. Empty fields appear first in ascending order.
| Year | Reference | Coupling | Pathway | Preparation | Organism | Tissue;cell | |
|---|---|---|---|---|---|---|---|
| Karavyraki 2022 BEC | BEC 2022.11 | Karavyraki M, Gnaiger E, Porter RK (2022) Bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells https://doi.org/10.26124/bec:2022-0011 | LEAK ROUTINE ET | S ROX | Permeabilized cells | Human | |
| Heimler 2022 BEC | BEC 2022.02 | Heimler SR, Phang HJ, Bergstrom J, Mahapatra G, Dozier S, Gnaiger E, Molina AJA (2022) Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older adult women. https://doi.org/10.26124/bec:2022-0002 | OXPHOS ET | F N S Gp ROX | Permeabilized cells | Human | Blood cells |
| Komlodi 2021 BEC Q | BEC 2021.3 | Komlódi T, Cardoso LHD, Doerrier C, Moore AL, Rich PR, Gnaiger E (2021) Coupling and pathway control of coenzyme Q redox state and respiration in isolated mitochondria. https://doi.org/10.26124/bec:2021-0003 | LEAK OXPHOS ET | N S NS | Isolated mitochondria | Mouse | Heart Nervous system |
| Cardoso 2021 BEC MgG | BEC 2021.1 | Cardoso LHD, Doerrier C, Gnaiger E (2021) Magnesium Green for fluorometric measurement of ATP production does not interfere with mitochondrial respiration. https://doi.org/10.26124/bec:2021-0001 | LEAK OXPHOS ET | N S ROX | Isolated mitochondria | Mouse | Heart |
| Gnaiger 2020 BEC MitoPathways | BEC 2020.2 | Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. https://doi.org/10.26124/bec:2020-0002 | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS ROX | Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria Intact cells | Human Mouse | Heart Skeletal muscle Fibroblast |
| BEC 2020.1 doi10.26124bec2020-0001.v1 | BEC 2020.1 | Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. https://doi.org/10.26124/bec:2020-0001.v1 | LEAK OXPHOS ET | F N S Gp DQ CIV NS Other combinations ROX | Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria | ||
| Karavyraki 2022 MitoFit | 2022-06-02 | Karavyraki M, Gnaiger E, Porter RK (2022) A comparison of bioenergetics in human tongue pre-cancerous dysplastic oral keratinocytes and squamous cancer cells. https://doi.org/10.26124/mitofit:2022-0022 — 2022-11-11 published in Bioenerg Commun 2022.11. | LEAK ROUTINE ET | S ROX | Permeabilized cells | Human | |
| Heimler 2022 MitoFit | 2022-04-12 | Heimler SR, Phang HJ, Bergstrom J, Mahapatra G, Dozier S, Gnaiger E, Molina AJA (2022) Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older women. https://doi.org/10.26124/mitofit:2022-0007 — 2022-06-28 published in Bioenerg Commun 2022.2. | ET OXPHOS | ROX F N S Gp | Permeabilized cells | Human | Blood cells |
| Torres-Quesada 2022 MitoFit | 2022-04-01 | Torres-Quesada O, Doerrier C, Strich S, Gnaiger E, Stefan E (2022) Human Plasma-Like Media fine-tune mitochondrial function and alter drug sensitivity in cancer cell lines. https://doi.org/10.26124/mitofit:2022-0008 — 2022-08-13 published in https://doi.org/10.3390/cancers14163917 | ROUTINE LEAK ET | ROX | Intact cells | Human | Other cell lines |
| Torres-Quesada 2022 Cancers (Basel) | 2022 | Torres-Quesada O, Doerrier C, Strich S, Gnaiger E, Stefan E (2022) Physiological cell culture media tune mitochondrial bioenergetics and drug sensitivity in cancer cell models. https://doi.org/10.3390/cancers14163917 | LEAK ROUTINE ET | ROX | Intact cells | Human | Other cell lines |
| Copperi 2022 Commun Biol | 2022 | Copperi F, Schleis I, Roumain M, Muccioli GG, Casola S, Klingenspor M, Pfeifer A, Gnad T (2022) EBI2 is a negative modulator of brown adipose tissue energy expenditure in mice and human brown adipocytes. https://doi.org/10.1038/s42003-022-03201-6 | LEAK OXPHOS ET | N | Intact cells | Mouse | Fat |
| Cano-Sanchez 2022 PLoS Negl Trop Dis | 2022 | Cano-Sanchez M, Ben-Hassen K, Louis OP, Dantin F, Gueye P, Roques F, Mehdaoui H, Resiere D, Neviere R (2022) Bothrops lanceolatus snake venom impairs mitochondrial respiration and induces DNA release in human heart preparation. https://doi.org/10.1371/journal.pntd.0010523 | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Human | Heart |
| Wang 2022 Redox Biol | 2022 | Wang P, Cui Y, Liu Y, Li Z, Bai H, Zhao Y, Chang YZ (2022) Mitochondrial ferritin alleviates apoptosis by enhancing mitochondrial bioenergetics and stimulating glucose metabolism in cerebral ischemia reperfusion. https://doi.org/10.1016/j.redox.2022.102475 | LEAK OXPHOS ET | N ROX | Homogenate | Mouse | Nervous system |
| Broome 2022 Redox Biol | 2022 | Broome SC, Pham T, Braakhuis AJ, Narang R, Wang HW, Hickey AJR, Mitchell CJ, Merry TL (2022) MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men. https://doi.org/10.1016/j.redox.2022.102341 | LEAK OXPHOS ET | N CIV NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Mandic 2022 J Comp Physiol B | 2022 | Mandic M, Frazier AJ, Naslund AW, Todgham AE (2022) A comparative and ontogenetic examination of mitochondrial function in antarctic notothenioid species. https://doi.org/10.1007/s00360-022-01461-6 | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Fishes | Heart |
| Lopes 2022 Int J Mol Sci | 2022 | Lopes JA, Collino F, Rodrigues-Ferreira C, Sampaio LDS, Costa-Sarmento G, Wendt CHC, Almeida FP, Miranda KR, Kasai-Brunswick TH, Lindoso RS, Vieyra A (2022) Early effects of extracellular vesicles secreted by adipose tissue mesenchymal cells in renal ischemia followed by reperfusion: mechanisms rely on a decrease in mitochondrial anion superoxide production. https://doi.org/10.3390/ijms23062906 | LEAK OXPHOS ET | S ROX | Isolated mitochondria | Human | Kidney |
| Nath 2022 Cell Rep | 2022 | Nath AS, Parsons BD, Makdissi S, Chilvers RL, Mu Y, Weaver CM, Euodia I, Fitze KA, Long J, Scur M, Mackenzie DP, Makrigiannis AP, Pichaud N, Boudreau LH, Simmonds AJ, Webber CA, Derfalvi B, Hammon Y, Rachubinski RA, Di Cara F (2022) Modulation of the cell membrane lipid milieu by peroxisomal β-oxidation induces Rho1 signaling to trigger inflammatory responses . Cell Rep 38:110433. | LEAK ROUTINE OXPHOS ET | N Gp CIV ROX | Permeabilized cells Intact cells | ||
| Pedersen 2022 Nat Commun | 2022 | Pedersen JS, Rygg MO, Chrøis K, Sustarsic EG, Gerhart-Hines Z, Wever Albrechtsen NJ, Serizawa RR, Kristiansen VB, Basse AL, Boilesen AEB, Olsen BH, Hansen T, Gluud LL, Madsbad S, Larsen S, Bendtsen F, Dela F (2022) Influence of NAFLD and bariatric surgery on hepatic and adipose tissue mitochondrial biogenesis and respiration. https://doi.org/10.1038/s41467-022-30629-5 | LEAK OXPHOS ET | F N S CIV NS | Permeabilized tissue | Human | Liver Fat |
| Wang 2022 Transl Cancer Res | 2022 | Wang B, Liu B, Luo Q, Sun D, Li H, Zhang J, Jin X, Cheng X, Niu J, Yuan Q, Chen Y (2022) PANK1 associates with cancer metabolism and immune infiltration in clear cell renal cell carcinoma: a retrospective prognostic study based on the TCGA database. https://doi.org/10.21037/tcr-22-1488 | LEAK OXPHOS ET | N NS S | Human | Kidney Endothelial;epithelial;mesothelial cell | |
| Della Noce 2022 J Biol Chem | 2022 | Della Noce B, Martins da Silva R, de Carvalho Uhl MV, Konnai S, Ohashi K, Calixto C, Arcanjo A, de Abreu LA, de Carvalho SS, da Silva Vaz I Jr, Logullo C (2022) Redox imbalance induces remodeling of glucose metabolism in Rhipicephalus microplus embryonic cell line. https://doi.org/10.1016/j.jbc.2022.101599 | LEAK ROUTINE ET | ROX | Intact cells | Chelicerates | Other cell lines |
| Belal 2022 Biomedicines | 2022 | Belal S, Goudenège D, Bocca C, Dumont F, Chao De La Barca JM, Desquiret-Dumas V, Gueguen N, Geffroy G, Benyahia R, Kane S, Khiati S, Bris C, Aranyi T, Stockholm D, Inisan A, Renaud A, Barth M, Simard G, Reynier P, Letournel F, Lenaers G, Bonneau D, Chevrollier A, Procaccio V (2022) Glutamate-induced deregulation of krebs cycle in mitochondrial encephalopathy lactic acidosis syndrome stroke-like episodes (MELAS) syndrome is alleviated by ketone body exposure. https://doi.org/10.3390/biomedicines10071665 | LEAK ROUTINE ET | Intact cells | Human | Neuroblastoma | |
| Hadanny 2022 Sports Med Open | 2022 | Hadanny A, Hachmo Y, Rozali D, Catalogna M, Yaakobi E, Sova M, Gattegno H, Abu Hamed R, Lang E, Polak N, Friedman M, Finci S, Zemel Y, Bechor Y, Gal N, Efrati S (2022) Effects of hyperbaric oxygen therapy on mitochondrial respiration and physical performance in middle-aged athletes: a blinded, randomized controlled trial. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Meszaros 2022 EBioMedicine | 2022 | Meszaros AT, Hofmann J, Buch ML , Cardini B, Dunzendorfer-Matt T, Nardin F, Blumer MJ, Fodor M, Hermann M, Zelger B, Otarashvili G, Schartner M, Weissenbacher A, Oberhuber R, Resch T, Troppmair J, Öfner D, Zoller H, Tilg H, Gnaiger E, Hautz T, Schneeberger S (2022) Mitochondrial respiration during normothermic liver machine perfusion predicts clinical outcome. https://doi.org/10.1016/j.ebiom.2022.104311 | OXPHOS ET LEAK | F N S NS ROX | Homogenate | Human | Liver |
| De Goede 2022 FASEB J | 2022 | de Goede P, Wüst RCI, Schomakers BV, Denis S, Vaz FM, Pras-Raves ML, van Weeghel M, Yi CX, Kalsbeek A, Houtkooper RH (2022) Time-restricted feeding during the inactive phase abolishes the daily rhythm in mitochondrial respiration in rat skeletal muscle. FASEB J 36:e22133. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Rat | Skeletal muscle |
| Bresciani 2022 J Hepatol | 2022 | Bresciani N, Demagny H, Lemos V, Pontanari F, Li X, Sun Y, Li H, Perino A, Auwerx J, Schoonjans K (2022) The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis. https://doi.org/10.1016/j.jhep.2022.05.040 | LEAK OXPHOS ET | F N S NS ROX | Isolated mitochondria | Mouse | Liver |
| Alexander 2022 Cardiovasc Drugs Ther | 2022 | Alexander ED, Aldridge JL, Burleson TS, Frasier CR (2022) Teriflunomide treatment exacerbates cardiac ischemia reperfusion injury in isolated rat hearts. https://doi.org/10.1007/s10557-022-07341-z | ET LEAK OXPHOS | N NS | Isolated mitochondria | Rat | Heart |
| Smith 2022 J Pineal Res | 2022 | Smith KLM, Swiderska A, Lock MC, Graham L, Iswari W, Choudhary T, Thomas D, Kowash HM, Desforges M, Cottrell EC, Trafford AW, Giussani DA, Galli GLJ (2022) Chronic developmental hypoxia alters mitochondrial oxidative capacity and reactive oxygen species production in the fetal rat heart in a sex-dependent manner. https://doi.org/10.1111/jpi.12821 | LEAK OXPHOS ET | N S CIV NS ROX | Homogenate | Rat | Heart |
| Salazar-Petres 2022 Biol Reprod | 2022 | Salazar-Petres E, Pereira-Carvalho D, Lopez-Tello J, Sferruzzi-Perri AN (2022) Placental structure, function, and mitochondrial phenotype relate to fetal size in each fetal sex in mice†. https://doi.org/10.1093/biolre/ioac056 | LEAK OXPHOS ET | F N S CIV NS ROX | Permeabilized tissue | Mouse | Genital |
| Zhang 2022 Ecotoxicol Environ Saf | 2022 | Zhang Y, Yuan F, Li P, Gu J, Han J, Ni Z, Liu F (2022) Resveratrol inhibits HeLa cell proliferation by regulating mitochondrial function. https://doi.org/10.1016/j.ecoenv.2022.113788 | LEAK ROUTINE ET | ROX | Intact cells | Human | HeLa |
| Fuertes-Agudo 2022 Antioxidants (Basel) | 2022 | Fuertes-Agudo M, Luque-Tévar M, Cucarella C, Brea R, Boscá L, Quintana-Cabrera R, Martín-Sanz P, Casado M (2022) COX-2 expression in hepatocytes improves mitochondrial function after hepatic ischemia-reperfusion injury. | OXPHOS ET | F N Gp CIV NS Other combinations ROX | Isolated mitochondria | Mouse | Liver |
| Pallag 2022 Int J Mol Sci | 2022 | Pallag G, Nazarian S, Ravasz D, Bui D, Komlódi T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C (2022) Proline oxidation supports mitochondrial ATP production when Complex I is inhibited. https://doi.org/10.3390/ijms23095111 | LEAK OXPHOS ET | N S Gp CIV NS Other combinations ROX | Isolated mitochondria | Mouse | Liver Kidney |
| Melin 2022 JHEP Rep | 2022 | Melin N, Yarahmadov T, Sanchez-Taltavull D, Birrer FE, Brodie TM, Petit B, Felser A, Nuoffer JM, Montani M, Vozenin MC, Herrmann E, Candinas D, Aebersold DM, Stroka D (2022) A new mouse model of radiation-induced liver disease reveals mitochondrial dysfunction as an underlying fibrotic stimulus. https://doi.org/10.1016/j.jhepr.2022.100508 | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Mouse | Liver |
| Paulus 2022 Basic Res Cardiol | 2022 | Paulus MG, Renner K, Nickel AG, Brochhausen C, Limm K, Zügner E, Baier MJ, Pabel S, Wallner S, Birner C, Luchner A, Magnes C, Oefner PJ, Stark KJ, Wagner S, Maack C, Maier LS, Streckfuss-Bömeke K, Sossalla S, Dietl A (2022) Tachycardiomyopathy entails a dysfunctional pattern of interrelated mitochondrial functions. https://doi.org/10.1007/s00395-022-00949-0 | OXPHOS ET | NS F ROX | Permeabilized tissue Isolated mitochondria | Rabbit | Heart |
| Antona 2022 Cancers (Basel) | 2022 | Antona A, Varalda M, Roy K, Favero F, Mazzucco E, Zuccalà M, Leo G, Soggia G, Bettio V, Tosi M, Gaggianesi M, Riva B, Reano S, Genazzani A, Manfredi M, Stassi G, Corà D, D'Alfonso S, Capello D (2022) Dissecting the mechanism of action of spiperone-a candidate for drug repurposing for colorectal cancer. https://doi.org/10.3390/cancers14030776 | LEAK OXPHOS ET | N ROX | Intact cells | Human | Endothelial;epithelial;mesothelial cell |
| Tilokani 2022 Sci Adv | 2022 | Tilokani L, Russell FM, Hamilton S, Virga DM, Segawa M, Paupe V, Gruszczyk AV, Protasoni M, Tabara LC, Johnson M, Anand H, Murphy MP, Hardie DG, Polleux F, Prudent J (2022) AMPK-dependent phosphorylation of MTFR1L regulates mitochondrial morphology. https://doi.org/10.1126/sciadv.abo7956 | LEAK ROUTINE ET | ROX | Intact cells | Human | Other cell lines |
| Fischer 2022 Metabolites | 2022 | Fischer C, Valente de Souza L, Komlódi T, Garcia-Souza LF, Volani C, Tymoszuk P, Demetz E, Seifert M, Auer K, Hilbe R, Brigo N, Petzer V, Asshoff M, Gnaiger E, Weiss G (2022) Mitochondrial respiration in response to iron deficiency anemia. Comparison of peripheral blood mononuclear cells and liver. https://doi.org/10.3390/metabo12030270 | LEAK ROUTINE OXPHOS ET | N S NS Other combinations ROX | Permeabilized cells Homogenate | Rat | Liver Blood cells |
| Graham 2022 Physiol Rep | 2022 | Graham ZA, DeBerry JJ, Cardozo CP, Bamman MM (2022) SS-31 does not prevent or reduce muscle atrophy 7 days after a 65 kdyne contusion spinal cord injury in young male mice. https://doi.org/10.14814/phy2.15266 | LEAK OXPHOS ET | N ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Ilha 2022 Cell Biol Int | 2022 | Ilha M, Meira Martins LA, da Silveira Moraes K, Dias CK, Thomé MP, Petry F, Rohden F, Borojevic R, Trindade VMT, Klamt F, Barbé-Tuana F, Lenz G, Guma FCR (2022) Caveolin-1 influences mitochondrial plasticity and function in hepatic stellate cell activation. https://doi.org/10.1002/cbin.11876 | LEAK ROUTINE ET | ROX | Intact cells | Mouse | Liver |
| Bina 2022 Mol Cell Biochem | 2022 | Bînă AM, Aburel OM, Avram VF, Lelcu T, Lința AV, Chiriac DV, Mocanu AG, Bernad E, Borza C, Craina ML, Popa ZL, Muntean DM, Crețu OM (2022) Impairment of mitochondrial respiration in platelets and placentas: a pilot study in preeclamptic pregnancies. https://doi.org/10.1007/s11010-022-04415-2 | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Isolated mitochondria Intact cells | Human | Genital Platelet |
| Gonzalez-Franquesa 2022 Redox Biol | 2022 | Gonzalez-Franquesa A, Gama-Perez P, Kulis M, Szczepanowska K, Dahdah N, Moreno-Gomez S, Latorre-Pellicer A, Fernández-Ruiz R, Aguilar-Mogas A, Hoffman A, Monelli E, Samino S, Miró-Blanch J, Oemer G, Duran X, Sanchez-Rebordelo E, Schneeberger M, Obach M, Montane J, Castellano G, Chapaprieta V, Sun W, Navarro L, Prieto I, Castaño C, Novials A, Gomis R, Monsalve M, Claret M, Graupera M, Soria G, Wolfrum C, Vendrell J, Fernández-Veledo S, Enríquez JA, Carracedo A, Perales JC, Nogueiras R, Herrero L, Trifunovic A, Keller MA, Yanes O, Sales-Pardo M, Guimerà R, Blüher M, Martín-Subero JI, Garcia-Roves PM (2022) Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue. https://doi.org/10.1016/j.redox.2022.102353 | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue Homogenate | Mouse | Skeletal muscle Nervous system Liver Fat |
| Crislip 2022 Biomolecules | 2022 | Crislip GR, Wohlgemuth SE, Wolff CA, Gutierrez-Monreal MA, Douglas CM, Ebrahimi E, Cheng KY, Masten SH, Barral D, Bryant AJ, Esser KA, Gumz ML (2022) Apparent absence of BMAL1-dependent skeletal muscle-kidney cross talk in mice. https://doi.org/10.3390/biom12020261 | LEAK OXPHOS ET | N S CIV NS ROX | Isolated mitochondria | Mouse | Kidney |
| Vizuete 2022 J Neuroinflammation | 2022 | Vizuete AFK, Fróes F, Seady M, Zanotto C, Bobermin LD, Roginski AC, Wajner M, Quincozes-Santos A, Gonçalves CA (2022) Early effects of LPS-induced neuroinflammation on the rat hippocampal glycolytic pathway. https://doi.org/10.1186/s12974-022-02612-w | LEAK OXPHOS ET | N S NS ROX | Homogenate | Rat | Nervous system |
| Pochakom 2022 Brain Sci | 2022 | Pochakom A, Mu C, Rho JM, Tompkins TA, Mayengbam S, Shearer J (2022) Selective probiotic treatment positively modulates the microbiota-gut-brain axis in the BTBR mouse model of autism. https://doi.org/10.3390/brainsci12060781 | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Mouse | Nervous system |
| Goudie 2022 Sci Rep | 2022 | Goudie L, Mancini NL, Shutt TE, Holloway GP, Mu C, Wang A, McKay DM, Shearer J (2022) Impact of experimental colitis on mitochondrial bioenergetics in intestinal epithelial cells. https://doi.org/10.1038/s41598-022-11123-w | LEAK OXPHOS ET | N S CIV ROX | Permeabilized cells | Mouse | Endothelial;epithelial;mesothelial cell |
| Erdem 2022 Nat Commun | 2022 | Erdem A, Marin S, Pereira-Martins DA, Geugien M, Cunningham A, Pruis MG, Weinhäuser I, Gerding A, Bakker BM, Wierenga ATJ, Rego EM, Huls G, Cascante M, Schuringa JJ (2022) Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability. https://doi.org/10.1038/s41467-022-29639-0 | LEAK OXPHOS ET | N | Permeabilized cells | Human | Other cell lines |
| Long 2022 Cell Commun Signal | 2022 | Long C, Guo R, Han R, Li K, Wan Y, Xu J, Gong X, Zhao Y, Yao X, Liu J (2022) Effects of macrophages on the proliferation and cardiac differentiation of human induced pluripotent stem cells. https://doi.org/10.1186/s12964-022-00916-1 | LEAK ROUTINE ET | ROX | Intact cells | Human | Macrophage-derived |
| Munoz-Pujol 2022 Brain Pathol | 2022 | Muñoz-Pujol G, Ortigoza-Escobar JD, Paredes-Fuentes AJ, Jou C, Ugarteburu O, Gort L, Yubero D, García-Cazorla A, O'Callaghan M, Campistol J, Muchart J, Yépez VA, Gusic M, Gagneur J, Prokisch H, Artuch R, Ribes A, Urreizti R, Tort F (2022) Leigh syndrome is the main clinical characteristic of PTCD3 deficiency. https://doi.org/10.1111/bpa.13134 | LEAK ROUTINE ET | ROX | Intact cells | Human | Fibroblast |
| Sarabhai 2022 Diabetologia | 2022 | Sarabhai T, Mastrototaro L, Kahl S, Bönhof GJ, Jonuscheit M, Bobrov P, Katsuyama H, Guthoff R, Wolkersdorfer M, Herder C, Meuth SG, Dreyer S, Roden M (2022) Hyperbaric oxygen rapidly improves tissue-specific insulin sensitivity and mitochondrial capacity in humans with type 2 diabetes: a randomised placebo-controlled crossover trial. https://doi.org/10.1007/s00125-022-05797-0 | LEAK OXPHOS ET | N NS ROX | Permeabilized tissue | Human | Skeletal muscle Fat |
| De Paula Nascimento-Castro 2022 Biomedicines | 2022 | de Paula Nascimento-Castro C, Winkelmann-Duarte EC, Mancini G, Welter PG, Plácido E, Farina M, Gil-Mohapel J, Rodrigues ALS, de Bem AF, Brocardo PS (2022) Temporal characterization of behavioral and hippocampal dysfunction in the YAC128 mouse model of Huntington's disease. https://doi.org/10.3390/biomedicines10061433 | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse | Nervous system |
| Kluckova 2022 Hemasphere | 2022 | Kluckova K, Clear AJ, D'Avola A, Rassenti LZ, Kipps TJ, Gribben JG, Riches JC (2022) B-cell receptor signaling induced metabolic alterations in chronic lymphocytic leukemia can be partially bypassed by TP53 abnormalities. https://doi.org/10.1097/hs9.0000000000000722 | LEAK ET | ROX | Intact cells | Blood cells | |
| Peugnet 2022 Antioxidants (Basel) | 2022 | Peugnet V, Chwastyniak M, Mulder P, Lancel S, Bultot L, Fourny N, Renguet E, Bugger H, Beseme O, Loyens A, Heyse W, Richard V, Amouyel P, Bertrand L, Pinet F, Dubois-Deruy E (2022) Mitochondrial-targeted therapies require mitophagy to prevent oxidative stress induced by SOD2 inactivation in hypertrophied cardiomyocytes. https://doi.org/10.3390/antiox11040723 | LEAK ROUTINE ET | ROX | Intact cells | Rat | Heart |
| Li 2022 Mol Med | 2022 | Li X, Zhou X, Liu X, Li X, Jiang X, Shi B, Wang S (2022) Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway. https://doi.org/10.1186/s10020-022-00533-1 | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Human | Blood cells |
| Markovic 2022 Biomedicines | 2022 | Marković A, Tauchmannová K, Šimáková M, Mlejnek P, Kaplanová V, Pecina P, Pecinová A, Papoušek F, Liška F, Šilhavý J, Mikešová J, Neckář J, Houštěk J, Pravenec M, Mráček T (2022) Genetic complementation of ATP synthase deficiency due to dysfunction of TMEM70 assembly factor in rat. https://doi.org/10.3390/biomedicines10020276 | LEAK OXPHOS ET | F N S NS | Homogenate | Rat | Heart Liver |
| Neupane 2022 Commun Biol | 2022 | Neupane N, Rajendran J, Kvist J, Harjuhaahto S, Hu B, Kinnunen V, Yang Y, Nieminen AI, Tyynismaa H (2022) Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle. https://doi.org/10.1038/s42003-022-04034-z | OXPHOS ET | N NS ROX | Isolated mitochondria | Mouse | Skeletal muscle |
| Crowder 2022 Islets | 2022 | Crowder JJ, Zeng Z, Novak AN, Alves NJ, Linnemann AK (2022) Stabilization protects islet integrity during respirometry in the Oroboros Oxygraph-2K analyzer. Islets 14:128-38. | LEAK ROUTINE ET | ROX | Intact cells | Mouse | Islet cell;pancreas;thymus |
| Desjardins 2022 Proc Natl Acad Sci U S A | 2022 | Desjardins EM, Smith BK, Day EA, Ducommun S, Sanders MJ, Nederveen JP, Ford RJ, Pinkosky SL, Townsend LK, Gutgesell RM, Lu R, Sakamoto K, Steinberg GR (2022) The phosphorylation of AMPKβ1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids. https://doi.org/10.1073/pnas.2119824119 | LEAK OXPHOS ET | N NS | Isolated mitochondria | Mouse | Liver |
| Jelenik 2022 Pharmacol Res | 2022 | Jelenik T, Kodde A, Pesta D, Phielix E, Oosting A, Rohbeck E, Dewidar B, Mastrototaro L, Trenkamp S, Keijer J, van der Beek EM, Roden M (2022) Dietary lipid droplet structure in postnatal life improves hepatic energy and lipid metabolism in a mouse model for postnatal programming. https://doi.org/10.1016/j.phrs.2022.106193 | LEAK OXPHOS ET | N NS ROX | Permeabilized tissue | Mouse | Skeletal muscle Liver |
| McKenna 2022 J Appl Physiol (1985) | 2022 | McKenna CF, Salvador AF, Keeble AR, Khan NA, De Lisio M, Konopka AR, Paluska SA, Burd NA (2022) Muscle strength after resistance training correlates to mediators of muscle mass and mitochondrial respiration in middle-aged adults. https://doi.org/10.1152/japplphysiol.00186.2022 | LEAK OXPHOS ET | NS | Permeabilized tissue | Human | Skeletal muscle |
| Napso 2022 Acta Physiol (Oxf) | 2022 | Napso T, Lean SC, Lu M, Mort EJ, Desforges M, Moghimi A, Bartels B, El-Bacha T, Fowden AL, Camm EJ, Sferruzzi-Perri AN (2022) Diet-induced maternal obesity impacts feto-placental growth and induces sex-specific alterations in placental morphology, mitochondrial bioenergetics, dynamics, lipid metabolism and oxidative stress in mice. https://doi.org/10.1111/apha.13795 | LEAK OXPHOS ET | F N S CIV NS ROX | Permeabilized tissue | Mouse | Genital |
| Babylon 2022 Int J Mol Sci | 2022 | Babylon L, Schmitt F, Franke Y, Hubert T, Eckert GP (2022) Effects of combining biofactors on bioenergetic parameters, Aβ levels and survival in Alzheimer model organisms. https://doi.org/10.3390/ijms23158670 | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Neuroblastoma |
| Dias 2022 Free Radic Biol Med | 2022 | Dias C, Lourenço CF, Laranjinha J, Ledo A (2022) Modulation of oxidative neurometabolism in ischemia/reperfusion by nitrite. https://doi.org/10.1016/j.freeradbiomed.2022.11.021 | ROUTINE OXPHOS ET | N S ROX | Permeabilized tissue Intact cells | Rat | Nervous system |
| Thapa 2022 Physiol Rep | 2022 | Thapa D, Bugga P, Mushala BAS, Manning JR, Stoner MW, McMahon B, Zeng X, Cantrell PS, Yates N, Xie B, Edmunds LR, Jurczak MJ, Scott I (2022) GCN5L1 impairs diastolic function in mice exposed to a high fat diet by restricting cardiac pyruvate oxidation. https://doi.org/10.14814/phy2.15415 | LEAK OXPHOS ET | N ROX | Mouse | Heart | |
| Soares 2022 Geroscience | 2022 | Soares RN, Ramirez-Perez FI, Cabral-Amador FJ, Morales-Quinones M, Foote CA, Ghiarone T, Sharma N, Power G, Smith JA, Rector RS, Martinez-Lemus LA, Padilla J, Manrique-Acevedo C (2022) SGLT2 inhibition attenuates arterial dysfunction and decreases vascular F-actin content and expression of proteins associated with oxidative stress in aged mice. https://doi.org/10.1007/s11357-022-00563-x | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Mouse | Endothelial;epithelial;mesothelial cell |
| Laehteenmaeki 2022 Physiol Rep | 2022 | Lähteenmäki EI, Koski M, Koskela I, Lehtonen E, Kankaanpää A, Kainulainen H, Walker S, Lehti M (2022) Resistance exercise with different workloads have distinct effects on cellular respiration of peripheral blood mononuclear cells. https://doi.org/10.14814/phy2.15394 | LEAK ROUTINE ET | ROX | Intact cells | Human | Blood cells |
| Loughland 2022 J Exp Biol | 2022 | Loughland I, Lau GY, Jolly J, Seebacher F (2022) Rates of warming impact oxidative stress in zebrafish (Danio rerio). | LEAK OXPHOS ET | N NS | Isolated mitochondria | Zebrafish | Skeletal muscle |
| Tang 2022 Sci China Life Sci | 2022 | Tang G, Ma C, Li L, Zhang S, Li F, Wu J, Yin Y, Zhu Q, Liang Y, Wang R, Huang H, Zhao TJ, Yang H, Li P, Chen FJ (2022) PITPNC1 promotes the thermogenesis of brown adipose tissue under acute cold exposure. https://doi.org/10.1007/s11427-022-2157-y | LEAK ET | N | Isolated mitochondria | Mouse | Fat |
| Vanweert 2022 Nat Commun | 2022 | Vanweert F, Neinast M, Tapia EE, van de Weijer T, Hoeks J, Schrauwen-Hinderling VB, Blair MC, Bornstein MR, Hesselink MKC, Schrauwen P, Arany Z, Phielix E (2022) A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes. https://doi.org/10.1038/s41467-022-31249-9 | LEAK OXPHOS ET | F N NS | Permeabilized tissue | Human | Skeletal muscle |
| Spagnuolo 2022 Mol Neurobiol | 2022 | Spagnuolo MS, Mazzoli A, Nazzaro M, Troise AD, Gatto C, Tonini C, Colardo M, Segatto M, Scaloni A, Pallottini V, Iossa S, Cigliano L (2022) Long-lasting Impact of sugar intake on neurotrophins and neurotransmitters from adolescence to young adulthood in rat frontal cortex. https://doi.org/10.1007/s12035-022-03115-8 | LEAK OXPHOS ET | N S NS ROX | Homogenate | Rat | Nervous system |
| Beaulant 2022 J Hepatol | 2022 | Beaulant A, Dia M, Pillot B, Chauvin MA, Ji-Cao J, Durand C, Bendridi N, Chanon S, Vieille-Marchiset A, Da Silva CC, Patouraux S, Anty R, Iannelli A, Tran A, Gual P, Vidal H, Gomez L, Paillard M, Rieusset J (2022) Endoplasmic reticulum-mitochondria miscommunication is an early and causal trigger of hepatic insulin resistance and steatosis. https://doi.org/10.1016/j.jhep.2022.03.017 | ET | Permeabilized cells Intact cells | Mouse | Liver | |
| Zhu 2022 Metabolism | 2022 | Zhu JY, Chen M, Mu WJ, Luo HY, Guo L (2022) Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice. https://doi.org/10.1016/j.metabol.2022.155241 | LEAK ROUTINE ET | ROX | Intact cells | Mouse | Liver |
| Chojnacka 2022 Mol Biol Cell | 2022 | Chojnacka KJ, Elancheliyan P, Mussulini BHM, Mohanraj K, Callegari S, Gosk A, Banach T, Góral T, Szczepanowska K, Rehling P, Serwa RA, Chacinska A (2022) Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel complex III-specific assembly factor in mitochondria. https://doi.org/10.1091/mbc.e21-03-0143 | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS ROX | Permeabilized cells Intact cells | Human | HEK |
| Fernandez-Vizarra 2022 Cell Metab | 2022 | Fernández-Vizarra E, López-Calcerrada S, Sierra-Magro A, Pérez-Pérez R, Formosa LE, Hock DH, Illescas M, Peñas A, Brischigliaro M, Ding S, Fearnley IM, Tzoulis C, Pitceathly RDS, Arenas J, Martín MA, Stroud DA, Zeviani M, Ryan MT, Ugalde C (2022) Two independent respiratory chains adapt OXPHOS performance to glycolytic switch. https://doi.org/10.1016/j.cmet.2022.09.005 | LEAK ET | N S Gp NS ROX | Permeabilized cells Intact cells | Human | HEK |
| Garcia-Roche 2022 J Dairy Sci | 2022 | García-Roche M, Talmón D, Cañibe G, Astessiano AL, Mendoza A, Quijano C, Cassina A, Carriquiry M (2022) Differential hepatic mitochondrial function and gluconeogenic gene expression in 2 Holstein strains in a pasture-based system. https://doi.org/10.3168/jds.2021-21358 | LEAK OXPHOS ET | N S NS ROX | Intact cells | Bovines | Liver |
| Hadjihambi 2022 J Hepatol | 2022 | Hadjihambi A, Konstantinou C, Klohs J, Monsorno K, Le Guennec A, Donnelly C, Cox J, Kusumbe A, Hosford PS, Soffientini U, Lecca S, Mameli M, Jalan R, Paolicelli RC, Pellerin L (2022) Partial MCT1 invalidation protects against diet-induced non-alcoholic fatty liver disease and the associated brain dysfunction. https://doi.org/10.1016/j.jhep.2022.08.008 | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue Homogenate | Mouse | Nervous system |
| Gomez 2022 Nutrients | 2022 | Gómez Rodríguez A, Talamonti E, Naudi A, Kalinovich AV, Pauter AM, Barja G, Bengtsson T, Jacobsson A, Pamplona R, Shabalina IG (2022) Elovl2-ablation leads to mitochondrial membrane fatty acid remodeling and reduced efficiency in mouse liver mitochondria. https://doi.org/10.3390/nu14030559 | LEAK OXPHOS ET | N | Isolated mitochondria | Mouse | Liver |
| Dieter 2022 Int J Mol Sci | 2022 | Dieter F, Esselun C, Eckert GP (2022) Redox active α-lipoic acid differentially improves mitochondrial dysfunction in a cellular model of Alzheimer and its control cells. https://doi.org/10.3390/ijms23169186 | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Neuroblastoma |
| Zdrazilova 2022 PLOS ONE | 2022 | Zdrazilova L, Hansikova H, Gnaiger E (2022) Comparable respiratory activity in attached and suspended human fibroblasts. https://doi.org/10.1371/journal.pone.0264496 | LEAK ROUTINE ET | ROX | Intact cells | Human | Fibroblast |
| Fedorov 2022 Naunyn Schmiedebergs Arch Pharmacol | 2022 | Fedorov A, Lehto A, Klein J (2022) Inhibition of mitochondrial respiration by general anesthetic drugs. https://doi.org/10.1007/s00210-022-02338-9 | LEAK OXPHOS ET | N S CIV NS ROX | Isolated mitochondria | Mouse | Nervous system |
| Adant 2022 Mol Metab | 2022 | Adant I, Bird M, Decru B, Windmolders P, Wallays M, de Witte P, Rymen D, Witters P, Vermeersch P, Cassiman D, Ghesquière B (2022) Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction. https://doi.org/10.1016/j.molmet.2022.101537 | LEAK OXPHOS ET | N S Gp CIV NS ROX | Permeabilized cells | Human | Fibroblast |
| Petry 2022 Antioxidants (Basel) | 2022 | Petry SF, Römer A, Rawat D, Brunner L, Lerch N, Zhou M, Grewal R, Sharifpanah F, Sauer H, Eckert GP, Linn T (2022) Loss and recovery of glutaredoxin 5 is inducible by diet in a murine model of diabesity and mediated by free fatty acids in vitro. https://doi.org/10.3390/antiox11040788 | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Mouse | Islet cell;pancreas;thymus |
| Trewin 2022 BMC Biol | 2022 | Trewin AJ, Silver J, Dillon HT, Della Gatta PA, Parker L, Hiam DS, Lee YP, Richardson M, Wadley GD, Lamon S (2022) Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle. https://doi.org/10.1186/s12915-022-01366-4 | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Mouse | Skeletal muscle |
| Bikman 2022 Eur J Clin Nutr | 2022 | Bikman BT, Shimy KJ, Apovian CM, Yu S, Saito ER, Walton CM, Ebbeling CB, Ludwig DS (2022) A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration. https://doi.org/10.1038/s41430-022-01097-3 | LEAK OXPHOS ET | N NS | Permeabilized cells | Human | Fat |
| Cherix 2022 Mol Psychiatry | 2022 | Cherix A, Poitry-Yamate C, Lanz B, Zanoletti O, Grosse J, Sandi C, Gruetter R, Cardinaux JR (2022) Deletion of Crtc1 leads to hippocampal neuroenergetic impairments associated with depressive-like behavior. https://doi.org/10.1038/s41380-022-01791-5 | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse | Nervous system |
| Risiglione 2022 Life (Basel) | 2022 | Risiglione P, Cubisino SAM, Lipari CLR, De Pinto V, Messina A, Magrì A (2022) α-Synuclein A53T promotes mitochondrial proton gradient dissipation and depletion of the organelle respiratory reserve in a neuroblastoma cell line. https://doi.org/10.3390/life12060894 | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Neuroblastoma |
| Leibold 2022 PLoS One | 2022 | Leibold S, Bagivalu Lakshminarasimha A, Gremse F, Hammerschmidt M, Michel M (2022) Long-term obesogenic diet leads to metabolic phenotypes which are not exacerbated by catch-up growth in zebrafish. https://doi.org/10.1371/journal.pone.0267933 | LEAK OXPHOS ET | N ROX | Isolated mitochondria | Zebrafish | |
| Siewiera 2022 Int J Mol Sci | 2022 | Siewiera K, Labieniec-Watala M, Kassassir H, Wolska N, Polak D, Watala C (2022) Potential role of mitochondria as modulators of blood platelet activation and reactivity in diabetes and effect of metformin on blood platelet bioenergetics and platelet activation. https://doi.org/10.3390/ijms23073666 | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Rat | Platelet |
| Gvozdjakova 2022 Environ Sci Pollut Res Int | 2022 | Gvozdjáková A, Sumbalová Z, Kucharská J, Rausová Z, Kovalčíková E, Takácsová T, Navas P, López-Lluch G, Mojto V, Palacka P (2022) Mountain spa rehabilitation improved health of patients with post-COVID-19 syndrome: pilot study. https://doi.org/10.1007/s11356-022-22949-2 | LEAK ROUTINE OXPHOS ET | N NS | Permeabilized cells Intact cells | Human | Platelet |
| De Jong 2022 Nutrients | 2022 | De Jong NP, Rudolph MC, Jackman MR, Sharp RR, Jones K, Houck J, Pan Z, Reusch JEB, MacLean PS, Bessesen DH, Bergouignan A (2022) Short-term adaptations in skeletal muscle mitochondrial oxidative capacity and metabolic pathways to breaking up sedentary behaviors in overweight or obese adults. https://doi.org/10.3390/nu14030454 | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Kampa 2022 Antioxidants (Basel) | 2022 | Kampa RP, Flori L, Sęk A, Spezzini J, Brogi S, Szewczyk A, Calderone V, Bednarczyk P, Testai L (2022) Luteolin-induced activation of mitochondrial BKCa channels: undisclosed mechanism of cytoprotection. https://doi.org/10.3390/antiox11101892 | ET | Intact cells | Human | Endothelial;epithelial;mesothelial cell | |
| Weiss 2022 J Cell Mol Med | 2022 | Weiss SL, Zhang D, Farooqi S, Wallace DC (2022) Sodium butyrate reverses lipopolysaccharide-induced mitochondrial dysfunction in lymphoblasts. https://doi.org/10.1111/jcmm.17342 | ROUTINE OXPHOS ET | N | Intact cells | Other cell lines | |
| Leggio 2022 Adv Healthc Mater | 2022 | Leggio L, L'Episcopo F, Magrì A, Ulloa-Navas MJ, Paternò G, Vivarelli S, Bastos CAP, Tirolo C, Testa N, Caniglia S, Risiglione P, Pappalardo F, Serra A, García-Tárraga P, Faria N, Powell JJ, Peruzzotti-Jametti L, Pluchino S, García-Verdugo JM, Messina A, Marchetti B, Iraci N (2022) Small extracellular vesicles secreted by nigrostriatal astrocytes rescue cell death and preserve mitochondrial function in Parkinson's disease. https://doi.org/10.1002/adhm.202201203 | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Neuroblastoma |
| Nadeu 2022 Nat Med | 2022 | Nadeu F, Royo R, Massoni-Badosa R, Playa-Albinyana H, Garcia-Torre B, Duran-Ferrer M, Dawson KJ, Kulis M, Diaz-Navarro A, Villamor N, Melero JL, Chapaprieta V, Dueso-Barroso A, Delgado J, Moia R, Ruiz-Gil S, Marchese D, Giró A, Verdaguer-Dot N, Romo M, Clot G, Rozman M, Frigola G, Rivas-Delgado A, Baumann T, Alcoceba M, González M, Climent F, Abrisqueta P, Castellví J, Bosch F, Aymerich M, Enjuanes A, Ruiz-Gaspà S, López-Guillermo A, Jares P, Beà S, Capella-Gutierrez S, Gelpí JL, López-Bigas N, Torrents D, Campbell PJ, Gut I, Rossi D, Gaidano G, Puente XS, Garcia-Roves PM, Colomer D, Heyn H, Maura F, Martín-Subero JI, Campo E (2022) Detection of early seeding of Richter transformation in chronic lymphocytic leukemia. https://doi.org/10.1038/s41591-022-01927-8 | LEAK ROUTINE ET | ROX | Intact cells | Human | Lymphocyte Blood cells |
| Rome 2022 Mol Metab | 2022 | Rome FI, Hughey CC (2022) Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction. https://doi.org/10.1016/j.molmet.2022.101452 | LEAK OXPHOS ET | N CIV ROX | Isolated mitochondria | Mouse | Liver |
| Donnarumma 2022 Nat Commun | 2022 | Donnarumma E, Kohlhaas M, Vimont E, Kornobis E, Chaze T, Gianetto QG, Matondo M, Moya-Nilges M, Maack C, Wai T (2022) Mitochondrial Fission Process 1 controls inner membrane integrity and protects against heart failure. https://doi.org/10.1038/s41467-022-34316-3 | LEAK OXPHOS ET | F N S CIV | Isolated mitochondria | Mouse | Heart |
| Molinie 2022 Biochim Biophys Acta Bioenerg | 2022 | Molinié T, Cougouilles E, David C, Cahoreau E, Portais JC, Mourier A (2022) MDH2 produced OAA is a metabolic switch rewiring the fuelling of respiratory chain and TCA cycle. Biochim Biophys Acta Bioenerg 1863:148532. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Mouse | Heart Liver |
| Quast 2022 Basic Res Cardiol | 2022 | Quast C, Kober F, Becker K, Zweck E, Hoffe J, Jacoby C, Flocke V, Gyamfi-Poku I, Keyser F, Piayda K, Erkens R, Niepmann S, Adam M, Baldus S, Zimmer S, Nickenig G, Grandoch M, Bönner F, Kelm M, Flögel U (2022) Multiparametric MRI identifies subtle adaptations for demarcation of disease transition in murine aortic valve stenosis. https://doi.org/10.1007/s00395-022-00936-5 | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Mouse | Heart |
| Pileggi 2022 EBioMedicine | 2022 | Pileggi CA, Blondin DP, Hooks BG, Parmar G, Alecu I, Patten DA, Cuillerier A, O'Dwyer C, Thrush AB, Fullerton MD, Bennett SAL, Doucet É, Haman F, Cuperlovic-Culf M, McPherson R, Dent RRM, Harper ME (2022) Exercise training enhances muscle mitochondrial metabolism in diet-resistant obesity. https://doi.org/10.1016/j.ebiom.2022.104192 | LEAK OXPHOS ET | N NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Hansen 2022 Magn Reson Med | 2022 | Hansen K, Hansen ESS, Jespersen NRV, Bøtker HE, Pedersen M, Wang T, Laustsen C (2022) Hyperpolarized 13C MRI reveals large changes in pyruvate metabolism during digestion in snakes. https://doi.org/10.1002/mrm.29239 | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Reptiles | Liver |
| Wu 2022 Antioxidants (Basel) | 2022 | Wu YL, Chang JC, Chao YC, Chan H, Hsieh M, Liu CS (2022) In vitro efficacy and molecular mechanism of curcumin analog in pathological regulation of spinocerebellar ataxia type 3. https://doi.org/10.3390/antiox11071389 | LEAK OXPHOS ET | N S NS ROX | Intact cells | Human | Neuroblastoma |
| Xu 2022 Nat Commun | 2022 | Xu Z, Fu T, Guo Q, Zhou D, Sun W, Zhou Z, Chen X, Zhang J, Liu L, Xiao L, Yin Y, Jia Y, Pang E, Chen Y, Pan X, Fang L, Zhu MS, Fei W, Lu B, Gan Z (2022) Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength. https://doi.org/10.1038/s41467-022-28557-5 | LEAK OXPHOS ET | N S ROX | Isolated mitochondria | Mouse | Skeletal muscle |
| Zhang 2022 Int J Mol Sci | 2022 | Zhang A, Gupte AA, Chatterjee S, Li S, Ayala AG, Miles BJ, Hamilton DJ (2022) Enhanced succinate oxidation with mitochondrial complex II reactive oxygen species generation in human prostate cancer. https://doi.org/10.3390/ijms232012168 | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Genital |
| Roy 2022 Am J Pathol | 2022 | Roy N, Alencastro F, Roseman BA, Wilson SR, Delgado ER, May MC, Bhushan B, Bello FM, Jurczak MJ, Shiva S, Locker J, Gingras S, Duncan AW (2022) Dysregulation of lipid and glucose homeostasis in hepatocyte-specific SLC25A34 knockout mice. https://doi.org/10.1016/j.ajpath.2022.06.002 | LEAK OXPHOS ET | N NS ROX | Homogenate | Mouse | Liver |
| Tremmel 2022 Sci Rep | 2022 | Tremmel DM, Sackett SD, Feeney AK, Mitchell SA, Schaid MD, Polyak E, Chlebeck PJ, Gupta S, Kimple ME, Fernandez LA, Odorico JS (2022) A human pancreatic ECM hydrogel optimized for 3-D modeling of the islet microenvironment. https://doi.org/10.1038/s41598-022-11085-z | LEAK ROUTINE ET | ROX | Intact cells | Human | Islet cell;pancreas;thymus |
| Gnaiger 2021 MitoFit BCA | 2021-09-21 | Gnaiger E (2021) Bioenergetic cluster analysis – mitochondrial respiratory control in human fibroblasts. https://doi.org/10.26124/mitofit:2021-0008 | LEAK OXPHOS ET | ROX | Intact cells | Human | Fibroblast |
| Zdrazilova 2021 MitoFit ace-sce | 2021-09-21 | Zdrazilova L, Hansikova H, Gnaiger E (2021) Comparable respiratory activity in attached and suspended human fibroblasts. https://doi.org/10.26124/mitofit:2021-0007 — 2022-03-03 published in PLOS ONE 17:e0264496 | LEAK ET ROUTINE | ROX | Intact cells | Human | Fibroblast |
| Flockhart 2021 Cell Metab | 2021 | Flockhart M, Nilsson LC, Tais S, Ekblom B, Apro W, Larsen FJ (2021) Excessive exercise training causes mitochondrial functional impairment and decreases glucose tolerance in healthy volunteers. Cell Metab 33:957-70. | LEAK OXPHOS ET | F N S NS | Isolated mitochondria | Human | Skeletal muscle |
| Szczerbinski 2021 Cells | 2021 | Szczerbinski L, Taylor MA, Puchta U, Konopka P, Paszko A, Citko A, Szczerbinski K, Goscik J, Gorska M, Larsen S, Kretowski A (2021) The response of mitochondrial respiration and quantity in skeletal muscle and adipose tissue to exercise in humans with prediabetes. Cells 10:3013. | LEAK OXPHOS ET | N S | Permeabilized tissue | Human | Skeletal muscle Fat |
| Cretin 2021 EMBO Mol Med | 2021 | Cretin E, Lopes P, Vimont E, Tatsuta T, Langer T, Gazi A, Sachse M, Yu-Wai-Man P, Reynier P, Wai T (2021) High-throughput screening identifies suppressors of mitochondrial fragmentation in OPA1 fibroblasts. EMBO Mol Med 13:13579. | LEAK ROUTINE ET | ROX | Intact cells | Mouse | Fibroblast |
| Zanou 2021 Nat Commun | 2021 | Zanou N, Dridi H, Reiken S, Imamura de Lima T, Donnelly C, De Marchi U, Ferrini M, Vidal J, Sittenfeld L, Feige JN, Garcia-Roves PM, Lopez-Mejia IC, Marks AR, Auwerx J, Kayser B, Place N (2021) Acute RyR1 Ca2+ leak enhances NADH-linked mitochondrial respiratory capacity. Nat Commun 12:7219. | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Mouse | Skeletal muscle |
| Whitehead 2021 Nat Commun | 2021 | Whitehead A, Krause FN, Moran A, MacCannell ADV, Scragg JL, McNally BD, Boateng E, Murfitt SA, Virtue S, Wright J, Garnham J, Davies GR, Dodgson J, Schneider JE, Murray AJ, Church C, Vidal-Puig A, Witte KK, Griffin JL, Roberts LD (2021) Brown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis. Nat Commun 12:1905. | LEAK OXPHOS ET | F N S NS | Permeabilized cells | Human | Skeletal muscle |
| King 2021 J Biol Chem | 2021 | King WT, Axelrod CL, Zunica ERM, Noland RC, Davuluri G, Fujioka H, Tandler B, Pergola K, Hermann GE, Rogers RC, López-Domènech S, Dantas WS, Stadler K, Hoppel CL, Kirwan JP (2021) Dynamin-related protein 1 regulates substrate oxidation in skeletal muscle by stabilizing cellular and mitochondrial calcium dynamics. J Biol Chem 297:101196. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized cells | Mouse | Skeletal muscle |
| Davis 2021 Comparative Exercise Physiology | 2021 | Davis Michael, Barrett Montana, Popken Andrea (2021) Effect of hyperthermia and acidosis on equine skeletal muscle mitochondrial oxygen consumption. Comparative Exercise Physiology 17:171-179. | LEAK OXPHOS ET | N S NS | Permeabilized cells | Horse | Skeletal muscle |
| Larsen 2021 Cell Mol Gastroenterol Hepatol | 2021 | Larsen LE, van den Boogert MAW, Rios-Ocampo WA, Jansen JC, Conlon D, Chong PLE, Levels JHM, Eilers RE, Sachdev VV, Zelcer N, Raabe T, He M, Hand NJ, Drenth JPH, Rader DJ, Stroes ESG, Lefeber DJ, Jonker JW, Holleboom AG (2021) Defective lipid droplet - lysosome interaction causes fatty liver disease as evidenced by human mutations in TMEM199 and CCDC115. Cell Mol Gastroenterol Hepatol 13:583-97. | OXPHOS ET | F N | Intact cells | Human | Liver |
| Meng 2021 FEBS Open Bio | 2021 | Meng L, Chen D, Meng G, Lu L, Han C (2021) Dysregulation of the Sirt5/IDH2 axis contributes to sunitinib resistance in human renal cancer cells. FEBS Open Bio 11:921-31. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Kidney |
| Babylon 2021 Antioxidants (Basel) | 2021 | Babylon L, Grewal R, Stahr PL, Eckert RW, Keck CM, Eckert GP (2021) Hesperetin nanocrystals improve mitochondrial function in a cell model of early Alzheimer disease. Antioxidants (Basel) 10:1003. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Neuroblastoma |
| Sahl 2021 Adipocyte | 2021 | Sahl RE, Høy Helms EF, Schmücker M, Flensted-Jensen M, Ingersen A, Morville T, Dela F, Helge JW, Larsen S (2021) Reliability and variation in mitochondrial respiration in human adipose tissue. Adipocyte 10:605-11. | LEAK OXPHOS ET | N NS | Permeabilized cells | Human | Fat |
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| Styles 2021 Cell Death Dis | 2021 | Styles FL, Al-Owais MM, Scragg JL, Chuntharpursat-Bon E, Hettiarachchi NT, Lippiat JD, Minard A, Bon RS, Porter K, Sukumar P, Peers C, Roberts LD (2021) Kv1.3 voltage-gated potassium channels link cellular respiration to proliferation through a non-conducting mechanism. Cell Death Dis 12:372. | LEAK ROUTINE ET | CIV ROX | Intact cells | Human | HEK |
| Connell 2021 J Nutr | 2021 | Connell NJ, Grevendonk L, Fealy CE, Moonen-Kornips E, Bruls YMH, Schrauwen-Hinderling VB, de Vogel J, Hageman R, Geurts J, Zapata-Perez R, Houtkooper RH, Havekes B, Hoeks J, Schrauwen P (2021) NAD+-precursor supplementation with L-tryptophan, nicotinic acid, and nicotinamide does not affect mitochondrial function or skeletal muscle function in physically compromised older adults. J Nutr 151:2917-31 | LEAK OXPHOS ET | F N NS | Permeabilized tissue | Human | Skeletal muscle |
| Krako 2021 Int J Mol Sci | 2021 | Krako Jakovljevic N, Pavlovic K, Jotic A, Lalic K, Stoiljkovic M, Lukic L, Milicic T, Macesic M, Stanarcic Gajovic J, Lalic NM (2021) Targeting mitochondria in diabetes. Int J Mol Sci 22:6642. | LEAK OXPHOS ET | F N S | Permeabilized tissue | Human | Skeletal muscle Liver Blood cells |
| Kladnicka 2021 Biomolecules | 2021 | Kladnicka I, Cedikova M, Jedlicka J, Kohoutova M, Muller L, Plavinova I, Kripnerova M, Bludovska M, Kuncova J, Mullerova D (2021) Chronic DDE exposure modifies mitochondrial respiration during differentiation of human adipose-derived mesenchymal stem cells into mature adipocytes. Biomolecules 11:1068. | LEAK ROUTINE ET | ROX | Intact cells | Human | Fat |
| Bandara 2021 Mitochondrion | 2021 | Bandara AB, Drake JC, James CC, Smyth JW, Brown DA (2021) Complex I protein NDUFS2 is vital for growth, ROS generation, membrane integrity, apoptosis, and mitochondrial energetics. Mitochondrion 58:160-68. | LEAK OXPHOS ET | N S | Permeabilized cells | Human | HEK |
| Gomez-Valades 2021 Cell Metab | 2021 | Gómez-Valadés AG, Pozo M, Varela L, Boudjadja MB, Ramírez S, Chivite I, Eyre E, Haddad-Tóvolli R, Obri A, Milà-Guasch M, Altirriba J, Schneeberger M, Imbernón M, Garcia-Rendueles AR, Gama-Perez P, Rojo-Ruiz J, Rácz B, Alonso MT, Gomis R, Zorzano A, D'Agostino G, Alvarez CV, Nogueiras R, Garcia-Roves PM, Horvath TL, Claret M (2021) Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis . Cell Metab 33:1820-35.e9. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue Homogenate | Mouse | Nervous system |
| Scalzo 2021 J Physiol | 2021 | Scalzo RL, Schauer IE, Rafferty D, Knaub LA, Kvaratskhelia N, Johnson TK, Pott GB, Abushamat LA, Whipple MO, Huebschmann AG, Cree-Green M, Reusch JEB, Regensteiner JG (2021) Single-leg exercise training augments in vivo skeletal muscle oxidative flux and vascular content and function in adults with type 2 diabetes. J Physiol 600:963-78. | LEAK OXPHOS ET | F N NS | Permeabilized tissue | Human | Skeletal muscle |
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| Fischer 2021 Antioxidants | 2021 | Fischer C, Volani C, Komlódi T, Seifert M, Demetz E, Valente de Souza L, Auer K, Petzer V, von Raffay L, Moser P, Gnaiger E, Weiss G (2021) Dietary iron overload and Hfe-/- related hemochromatosis alter hepatic mitochondrial function. https://doi.org/10.3390/antiox10111818 | LEAK OXPHOS ET | ROX N S Gp | Mouse | Liver | |
| Willis 2021 Sci Rep | 2021 | Willis JR, Hickey AJR, Devaux JBL (2021) Thermally tolerant intertidal triplefin fish (Tripterygiidae) sustain ATP dynamics better than subtidal species under acute heat stress. Sci Rep 11:11074. | LEAK OXPHOS ET ROUTINE | N ROX NS | Homogenate | Fishes | Nervous system |
| Mazzoli 2021 Nutrients | 2021 | Mazzoli A, Gatto C, Crescenzo R, Cigliano L, Iossa S (2021) Prolonged changes in hepatic mitochondrial activity and insulin sensitivity by high fructose intake in adolescent rats. Nutrients 13:1370. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Rat | Liver |
| Sanchez-de-Diego 2021 Redox Biol | 2021 | Sánchez-de-Diego C, Pedrazza L, Pimenta-Lopes C, Martinez-Martinez A, Dahdah N, Valer JA, Garcia-Roves P, Rosa JL, Ventura F (2021) NRF2 function in osteocytes is required for bone homeostasis and drives osteocytic gene expression. Redox Biol 40:101845. | LEAK ROUTINE ET | ROX | Intact cells | Mouse | Other cell lines |
| Rossetti 2021 Sci Adv | 2021 | Rossetti G, Ermer JA, Stentenbach M, Siira SJ, Richman TR, Milenkovic D, Perks KL, Hughes LA, Jamieson E, Xiafukaiti G, Ward NC, Takahashi S, Gray N, Viola HM, Hool LC, Rackham O, Filipovska A (2021) A common genetic variant of a mitochondrial RNA processing enzyme predisposes to insulin resistance. Sci Adv 7:eabi7514. | LEAK OXPHOS ET | F N S ROX | Isolated mitochondria | Mouse | Liver |
| Furihata 2021 Commun Biol | 2021 | Furihata T, Takada S, Kakutani N, Maekawa S, Tsuda M, Matsumoto J, Mizushima W, Fukushima A, Yokota T, Enzan N, Matsushima S, Handa H, Fumoto Y, Nio-Kobayashi J, Iwanaga T, Tanaka S, Tsutsui H, Sabe H, Kinugawa S (2021) Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure. Commun Biol 4:138. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Mouse | Heart |
| Chowdhury 2021 Cancers (Basel) | 2021 | Chowdhury SR, Peltier C, Hou S, Singh A, Johnston JB, Gibson SB, Marshall A, Banerji V (2021) Ex vivo mitochondrial respiration parallels biochemical response to ibrutinib in CLL cells. Cancers (Basel) 13:E354. | LEAK ROUTINE ET | ROX | Intact cells | Human | Lymphocyte |
| Akinbiyi 2021 Sci Rep | 2021 | Akinbiyi EO, Abramowitz LK, Bauer BL, Stoll MSK, Hoppel CL, Hsiao CP, Hanover JA, Mears JA (2021) Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass. Sci Rep 11:22106. | LEAK OXPHOS ET | F N S DQ CIV NS ROX | Permeabilized cells | ||
| Dunn 2021 Arterioscler Thromb Vasc Biol | 2021 | Dunn LL, Kong SMY, Tumanov S, Chen W, Cantley J, Ayer A, Maghzal GJ, Midwinter RG, Chan KH, Ng MKC, Stocker R (2021) Hmox1 (heme oxygenase-1) protects against ischemia-mediated injury via stabilization of HIF-1α (hypoxia-inducible factor-1α). Arterioscler Thromb Vasc Biol 41:317-30. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Bischof 2021 Sci Transl Med | 2021 | Bischof C, Mirtschink P, Yuan T, Wu M, Zhu C, Kaur J, Pham MD, Gonzalez-Gonoggia S, Hammer M, Rogg EM, Sharma R, Bottermann K, Gercken B, Hagag E, Berthonneche C, Sossalla S, Stehr SN, Maxeiner J, Duda MA, Latreille M, Zamboni N, Martelli F, Pedrazzini T, Dimmeler S, Krishnan J (2021) Mitochondrial-cell cycle cross-talk drives endoreplication in heart disease. Sci Transl Med 13:eabi7964. | LEAK OXPHOS ET | S | |||
| Cannon 2021 Respir Physiol Neurobiol | 2021 | Cannon DT, Nogueira L, Gutierrez-Gonzalez AK, Gilmore NK, Bigby TD, Breen EC (2021) Role of IL-33 receptor (ST2) deletion in diaphragm contractile and mitochondrial function in the Sugen5416/hypoxia model of pulmonary hypertension. Respir Physiol Neurobiol 295:103783. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Lei 2021 Ecotoxicol Environ Saf | 2021 | Lei C, Liao J, Li Q, Shi J, Zhang H, Guo J, Han Q, Hu L, Li Y, Pan J, Tang Z (2021) Copper induces mitochondria-mediated apoptosis via AMPK-mTOR pathway in hypothalamus of pigs. Ecotoxicol Environ Saf 220:112395. | LEAK OXPHOS ET | N S ROX | Pig | Nervous system | |
| McKenna 2021 Redox Biol | 2021 | McKenna HT, O'Brien KA, Fernandez BO, Minnion M, Tod A, McNally BD, West JA, Griffin JL, Grocott MP, Mythen MG, Feelisch M, Murray AJ, Martin DS (2021) Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness. Redox Biol 41:101907. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Schmidt 2021 Cancer Metab | 2021 | Schmidt CA, McLaughlin KL, Boykov IN, Mojalagbe R, Ranganathan A, Buddo KA, Lin CT, Fisher-Wellman KH, Neufer PD (2021) Aglycemic growth enhances carbohydrate metabolism and induces sensitivity to menadione in cultured tumor-derived cells. Cancer Metab 9:3. | LEAK OXPHOS ET | N S Gp CIV ROX | Isolated mitochondria | Human | Liver |
| Ljubojevic-Holzer 2021 Cardiovasc Res | 2021 | Ljubojevic-Holzer S, Kraler S, Djalinac N, Abdellatif M, Voglhuber J, Schipke J, Schmidt M, Kling KM, Franke GT, Herbst V, Zirlik A, von Lewinski D, Scherr D, Rainer PP, Kohlhaas M, Nickel A, Muehlfeld C, Maack C, Sedej S (2021) Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca2+ cycling. https://doi.org/10.1093/cvr/cvab112 | LEAK OXPHOS ET | F N | Isolated mitochondria | Mouse | Heart |
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| Pamenter 2021 Biol Lett | 2021 | Pamenter ME, Gomez CR, Richards JG, Milsom WK (2021) Mitochondrial responses to prolonged anoxia in brain of red-eared slider turtles. Biol Lett 12:20150797. | LEAK OXPHOS ET | N S CIV ROX | Permeabilized cells | Reptiles | Nervous system |
| Vernerova 2021 Biomedicines | 2021 | Vernerova A, Garcia-Souza LF, Soucek O, Kostal M, Rehacek V, Krcmova LK, Gnaiger E, Sobotka O (2021) Mitochondrial respiration of platelets: comparison of isolation methods. https://doi.org/10.3390/biomedicines9121859 | LEAK ROUTINE ET | ROX | Intact cells | Human | Platelet |
| Chang 2021 J Fungi (Basel) | 2021 | Chang CK, Kao MC, Lan CY (2021) Antimicrobial activity of the peptide LfcinB15 against Candida albicans. J Fungi (Basel) 7:519. | ET ROUTINE | Intact cells | Fungi | ||
| Leo 2021 Conserv Physiol | 2021 | Leo E, Dahlke FT, Storch D, Poertner HO, Mark FC (2021) Impact of ocean acidification and warming on the bioenergetics of developing eggs of atlantic herring Clupea harengus. Conserv Physiol 6:50. | ET | N ROX NS | Intact organism | Fishes | |
| Sun 2021 J Genet Genomics | 2021 | Sun Y, Wei X, Fang F, Shen Y, Wei H, Li J, Ye X, Zhan Y, Ye X, Liu X, Yang W, Li Y, Geng X, Huang X, Ruan Y, Qin Z, Yi S, Lyu J, Fang H, Yu Y (2021) HPDL deficiency causes a neuromuscular disease by impairing the mitochondrial respiration. J Genet Genomics 48:727-36. | LEAK ROUTINE ET | N S NS | Permeabilized cells Intact cells | Human | HeLa Lymphocyte |
| Schroeder 2021 Cell Rep | 2021 | Schroeder S, Hofer SJ, Zimmermann A, Pechlaner R, Dammbrueck C, Pendl T, Marcello GM, Pogatschnigg V, Bergmann M, Mueller M, Gschiel V, Ristic S, Tadic J, Iwata K, Richter G, Farzi A, Uecal M, Schaefer U, Poglitsch M, Royer P, Mekis R, Agreiter M, Toelle RC, Sotonyi P, Willeit J, Mairhofer B, Niederkofler H, Pallhuber I, Rungger G, Tilg H, Defrancesco M, Marksteiner J, Sinner F, Magnes C, Pieber TR, Holzer P, Kroemer G, Carmona-Gutierrez D, Scorrano L, Dengjel J, Madl T, Sedej S, Sigrist SJ, Racz B, Kiechl S, Eisenberg T, Madeo F (2021) Dietary spermidine improves cognitive function. Cell Rep 35:108985. | LEAK OXPHOS ET | N NS ROX S | Homogenate | Mouse Drosophila | Nervous system |
| Santana-Roman 2021 Insects | 2021 | Santana-Román ME, Maycotte P, Uribe-Carvajal S, Uribe-Alvarez C, Alvarado-Medina N, Khan M, Siddiqui A, Pando-Robles V (2021) Monitoring mitochondrial function in Aedes albopictus C6/36 cell line during dengue virus infection. Insects 12:934. | LEAK OXPHOS ET | S | Permeabilized cells | ||
| Tungtur 2021 Sci Rep | 2021 | Tungtur SK, Wilkins HM, Rogers RS, Badawi Y, Sage JM, Agbas A, Jawdat O, Barohn RJ, Swerdlow RH, Nishimune H (2021) Oxaloacetate treatment preserves motor function in SOD1G93A mice and normalizes select neuroinflammation-related parameters in the spinal cord. Sci Rep 11:11051. | LEAK OXPHOS ET | N ROX | Isolated mitochondria | Mouse | Nervous system |
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| Souza 2021 PLoS Pathog | 2021 | Souza ROO, Damasceno FS, Marsiccobetre S, Biran M, Murata G, Curi R, Bringaud F, Silber AM (2021) Fatty acid oxidation participates in resistance to nutrient-depleted environments in the insect stages of Trypanosoma cruzi. PLoS Pathog 17:1009495. | LEAK ET | Intact cells | Other cell lines | ||
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| Dorigatti 2021 Geroscience | 2021 | Dorigatti JD, Thyne KM, Ginsburg BC, Salmon AB (2021) Beta-guanidinopropionic acid has age-specific effects on markers of health and function in mice. Geroscience 43:1497-511. | LEAK OXPHOS ET | N S NS ROX F | Permeabilized tissue | Mouse | Skeletal muscle |
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| Scheffer 2021 Brain Commun | 2021 | Scheffer DDL, Freitas FC, Aguiar AS Jr, Ward C, Guglielmo LGA, Prediger RD, Cronin SJF, Walz R, Andrews NA, Latini A (2021) Impaired dopamine metabolism is linked to fatigability in mice and fatigue in Parkinson's disease patients. Brain Commun 3:fcab116. | LEAK ROUTINE ET | ROX | Intact cells | Rat | Skeletal muscle |
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| Zunica 2021 Cancer Metab | 2021 | Zunica ERM, Axelrod CL, Cho E, Spielmann G, Davuluri G, Alexopoulos SJ, Beretta M, Hoehn KL, Dantas WS, Stadler K, King WT, Pergola K, Irving BA, Langohr IM, Yang S, Hoppel CL, Gilmore LA, Kirwan JP (2021) Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15. Cancer Metab 9:36. | LEAK OXPHOS ET | N S CIV NS ROX F DQ | Permeabilized cells Homogenate | Human Mouse | Endothelial;epithelial;mesothelial cell |
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| Zhang 2021 Pharmaceutics | 2021 | Zhang H, Zhang A, Gupte AA, Hamilton DJ (2021) Plumbagin elicits cell-specific cytotoxic effects and metabolic responses in melanoma cells. Pharmaceutics 13:706. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Endothelial;epithelial;mesothelial cell Other cell lines |
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| Brito 2021 BMC Cancer | 2021 | Brito A, Merle C, Lagarde P, Faustin B, Devin A, Lartigue L, Chibon F (2021) Cell fusion enhances energy metabolism of mesenchymal tumor hybrid cells to sustain their proliferation and invasion. BMC Cancer 21:863. | LEAK ET | N | Intact cells | Human | Fibroblast |
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| Elliehausen 2021 Exp Gerontol | 2021 | Elliehausen CJ, Minton DM, Nichol AD, Konopka AR (2021) Skeletal muscle mitochondrial respiration in a model of age-related osteoarthritis is impaired after dietary rapamycin. https://doi.org/10.1016/j.exger.2021.111579 | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Guinea pig | Skeletal muscle |
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| Flouda 2021 Free Radic Biol Med | 2021 | Flouda K, Mercer J, Davies MJ, Hawkins CL (2021) Role of myeloperoxidase-derived oxidants in the induction of vascular smooth muscle cell damage. Free Radic Biol Med 166:165-77. | LEAK ROUTINE ET | ROX | Intact cells | Human | Other cell lines |
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| Gratl 2021 J Transl Med | 2021 | Gratl A, Pesta D, Gruber L, Speichinger F, Raude B, Omran S, Greiner A, Frese JP (2021) The effect of revascularization on recovery of mitochondrial respiration in peripheral artery disease: a case control study. https://doi.org/10.1186/s12967-021-02908-0J | LEAK OXPHOS ET | F N NS | Permeabilized tissue | Human | Skeletal muscle |
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| Chambers 2021 JCI Insight | 2021 | Chambers KT, Cooper MA, Swearingen AR, Brookheart RT, Schweitzer GG, Weinheimer CJ, Kovacs A, Koves TR, Muoio DM, McCommis KS, Finck BN (2021) Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations. JCI Insight 6:134340. | LEAK OXPHOS ET | F N S | Permeabilized tissue | Mouse | Heart |
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| Avram 2021 Life (Basel) | 2021 | Avram VF, Bina AM, Sima A, Aburel OM, Sturza A, Burlacu O, Timar RZ, Muntean DM, Elmer E, Cretu OM (2021) Improvement of platelet respiration by cell-permeable succinate in diabetic patients treated with statins. Life (Basel) 11:288. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Platelet |
| Theall 2021 Physiol Rep | 2021 | Theall B, Stampley J, Cho E, Granger J, Johannsen NM, Irving BA, Spielmann G (2021) Impact of acute exercise on peripheral blood mononuclear cells nutrient sensing and mitochondrial oxidative capacity in healthy young adults. Physiol Rep 9:e15147. | LEAK ROUTINE OXPHOS ET | N NS ROX | Permeabilized cells Intact cells | Human | Blood cells |
| Mendham 2021 Diabetologia | 2021 | Mendham AE, Goedecke JH, Zeng Y, Larsen S, George C, Hauksson J, Fortuin-de Smidt MC, Chibalin AV, Olsson T, Chorell E (2021) Exercise training improves mitochondrial respiration and is associated with an altered intramuscular phospholipid signature in women with obesity. Diabetologia 64:1642-59. | LEAK OXPHOS ET | F N S NS ROX | Intact cells | Human | Skeletal muscle |
| Hoppel 2021 Cells | 2021 | Hoppel F, Garcia-Souza LF, Kantner-Rumplmair W, Burtscher M, Gnaiger E, Pesta D, Calabria E (2021) Human platelet mitochondrial function reflects systemic mitochondrial alterations: a protocol for application in field studies. https://doi.org/10.3390/cells10082088 | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Platelet |
| Brodnanova 2021 Eur J Pharmacol | 2021 | Brodnanova M, Hatokova Z, Evinova A, Cibulka M, Racay P (2021) Differential impact of imipramine on thapsigargin- and tunicamycin-induced endoplasmic reticulum stress and mitochondrial dysfunction in neuroblastoma SH-SY5Y cells. Eur J Pharmacol 902:174073. | LEAK ROUTINE ET | N S ROX | Permeabilized cells Intact cells | Human | Neuroblastoma |
| Alves 2021 Eur J Nutr | 2021 | Alves BL, Araújo TDR, Guimarães DSPSF, Zoppi CC, Figueiredo MS, Carneiro EM (2021) Amino acid restriction alters survival mechanisms in pancreatic beta cells: possible role of the PI3K/Akt pathway. Eur J Nutr 60:3947-57. | LEAK ROUTINE ET | ROX | Intact cells | Rat | Islet cell;pancreas;thymus |
| Van Polanen 2021 Physiol Rep | 2021 | van Polanen N, Zacharewicz E, de Ligt M, Timmers S, Moonen-Kornips E, Schaart G, Hoeks J, Schrauwen P, Hesselink MKC (2021) Resveratrol-induced remodelling of myocellular lipid stores: A study in metabolically compromised humans. Physiol Rep 9:e14692. | OXPHOS ET | F N | Permeabilized tissue | Human | Skeletal muscle |
| Goncalves 2021 Redox Biol | 2021 | Goncalves LS, Sales LP, Saito TR, Campos JC, Fernandes AL, Natali J, Jensen L, Arnold A, Ramalho L, Bechara LRG, Esteca MV, Correa I, Sant'Anna D, Ceroni A, Michelini LC, Gualano B, Teodoro W, Carvalho VH, Vargas BS, Medeiros MHG, Baptista IL, Irigoyen MC, Sale C, Ferreira JCB, Artioli GG (2021) Histidine dipeptides are key regulators of excitation-contraction coupling in cardiac muscle: evidence from a novel CARNS1 knockout rat model. Redox Biol 44:102016. | LEAK OXPHOS ET | NS | Isolated mitochondria | Rat | Heart |
| Rodrigues 2021 Sci Rep | 2021 | Rodrigues AQ, Picolo VL, Goulart JT, Silva IMG, Ribeiro RB, Aguiar BA, Ferreira YB, Oliveira DM, Lucci CM, de Bem AF, Paulini F (2021) Metabolic activity in cryopreserved and grafted ovarian tissue using high-resolution respirometry. Sci Rep 11:21517. | LEAK OXPHOS ET | S | Homogenate | Mouse | Genital |
| Vidimce 2021 Front Pharmacol | 2021 | Vidimce J, Pillay J, Shrestha N, Dong LF, Neuzil J, Wagner KH, Holland OJ, Bulmer AC (2021) Mitochondrial function, fatty acid metabolism, and body composition in the hyperbilirubinemic gunn rat. Front Pharmacol 12:586715. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue Homogenate | Rat | Skeletal muscle Liver |
| MacCannell 2021 Int J Obes (Lond) | 2021 | MacCannell ADV, Futers TS, Whitehead A, Moran A, Witte KK, Roberts LD (2021) Sexual dimorphism in adipose tissue mitochondrial function and metabolic flexibility in obesity. Int J Obes (Lond) 45:1773-81. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Fat |
| Schumann 2021 Commun Biol | 2021 | Schumann T, Koenig J, von Loeffelholz C, Vatner DF, Zhang D, Perry RJ, Bernier M, Chami J, Henke C, Kurzbach A, El-Agroudy NN, Willmes DM, Pesta D, de Cabo R, O Sullivan JF, Simon E, Shulman GI, Hamilton BS, Birkenfeld AL (2021) Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance. Commun Biol 4:826. | LEAK ROUTINE OXPHOS ET | F N NS ROX | Intact cells | Mouse | Liver |
| Friederich 2021 Mol Genet Metab | 2021 | Friederich MW, Geddes GC, Wortmann SB, Punnoose A, Wartchow E, Knight KM, Prokisch H, Creadon-Swindell G, Mayr JA, Van Hove JLK (2021) Pathogenic variants in MRPL44 cause infantile cardiomyopathy due to a mitochondrial translation defect. Mol Genet Metab 133:362-71. | LEAK OXPHOS ET | N | Human | Fibroblast | |
| Branco Haas 2021 Thesis | 2021 | Branco Haas C (2021) Insulin signaling and microglia in the young and aged brain. PhD Thesis 135. | LEAK OXPHOS ET | N ROX | Intact cells | ||
| Moon 2021 J Lipid Res | 2021 | Moon SH, Dilthey BG, Liu X, Guan S, Sims HF, Gross RW (2021) High-Fat diet activates liver iPLA2γ generating eicosanoids that mediate metabolic stress. J Lipid Res 62:100052. | LEAK OXPHOS ET | N S NS | Isolated mitochondria | Mouse | Liver |
| Young 2021 J Biol Chem | 2021 | Young MP, Schug ZT, Booth DM, Yule DI, Mikoshiba K, Hajnóczky G, Joseph SK (2021) Metabolic adaptation to the chronic loss of Ca2+ signaling induced by knockout of IP 3 receptors or the mitochondrial Ca2+ uniporter. J Biol Chem 298:101436. | LEAK ROUTINE ET | ROX | Intact cells | Human | HEK HeLa |
| Garcia 2021 J Steroid Biochem Mol Biol | 2021 | Garcia AM, Bishop EL, Li D, Jeffery LE, Garten A, Thakker A, Certo M, Mauro C, Tennant DA, Dimeloe S, Evelo CT, Coort SL, Hewison M (2021) Tolerogenic effects of 1,25-dihydroxyvitamin D on dendritic cells involve induction of fatty acid synthesis. J Steroid Biochem Mol Biol 211:105891. | LEAK ET | ROX | Intact cells | Human | Nervous system |
| Dubinin 2021 Membranes (Basel) | 2021 | Dubinin MV, Semenova AA, Nedopekina DA, Davletshin EV, Spivak AY, Belosludtsev KN (2021) Effect of F16-betulin conjugate on mitochondrial membranes and its role in cell death initiation. Membranes (Basel) 11:352. | LEAK OXPHOS ET | N S | Isolated mitochondria | Rat | Liver |
| Ayer 2021 Redox Biol | 2021 | Ayer A, Fazakerley DJ, Suarna C, Maghzal GJ, Sheipouri D, Lee KJ, Bradley MC, Fernández-Del-Rio L, Tumanov S, Kong SM, van der Veen JN, Yang A, Ho JWK, Clarke SG, James DE, Dawes IW, Vance DE, Clarke CF, Jacobs RL, Stocker R (2021) Genetic screening reveals phospholipid metabolism as a key regulator of the biosynthesis of the redox-active lipid coenzyme Q. Redox Biol 46:102127. | ROUTINE ET | Intact organism | Saccharomyces cerevisiae | ||
| Saura-Esteller 2021 Int J Mol Sci | 2021 | Saura-Esteller J, Sánchez-Vera I, Núñez-Vázquez S, Cosialls AM, Gama-Pérez P, Bhosale G, Mendive-Tapia L, Lavilla R, Pons G, Garcia-Roves PM, Duchen MR, Iglesias-Serret D, Gil J (2021) Activation of the integrated stress response and ER stress protect from fluorizoline-induced apoptosis in HEK293T and U2OS cell lines. Int J Mol Sci 22:6117. | LEAK ROUTINE ET | ROX | Intact cells | Human | Lymphocyte |
| Valera-Alberni 2021 Cell Rep | 2021 | Valera-Alberni M, Joffraud M, Miro-Blanch J, Capellades J, Junza A, Dayon L, Núñez Galindo A, Sanchez-Garcia JL, Valsesia A, Cercillieux A, Söllner F, Ladurner AG, Yanes O, Cantó C (2021) Crosstalk between Drp1 phosphorylation sites during mitochondrial remodeling and their impact on metabolic adaptation. Cell Rep 36:109565. | LEAK OXPHOS ET | N S NS ROX | Homogenate Isolated mitochondria | Mouse | Liver Fat |
| Pesta 2021 Front Endocrinol (Lausanne) | 2021 | Pesta D, Jelenik T, Zaharia OP, Bobrov P, Görgens S, Bódis K, Karusheva Y, Krako Jakovljevic N, Lalic NM, Markgraf DF, Burkart V, Müssig K, Knebel B, Kotzka J, Eckel J, Strassburger K, Szendroedi J, Roden M (2021) NDUFB6 polymorphism is associated with physical activity-mediated metabolic changes in type 2 diabetes. https://doi.org/10.3389/fendo.2021.693683 | LEAK OXPHOS ET | F N | Permeabilized cells | Mouse | Skeletal muscle |
| Daura 2021 Neurobiol Dis | 2021 | Daura E, Tegelberg S, Yoshihara M, Jackson C, Simonetti F, Aksentjeff K, Ezer S, Hakala P, Katayama S, Kere J, Lehesjoki AE, Joensuu T (2021) Cystatin B-deficiency triggers ectopic histone H3 tail cleavage during neurogenesis. Neurobiol Dis 156:105418. | LEAK OXPHOS ET | N CIV NS | Permeabilized cells | Mouse | Stem cells Nervous system |
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| Hassan 2020 MitoFit Preprint Arch | 2020-04-30 | Hassan Hazirah, Gnaiger Erich, Zakaria Fazaine, Makpol Suzana, Abdul Karim Norwahidah (2020) Alterations in mitochondrial respiratory capacity and membrane potential: a link between mitochondrial dysregulation and autism. https://doi.org/10.26124/mitofit:200003 | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | |
| Russell 2020 Nutrients | 2020 | Russell JS, Griffith TA, Naghipour S, Vider J, Du Toit EF, Patel HH, Peart JN, Headrick JP (2020) Dietary α-linolenic acid counters cardioprotective dysfunction in diabetic mice: unconventional PUFA protection. Nutrients 12:E2679. | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
| Schoepf 2020 Nat Commun | 2020 | Schöpf Bernd, Weissensteiner Hansi, Schäfer Georg, Fazzini Federica, Charoentong Pornpimol, Naschberger Andreas, Rupp Bernhard, Fendt Liane, Bukur Valesca, Giese Irina, Sorn Patrick, Sant’Anna-Silva Ana Carolina, Iglesias-Gonzalez Javier, Sahin Ugur, Kronenberg Florian, Gnaiger Erich, Klocker Helmut (2020) OXPHOS remodeling in high-grade prostate cancer involves mtDNA mutations and increased succinate oxidation. https://doi.org/10.1038/s41467-020-15237-5 | LEAK ROUTINE OXPHOS ET | N S NS | Permeabilized cells Permeabilized tissue | Human | Genital Other cell lines |
| Keller 2020 Oxid Med Cell Longev | 2020 | Keller Amy, Hull Sara E, Elajaili Hanan, Johnston Aspen, Knaub Leslie A, Chun Ji hye, Walker Lori, Nozik-Grayck Eva, Reusch Jane EB (2020) (–)-Epicatechin modulates mitochondrial redox in vascular cell models of oxidative stress. Oxid Med Cell Longev 2020:6392629. | LEAK OXPHOS ET | N NS | Permeabilized cells | Human | Endothelial;epithelial;mesothelial cell |
| Wei 2020 Cell Rep | 2020 | Wei X, Lu Z, Li L, Zhang H, Sun F, Ma H, Wang L, Hu Y, Yan Z, Zheng H, Yang G, Liu D, Tepel M, Gao P, Zhu Z (2020) Reducing NADPH synthesis counteracts diabetic nephropathy through restoration of AMPK activity in type 1 diabetic rats. Cell Rep 32:108207. | LEAK OXPHOS ET | F N S NS ROX | Isolated mitochondria | Rat | Kidney |
| Cassereau 2020 Exp Neurol | 2020 | Cassereau J, Chevrollier A, Codron P, Goizet C, Gueguen N, Verny C, Reynier P, Bonneau D, Lenaers G, Procaccio V (2020) Oxidative stress contributes differentially to the pathophysiology of Charcot-Marie-Tooth disease type 2K. Exp Neurol 323:113069. | LEAK OXPHOS ET | N S NS | Permeabilized cells | Human | Fibroblast |
| Burgin 2020 Int J Mol Sci | 2020 | Burgin HJ, Lopez Sanchez MIG, Smith CM, Trounce IA, McKenzie M (2020) Pioglitazone and deoxyribonucleoside combination treatment increases mitochondrial respiratory capacity in m.3243A>G MELAS cybrid cells. Int J Mol Sci 21:E2139. | LEAK ROUTINE ET | ROX | Intact cells | Human | Other cell lines |
| Karabatsiakis 2020 Transl Psychiatry | 2020 | Karabatsiakis DA, Schönfeldt-Lecuona PDC (2020) Depression, mitochondrial bioenergetics, and electroconvulsive therapy: a new approach towards personalized medicine in psychiatric treatment - a short review and current perspective. Transl Psychiatry 10:226. | LEAK ROUTINE ET | ROX | Intact cells | Human | Blood cells |
| Palavicini 2020 JCI Insight | 2020 | Palavicini JP, Chen J, Wang C, Wang J, Qin C, Baeuerle E, Wang X, Woo JA, Kang DE, Musi N, Dupree JL, Han X (2020) Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes. JCI Insight 5:137286. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Mouse | Nervous system |
| Lin 2020 EBioMedicine | 2020 | Lin Y, Nan J, Shen J, Lv X, Chen X, Lu X, Zhang C, Xiang P, Wang Z, Li Z (2020) Canagliflozin impairs blood reperfusion of ischaemic lower limb partially by inhibiting the retention and paracrine function of bone marrow derived mesenchymal stem cells. EBioMedicine 52:102637. | ROUTINE ET | Intact cells | Mouse | Stem cells | |
| Chen 2020 Biochim Biophys Acta Mol Basis Dis | 2020 | Chen T, Hill JT, Moore TM, Cheung ECK, Olsen ZE, Piorczynski TB, Marriott TD, Tessem JS, Walton CM, Bikman BT, Hansen JM, Thomson DM (2020) Lack of skeletal muscle liver kinase B1 alters gene expression, mitochondrial content, inflammation and oxidative stress without affecting high-fat diet-induced obesity or insulin resistance. Biochim Biophys Acta Mol Basis Dis 1866:165805. | LEAK OXPHOS ET | N NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Smith 2020 J Biol Chem | 2020 | Smith CD, Schmidt CA, Lin CT, Fisher-Wellman KH, Neufer PD (2020) Flux through mitochondrial redox circuits linked to nicotinamide nucleotide transhydrogenase generates counterbalance changes in energy expenditure. J Biol Chem 295:16207-16. | LEAK OXPHOS ET | F N | Isolated mitochondria | Mouse | Skeletal muscle |
| Marquez 2020 J Am Heart Assoc | 2020 | Marquez AM, Morgan RW, Ko T, Landis WP, Hefti MM, Mavroudis CD, McManus MJ, Karlsson M, Starr J, Roberts AL, Lin Y, Nadkarni V, Licht DJ, Berg RA, Sutton RM, Kilbaugh TJ (2020) Oxygen exposure during cardiopulmonary resuscitation is associated with cerebral oxidative injury in a randomized, blinded, controlled, preclinical trial. J Am Heart Assoc 9:015032. | LEAK OXPHOS ET | N S CIV NS | Homogenate | Pig | Nervous system |
| Cornelissen 2020 Hum Mol Genet | 2020 | Cornelissen T, Spinazzi M, Martin S, Imberechts D, Vangheluwe P, Bird M, De Strooper B, Vandenberghe W (2020) CHCHD2 harboring the Parkinson's disease-linked T61I mutation precipitates inside mitochondria and induces precipitation of wild-type CHCHD2. Hum Mol Genet 29:1096-106. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Fibroblast |
| Messner 2020 Thesis | 2020 | Messner M (2020) Sorafenib resistance of hepatocellular carcinoma. PhD Thesis 130. | LEAK ROUTINE ET | ROX | Intact cells | Human | Liver |
| Ferreira 2020 PLoS Genet | 2020 | Ferreira N, Andoniou CE, Perks KL, Ermer JA, Rudler DL, Rossetti G, Periyakaruppiah A, Wong JKY, Rackham O, Noakes PG, Degli-Esposti MA, Filipovska A (2020) Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease. PLoS Genet 16:e1008604. | LEAK OXPHOS ET | N ROX | Isolated mitochondria | Mouse | Liver |
| Fisher 2020 Placenta | 2020 | Fisher J, McKeating D, Pennell E, Cuffe J, Holland O, Perkins A (2020) Mitochondrial isolation, cryopreservation and preliminary biochemical characterisation from placental cytotrophoblast and syncytiotrophoblast. Placenta 82:1-4. | LEAK OXPHOS ET | N NS ROX | Isolated mitochondria | Human | Genital |
| Alahmad 2020 EMBO Mol Med | 2020 | Alahmad A, Nasca A, Heidler J, Thompson K, Oláhová M, Legati A, Lamantea E, Meisterknecht J, Spagnolo M, He L, Alameer S, Hakami F, Almehdar A, Ardissone A, Alston CL, McFarland R, Wittig I, Ghezzi D, Taylor RW (2020) Bi-allelic pathogenic variants in NDUFC2 cause early-onset Leigh syndrome and stalled biogenesis of complex I. EMBO Mol Med 12:e12619. | LEAK ROUTINE ET | ROX | Intact cells | Human | Fibroblast |
| Tichanek 2020 Sci Rep | 2020 | Tichanek F, Salomova M, Jedlicka J, Kuncova J, Pitule P, Macanova T, Petrankova Z, Tuma Z, Cendelin J (2020) Hippocampal mitochondrial dysfunction and psychiatric-relevant behavioral deficits in spinocerebellar ataxia 1 mouse model. Sci Rep 10:5418. | LEAK OXPHOS ET | N S CIV NS ROX | Homogenate | Mouse | Nervous system |
| Nascimento-Dos-Santos 2020 Biochim Biophys Acta Mol Basis Dis | 2020 | Nascimento-Dos-Santos G, de-Souza-Ferreira E, Lani R, de Faria CC, Araujo VG, Teixeira-Pinheiro LC, de Souza Vasconcelos T, Leandro TG, Santiago MF, Linden R, Galina A, Petrs-Silva H (2020) Neuroprotection from optic nerve injury and modulation of oxidative metabolism by transplantation of active mitochondria to the retina. Biochim Biophys Acta Mol Basis Dis 1866:165686. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Isolated mitochondria Intact cells | Rat | Liver Nervous system |
| Boel 2020 J Exp Biol | 2020 | Boël M, Romestaing C, Duchamp C, Veyrunes F, Renaud S, Roussel D, Voituron Y (2020) Improved mitochondrial coupling as a response to high mass-specific metabolic rate in extremely small mammals. J Exp Biol 223:jeb215558. | LEAK ET | N NS | Permeabilized tissue | Mouse | Skeletal muscle |
| Pelster 2020 PLoS One | 2020 | Pelster B, Wood CM, Campos DF, Val AL (2020) Cellular oxygen consumption, ROS production and ROS defense in two different size-classes of an Amazonian obligate air-breathing fish (Arapaima gigas). PLoS One 15:e0236507. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Fishes | Kidney Lung;gill |
| Wen 2020 Biomedicines | 2020 | Wen JJ, Cummins CB, Williams TP, Radhakrishnan RS (2020) The genetic evidence of burn-induced cardiac mitochondrial metabolism dysfunction . Biomedicines 8:E566. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Rat | Heart |
| Ehrlicher 2020 FASEB J | 2020 | Ehrlicher SE, Stierwalt HD, Miller BF, Newsom SA, Robinson MM (2020) Mitochondrial adaptations to exercise do not require Bcl2-mediated autophagy but occur with BNIP3/Parkin activation. FASEB J 34:4602-18. | LEAK OXPHOS ET | F N S NS | Isolated mitochondria | Mouse | Skeletal muscle |
| Lozano 2020 Part Fibre Toxicol | 2020 | Lozano O, Silva-Platas C, Chapoy-Villanueva H, Pérez BE, Lees JG, Ramachandra CJA, Contreras-Torres FF, Lázaro-Alfaro A, Luna-Figueroa E, Bernal-Ramírez J, Gordillo-Galeano A, Benitez A, Oropeza-Almazán Y, Castillo EC, Koh PL, Hausenloy DJ, Lim SY, García-Rivas G (2020) Amorphous SiO2 nanoparticles promote cardiac dysfunction via the opening of the mitochondrial permeability transition pore in rat heart and human cardiomyocytes. Part Fibre Toxicol 17:15. | LEAK OXPHOS ET | S | Isolated mitochondria | Rat | Heart |
| D'Souza 2020 Nutrients | 2020 | D'Souza K, Mercer A, Mawhinney H, Pulinilkunnil T, Udenigwe CC, Kienesberger PC (2020) Whey peptides stimulate differentiation and lipid metabolism in adipocytes and ameliorate lipotoxicity-induced insulin resistance in muscle cells. Nutrients 12:E425. | LEAK ET | F N | Permeabilized cells | Mouse | Skeletal muscle Fat |
| Beninca 2020 J Med Genet | 2020 | Beninca C, Zanette V, Brischigliaro M, Johnson M, Reyes A, Valle DAD, Robinson AJ, Degiorgi A, Yeates A, Telles BA, Prudent J, Baruffini E, Santos ML, de Souza RL, Fernandez-Vizarra E, Whitworth A, Zeviani M (2020) Mutation in the MICOS subunit gene APOO (MIC26) associated with an X-linked recessive mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features. J Med Genet 58:155-67. | LEAK ROUTINE ET | Intact cells | Human | Fibroblast | |
| Rodrigues 2020 J Appl Physiol (1985) | 2020 | Rodrigues GC, Rocha NN, Maia LA, Melo I, Simões AC, Antunes MA, Bloise FF, Woyames J, da-Silva WS, Capelozzi VL, Abela G, Ball L, Pelosi P, Rocco PRM, Silva PL (2020) Impact of experimental obesity on diaphragm structure, function and bioenergetics. J Appl Physiol (1985) 129:1062-74. | LEAK OXPHOS ET | N CIV NS | Permeabilized tissue | Rat | Skeletal muscle |
| Bloise 2020 Thyroid | 2020 | Bloise FF, Santos AT, Brito JT, Andrade CBV, Oliveira TS, Souza AF, Fontes KN, Silva JD, Blanco NG, Silva PL, Rocco PRM, Fliers E, Boelen A, da-Silva WS, Ortiga-Carvalho TM (2020) Sepsis impairs thyroid hormone signaling and mitochondrial function in the mouse diaphragm. Thyroid 30:1079-90. | LEAK OXPHOS ET | N CIV NS | Permeabilized tissue | Mouse | Skeletal muscle |
| Silva Ferraz 2020 Biochem Pharmacol | 2020 | Silva Ferraz L, Torres da Costa R, Alves da Costa C, Augusto João Ribeiro C, Costa Arruda D, Stuchi Maria-Engler S, Rodrigues T (2020) Targeting mitochondria in melanoma: interplay between MAPK signaling pathway and mitochondrial dynamics . Biochem Pharmacol 178:114104. | LEAK ROUTINE ET | Intact cells | Human | Endothelial;epithelial;mesothelial cell | |
| Vanweert 2020 J Clin Endocrinol Metab | 2020 | Vanweert F, de Ligt M, Hoeks J, Hesselink MKC, Schrauwen P, Phielix E (2020) Elevated plasma branched-chain amino acid levels correlate with type 2 diabetes-related metabolic disturbances. J Clin Endocrinol Metab 106:e1827-36. | LEAK OXPHOS ET | F N | Permeabilized tissue | Human | Skeletal muscle |
| Courtes 2020 Brain Res Bull | 2020 | Courtes AA, Gonçalves DF, Hartmann DD, da Rosa PC, Cassol G, Royes LFF, de Carvalho NR, Soares FAA (2020) Guanosine protects against behavioural and mitochondrial bioenergetic alterations after mild traumatic brain injury. Brain Res Bull 163:31-39. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Rat | Nervous system |
| Piel 2020 FEBS J | 2020 | Piel MS, Masscheleyn S, Bouillaud F, Moncoq K, Miroux B (2020) Structural models of mitochondrial uncoupling proteins obtained in DPC micelles are not functionally relevant. FEBS J 288:3024-33. | LEAK OXPHOS ET | Permeabilized cells | Saccharomyces cerevisiae | ||
| Shi 2020 Diabetes | 2020 | Shi JH, Lu JY, Chen HY, Wei CC, Xu X, Li H, Bai Q, Xia FZ, Lam SM, Zhang H, Shi YN, Cao D, Chen L, Shui G, Yang X, Lu Y, Chen YX, Zhang WJ (2020) Liver ChREBP protects against fructose-induced glycogenic hepatotoxicity by regulating L-type pyruvate kinase. Diabetes 120:29. | LEAK ROUTINE ET | Intact cells | Mouse | Liver | |
| Souza da Silva 2020 Mol Neurobiol | 2020 | Souza da Silva J, Nonose Y, Rohden F, Lukasewicz Ferreira PC, Fontella FU, Rocha A, Wigner Brochier A, Vieira Apel R, de Lima TM, Seminotti B, Amaral AU, Galina A, Souza DO (2020) Guanosine neuroprotection of presynaptic mitochondrial calcium homeostasis in a mouse study with amyloid-β oligomers. Mol Neurobiol 57:4790-809. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse | Nervous system |
| Zavadskis 2020 Pharmaceutics | 2020 | Zavadskis S, Weidinger A, Hanetseder D, Banerjee A, Schneider C, Wolbank S, Marolt Presen D, Kozlov AV (2020) Effect of diphenyleneiodonium chloride on intracellular reactive oxygen species metabolism with emphasis on NADPH oxidase and mitochondria in two therapeutically relevant human cell types. Pharmaceutics 13:E10. | LEAK OXPHOS ET | N S | Permeabilized cells | Human | Other cell lines |
| Doig 2020 Skelet Muscle | 2020 | Doig CL, Zielinska AE, Fletcher RS, Oakey LA, Elhassan YS, Garten A, Cartwright D, Heising S, Alsheri A, Watson DG, Prehn C, Adamski J, Tennant DA, Lavery GG (2020) Induction of the nicotinamide riboside kinase NAD+ salvage pathway in a model of sarcoplasmic reticulum dysfunction. Skelet Muscle 10:5. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Catalan-Garcia 2020 J Clin Med | 2020 | Catalán-García M, García-García FJ, Moreno-Lozano PJ, Alcarraz-Vizán G, Tort-Merino A, Milisenda JC, Cantó-Santos J, Barcos-Rodríguez T, Cardellach F, Lladó A, Novials A, Garrabou G, Grau-Junyent JM (2020) Mitochondrial dysfunction: A common hallmark underlying comorbidity between sIBM and other degenerative and age-related diseases. J Clin Med 9:E1446. | LEAK ET | Permeabilized cells | Human | Fibroblast | |
| Simard 2020 Metabolites | 2020 | Simard C, Lebel A, Allain EP, Touaibia M, Hebert-Chatelain E, Pichaud N (2020) Metabolic characterization and consequences of mitochondrial pyruvate carrier deficiency in Drosophila melanogaster. Metabolites 109:E363. | LEAK OXPHOS ET | N S Gp NS ROX | Permeabilized tissue | Drosophila | |
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| Khamoui 2020 Physiol Genomics | 2020 | Khamoui AV, Tokmina-Roszyk D, Rossiter HB, Fields GB, Visavadiya NP (2020) Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia. Physiol Genomics 52:203-16. | LEAK OXPHOS ET | N NS | Intact cells | Mouse | Liver |
| Vaccari 2020 Eur J Appl Physiol | 2020 | Vaccari F, Passaro A, D'Amuri A, Sanz JM, Di Vece F, Capatti E, Magnesa B, Comelli M, Mavelli I, Grassi B, Fiori F, Bravo G, Avancini A, Parpinel M, Lazzer S (2020) Effects of 3-month high-intensity interval training vs. moderate endurance training and 4-month follow-up on fat metabolism, cardiorespiratory function and mitochondrial respiration in obese adults. Eur J Appl Physiol 120:1787-803. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Human | Skeletal muscle |
| Simard 2020b Metabolites | 2020 | Simard CJ, Touaibia M, Allain EP, Hebert-Chatelain E, Pichaud N (2020) Role of the mitochondrial pyruvate carrier in the occurrence of metabolic inflexibility in Drosophila melanogaster exposed to dietary sucrose. Metabolites 10:E411. | LEAK OXPHOS ET | N Gp NS Other combinations ROX | Permeabilized tissue | Drosophila | |
| Ugarteburu 2020 J Clin Med | 2020 | Ugarteburu O, Sánchez-Vilés M, Ramos J, Barcos-Rodríguez T, Garrabou G, García-Villoria J, Ribes A, Tort F (2020) Physiopathological bases of the disease caused by HACE1 mutations: alterations in autophagy, mitophagy and oxidative stress response. J Clin Med 9:E913. | LEAK ROUTINE ET | ROX | Intact cells | Human | Fibroblast |
| Wefers 2020 Mol Metab | 2020 | Wefers J, Connell NJ, Fealy CE, Andriessen C, de Wit V, van Moorsel D, Moonen-Kornips E, Jörgensen JA, Hesselink MKC, Havekes B, Hoeks J, Schrauwen P (2020) Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals. Mol Metab 41:101050. | LEAK OXPHOS ET | F N NS | Permeabilized tissue | Human | Skeletal muscle |
| Fisher 2020 J Physiol | 2020 | Fisher JJ, Vanderpeet CL, Bartho LA, McKeating DR, Cuffe JSM, Holland OJ, Perkins AV (2020) Mitochondrial dysfunction in placental trophoblast cells experiencing gestational diabetes mellitus. J Physiol 599:1291-305. | OXPHOS ET | N NS ROX | Isolated mitochondria | Human | Genital |
| Woessner 2020 Thesis | 2020 | Woessner MN (2020) BEET-HF: The effects of dietary inorganic nitrate supplementation on aerobic exercise performance, vascular function, cardiac performance and mitochondrial respiration in patients with heart failure with reduced ejection fraction. PhD Thesis 198. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Lara-Marqueza 2020 J Funct Foods | 2020 | Lara-Márquez M, Báez-Magaña M, Raymundo-Ramos C, Spagnuolo PA, Macías-Rodríguez L, Salgado-Garciglia R, Ochoa-Zarzosa A, López-Meza JE (2020) Lipid-rich extract from Mexican avocado (Persea americana var. drymifolia) induces apoptosis and modulates the inflammatory response in Caco-2 human colon cancer cells. J Funct Foods 64:103658. | LEAK ROUTINE ET | Intact cells | Human | Endothelial;epithelial;mesothelial cell | |
| Zussman 2020 J Autoimmun | 2020 | Zussman R, Xu LY, Damani T, Groom KM, Chen Q, Seers B, Viall CA, Chamley LW, Hickey A (2020) Antiphospholipid antibodies can specifically target placental mitochondria and induce ROS production. J Autoimmun 111:102437. | LEAK ET | N S Gp CIV NS ROX | Permeabilized tissue | Human | Genital |
| Heinonen 2020 Sci Rep | 2020 | Heinonen I, Sorop O, van Dalen BM, Wüst RCI, van de Wouw J, de Beer VJ, Octavia Y, van Duin RWB, Hoogstrate Y, Blonden L, Alkio M, Anttila K, Stubbs A, van der Velden J, Merkus D, Duncker DJ (2020) Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement. Sci Rep 10:13173. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Pig | Heart |
| Pola 2020 Invest New Drugs | 2020 | Pola M, Kolarova H, Ruzicka J, Zholobenko A, Modriansky M, Mosinger J, Bajgar R (2020) Effects of zinc porphyrin and zinc phthalocyanine derivatives in photodynamic anticancer therapy under different partial pressures of oxygen in vitro. Invest New Drugs 39:89-97. | LEAK ROUTINE ET | ROX | Intact cells | Human | HeLa |
| Jayakumari 2020 J Diabetes | 2020 | Jayakumari NR, Rajendran RS, Sivasailam A, Vimala SS, Nanda S, Manjunatha S, Pillai VV, Karunakaran J, Gopala S (2020) Impaired substrate-mediated cardiac mitochondrial complex I respiration with unaltered regulation of fatty acid metabolism and oxidative stress status in type 2 diabetic Asian Indians. J Diabetes 12:542-55. | LEAK OXPHOS ET | F N S NS ROX | Isolated mitochondria | Human | Heart |
| Truong 2020 Cytokine | 2020 | Truong NTT, Lydic TA, Bazil JN, Suryadevara A, Olson LK (2020) Regulation of lipid metabolism in pancreatic beta cells by interferon gamma: a link to anti-viral function. Cytokine 133:155147. | LEAK ROUTINE ET | Intact cells | Rat | Islet cell;pancreas;thymus | |
| Gumpp 2020 Proc Natl Acad Sci U S A | 2020 | Gumpp AM, Boeck C, Behnke A, Bach AM, Ramo-Fernández L, Welz T, Gündel H, Kolassa IT, Karabatsiakis A (2020) Childhood maltreatment is associated with changes in mitochondrial bioenergetics in maternal, but not in neonatal immune cells. Proc Natl Acad Sci U S A 117:24778-84. | LEAK ROUTINE ET | ROX | Intact cells | Human | Blood cells |
| Oellermann 2020 Sci Rep | 2020 | Oellermann M, Hickey AJR, Fitzgibbon QP, Smith G (2020) Thermal sensitivity links to cellular cardiac decline in three spiny lobsters. Sci Rep 10:202. | LEAK OXPHOS ET | N S NS | Homogenate | Crustaceans | Heart |
| Hayes 2020 Nutrients | 2020 | Hayes P, Fergus C, Ghanim M, Cirzi C, Burtnyak L, McGrenaghan CJ, Tuorto F, Nolan DP, Kelly VP (2020) Queuine micronutrient deficiency promotes Warburg metabolism and reversal of the mitochondrial ATP synthase in HeLa cells. Nutrients 12:E871. | LEAK ROUTINE OXPHOS ET | N S Gp CIV ROX | Permeabilized cells Intact cells | Human | HeLa |
| Gnad 2020 Cell Metab | 2020 | Gnad T, Navarro G, Lahesmaa M, Reverte-Salisa L, Copperi F, Cordomi A, Naumann J, Hochhäuser A, Haufs-Brusberg S, Wenzel D, Suhr F, Jespersen NZ, Scheele C, Tsvilovskyy V, Brinkmann C, Rittweger J, Dani C, Kranz M, Deuther-Conrad W, Eltzschig HK, Niemi T, Taittonen M, Brust P, Nuutila P, Pardo L, Fleischmann BK, Blüher M, Franco R, Bloch W, Virtanen KA, Pfeifer A (2020) Adenosine/A2B receptor signaling ameliorates the effects of aging and counteracts obesity. Cell Metab 32:56-70.e7. | LEAK OXPHOS ET | N S | Permeabilized tissue | Mouse | Skeletal muscle |
| Tepp 2020 Biochim Biophys Acta Gen Subj | 2020 | Tepp K, Puurand M, Timohhina N, Aid-Vanakova J, Reile I, Shevchuk I, Chekulayev V, Eimre M, Peet N, Kadaja L, Paju K, Kaambre T (2020) Adaptation of striated muscles to Wolframin deficiency in mice: Alterations in cellular bioenergetics. Biochim Biophys Acta Gen Subj 1864:129523. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Mouse | Heart Skeletal muscle |
| Silaidos 2020 Mitochondrion | 2020 | Silaidos C, Grube J, Muley C, Eckert GP (2020) Time-dependent melatonin secretion is associated with mitochondrial function in peripheral blood mononuclear cells (PBMC) of male volunteers. Mitochondrion 53:21-29. | LEAK ROUTINE OXPHOS ET | N S CIV NS ROX | Permeabilized cells Intact cells | Human | Blood cells |
| Marrocco 2020 Thesis | 2020 | Marrocco A (2020) Alterations of CCSP expression and macrophages metabolism in the development of silica-induced pulmonary inflammation and fibrosis. PhD Thesis 108. | LEAK OXPHOS ET | S ROX | Intact cells | Mouse | Macrophage-derived |
| Rocha 2020 Sci Adv | 2020 | Rocha AL, de Lima TI, de Souza GP, Corrêa RO, Ferrucci DL, Rodrigues B, Lopes-Ramos C, Nilsson D, Knittel TL, Castro PR, Fernandes MF, Dos Santos Martins F, Parmigiani RB, Silveira LR, Carvalho HF, Auwerx J, Vinolo MAR, Boucher J, Mori MA (2020) Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression. Sci Adv 6:eabc6250. | LEAK ROUTINE ET | ROX | Intact cells | Mouse | Fat |
| Ost 2020 EMBO Rep | 2020 | Ost M, Igual Gil C, Coleman V, Keipert S, Efstathiou S, Vidic V, Weyers M, Klaus S (2020) Muscle-derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress. EMBO Rep 21:e48804. | LEAK OXPHOS ET | N NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Makrecka-Kuka 2020 Cardiovasc Drugs Ther | 2020 | Makrecka-Kuka Marina, Korzh Stanislava, Videja Melita, Vilks Karlis, Cirule Helena, Kuka Janis, Dambrova Maija, Liepinsh Edgars (2020) Empagliflozin protects cardiac mitochondrial fatty acid metabolism in a mouse model of diet-induced lipid overload. Cardiovasc Drugs Ther 34:791-97. | OXPHOS ET | F N S NS ROX | Permeabilized tissue | Mouse | Heart |
| Owiredu 2020 Toxicol Rep | 2020 | Owiredu S, Ranganathan A, Greenwood JC, Piel S, Janowska JI, Eckmann DM, Kelly M, Ehinger JK, Kilbaugh TJ, Jang DH (2020) In vitro comparison of hydroxocobalamin (B12a) and the mitochondrial directed therapy by a succinate prodrug in a cellular model of cyanide poisoning. Toxicol Rep 7:1263-71. | ROUTINE ET | CIV ROX | Intact cells | Human | Blood cells Other cell lines |
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| Garcia 2020 Mol Hum Reprod | 2020 | Garcia BM, Machado TS, Carvalho KF, Nolasco P, Nociti RP, Del Collado M, Capo Bianco MJD, Grejo MP, Neto JDA, Sugiyama FHC, Tostes K, Pandey AK, Gonçalves LM, Perecin F, Meirelles FV, Ferraz JBS, Vanzela EC, Boschero AC, Guimarães FEG, Abdulkader F, Laurindo FRM, Kowaltowski AJ, Chiaratti MR (2020) Mice born to females with oocyte-specific deletion of mitofusin 2 have increased weight gain and impaired glucose homeostasis. Mol Hum Reprod 26:938-52. | LEAK OXPHOS ET | S | Isolated mitochondria | Mouse | Liver |
| Purhonen 2020 Nat Commun | 2020 | Purhonen J, Grigorjev V, Ekiert R, Aho N, Rajendran J, Pietras R, Truvé K, Wikström M, Sharma V, Osyczka A, Fellman V, Kallijärvi J (2020) A spontaneous mitonuclear epistasis converging on Rieske Fe-S protein exacerbates complex III deficiency in mice. Nat Commun 11:322. | LEAK OXPHOS ET | N NS ROX | Isolated mitochondria | Mouse | Liver Kidney |
| Piel 2020 PLoS One | 2020 | Piel S, Chamkha I, Dehlin AK, Ehinger JK, Sjövall F, Elmér E, Hansson MJ (2020) Cell-permeable succinate prodrugs rescue mitochondrial respiration in cellular models of acute acetaminophen overdose. PLoS One 15:e0231173. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Liver Platelet |
| Mayoral-Varo 2020 PLoS One | 2020 | Mayoral-Varo V, Calcabrini A, Sánchez-Bailón MP, Martínez-Costa ÓH, González-Páramos C, Ciordia S, Hardisson D, Aragón JJ, Fernández-Moreno MÁ, Martín-Pérez J (2020) c-Src functionality controls self-renewal and glucose metabolism in MCF7 breast cancer stem cells . PLoS One 15:e0235850. | LEAK ROUTINE ET | Intact cells | Human | Endothelial;epithelial;mesothelial cell | |
| Kupats 2020 Oxid Med Cell Longev | 2020 | Kupats E, Stelfa G, Zvejniece B, Grinberga S, Vavers E, Makrecka-Kuka M, Svalbe B, Zvejniece L, Dambrova M (2020) Mitochondrial-protective effects of R-phenibut after experimental traumatic brain injury. Oxid Med Cell Longev 2020:9364598. | LEAK OXPHOS ET | N S NS | Homogenate Isolated mitochondria | Mouse | Nervous system |
| Reutzel 2020 Oxid Med Cell Longev | 2020 | Reutzel M, Grewal R, Dilberger B, Silaidos C, Joppe A, Eckert GP (2020) Cerebral mitochondrial function and cognitive performance during aging: A longitudinal study in NMRI mice. Oxid Med Cell Longev 2020:4060769. | LEAK ET OXPHOS | N S CIV ROX | Isolated mitochondria | Mouse | Nervous system |
| Wu 2020 Chemosphere | 2020 | Wu F, Sokolov EP, Dellwig O, Sokolova IM (2020) Season-dependent effects of ZnO nanoparticles and elevated temperature on bioenergetics of the blue mussel Mytilus edulis. Chemosphere 263:127780. | LEAK OXPHOS ET | N NS | Isolated mitochondria | Molluscs | Other cell lines |
| Boehmert 2020 Transfusion | 2020 | Böhmert S, Kübel S, Müller MM, Weber CF, Adam EH, Dröse S, Zacharowski K, Fischer D (2020) The effect of the interruption of agitation, temporary cooling, and pneumatic tube transportation on platelet quality during storage for transfusion. Transfusion [Epub ahead of print]. | LEAK ROUTINE ET | CIV | Intact cells | Human | Platelet |
| Dawson 2020 Exp Gerontol | 2020 | Dawson NJ, Salmón P (2020) Age-related increase in mitochondrial quantity may mitigate a decline in mitochondrial quality in red blood cells from zebra finches (Taeniopygia guttata). Exp Gerontol 133:110883. | LEAK ROUTINE ET | ROX | Intact cells | Birds | Blood cells |
| Ayari 2020 Commun Biol | 2020 | Ayari Asma, Rosa-Calatrava Manuel, Lancel Steve, Barthelemy Johanna, Pizzorno Andres, Mayeuf-Louchart Alicia, Baron Morgane, Hot David, Deruyter Lucie, Soulard Daphnee, Julien Thomas, Faveeuw Christelle, Molendi-Coste Olivier, Dombrowicz David, Sedano Laura, Sencio Valentin, Le Goffic Ronan, Trottein Francois, Wolowczuk Isabelle (2020) Influenza infection rewires energy metabolism and induces browning features in adipose cells and tissues. Commun Biol 3:237. | LEAK ROUTINE ET | ROX | Intact cells | Mouse | Fat |
| Mikulas 2020 Materials | 2020 | Mikulás K, Komlódi T, Földes A, Sváb G, Horváth G, Nagy AM, Ambrus A, Gyulai-Gaál Sz, Gera I, Hermann P, Varga G, Tretter L (2020) Bioenergetic Impairment of triethylene glycol dimethacrylate- (TEGDMA-) treated dental pulp stem cells (DPSCs) and isolated brain mitochondria are amended by redox compound methylene blue. Materials (Basel) 13(16):3472. | OXPHOS ET ROUTINE | N S ROX | Isolated mitochondria Permeabilized cells Intact cells | Guinea pig Human | Stem cells |
| Locatelli 2020 FASEB J | 2020 | Locatelli L, Cazzaniga A, De Palma C, Castiglioni S, Maier JAM (2020) Mitophagy contributes to endothelial adaptation to simulated microgravity. FASEB J 34:1833-45. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria Intact cells | Human | Endothelial;epithelial;mesothelial cell |
| Roy Chowdhury 2020 Cancers (Basel) | 2020 | Roy Chowdhury S, Bouchard EDJ, Saleh R, Nugent Z, Peltier C, Mejia E, Hou S, McFall C, Squires M, Hewitt D, Davidson L, Shen GX, Johnston JB, Doucette C, Hatch GM, Fernyhough P, Marshall A, Gibson SB, Dawe DE, Banerji V (2020) Mitochondrial respiration correlates with prognostic markers in chronic lymphocytic leukemia and Is normalized by ibrutinib treatment. Cancers (Basel) 12:E650. | LEAK ET | ROX | Intact cells | Human | Lymphocyte |
| Falcao-Tebas 2020 J Physiol | 2020 | Falcão-Tebas F, Marin EC, Kuang J, Bishop DJ, McConell GK (2020) Maternal exercise attenuates the lower skeletal muscle glucose uptake and insulin secretion caused by paternal obesity in female adult rat offspring. J Physiol 598:4251-70. | LEAK OXPHOS ET | N NS ROX | Permeabilized tissue | Rat | Skeletal muscle |
| He 2020 Clin Transl Med | 2020 | He C, Gao P, Cui Y, Li Q, Li Y, Lu Z, Ma H, Zhao Y, Li L, Sun F, Chen, X, Jia H, Liu D, Yang G, Zheng H, Zhu Z (2020) Low‐glucose‐sensitive TRPC6 dysfunction drives hypoglycemia‐induced cognitive impairment in diabetes. Clin Transl Med 10:e205. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Mouse | Nervous system |
| Baxter 2020 Elife | 2020 | Baxter M, Voronkov M, Poolman T, Galli G, Pinali C, Goosey L, Knight A, Krakowiak K, Maidstone R, Iqbal M, Zi M, Prehar S, Cartwright EJ, Gibbs J, Matthews LC, Adamson AD, Humphreys NE, Rebelo-Guiomar P, Minczuk M, Bechtold DA, Loudon A, Ray D (2020) Cardiac mitochondrial function depends on BUD23 mediated ribosome programming. Elife 9:e50705. | LEAK OXPHOS ET | N S CIV NS ROX | Homogenate | Mouse | Heart |
| Kanellopoulos 2020 Cell | 2020 | Kanellopoulos AK, Mariano V, Spinazzi M, Woo YJ, McLean C, Pech U, Li KW, Armstrong JD, Giangrande A, Callaerts P, Smit AB, Abrahams BS, Fiala A, Achsel T, Bagni C (2020) Aralar sequesters GABA into hyperactive mitochondria, causing social behavior deficits. Cell 180:1178-97. | LEAK OXPHOS ET | N S CIV NS ROX | Homogenate | Drosophila | Nervous system Other cell lines |
| Leguina-Ruzzi 2020 Biomolecules | 2020 | Leguina-Ruzzi A, Vodičková A, Holendová B, Pavluch V, Tauber J, Engstová H, Dlasková A, Ježek P (2020) Glucose-induced expression of DAPIT in pancreatic β-cells. Biomolecules 10:E1026. | LEAK ROUTINE ET | Intact cells | Rat | Islet cell;pancreas;thymus | |
| Pelaez Coyotl 2020 Pharmaceutics | 2020 | Peláez Coyotl EA, Barrios Palacios J, Muciño G, Moreno-Blas D, Costas M, Montiel Montes T, Diener C, Uribe-Carvajal S, Massieu L, Castro-Obregón S, Espinosa OR, Mata Espinosa D, Barrios-Payan J, León Contreras JC, Corzo G, Hernández-Pando R, Del Rio G (2020) Antimicrobial peptide against Mycobacterium tuberculosis that activates autophagy is an effective treatment for tuberculosis. Pharmaceutics 12:E1071. | ROUTINE ET | Intact cells | Mouse | Fibroblast | |
| Madeo 2020 US Patent | 2020 | Madeo F, Eisenberg T, Stekovic S (2020) Use of spermidine for the enhancement of mitochondrial respiration. US Patent US20200054579 A1. | LEAK OXPHOS ET | N ROX | Isolated mitochondria | Mouse | Heart |
| Kahancova 2020 Sci Rep | 2020 | Kahancová A, Sklenář F, Ježek P, Dlasková A (2020) Overexpression of native IF1 downregulates glucose-stimulated insulin secretion by pancreatic INS-1E cells. Sci Rep 10:1551. | LEAK ROUTINE ET | Intact cells | Rat | Islet cell;pancreas;thymus | |
| Larsen 2020 Cardiovasc Drugs Ther | 2020 | Larsen AH, Wiggers H, Dollerup OL, Jespersen NR, Hansson NH, Frøkiær J, Brøsen K, Nørrelund H, Bøtker HE, Møller N, Jessen N (2020) Metformin lowers body weight but fails to increase insulin sensitivity in chronic heart failure patients without diabetes: a randomized, double-blind, placebo-controlled study. Cardiovasc Drugs Ther 35:491-503. | LEAK OXPHOS ET | N NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Alston 2020 Am J Hum Genet | 2020 | Alston CL, Veling MT, Heidler J, Taylor LS, Alaimo JT, Sung AY, He L, Hopton S, Broomfield A, Pavaine J, Diaz J, Leon E, Wolf P, McFarland R, Prokisch H, Wortmann SB, Bonnen PE, Wittig I, Pagliarini DJ, Taylor RW (2020) Pathogenic bi-allelic mutations in NDUFAF8 cause Leigh syndrome with an isolated complex I deficiency. Am J Hum Genet 106:92-101. | LEAK ROUTINE OXPHOS ET | N NS | Permeabilized cells Intact cells | Human | Fibroblast |
| Cecatto 2020 Toxicol In Vitro | 2020 | Cecatto C, Amaral AU, Roginski AC, Castilho RF, Wajner M (2020) Impairment of mitochondrial bioenergetics and permeability transition induction caused by major long-chain fatty acids accumulating in VLCAD deficiency in skeletal muscle as potential pathomechanisms of myopathy. Toxicol In Vitro 62:104665. | LEAK OXPHOS ET | N S | Permeabilized tissue Isolated mitochondria | Rat | Skeletal muscle |
| Xia 2020 Biomed Res Int | 2020 | Xia W, Wang Q, Lu Y, Hu Y, Zhang X, Zhang J, Liu D, Song J, Zhu Z, Liu D, Zhang H (2020) Transient receptor potential channel canonical type 3 deficiency antagonizes myofibroblast transdifferentiation in vivo. Biomed Res Int 2020:1202189. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Fibroblast |
| Luevano-Martinez 2020 FEBS Lett | 2020 | Luévano-Martínez LA, Girard RMBM, Alencar MB, Silber AM (2020) ATP regulates the activity of an alternative oxidase in Trypanosoma brucei. FEBS Lett [Epub ahead of print]. | LEAK ROUTINE ET | Intact cells | Protists | ||
| Avila-Rojas 2020 Food Chem Toxicol | 2020 | Avila-Rojas SH, Aparicio-Trejo OE, Briones-Herrera A, Medina-Campos ON, Reyes-Fermín LM, Martínez-Klimova E, León-Contreras JC, Hernández-Pando R, Tapia E, Pedraza-Chaverri J (2020) Alterations in mitochondrial homeostasis in a potassium dichromate model of acute kidney injury and their mitigation by curcumin. Food Chem Toxicol 145:111774. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Rat | Kidney |
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| Maeda 2020 J Cell Mol Med | 2020 | Maeda H, Kami D, Maeda R, Murata Y, Jo JI, Kitani T, Tabata Y, Matoba S, Gojo S (2020) TAT-dextran-mediated mitochondrial transfer enhances recovery from models of reperfusion injury in cultured cardiomyocytes. J Cell Mol Med 24:5007-20. | LEAK ROUTINE OXPHOS ET | N ROX | Isolated mitochondria Intact cells | Rat | Heart |
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| Maddison 2020 PLoS Genet | 2020 | Maddison DC, Alfonso-Núñez M, Swaih AM, Breda C, Campesan S, Allcock N, Straatman-Iwanowska A, Kyriacou CP, Giorgini F (2020) A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics. PLoS Genet 16:e1009129. | OXPHOS ET | N S NS | Homogenate | Drosophila | |
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| Ledur 2020 Sci Rep | 2020 | Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218. | LEAK ROUTINE ET | ROX | Intact cells | Human | Nervous system |
| Remie 2020 Am J Clin Nutr | 2020 | Remie CME, Roumans KHM, Moonen MPB, Connell NJ, Havekes B, Mevenkamp J, Lindeboom L, de Wit VHW, van de Weijer T, Aarts SABM, Lutgens E, Schomakers BV, Elfrink HL, Zapata-Pérez R, Houtkooper RH, Auwerx J, Hoeks J, Schrauwen-Hinderling VB, Phielix E, Schrauwen P (2020) Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr 112:413-26. | LEAK OXPHOS ET | F N S NS | Permeabilized tissue | Human | Skeletal muscle |
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| Cipullo 2020 Nucleic Acids Res | 2020 | Cipullo M, Pearce SF, Lopez Sanchez IG, Gopalakrishna S, Krüger A, Schober F, Busch JD, Li X, Wredenberg A, Atanassov I, Rorbach J (2020) Human GTPBP5 is involved in the late stage of mitoribosome large subunit assembly. Nucleic Acids Res 49:354-70. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | HEK |
| Grewal 2020 Exp Neurol | 2020 | Grewal R, Reutzel M, Dilberger B, Hein H, Zotzel J, Marx S, Tretzel J, Sarafeddinov A, Fuchs C, Eckert GP (2020) Purified oleocanthal and ligstroside protect against mitochondrial dysfunction in models of early Alzheimer's disease and brain ageing. Exp Neurol 328:113248. | LEAK ROUTINE OXPHOS ET | N S CIV NS ROX | Permeabilized cells Intact cells | Human | Neuroblastoma |
| Vulczak 2020 Cells | 2020 | Vulczak A, Souza AO, Ferrari GD, Azzolini AECS, Pereira-da-Silva G, Alberici LC (2020) Moderate exercise modulates tumor metabolism of triple-negative breast cancer. Cells 9:E628. | LEAK OXPHOS ET | N ROX | Permeabilized cells | Mouse | Endothelial;epithelial;mesothelial cell |
| Pham 2020 Eur J Appl Physiol | 2020 | Pham T, MacRae CL, Broome SC, D'souza RF, Narang R, Wang HW, Mori TA, Hickey AJR, Mitchell CJ, Merry TL (2020) MitoQ and CoQ10 supplementation mildly suppresses skeletal muscle mitochondrial hydrogen peroxide levels without impacting mitochondrial function in middle-aged men. Eur J Appl Physiol 120:1657-69. | LEAK OXPHOS ET | N CIV NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Chen 2020 Chem Biol Interact | 2020 | Chen HY, Ho YJ, Chou HC, Liao EC, Tsai YT, Wei YS, Lin LH, Lin MW, Wang YS, Ko ML, Chan H (2020) TGF-β1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1/Nrf2 pathway. Chem Biol Interact 331:109249. | LEAK ROUTINE ET | ROX | Intact cells | Mouse | Nervous system |
| Roginski 2020 Biochim Biophys Acta Mol Basis Dis | 2020 | Roginski AC, Wajner A, Cecatto C, Wajner SM, Castilho RF, Wajner M, Amaral AU (2020) Disturbance of bioenergetics and calcium homeostasis provoked by metabolites accumulating in propionic acidemia in heart mitochondria of developing rats. Biochim Biophys Acta Mol Basis Dis 1866:165682. | LEAK OXPHOS ET | N S NS | Permeabilized cells Isolated mitochondria Homogenate | Rat | Heart Other cell lines |
| Jespersen 2020 Sci Rep | 2020 | Jespersen NR, Hjortbak MV, Lassen TR, Støttrup NB, Johnsen J, Tonnesen PT, Larsen S, Kimose HH, Bøtker HE (2020) Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus. Sci Rep 10:10344. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Rat | Heart |
| Risiglione 2020 Int J Mol Sci | 2020 | Risiglione P, Leggio L, Cubisino SAM, Reina S, Paternò G, Marchetti B, Magrì A, Iraci N, Messina A (2020) High-resolution respirometry reveals MPP+ mitochondrial toxicity mechanism in a cellular model of parkinson's disease. Int J Mol Sci 21:E7809. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Neuroblastoma |
| Parker 2020 Thesis | 2020 | Parker EP (2020) The effect of isoleucine supplementation of peripheral blood mononuclear cell metabolism in subjects with type 2 diabetes. URS Thesis 31. | LEAK ROUTINE OXPHOS ET | N S CIV NS ROX | Permeabilized cells Intact cells | Human | Blood cells |
| Herpich 2020 Exp Gerontol | 2020 | Herpich C, Franz K, Klaus S, Müller-Werdan U, Ost M, Norman K (2020) Age-related fatigue is associated with reduced mitochondrial function in peripheral blood mononuclear cells. Exp Gerontol 144:111177. | LEAK ROUTINE ET | ROX | Intact cells | Human | Blood cells |
| Hartmann 2020 Free Radic Res | 2020 | Hartmann DD, Gonçalves DF, Da Rosa PC, Martins RP, Courtes AA, Franco JL, A Soares FA, Puntel GO (2020) A single muscle contusion promotes an immediate alteration in mitochondrial bioenergetics response in skeletal muscle fibres with different metabolism. Free Radic Res 54:137-49. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Rat | Skeletal muscle |
| De Souza 2020 Heliyon | 2020 | De Souza CEA, Andrade Pires AR, Cardoso CR, Carlos RM, Cadena SMSC, Acco A (2020) Antineoplastic activity of a novel ruthenium complex against human hepatocellular carcinoma (HepG2) and human cervical adenocarcinoma (HeLa) cells. Heliyon 6:e03862. | LEAK ROUTINE ET | ROX | Intact cells | Human | Liver HeLa |
| Magnesa 2020 Thesis | 2020 | Magnesa B (2020) Skeletal muscle mitochondrial oxidative phosphorylation plasticity in two studies on humans: exercise training effect in obese subjects and bed rest effect in healthy subjects. PhD Thesis 81. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Xiong 2020 Biomed Pharmacother | 2020 | Xiong Xiaowei, Lu Weihang, Qin Xuan, Luo Qingyu, Zhou Weimin (2020) Downregulation of the GLP-1/CREB/adiponectin pathway is partially responsible for diabetes-induced dysregulated vascular tone and VSMC dysfunction. Biomed Pharmacother 127:110218. | LEAK OXPHOS ET | N S NS | Permeabilized cells | Human Rat | Endothelial;epithelial;mesothelial cell |
| Hingst 2020 Mol Metab | 2020 | Hingst JR, Kjøbsted R, Birk JB, Jørgensen NO, Larsen MR, Kido K, Larsen JK, Kjeldsen SAS, Fentz J, Frøsig C, Holm S, Fritzen AM, Dohlmann TL, Larsen S, Foretz M, Viollet B, Schjerling P, Overby P, Halling JF, Pilegaard H, Hellsten Y, Wojtaszewski JFP (2020) Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise. Mol Metab 40:101028. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Mouse | Skeletal muscle |
| Jaber 2020 BM Exp Neurol | 2020 | Jaber SM, Yadava N, Polster BM (2020) Mapping mitochondrial respiratory chain deficiencies by respirometry: beyond the Mito Stress Test. BM Exp Neurol 328:113282. | LEAK ROUTINE ET | ROX | Intact cells | Nervous system | |
| Baggio 2020 Neurotoxicology | 2020 | Baggio S, Zenki K, Martins Silva A, Dos Santos TG, Rech G, Lazzarotto G, Dias RD, Mussulini BH, Rico EP, de Oliveira DL (2020) Fetal alcohol spectrum disorders model alters the functionality of glutamatergic neurotransmission in adult zebrafish. Neurotoxicology 78:152-160. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Zebrafish | Nervous system |
| Kuzniewska 2020 EMBO Rep | 2020 | Kuzniewska B, Cysewski D, Wasilewski M, Sakowska P, Milek J, Kulinski TM, Winiarski M, Kozielewicz P, Knapska E, Dadlez M, Chacinska A, Dziembowski A, Dziembowska M (2020) Mitochondrial protein biogenesis in the synapse is supported by local translation. EMBO Rep 21:e48882. | LEAK ET | N S | Permeabilized cells | Human Mouse | Nervous system HEK |
| McLaughlin 2020b Sci Rep | 2020 | McLaughlin KL, Hagen JT, Coalson HS, Nelson MAM, Kew KA, Wooten AR, Fisher-Wellman KH (2020) Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs. Sci Rep 10:17599. | LEAK OXPHOS ET | F N S Gp CIV ROX | Isolated mitochondria | Mouse | Heart Liver Kidney Fat |
| Ajime 2020 Nicotine Tob Res | 2020 | Ajime TT, Serré J, Wüst RCI, Messa GAM, Poffé C, Swaminathan A, Maes K, Janssens W, Troosters T, Degens H, Gayan-Ramirez G (2020) Two weeks smoking cessation reverses cigarette smoke-induced skeletal muscle atrophy and mitochondrial dysfunction in mice. Nicotine Tob Res 23:143-51. | LEAK ET | S | Permeabilized tissue | Mouse | Skeletal muscle |
| Cruz 2020 Cancers (Basel) | 2020 | Cruz B, Oliveira A, Viana LR, Lopes-Aguiar L, Canevarolo R, Colombera MC, Valentim RR, Garcia-Fóssa F, de Sousa LM, Castelucci BG, Consonni SR, Martins-de-Souza D, de Jesus MB, Russell ST, Gomes-Mardondes MCC (2020) Leucine-tich diet modulates the metabolomic and proteomic profile of skeletal muscle during cancer cachexia. Cancers (Basel) 12:E1880. | LEAK ROUTINE ET | Intact cells | Mouse | Skeletal muscle | |
| Contreras Mostazo 2020 Cancers (Basel) | 2020 | Mostazo MGC, Kurrle N, Casado M, Fuhrmann D, Alshamleh I, Häupl B, Martín-Sanz P, Brüne B, Serve H, Schwalbe H, Schnütgen F, Marin S, Cascante M (2020) Metabolic plasticity is an essential requirement of acquired tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Cancers (Basel) 12:E3443. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV ROX | Permeabilized cells Intact cells | Human | Blood cells |
| Duong 2020 Mitochondrion | 2020 | Duong QV, Hoffman A, Zhong K, Dessinger MJ, Zhang Y, Bazil JN (2020) Calcium overload decreases net free radical emission in cardiac mitochondria. Mitochondrion 51:126-39. | LEAK OXPHOS ET | F N S | Isolated mitochondria | Guinea pig | Heart |
| Visavadiya 2020 Mol Cell Biochem | 2020 | Visavadiya NP, Pena GS, Khamoui AV (2020) Mitochondrial dynamics and quality control are altered in a hepatic cell culture model of cancer cachexia. Mol Cell Biochem 476:23-34. | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells | Mouse | Liver |
| Esselun 2020 Neuromolecular Med | 2020 | Esselun C, Dilberger B, Silaidos CV, Koch E, Schebb NH, Eckert GP (2020) A walnut diet in combination with enriched environment improves cognitive function and affects lipid metabolites in brain and liver of aged NMRI mice. Neuromolecular Med 23:140-60. | LEAK OXPHOS ET | N S CIV NS ROX | Isolated mitochondria | Mouse | Nervous system |
| Chabi 2019 MitoFit Preprint Arch EA | 2019-10-10 | Chabi Béatrice, Ost M, Gama-Perez P, Dahdah N, Lemieux H, Holody CD, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Pesta D, Calabria E, Casado M, Fernandez-Ortiz M, Acuña-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wüst R, Dayanidhi S, Gnaiger E, Doerrier C, Garcia-Roves PM (2019) Generating reference values on mitochondrial respiration in permeabilized muscle fibers. https://doi.org/10.26124/mitofit:ea19.MitoEAGLE.0001 | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Doerrier 2019 MitoFit Preprint Arch EA | 2019-07-04 | Doerrier C, Gama-Perez P, Distefano G, Pesta D, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen P, Larsen S, Gnaiger E, Garcia-Roves PM (2019) Inter-laboratory harmonization of respiratory protocols in permeabilized human muscle fibers. https://doi.org/10.26124/mitofit:ea19.MiPSchool.0009 | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| MiPNet20.13 Safranin mt-membranepotential | 2019-06-24 | | LEAK ET | S ROX | Homogenate | Mouse | Nervous system |
| MiPNet20.14 AmplexRed H2O2-production | 2019-06-24 | | LEAK OXPHOS ET | S | Isolated mitochondria | Mouse | Heart |
| MiPNet18.05 Amplex-Mouse-heart | 2019-06-24 | | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
| Mueller 2019 Thesis | 2019 | Müller T (2019) Role of MICOS for mitochondrial morphology and function. PhD Thesis 77. | LEAK ROUTINE ET | Intact cells | Human | HEK | |
| Gregg 2019 J Biol Chem | 2019 | Gregg T, Sdao SM, Dhillon RS, Rensvold JW, Lewandowski SL, Pagliarini DJ, Denu JM, Merrins MJ (2019) Obesity-dependent CDK1 signaling stimulates mitochondrial respiration at Complex I in pancreatic β-cells. J Biol Chem 294:4656-66. | OXPHOS ET LEAK | N S NS ROX | Permeabilized tissue | Mouse | Islet cell;pancreas;thymus |
| Pedrotti 2019 Sci Adv | 2019 | Pedrotti S, Caccia R, Neguembor MV, Garcia-Manteiga JM, Ferri G, de Palma C, Canu T, Giovarelli M, Marra P, Fiocchi A, Molineris I, Raso M, Sanvito F, Doglioni C, Esposito A, Clementi E, Gabellini D (2019) The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli. Sci Adv 5:eaav1472. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Intact cells | Mouse | Fat |
| Schweitzer 2019 FASEB J | 2019 | Schweitzer GG, Collier SL, Chen Z, McCommis KS, Pittman SK, Yoshino J, Matkovich SJ, Hsu FF, Chrast R, Eaton JM, Harris TE, Weihl CC, Finck BN (2019) Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice. FASEB J 33:652-67. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Mouse | Skeletal muscle |
| Papadimitriou 2019 Sci Rep | 2019 | Papadimitriou ID, Eynon N, Yan X, Munson F, Jacques M, Kuang J, Voisin S, North KN, Bishop DJ (2019) A "human knockout" model to investigate the influence of the α-actinin-3 protein on exercise-induced mitochondrial adaptations. Sci Rep 9:12688. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Braz-De-Melo 2019 Sci Rep | 2019 | Braz-De-Melo HA, Pasquarelli-do-Nascimento G, Corrêa R, das Neves Almeida R, de Oliveira Santos I, Prado PS, Picolo V, de Bem AF, Pizato N, Magalhães KG (2019) Potential neuroprotective and anti-inflammatory effects provided by omega-3 (DHA) against Zika virus infection in human SH-SY5Y cells. Sci Rep 9:20119. | LEAK ET | ROX | Intact cells | Human | Neuroblastoma |
| Devaux 2019 Front Physiol | 2019 | Devaux JBL, Hedges CP, Birch N, Herbert N, Renshaw GMC, Hickey AJR (2019) Acidosis maintains the function of brain mitochondria in hypoxia-tolerant triplefin fish: a strategy to survive acute hypoxic exposure? Front Physiol 9:1941. | LEAK OXPHOS ET | Other combinations N NS | Permeabilized tissue Isolated mitochondria | Fishes | Nervous system |
| Chiurillo 2019 Mol Biol Cell | 2019 | Chiurillo MA, Lander N, Bertolini MS, Vercesi AE, Docampo R (2019) Functional analysis and importance for host cell infection of the Ca2+-conducting subunits of the mitochondrial calcium uniporter of Trypanosoma cruzi. Mol Biol Cell 30:1676-90. | LEAK OXPHOS ET | S | Permeabilized cells | Protists | |
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| Carteri 2019 Toxicol Lett | 2019 | Carteri RB, Kopzynski A, Menegassi LN, Rodolphi MS, Strogulski NR, Portela LV (2019) Anabolic-androgen steroids effects on bioenergetics responsiveness of synaptic and extrasynaptic mitochondria. Toxicol Lett 307:72-80. | LEAK OXPHOS ET | N NS ROX | Isolated mitochondria | Mouse | Nervous system |
| Silva Ramos 2019 PLoS Genet | 2019 | Silva Ramos E, Motori E, Brüser C, Kühl I, Yeroslaviz A, Ruzzenente B, Kauppila JHK, Busch JD, Hultenby K, Habermann BH, Jakobs S, Larsson NG, Mourier A (2019) Mitochondrial fusion is required for regulation of mitochondrial DNA replication. PLoS Genet 15:e1008085. | LEAK OXPHOS ET | N S Gp | Permeabilized cells Isolated mitochondria | Mouse | Heart Fibroblast |
| Diao 2019 Brain Res | 2019 | Diao X, Zhou Z, Xiang W, Jiang Y, Tian N, Tang X, Chen S, Wen J, Chen M, Liu K, Li Q, Liao R (2019) Glutathione alleviates acute intracerebral hemorrhage injury via reversing mitochondrial dysfunction. Brain Res 1727:146514. | LEAK OXPHOS ET | N | Isolated mitochondria | Mouse | Nervous system |
| Mann 2019 Oncogene | 2019 | Mann J, Githaka JM, Buckland TW, Yang N, Montpetit R, Patel N, Li L, Baksh S, Godbout R, Lemieux H, Goping IS (2019) Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism. Oncogene 38:3325-39. | LEAK ROUTINE OXPHOS ET | N S CIV NS ROX F | Permeabilized cells Intact cells | Human | Endothelial;epithelial;mesothelial cell |
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| Glombik 2019 Neurotox Res | 2019 | Głombik K, Detka J, Góralska J, Kurek A, Solnica B, Budziszewska B (2019) Brain metabolic alterations in rats showing depression-like and obesity phenotypes. Neurotox Res 37:406-24. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Rat | Nervous system |
| Sundstroem 2019 Acta Neuropathol Commun | 2019 | Sundstrøm T, Prestegarden L, Azuaje F, Aasen SN, Røsland GV, Varughese JK, Bahador M, Bernatz S, Braun Y, Harter PN, Skaftnesmo KO, Ingham ES, Mahakian LM, Tam S, Tepper CG, Petersen K, Ferrara KW, Tronstad KJ, Lund-Johansen M, Beschorner R, Bjerkvig R, Thorsen F (2019) Inhibition of mitochondrial respiration prevents BRAF-mutant melanoma brain metastasis. Acta Neuropathol Commun 7:55. | ET LEAK | N S NS ROX | Permeabilized cells | Human | Endothelial;epithelial;mesothelial cell |
| Dannheisig 2019 Cells | 2019 | Dannheisig DP, Beck E, Calzia E, Walther P, Behrends C, Pfister AS (2019) Loss of Peter Pan (PPAN) affects mitochondrial homeostasis and autophagic flux. Cells 8:E894. | LEAK ROUTINE ET | N S CIV NS ROX | Intact cells Permeabilized cells | Human | HeLa |
| Rudler 2019 Sci Adv | 2019 | Rudler DL, Hughes LA, Perks KL, Richman TR, Kuznetsova I, Ermer JA, Abudulai LN, Shearwood AJ, Viola HM, Hool LC, Siira SJ, Rackham O, Filipovska A (2019) Fidelity of translation initiation is required for coordinated respiratory complex assembly. Sci Adv 5:eaay2118. | LEAK OXPHOS ET | N S | Isolated mitochondria | Mouse | Heart |
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| Szibor 2019 Biochim Biophys Acta Bioenerg | 2019 | Szibor Marten, Gainutdinov Timur, Fernandez-Vizarra Erika, Dufour Eric, Gizatullina Zemfira, Debska-Vielhaber Grazyna, Heidler Juliana, Wittig Ilka, Viscomi Carlo, Gellerich Frank Norbert, Moore Anthony L (2019) Bioenergetic consequences from xenotopic expression of a tunicate AOX in mouse mitochondria: switch from RET and ROS to FET. Biochim Biophys Acta Bioenerg 1861:148137. | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Mouse | Heart |
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| Bertolini 2019 MBio | 2019 | Bertolini MS, Chiurillo MA, Lander N, Vercesi AE, Docampo R (2019) MICU1 and MICU2 play an essential role in mitochondrial Ca2+ uptake, growth, and infectivity of the human pathogen Trypanosoma cruzi. MBio 10:e00348-19. | LEAK OXPHOS ET | Permeabilized cells | Protists | ||
| Kumar 2019 Free Radic Biol Med | 2019 | Kumar A, Davuluri G, Welch N, Kim A, Gangadhariah M, Allawy A, Priyadarshini A, McMullen MR, Sandlers Y, Willard B, Hoppel CL, Nagy LE, Dasarathy S (2019) Oxidative stress mediates ethanol-induced skeletal muscle mitochondrial dysfunction and dysregulated protein synthesis and autophagy. Free Radic Biol Med 145:284-99. | LEAK ROUTINE OXPHOS ET | F N S DQ CIV NS ROX | Permeabilized cells Permeabilized tissue Intact cells | Mouse | Skeletal muscle |
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| Cesnekova 2019 Thesis | 2019 | Cesnekova J (2019) Functional characterization of LACE1 APTase and mitochondrial AAA proteases YME1L and AFG3L2 in mitochondrial protein homeostasis. PhD Thesis 133. | OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | HEK |
| Jansen 2019 Am J Physiol Heart Circ Physiol | 2019 | Jansen KM, Moreno S, Garcia-Roves PM, Larsen TS (2019) Dietary Calanus oil recovers metabolic flexibility and rescues post-ischemic cardiac function in obese female mice. Am J Physiol Heart Circ Physiol 317:H290-H299. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse | Heart |
| Noz 2019 J Am Heart Assoc | 2019 | Noz MP, Hartman YAW, Hopman MTE, Willems PHGM, Tack CJ, Joosten LAB, Netea MG, Thijssen DHJ, Riksen NP (2019) Sixteen-week physical activity intervention in subjects with increased cardiometabolic risk shifts innate immune function towards a less proinflammatory state. J Am Heart Assoc 8:e013764. | LEAK ET | ROX | Intact cells | Human | Blood cells |
| Kladnicka 2019 Physiol Res | 2019 | Kladnická I, Čedíková M, Kripnerová M, Dvořáková J, Kohoutová M, Tůma Z, Müllerová D, Kuncová J (2019) Mitochondrial respiration of adipocytes differentiating from human mesenchymal stem cells derived from adipose tissue. Physiol Res 68:287-96. | LEAK ROUTINE ET | ROX | Intact cells | Human | Fat Stem cells |
| Catalao 2019 Brain Res | 2019 | Catalão CHR, Souza AO, Santos-Júnior NN, da Silva SC, da Costa LHA, Alberici LC, Rocha MJA, da Silva Lopes L (2019) Kaolin-induced hydrocephalus causes acetylcholinesterase activity dysfunction following hypothalamic damage in infant rats. Brain Res 1724:146408. | LEAK OXPHOS ET | N ROX | Homogenate | Rat | Nervous system |
| Garcia-Roche 2019 PLoS One | 2019 | García-Roche M, Casal A, Mattiauda DA, Ceriani M, Jasinsky A, Mastrogiovanni M, Trostchansky A, Carriquiry M, Cassina A, Quijano C (2019) Impaired hepatic mitochondrial function during early lactation in dairy cows: Association with protein lysine acetylation. PLoS One 14:e0213780. | LEAK OXPHOS ET | N S NS ROX | Intact cells | Bovines | Liver |
| Halling 2019 Am J Physiol Endocrinol Metab | 2019 | Halling JF, Jessen H, Nøhr-Meldgaard J, Thiellesen Buch B, Masselkhi Christensen N, Gudiksen A, Ringholm S, Neufer PD, Prats C, Pilegaard H (2019) PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training. Am J Physiol Endocrinol Metab 317:E513-E525. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Dollerup 2019 J Physiol | 2019 | Dollerup OL, Chubanava S, Agerholm M, Søndergård SD, Altıntaş A, Møller AB, Høyer KF, Ringgaard S, Stødkilde-Jørgensen H, Lavery GG, Barres R, Larsen S, Prats C, Jessen N, Treebak JT (2019) Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin resistant men. J Physiol 598:731-54. | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Berg 2019 Front Physiol | 2019 | Berg J, Undebakke V, Rasch-Halvorsen Ø, Aakerøy L, Sandbakk Ø, Tjønna AE (2019) Comparison of mitochondrial respiration in M. triceps brachii and M. vastus lateralis between elite cross-country skiers and physically active controls. Front Physiol 10:365. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Zverova 2019 Neuropsychiatr Dis Treat | 2019 | Zvěřová M, Hroudová J, Fišar Z, Hansíková H, Kališová L, Kitzlerová E, Lambertová A, Raboch J (2019) Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder. Neuropsychiatr Dis Treat 15:233-40. | LEAK ROUTINE ET | ROX | Intact cells | Human | Platelet Blood cells |
| Desmoulins 2019 Mol Metab | 2019 | Desmoulins L, Chrétien C, Paccoud R, Collins S, Cruciani-Guglielmacci C, Galinier A, Liénard F, Quinault A, Grall S, Allard C, Fenech C, Carneiro L, Mouillot T, Fournel A, Knauf C, Magnan C, Fioramonti X, Pénicaud L, Leloup C (2019) Mitochondrial Dynamin-Related Protein 1 (DRP1) translocation in response to cerebral glucose is impaired in a rat model of early alteration in hypothalamic glucose sensing. Mol Metab 20:166-77. | OXPHOS ET LEAK | N NS | Homogenate | Rat | Nervous system |
| Bettinazzi 2019 Cryobiology | 2019 | Bettinazzi S, Gendron AD, Breton S (2019) The effect of cryopreservation on mitochondrial function in freshwater mussel tissue samples (Bivalvia: Unionida). Cryobiology 88:106-109. | LEAK OXPHOS ET | N Gp CIV NS ROX S Other combinations | Permeabilized tissue | Molluscs | Lung;gill |
| Svab 2019 Neurochem Res | 2019 | Svab G, Doczi J, Gerencser AA, Ambrus A, Gallyas F, Sümegi B, Tretter L (2019) The mitochondrial targets of neuroprotective drug vinpocetine on primary neuron cultures, brain capillary endothelial cells, synaptosomes, and brain mitochondria. Neurochem Res 44:2435-47. | LEAK OXPHOS ET | N S | Isolated mitochondria Intact cells | Guinea pig | Nervous system |
| Chen 2019 Ecotoxicol Environ Saf | 2019 | Chen H, Liu G, Qiao N, Kang Z, Hu L, Liao J, Yang F, Pang C, Liu B, Zeng Q, Li Y, Li Y (2019) Toxic effects of arsenic trioxide on spermatogonia are associated with oxidative stress, mitochondrial dysfunction, autophagy and metabolomic alterations. Ecotoxicol Environ Saf 190:110063. | LEAK ROUTINE ET | ROX | Intact cells | Mouse | Genital |
| Douros 2019 JCI Insight | 2019 | Douros JD, Niu J, Sdao SM, Gregg T, Fisher-Wellman KH, Bharadwaj MS, Molina A, Arumugam R, Martin MD, Petretto E, Merrins MJ, Herman MA, Tong J, Campbell JE, D'Alessio D (2019) Sleeve gastrectomy rapidly enhances islet function independently of body weight. JCI Insight 4:126688. | LEAK OXPHOS ET | N Gp NS | Permeabilized tissue | Mouse | Islet cell;pancreas;thymus |
| Lerchner 2019 Anal Bioanal Chem | 2019 | Lerchner J, Sartori MR, Volpe POL, Lander N, Mertens F, Vercesi AE (2019) Direct determination of anaerobe contributions to the energy metabolism of Trypanosoma cruzi by chip calorimetry. Anal Bioanal Chem 411:3763-68. | LEAK OXPHOS ET | ROX | Intact cells | Protists | |
| Gvozdjakova 2019 Bratisl Lek Listy | 2019 | Gvozdjakova A, Sumbalova Z, Kucharska J, Chladekova A, Rausova Z, Vancova O, Komlosi M, Ulicna O, Mojto V (2019) Platelet mitochondrial bioenergetic analysis in patients with nephropathies and non-communicable diseases: a new method. Bratisl Lek Listy 120:630-35. | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Platelet Blood cells |
| Djeungoue-Petga 2019 Cell Death Dis | 2019 | Djeungoue-Petga MA, Lurette O, Jean S, Hamel-Côté G, Martín-Jiménez R, Bou M, Cannich A, Roy P, Hebert-Chatelain E (2019) Intramitochondrial Src kinase links mitochondrial dysfunctions and aggressiveness of breast cancer cells. Cell Death Dis 10:940. | LEAK ROUTINE ET | Intact cells | Human | Endothelial;epithelial;mesothelial cell | |
| Wiberg 2019 Eur Heart J Acute Cardiovasc Care | 2019 | Wiberg S, Stride N, Bro-Jeppesen J, Holmberg MJ, Kjærgaard J, Larsen S, Donnino MW, Hassager C, Dela F (2019) Mitochondrial dysfunction in adults after out-of-hospital cardiac arrest. Eur Heart J Acute Cardiovasc Care 9:S138-44. | OXPHOS ET LEAK | N NS | Permeabilized tissue | Human | Skeletal muscle |
| Zhao 2019 Pharmacol Res | 2019 | Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, Yin L, Peng J (2019) MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1. Pharmacol Res 146:104276. | LEAK ROUTINE ET | ROX | Intact cells | Mouse | Liver Other cell lines |
| Wolf 2019 Cells | 2019 | Wolf C, Zimmermann R, Thaher O, Bueno D, Wüllner V, Schäfer MKE, Albrecht P, Methner A (2019) The Charcot-Marie tooth disease mutation R94Q in MFN2 decreases ATP production but increases mitochondrial respiration under conditions of mild oxidative stress. Cells 8:E1289. | LEAK ROUTINE ET OXPHOS | ROX N NS | Intact cells Permeabilized cells | Mouse | Fibroblast |
| Ferreira 2019 Nat Commun | 2019 | Ferreira JCB, Campos JC, Qvit N, Qi X, Bozi LHM, Bechara LRG, Lima VM, Queliconi BB, Disatnik MH, Dourado PMM, Kowaltowski AJ, Mochly-Rosen D (2019) A selective inhibitor of mitofusin 1-βIIPKC association improves heart failure outcome in rats. Nat Commun 10:329. | LEAK OXPHOS ET | NS | Isolated mitochondria | Rat | Heart |
| Bajzikova 2019 Cell Metab | 2019 | Bajzikova M, Kovarova J, Coelho AR, Boukalova S, Oh S, Rohlenova K, Svec D, Hubackova S, Endaya B, Judasova K, Bezawork-Geleta A, Kluckova K, Chatre L, Zobalova R, Novakova A, Vanova K, Ezrova Z, Maghzal GJ, Magalhaes Novais S, Olsinova M, Krobova L, An YJ, Davidova E, Nahacka Z, Sobol M, Cunha-Oliveira T, Sandoval-Acuña C, Strnad H, Zhang T, Huynh T, Serafim TL, Hozak P, Sardao VA, Koopman Werner JH, Ricchetti M, Oliveira PJ, Kolar F, Kubista M, Truksa J, Dvorakova-Hortova K, Pacak K, Gurlich R, Stocker R, Zhou Y, Berridge MV, Park S, Dong L, Rohlena J, Neuzil J (2019) Reactivation of dihydroorotate dehydrogenase-driven pyrimidine biosynthesis restores tumor growth of respiration-deficient cancer cells. Cell Metab 29:399-416. | OXPHOS ET | N S ROX | Permeabilized cells Homogenate | Mouse | Endothelial;epithelial;mesothelial cell Genital Other cell lines |
| Germain 2019 Int J Med Sci | 2019 | Germain N, Dessein AF, Vienne JC, Dobbelaere D, Mention K, Joncquel M, Dekiouk S, Laine W, Kluza J, Marchetti P (2019) First-line screening of OXPHOS deficiencies using microscale oxygraphy in human skin fibroblasts: A preliminary study. Int J Med Sci 16:931-38. | LEAK ET | ROX N | Intact cells | Human | Fibroblast |
| Esselun 2019 Oxid Med Cell Longev | 2019 | Esselun C, Bruns B, Hagl S, Grewal R, Eckert GP (2019) Differential effects of silibinin A on mitochondrial function in neuronal PC12 and HepG2 liver cells. Oxid Med Cell Longev 2019:1652609. | LEAK OXPHOS ET | N S CIV NS | Permeabilized cells | Human Rat | Nervous system Liver |
| Mayer 2019 Lipids | 2019 | Mayer K, Sommer N, Hache K, Hecker A, Reiche S, Schneck E, Weissmann N, Seeger W, Hecker M (2019) Resolvin E1 improves mitochondrial function in human alveolar epithelial cells during severe inflammation. Lipids 54:53-65. | LEAK ROUTINE ET | ROX | Intact cells | Human | Lung;gill Endothelial;epithelial;mesothelial cell Other cell lines |
| ... further results | |||||||
- Abstracts: ET pathway
Sort in ascending/descending order by a click on one of the small symbols in squares below.
| Year | Reference | Coupling | Pathway | Preparation | Organism | Tissue;cell | |
|---|---|---|---|---|---|---|---|
| Cardoso 2022a EBEC | 2022 |  | LEAK OXPHOS ET | F N S NS | Permeabilized cells | Human | HEK |
| Molina 2022 Abstract Bioblast | 2022 | 3.2. «10+5»  »Bioenergetics Communications«  | OXPHOS ET | F N S Gp ROX | Permeabilized cells | Human | Blood cells |
| Magri 2022 Abstract Bioblast | 2022 | 8.5. «5 min»  | LEAK ROUTINE OXPHOS ET | N S NS ROX | Permeabilized cells Intact cells | Human | Nervous system |
| Cardoso 2022 ESCI Bari | 2022 | | LEAK OXPHOS ET | N S NS | Permeabilized cells | Human | HEK |
| Isola 2022 Abstract Bioblast | 2022 | P12.  | OXPHOS ET | F N S DQ CIV | Isolated mitochondria | Rat | Heart Nervous system |
| Porter 2022 Abstract Bioblast | 2022 | 6.3. «10+5»  »MitoFit Preprint« | LEAK ROUTINE ET | S ROX | Permeabilized cells | Human | |
| Irving 2022 Abstract Bioblast | 2022 | 7.4. «5 min»  | LEAK OXPHOS ET | N Gp NS ROX | Permeabilized tissue Homogenate | Mouse | Nervous system |
| Axelrod 2022 Abstract Bioblast | 2022 | 3.6. «5 min»  | LEAK OXPHOS ET | N S CIV | Isolated mitochondria | Mouse | Endothelial;epithelial;mesothelial cell |
| Cecatto 2022 EBEC | 2022 |  | LEAK OXPHOS ET | N S NS ROX | Isolated mitochondria | Mouse | Liver |
| Cardoso 2022 Abstract Bioblast | 2022 | 4.3. «10+5» | LEAK OXPHOS ET | N S NS ROX | Permeabilized cells Isolated mitochondria | Mouse | Liver HEK |
| Gnaiger 2022 ESCI Bari | 2022 |  | LEAK ROUTINE ET | ROX | Intact cells | Human | Fibroblast |
| Doerrier 2020 PaduaMuscleDays Poster | 2020 | Doerrier C, Gama-Perez P, Chabi B, Ost M, Distefano G, Pesta D, Dahdah N, Lemieux H, Holody C, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Calabria E, Casado M, Fernandez-Ortiz M, Acuna-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wuest R, Dayanidhi S, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen PM, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Commitment to reproducibility in mitochondrial respiration studies with permeabilized muscle fibers. PaduaMuscleDays. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human Mouse | Skeletal muscle |
| Chabi 2019 MiP2019 | 2019 |  | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Axelrod 2019 Abstract IOC141 | 2019 | Axelrod CL, Davuluri G, Zunica ERM, Noland RC, Hoppel CL, Kirwan JP (2019) Administration of BAM15 to obese C57BL/6J mice increases skeletal muscle fatty acid oxidation independent of OXPHOS or ETC capacity. Mitochondr Physiol Network 24.02. | OXPHOS ET | F | Mouse | Skeletal muscle | |
| Goncalves Debora 2019 MiPschool Coimbra | 2019 |  | LEAK OXPHOS ET | N S NS ROX | Homogenate | Drosophila | |
| Doerrier 2019 MiP2019 | 2019 |  | LEAK ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Hatokova 2019 MiPschool Coimbra | 2019 | | LEAK ROUTINE ET | Intact cells | Human | Neuroblastoma | |
| Dominguez-Amorocho 2019 MiP2019 | 2019 | | LEAK ET OXPHOS | ROX | Mouse | Lymphocyte | |
| Garcia-Roves 2019 MiPschool Coimbra | 2019 |  | LEAK OXPHOS ET | N S CIV NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Gao 2019 MiPschool Coimbra | 2019 | | ET | Rat | Skeletal muscle | ||
| Lemieux 2019a MiP2019 | 2019 |  | LEAK OXPHOS ET | N S CIV NS | Other invertebrates | ||
| Kramer 2019 Abstract IOC141 | 2019 | Kramer P, Distefano G, Monte J, Mills A, Edmunds L, Jurczak M, Cummings SR, Kritchevsky S, Newman AB, Hepple RT, Goodpaster B, Coen PM, Molina A (2019) The Study of Muscle, Mobility, and Aging (SOMMA): A multi-institutional respirometry study. Mitochondr Physiol Network 24.02. | LEAK OXPHOS ET | N CIV NS ROX | Human | Skeletal muscle | |
| Silva 2019 MiPschool Coimbra | 2019 |  | OXPHOS ET | F N Other combinations | Permeabilized cells Isolated mitochondria | Human Mouse | Liver |
| Van der Ende 2019 MiPschool Coimbra | 2019 |  | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Cardoso 2019 MiP2019 | 2019 | | LEAK ROUTINE ET | ROX | Intact cells | Human | Liver |
| Scandalis 2019 Abstract IOC141 | 2019 | Scandalis LM, Kramer P, Nelson B, Dozier S, Stone J, Kitzman D, Molina AJA (2019) Oxygen consumption of skeletal muscle in heart failure with preserved ejection fraction. Mitochondr Physiol Network 24.02. | ET | N S | Permeabilized tissue | Human | Skeletal muscle |
| Timohhina 2019 MiP2019 | 2019 |  | LEAK OXPHOS ET | ROX | Human | Endothelial;epithelial;mesothelial cell | |
| Minuzzi 2019 MiPschool Coimbra | 2019 | | LEAK OXPHOS ET | F N S | Permeabilized tissue | Mouse | Endothelial;epithelial;mesothelial cell |
| Betiu 2019 MiP2019 | 2019 | | LEAK ET | ROX | Permeabilized cells Intact cells | Human | Platelet |
| Silva 2019 ESCI2019 | 2019 | Silva FSG, Komlodi T, Garcia-Souza LF, Bento G, Doerrier C, Oliveira PJ, Gnaiger E (2019) Can fatty acid oxidation be specifically blocked by the CPT1 inhibitor etomoxir? | OXPHOS ET | F N S | Permeabilized cells Isolated mitochondria | Human Mouse | Liver |
| Lelcu 2019 MiP2019 | 2019 |  | LEAK OXPHOS ET | N NS ROX | Permeabilized cells | Human | Platelet |
| Evinova 2019 MiPschool Coimbra | 2019 | | LEAK ROUTINE ET | N | Intact cells | Human | Neuroblastoma |
| Nickel 2018 IOC130 | 2018 | Defects in mitochondrial calcium uptake precede defects of the respiratory chain in X-linked Barth syndrome cardiomyopathy. | ET | Isolated mitochondria | Mouse | Heart | |
| Doerrier 2018 MiP2018a | 2018 | | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Meszaros 2018 Mt Med Hinxton | 2018 | High-resolution mitochondrial oxygen kinetics as diagnostic tool in Complex IV impairments. | LEAK OXPHOS ET | N CIV NS | Isolated mitochondria | Mouse | Heart Nervous system Liver |
| Schoepf 2018 33rd Annual EAU Congress Copenhagen | 2018 | Shift of mitochondrial oxidative phosphorylation is associated with mtDNA mutational load in primary prostate cancer tissue. | LEAK OXPHOS ET | F N NS Other combinations ROX | Permeabilized cells Permeabilized tissue | Human | Genital |
| McCurdy 2018 Endocrine Reviews | 2018 | McCurdy CE, True C, Takahashi D, Hetrick B, Varlamov O, Roberts CT (2018) Chronic hyperandrogenemia impairs oxidative metabolism in skeletal muscle from adolescent female rhesus macaques. Endocrine Reviews. | ET | F | Permeabilized tissue | Other mammals | Skeletal muscle |
| Garipi 2018 MiPschool Tromso E2 | 2018 | Phenotyping mitochondrial metabolism in Barrett’s metaplasia-dysplasia-adenocarcinoma sequence: respiratory capacity, extracelular proton flux and ROS production | LEAK ROUTINE OXPHOS ET | CIV NS ROX | Permeabilized cells Permeabilized tissue | Human | Endothelial;epithelial;mesothelial cell Other cell lines |
| Meszaros 2018 EBEC2018 | 2018 | Tissue- and substrate-specific patterns in the oxygen kinetics of mitochondrial respiration. | LEAK OXPHOS ET | N | Isolated mitochondria | Mouse | Heart Nervous system Liver |
| Krajcova 2018 ICO134 | 2018 | Skeletal muscle bioenergetics in critically ill patients: effect of early rehabilitation on mitochondrial functions and insulin resistance during and 6 months after critical illness. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Human | Skeletal muscle |
| Doerrier 2018 MiP2018c | 2018 | | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Garcia-Souza 2018 Life Sciences Meeting 2018 Innsbruck AT | 2018 | A respirometric cell viability test for peripheral-blood mononuclear cells and platelets. | LEAK ROUTINE ET | S | Intact cells | Human | Blood cells Platelet |
| Liu 2018 Atherosclerosis Suppl | 2018 | Liu D (2018) Enhanced Trpc3-mediated mitochondrial respiratory dysfunction by inhibition of mitochondria-hexokinase in monocytes from hypertension rats. Atherosclerosis Suppl. | ROUTINE OXPHOS ET | N NS | Intact cells | Rat | Blood cells |
| Krajcova 2018 MiPschool Tromso E2 | 2018 |  | LEAK OXPHOS ET | N NS ROX | Homogenate | Human | Heart |
| Avram 2018 MiP2018 | 2018 |  | LEAK ET | S | Permeabilized cells Intact cells | Human | Platelet |
| Doerrier 2018 EBEC2018 | 2018 | | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Permeabilized cells Homogenate Isolated mitochondria | Human Mouse | Heart Nervous system Blood cells HEK Platelet |
| Chicco 2018 MiP2018a | 2018 |  | OXPHOS ET | Horse | Genital | ||
| Chang 2018 Life Sciences Meeting 2018 Innsbruck AT | 2018 | pH dependence of mitochondrial respiration and H2O2 production in oral cancer cells – a pilot study. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Permeabilized cells | Human | HEK Kidney |
| Bastos Sant'Anna Silva 2018 TRANSMIT Bertinoro di Romagna IT | 2018 | Cellular succinate transport and mitochondrial respiratory function in prostate cancer. | ROUTINE LEAK OXPHOS ET | S ROX | Permeabilized cells Intact cells | Human | HEK Genital |
| Konopka 2018 FASEB J | 2018 | Konopka AR, Castor WM, Reid J, Schoenberg H, Laurin J, Wolff C, Hamilton K, Miller B (2018) Metformin blunts exercise-induced improvements in skeletal muscle mitochondrial respiration independent of changes in mitochondrial biogenesis. FASEB J. | OXPHOS ET | F N NS | Permeabilized tissue | Human | Skeletal muscle |
| Pereira da Silva Grilo da Silva 2018 MiP2018 | 2018 | | OXPHOS ET | F N S NS Other combinations | Permeabilized cells Isolated mitochondria | Human Mouse | Nervous system Liver Other cell lines |
| Han 2018 MiP2018 | 2018 | | LEAK ROUTINE ET | Human | Kidney HEK | ||
| Arnould 2018 MiP2018b | 2018 | | ET | Intact cells | Mouse | Fat Fibroblast | |
| Doerrier 2018 ESCI2018 | 2018 | | LEAK ROUTINE OXPHOS ET | F N S Gp ROX CIV | Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria | Human Mouse | Heart Skeletal muscle Nervous system Blood cells HEK |
| Kovalev 2018 EMBS | 2018 | Kovalev A, Sokolova I, Sukhotin A (2018) Allometry of mitochondrial respiration in mussels. EMBS. | LEAK OXPHOS ET | CIV | Isolated mitochondria | Molluscs | Liver Islet cell;pancreas;thymus |
| Evinova 2018 MiP2018 | 2018 | | LEAK ROUTINE ET | Intact cells | Human | Other cell lines Neuroblastoma | |
| Gnaiger 2018 MiPschool Tromso A1 | 2018 | | LEAK ET OXPHOS | F N S Gp DQ CIV NS Other combinations | |||
| Stankova 2018 MiP2018 | 2018 |  | OXPHOS ET | S F N | Homogenate | Mouse | Liver |
| Garcia-Roves 2018 MiP2018b | 2018 | | OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Chao 2018 J Burn Care Res | 2018 | Altered renal and cardiac mitochondrial activity after 40% TBSA in a swine model. | ET | Pig | Heart Kidney | ||
| McMaster 2018 Am J Obstet Gynecol | 2018 | Preeclampsia is associated with placental mitochondrial dysfunction. | LEAK ROUTINE OXPHOS ET | N | Isolated mitochondria | Human | |
| Keppner 2018 MiP2018 | 2018 |  | ET | Intact cells | Blood cells | ||
| Bastos Sant'Anna Silva 2018 MiPschool Tromso C4 | 2018 |  | LEAK ROUTINE OXPHOS ET | S ROX | Intact cells | Human | Genital |
| De Goede 2018 MiP2018 | 2018 | | OXPHOS ET | Permeabilized tissue | Rat | Skeletal muscle | |
| Wuest 2018 MiP2018b | 2018 |  | OXPHOS ET | N S | Rat | Heart Other cell lines | |
| Alan 2017 MiP2017 | 2017 |  | ET | Human | Kidney | ||
| Garcia-Souza 2017 MiPschool Obergurgl | 2017 |  | ROUTINE ET | S CIV ROX | Intact cells Permeabilized cells | Human | Blood cells Platelet |
| Gnaiger 2017 MiPschool A1 | 2017 |  | LEAK ROUTINE OXPHOS ET | ROX | Intact cells Permeabilized cells Permeabilized tissue Isolated mitochondria | ||
| Nemec 2017 Abstract MITOEAGLE Barcelona | 2017 |  | OXPHOS ET | F | Permeabilized tissue | Human | Skeletal muscle |
| Krylova 2017 MiPschool Obergurgl | 2017 |  | LEAK ROUTINE ET | N S | Intact cells Permeabilized cells | Endothelial;epithelial;mesothelial cell Fibroblast | |
| Irving 2017 MiP2017 | 2017 | | LEAK ROUTINE OXPHOS ET | N NS ROX | Blood cells | ||
| Sobotka 2017 Abstract MITOEAGLE Barcelona | 2017 | | OXPHOS ET | F N S Gp ROX | Isolated mitochondria | Rat | Liver |
| Michalak 2017 MiP2017 | 2017 | | LEAK ROUTINE ET | ROX | Intact cells | Human | Blood cells |
| White 2017 J Anim Sci | 2017 | Influence of temperament on skeletal muscle mitochondrial capacity of Brahman cows. | OXPHOS ET | N S NS | Bovines | Skeletal muscle | |
| Distefano 2017 MiPschool Obergurgl | 2017 |  | LEAK OXPHOS ET | F NS | Permeabilized tissue | Human | Skeletal muscle |
| Doerrier 2017 MiPschool C2 | 2017 | | LEAK ROUTINE OXPHOS ET | F N S Gp CIV | Permeabilized cells Homogenate Isolated mitochondria | Human Mouse | Heart Nervous system HEK |
| Gnaiger 2017 Abstract EUROMIT2017 Cologne | 2017 |  | OXPHOS ET | N NS S | Human | Endothelial;epithelial;mesothelial cell Genital Fibroblast | |
| Ukropec 2017 MITOEAGLE Obergurgl | 2017 | | LEAK OXPHOS ET | F N S Gp NS | Permeabilized cells | Skeletal muscle | |
| Meszaros 2017 MiP2017 | 2017 |  | LEAK OXPHOS ET | N NS | Isolated mitochondria | Mouse | Nervous system Liver Kidney |
| Hartmann 2017 Abstract MITOEAGLE Barcelona | 2017 | | LEAK ROUTINE ET | Intact cells | Human Pig | Blood cells | |
| Cizmarova 2017 Abstract MITOEAGLE Barcelona | 2017 | | ROUTINE ET | Intact cells | Human | Blood cells Platelet | |
| Rybacka-Mossakowska 2017 MiP2017 | 2017 | | LEAK ROUTINE ET | ROX | Intact cells | Human | Blood cells |
| Keppner 2017 MiPschool Obergurgl | 2017 | | LEAK OXPHOS ET | N NS | Permeabilized cells | Blood cells | |
| Labieniec-Watala 2017 MiP2017 | 2017 |  | OXPHOS ET | N S NS ROX | Permeabilized cells | Human | Genital |
| Krajcova 2017 MITOEAGLE Obergurgl | 2017 | | LEAK OXPHOS ET | N NS | Homogenate | Human | |
| Sobotka 2017 MiP2017 | 2017 |  | OXPHOS ET | N NS | Isolated mitochondria | Rat | Liver |
| Michalak 2017 Abstract MITOEAGLE Barcelona | 2017 | | LEAK ROUTINE OXPHOS ET | ROX | Intact cells | Human | Blood cells |
| Cizmarova 2017 MiP2017 | 2017 |  | LEAK ROUTINE ET | Intact cells | Human | Blood cells | |
| Doerrier 2017 MiP2017 WG2 | 2017 | | LEAK OXPHOS ET | N NS | Permeabilized tissue | Mouse | Skeletal muscle |
| Siewiera 2017 MiPschool Obergurgl | 2017 |  | LEAK ROUTINE ET | Intact cells | Rat | Blood cells Platelet | |
| Garcia-Roves 2017 MiP2017 | 2017 | | OXPHOS ET | N S NS ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Gnaiger 2017 Abstract MitoEAGLE Barcelona | 2017 | | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Human Mouse | Heart Genital |
| Nogueras 2017 MiPschool Obergurgl | 2017 |  | LEAK ROUTINE ET | ROX | Intact cells | Blood cells | |
| Bento 2017 MITOEAGLE Obergurgl | 2017 |  | LEAK ET | ROX | Intact cells | Human | Stem cells |
| Calabria 2017 MiP2017 | 2017 |  | LEAK ET | S | Permeabilized cells | Human | Blood cells |
| Siewiera 2017 Abstract MITOEAGLE Barcelona | 2017 | | ROUTINE ET | N | Intact cells | Human | Blood cells Platelet |
| Doerrier 2017 MiP2017 C1 | 2017 | | LEAK ET | F N S CIV NS | Isolated mitochondria | Mouse | Heart |
| Reboredo-Rodriguez 2017 MiPschool Obergurgl | 2017 |  | LEAK ET | ROX | Human | Liver | |
| Siewiera 2017 MiP2017 | 2017 | | LEAK ET | N | Homogenate Intact cells | Rat | Nervous system Blood cells Platelet |
| Doerrier 2017 Abstract MitoEAGLE Barcelona | 2017 | | LEAK ROUTINE OXPHOS ET | F N S Gp CIV | Permeabilized cells Homogenate Isolated mitochondria | Human Mouse | Heart Nervous system HEK |
| Hellgren 2017 MiPschool Obergurgl | 2017 |  | LEAK ROUTINE ET | N | Homogenate | Mouse | Heart |
| Waldauf 2017 MITOEAGLE Obergurgl | 2017 | | LEAK OXPHOS ET | F N S CIV NS | Homogenate | Human | Skeletal muscle |
| Calabria 2017 Abstract MITOEAGLE Barcelona | 2017 | | ROUTINE ET | Human | Blood cells | ||
| MitoFit Open Seminar 2017-07-14 | 2017 |  Investigating the role of mitochondria in healthy and psychopathological aging. | LEAK ROUTINE ET | Intact cells | Human | Blood cells | |
| Garcia-Souza 2017 MiP2017 | 2017 | | ROUTINE ET | Human | Blood cells Platelet | ||
| Komlodi 2017 Abstract MITOEAGLE Barcelona | 2017 | | OXPHOS LEAK ET | N S | Isolated mitochondria Homogenate | Guinea pig Mouse | Nervous system Kidney Heart Liver |
| Soendergaard 2016 Abstract IOC109 | 2016 | Soendergaard SD (2016) Acute exposure of human muscle fibers to EPO or Actovegin has a marked effect on the mitochondrial respiratory capacity. Mitochondr Physiol Network 21.01. | OXPHOS ET | N NS | Permeabilized tissue | Human | Skeletal muscle |
| Laner 2016 Abstract MitoFit Science Camp 2016 | 2016 | OXPHOS and ET-capacity in permeabilized fibers of canine superathletes. Analysis of HRR data presenting unexpected challenges. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Dog | Skeletal muscle |
| Sumbalova 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | Methods for evaluation of mitochondrial membrane potential with multi-sensor high-resolution respirometry: potentiometry vs fluorometry. | LEAK OXPHOS ET | F N S NS ROX | Mouse | Nervous system | |
| Bezuidenhout 2016b Abstract MitoFit Science Camp 2016 | 2016 | Analysis and comparison of mitochondrial function using cooling plate or ice during mechanical separation of mouse skeletal muscle fibers. | LEAK OXPHOS ET | N S ROX | Permeabilized tissue | Mouse | Skeletal muscle |
| Calzia 2016 Abstract MitoFit Science Camp 2016 | 2016 | Mitochondrial respiration shows tissue- and strain-specific aging in short- and long-lived N. furzeri strains. | LEAK OXPHOS ET | NS | Fishes | Heart Skeletal muscle Nervous system Liver | |
| Louw 2016 Abstract FASEB J | 2016 | Exercise limits loss of respiratory function seen with doxorubicin treatment without affecting muscle function. | ET | N S | Permeabilized tissue | Mouse | Skeletal muscle |
| Gnaiger 2016 Abstract UMDF2016 | 2016 | Schöpf B, Schäfer G, Weber A, Talasz H, Eder IE, Klocker H, Gnaiger E (2016) Oxidative phosphorylation and mitochondrial function differ between human prostate tissue and cultured cells. | LEAK OXPHOS ET | F N NS | Permeabilized cells Permeabilized tissue | Human | Endothelial;epithelial;mesothelial cell Genital Other cell lines Fibroblast |
| Laner 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | OXPHOS and ET capacity in permeabilized fibers of canine superathletes. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Dog | Skeletal muscle |
| Lamberti 2016 Abstract MitoFit Science Camp 2016 | 2016 | Development of a reference sample for HRR. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Human | Kidney HEK | |
| Murphy 2016 Abstract FASEB J | 2016 | Metformin limits loss of mitochondrial respiration seen with doxorubicin treatment without affecting muscle function. | ET | N S | Permeabilized tissue | Mouse | Skeletal muscle |
| Burtscher J 2016 Abstract MitoFit Science Camp 2016 | 2016 | Oxidative phosphorylation in the healthy and epileptic mouse brain. | OXPHOS ET | N S | Homogenate | Mouse | Nervous system |
| Chicco 2016b Abstract MitoFit Science Camp 2016 | 2016 | OXPHOS coupling efficiency of permeabilized muscle fibers predicts metabolic efficiency of subjects exercising at 5260 m. | LEAK OXPHOS ET | F N | Permeabilized tissue | Human | Skeletal muscle |
| Doerrier 2016b Abstract Mito Xmas Meeting Innsbruck | 2016 | Searching for specific targets of ischemic damage of cardiac mitochondria using O2k-Fluorometry. | LEAK OXPHOS ET | F N S Gp CIV ROX | Isolated mitochondria | Mouse | Heart |
| Krumschnabel 2016a Abstract MitoFit Science Camp 2016 | 2016 | O2k-Protocols: Mitochondrial preparations for HRR. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue Homogenate Isolated mitochondria | Mouse | Heart |
| Sumbalova 2016b Abstract MitoFit Science Camp 2016 | 2016 | Human blood cells: isolation and HRR. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Permeabilized cells Intact cells | Human | Blood cells Lymphocyte Platelet |
| Hoppel 2016c Abstract MitoFit Science Camp 2016 | 2016 | Mitochondrial respiration in permeabilized skin fibroblasts. | OXPHOS ET | N S CIV NS ROX | Permeabilized cells | Human | Endothelial;epithelial;mesothelial cell Fibroblast |
| Osiki 2016 Abstract MitoFit Science Camp 2016 | 2016 | Suitability of octanoylcarnitine & malate for assessment of beta oxidation capacity by respirometry in aconitase-inhibited samples. | OXPHOS ET | F N Other combinations | Rat | Skeletal muscle | |
| Schoepf 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | Mitochondrial function in primary prostate cancer. | LEAK OXPHOS ET | N S Other combinations | Permeabilized tissue | Human | |
| Doerrier 2016 Abstract MitoFit Science Camp 2016 | 2016 | Development of a SUIT reference protocol for OXPHOS analysis by high-resolution respirometry. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV NS ROX | Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria | Human Mouse | Heart Blood cells HEK Platelet |
| Sobotka 2016 Abstract IOC116 | 2016 | Sobotka O, Kucera Otto, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11 | LEAK OXPHOS ET | F N S Gp CIV NS Other combinations ROX | Isolated mitochondria | Rat | Liver |
| Volani 2016 Abstract MitoFit Science Camp 2016 | 2016 | Effects of iron imbalances on mitochondrial activity in mouse liver homogenate and permabilized rat PBMCs. | LEAK OXPHOS ET | N S | Homogenate | Mouse Rat | Liver Blood cells Lymphocyte |
| Madlala 2016 Abstract MitoFit Science Camp 2016 | 2016 | Fructose-induced defects in selected mitochondrial enzymes is detected by respirometry using glutamate&malate but not pyruvate&malate substrates. | LEAK OXPHOS ET | N | Permeabilized cells | Human | Liver |
| Volani 2016 Abstract Mito Xmas Meeting Innsbruck | 2016 | Effects of systemic iron perturbations on mitochondrial activity and on cellular metabolism in vivo. | LEAK ROUTINE OXPHOS ET | N S | Homogenate | Mouse | Liver |
| Sumbalova 2016a Abstract MitoFit Science Camp 2016 | 2016 | Optimizing strategies on the malate concentration in SUIT protocols. | OXPHOS ET | N S NS | Rat | Nervous system | |
| Cecatto 2016 Abstract IOC116 | 2016 | Cecatto C, Silva JC, Wajner A, Godoy KS, Ribeiro, RT, Amaral AU, Wajner M (2016) cis-4-Decenoic and decanoic acids impair mitochondrial energy, redox and Ca2+ homeostasis and induce mitochondrial permeability transition pore opening in rat brain and liver. Mitochondr Physiol Network 21.11 | LEAK OXPHOS ET | F N CIV Other combinations | Permeabilized tissue Isolated mitochondria | Rat | Nervous system Liver |
| Krumschnabel 2016b Abstract MitoFit Science Camp 2016 | 2016 | O2k-MultiSensor: Mitochondrial respiration media for HRR and simultaneous O2k-Fluorometry. | LEAK OXPHOS ET | N S NS ROX | Human | Kidney HEK | |
| Krajcova 2016 Abstract MitoFit Science Camp 2016 | 2016 | Mitochondrial pathogenesis of propofol infusion syndrome in an in vitro model of human skeletal muscle. | LEAK ET | F | Homogenate | Human | Skeletal muscle |
| Mussulini 2015 Abstract MiPschool London | 2015 | Changes of brain substrates preference and metabolism during seizure induced by pentylenetetrazole in adult zebrafish. | ROUTINE ET | N S | Intact organ | Zebrafish | Nervous system |
| Devaux 2015 Abstract MiP2015 | 2015 | Mitochondrial complexes I and II behave differently in two anoxia-tolerant species: adaptive mitochondrial plasticity may be related to the ability to undergo metabolic depression. | LEAK OXPHOS ET | N S | Homogenate | Fishes | Nervous system |
| Laner 2015 Abstract MiPschool Cape Town 2015 | 2015 | The Oroboros Oxygraph-2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. | LEAK ROUTINE OXPHOS ET | N S NS | Isolated mitochondria Intact cells | Mouse Saccharomyces cerevisiae | Heart |
| Karabatsiakis 2015 Abstract MiP2015 | 2015 | Mitochondrial respiration of peripheral blood mononuclear cells in patients with borderline personality disorder. | LEAK ROUTINE OXPHOS ET | ROX | Human | Blood cells | |
| Ojuka 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Ojuka 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | OXPHOS ET | F | Permeabilized tissue | ||
| Morris 2015 Abstract MiPschool Greenville 2015 | 2015 | Intrinsic high aerobic capacity is associated with protection of mitochondrial respiratory capacity and decreased inflammation following chronic high-fat/high-cholesterol diet challenge. | OXPHOS ET | N | Rat | Liver | |
| Lindquist 2015 Abstract IOC106 | 2015 | Alteraas EK, Lindquist C, Berge RK, Bjorndal B (2015) OXPHOS capacity in mouse liver altered by modified fatty acids that inhibit or stimulate beta-oxidation. Mitochondr Physiol Network 20.10. | OXPHOS ET | Homogenate | Mouse | Liver | |
| Dyrstad 2015 Abstract MiPschool London 2015 | 2015 | Activation of epithelial to mesenchymal transition (EMT) regulates stemness and metabolic reprogramming in mammary epithelial cells. | LEAK ROUTINE ET | N ROX | Human | Endothelial;epithelial;mesothelial cell Other cell lines | |
| Renshaw 2015 Abstract MiP2015 | 2015 | Mitochondrial responses to thermal stress: is the ability to withstand anoxia-induced stress associated with cross-tolerance to thermal stress? | LEAK OXPHOS ET | N S | Homogenate | Fishes | Nervous system |
| Gnaiger 2015 Abstract MiPschool Cape Town 2015 II | 2015 | On coupling control of mitochondrial respiration. What is wrong with the RCR? | LEAK ROUTINE OXPHOS ET | N S ROX | |||
| Ali 2015 Abstract MiP2015 | 2015 | Mitochondrial function and ROS homeostasis in young mouse heart and brain: the sex factor! | LEAK OXPHOS ET | Homogenate | Mouse | Heart Nervous system | |
| Smith 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Smith 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | OXPHOS ET | F | Permeabilized tissue | ||
| Blecha 2015 Abstract MiP2015 | 2015 | Modulation of mitochondrial electron transport chain activity differentially regulates cell death in proliferating and quiescent cells. | LEAK ET | ROX | |||
| Hill 2015 Abstract MiPschool London 2015 | 2015 | A novel inhibitor of the mitochondrial permeability transition pore is beneficial in an experimental model of multiple sclerosis. | OXPHOS ET | Isolated mitochondria | Mouse | Liver | |
| Sumbalova 2015 Abstract MiP2015 | 2015 | High-resolution measurement of mitochondrial membrane potential and respiration – comparison of potentiometric and fluorometric methods. | LEAK OXPHOS ET | N S NS | Isolated mitochondria | Mouse | Nervous system |
| Ojuka 2015 Abstract MiPschool Cape Town 2015 | 2015 | Use of malate or carnitine as co-substrates for assessment of fatty acid oxidation. | LEAK OXPHOS ET | Permeabilized cells Permeabilized tissue Isolated mitochondria | |||
| Rohlena 2015 Abstract MiP2015 | 2015 | Ubiquinone-binding site mutagenesis reveals the role of mitochondrial complex II in cell death initiation. | ROUTINE OXPHOS ET | S ROX | Permeabilized cells Isolated mitochondria | Human | Other cell lines |
| Schauer 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Schauer 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | OXPHOS ET | F | Permeabilized tissue | ||
| Van Dyk 2015 Abstract MiPschool Cape Town 2015 | 2015 | Optimization of selected cell lines for use on the Seahorse extracellular flux analyzer. | LEAK ROUTINE ET | N ROX | Isolated mitochondria | Human | Other cell lines Fibroblast |
| Calzia 2015 Abstract MiP2015 | 2015 | Mitochondrial respiration in homogenized small tissue biopsies from the M. Vastus lateralis of patients with Huntington's Disease before and after cycling exercise. | LEAK OXPHOS ET | N S ROX | Human | Skeletal muscle | |
| Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Cannon 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human Mouse | Skeletal muscle |
| Sheldon 2015 Abstract MiPschool Greenville 2015 | 2015 | eNOS is required to preserve hepatic mitochondrial function in western diet-induced nonalcoholic fatty liver disease. | LEAK OXPHOS ET | N NS | Mouse | Liver | |
| Laner 2015 Abstract MiP2015 | 2015 | Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Dog | Skeletal muscle |
| Ali 2015 Abstract MiPschool Cape Town 2015 | 2015 | Early gender-related dimorphism in heart and brain mitochondria function and ROS dynamics. | LEAK OXPHOS ET | Mouse | Heart Nervous system | ||
| Sleiman 2015 Abstract MiP2015 | 2015 | Mitochondrial respiration in sequential biospies from skeletal muscles during hemorrhagic shock and over the course of 48h of reperfusion in pigs. | LEAK OXPHOS ET | N S | Homogenate | Pig | Skeletal muscle |
| Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Ciapaite 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | LEAK OXPHOS ET | F | Permeabilized tissue | Human Rat | Skeletal muscle |
| Smenes 2015 Abstract IOC100 | 2015 | Smenes BT, Baekkerud FH, Hassel E, Wohlwend M, Slagsvold KH, Rognmo O, Wahba A (2015) Mitochondrial function in patients exercising prior to coronary surgery – A single blinded randomized controlled trial. Mitochondr Physiol Network 20.01. | LEAK ROUTINE ET | N S | Human | Skeletal muscle | |
| Hoppel 2015 Abstract MiP2015 | 2015 | Effects of ultramarathon performance on mitochondrial respiration in human platelets. | ROUTINE OXPHOS ET | N S NS | Permeabilized cells | Human | Blood cells Platelet |
| Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Wuest 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | OXPHOS ET | F N S NS ROX | Permeabilized tissue | Rat | Heart |
| Laner 2015 Abstract MiPschool Greenville 2015 | 2015 | Comparative mitochondrial physiology: OXPHOS and ET capacity in permeabilized fibers of canine superathletes. | OXPHOS ET | F N S NS | Permeabilized tissue | Dog | Skeletal muscle |
| Komelina 2015 Abstract MiP2015 | 2015 | Artificial hypothermia of rats, as opposed to natural hibernation of ground squirrels Spermophilus undulatus, is not accompanied by inhibition of mitochondrial respiration in liver. | ET | Rat Other mammals | Liver | ||
| Nardin 2015 Abstract MiPschool London 2015 | 2015 | Parkin translocation is triggered by its dephosporylation by calcineurin. | ET | ||||
| Weidgang 2015 Abstract MiP2015 | 2015 | Mitochondrial respiration in homogenized biopsies from kidney, liver, heart and diaphragm from mice after blunt thoracic trauma and hemorrhagic shock. Effects of a novel hydrogen sulfide donor AP39. | LEAK OXPHOS ET | N S | Homogenate | Mouse | Heart Skeletal muscle Liver Kidney |
| Chou 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Chou 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | OXPHOS ET | F N S NS ROX | Permeabilized cells Permeabilized tissue | Blood cells Lymphocyte Platelet | |
| Gnaiger 2015 Abstract MiPschool Cape Town 2015 | 2015 | The functional design of the electron transfer system (ETS) and mitochondrial respiratory control. | LEAK ROUTINE OXPHOS ET | N S NS | Permeabilized cells Permeabilized tissue Homogenate Isolated mitochondria | ||
| Gnaiger 2015 Abstract MiP2015 | 2015 | Mitochondrial function of cyropreserved HEK 293T cells: development of a reference sample for high-resolution respirometry. | LEAK ROUTINE OXPHOS ET | N S NS | Permeabilized cells Intact cells | Human | HEK |
| Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | 2015 | Ljubkovic 2015 Fatty Acid Oxidation O2k-Network Discussion Forum | OXPHOS ET | F N NS | Permeabilized tissue | Human | Heart |
| Rutkai 2015 Abstract MiPschool Greenville 2015 | 2015 | Sex-differences in mitochondrial respiration is mediated by nitric oxide in rat cerebral arteries. | LEAK ROUTINE ET | Rat | Endothelial;epithelial;mesothelial cell | ||
| Volani 2015 Abstract IOC106 | 2015 | Volani C, Haschka D, Demetz E, Doerrier C, Gnaiger E, Weiss G (2015) Determination of mitochondrial respiration in peripheral blood mononuclear cells. Mitochondr Physiol Network 20.10. | ROUTINE OXPHOS ET | N S | Homogenate Intact cells | Human Mouse | Heart Liver Blood cells Lymphocyte |
| El-Bacha 2014 Abstract MiP2014 | 2014 | Cytotoxicity of grape pomace extract (Vitis vinifera L.) from Brazilian wine industry in human hepatocarcinoma HepG2 cells. | LEAK ROUTINE ET | Intact cells | Human | Liver | |
| Dohlmann 2014 Abstract MiP2014 | 2014 | Mitochondrial adaptations to high-intensity training in young and elderly men and women. | OXPHOS ET | Permeabilized cells | Human | Skeletal muscle HeLa Fibroblast | |
| Laner 2014 Abstract MiP2014 | 2014 | Cytochrome c flux control factor as a quality criterion in respiratory OXPHOS analysis in canine permeabilized fibers. | LEAK ROUTINE OXPHOS ET | N NS | Permeabilized tissue | Dog | Skeletal muscle |
| Felser 2014 Abstract MiP2014 | 2014 | Assessing mitochondrial dysfunction in fibroblast cells – a comparison between O2k and multiwell respirometry. | ROUTINE ET | ROX | Intact cells | Human | Endothelial;epithelial;mesothelial cell HeLa Fibroblast |
| Nagy 2014 Abstract MiP2014 | 2014 | Investigation of the energy metabolism of microglial cells. | ROUTINE ET | Intact cells | Human | Nervous system | |
| Paes 2014 Abstract IOC 2014-04 Schroecken | 2014 | Paes MC, Saraiva FMS, Nogueira NP, Laranja GAT, Coelho MGP, Oliveira MF (2014) Heme increases mitochondrial membrane potential and ROS production in Trypanosoma cruzi epimastigotes. Mitochondr Physiol Network 19.02. | LEAK OXPHOS ET | S Other combinations | Permeabilized cells Oxidase;biochemical oxidation | Protists | |
| Karabatsiakis 2014 Abstract IOC96 | 2014 | Karabatsiakis A (2014) Consequences of depression on respiratory activity in peripheral blood mononuclear cells. Mitochondr Physiol Network 19.11. | LEAK ROUTINE ET | Intact cells | Human | Blood cells Lymphocyte | |
| Doerrier 2014 Abstract SECF | 2014 | Evaluation of melatonin treatment in mitochondria of permeabilized myocardial fibers from septic mice. | LEAK OXPHOS ET | N S NS ROX | Permeabilized tissue Isolated mitochondria | Mouse | Heart |
| Kluckova 2014 Abstract MiP2014 | 2014 | Proximal ubiquinone binding site in mitochondrial respiratory Complex II is a target for vitamin E analog MitoVES, an experimental anti-cancer agent. Mitochondr Physiol Network 19.13. | OXPHOS ET | S | Other cell lines | ||
| Schoepf 2014 Abstract MiP2014 | 2014 | OXPHOS analysis in small prostate biopsies. | LEAK OXPHOS ET | N S CIV NS | Permeabilized tissue | Human | Genital |
| Mendonca 2014 Abstract IOC 2014-04 Schroecken | 2014 | Mendonca AP, Rodrigues MF, Amoedo ND, Oliveira MF (2014) Effects of iron on mitochondrial physiology of central nervous system cell lines. Mitochondr Physiol Network 19.02. | LEAK OXPHOS ET | Nervous system Other cell lines Neuroblastoma | |||
| Komlodi 2014 Abstract MiP2014 | 2014 | Methylenblue, an enhancer of mitochondrial substrate-level phosphorylation. | OXPHOS ET | N S | Isolated mitochondria | Guinea pig | Nervous system |
| Sumbalova 2014 Abstract MiP2014 | 2014 | Optimization of malate concentration for high-resolution respirometry: mitochondria from rat liver and brain. | OXPHOS ET | F N S NS | Isolated mitochondria | Rat | Nervous system Liver |
| Alberici 2014 Abstract MiP2014 | 2014 | Effects of long-chain acyl-CoA synthetase 6 knockdown in primary skeletal muscle cells metabolism. | LEAK ROUTINE ET | Intact cells | Rat | Skeletal muscle | |
| Volodina 2014 Abstract MiP2014 | 2014 | Multipotent stromal cells injection improves rat liver regeneration through activation of mitochondrial functions after subtotal hepatectomy. | LEAK OXPHOS ET | N NS | Isolated mitochondria | Rat | Liver |
| Krumschnabel 2014 Abstract MiP2014 | 2014 | Simultaneous high-resolution measurement of mitochondrial respiration and hydrogen peroxide production. | LEAK OXPHOS ET | N S NS | Homogenate Isolated mitochondria | Mouse | Nervous system |
| Burtscher 2014 Abstract MiP2014 | 2014 | Region-specific differences in Complex I- and Complex II-linked respiration in the mouse brain. | OXPHOS ET | N S CIV NS | Permeabilized tissue | Mouse | Nervous system |
| Porter 2014 Abstract IOC95 | 2014 | Porter C (2014) The impact of resistance exercise training on skeletal muscle mitochondrial respiration in healthy young adults. Mitochondr Physiol Network 19.10 | LEAK OXPHOS ET | Permeabilized tissue | Human | Skeletal muscle | |
| Shabalina 2013 Abstract IOC79 | 2013 | Shabalina IG (2013) Enhanced Complex I but low Complex II substrate-derived ROS production rates in mice, prematurely aging due to enhanced mitochondrial DNA mutation rate. Mitochondr Physiol Network 18.07 | LEAK OXPHOS ET | N S NS | Isolated mitochondria | Mouse | Heart Skeletal muscle Liver |
| Shabalina 2013 Abstract MiP2013 | 2013 | Shabalina IG, Petrovic N, Kalinovich AV, Cannon B, Nedergaard J (2013) Comparative study of brown and white adipose tissue mitochondria in mice upon cold acclimation. Mitochondr Physiol Network 18.08. | OXPHOS ET | Gp | Isolated mitochondria | Fat | |
| Matallo 2013 Abstract MiP2013 | 2013 | Matallo J, Gröger M, Wagner K, Wagner F, Radermacher P, Calzia E (2013) Effects of mechanical ventilation after blunt chest trauma on diaphragmatic mitochondrial respiration in chronically cigarette smoke exposed mice: A clinically relevant model? Mitochondr Physiol Network 18.08. | ET | NS | Homogenate | Mouse | Heart Skeletal muscle Lung;gill |
| Gnaiger 2013 Abstract Mito2013 | 2013 | Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Conserved mitochondrial coupling efficiency and adaptive substrate control in Inuit and Caucasians: adaptation and acclimatization to the Arctic winter. | LEAK OXPHOS ET | F N S NS | Permeabilized tissue | Human | Skeletal muscle |
| Irving 2013 Abstract MiP2013 | 2013 | Irving BA, Stahl R, Kane CJ, Chernousov M, Argyropoulos G, Carey D (2013) Sex differences in murine mitochondrial oxidative capacity following a 24 week high-fat diet. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N NS | Permeabilized tissue Homogenate | Mouse | Skeletal muscle Liver Fat |
| Skulachev 2013 Abstract MiP2013 | 2013 | Skulachev VP (2013) SkQ1, the first mitochondria-targeted medicine available in drugstores. Mitochondr Physiol Network 18.08. | LEAK ET | Intact organism Isolated mitochondria SMP Intact cells | Human Mouse Horse Dog Rabbit Fishes Other invertebrates Fungi Plants | Heart Skeletal muscle Nervous system Kidney Islet cell;pancreas;thymus Other cell lines HeLa Fibroblast Stem cells | |
| Amoedo 2013 Abstract MiP2013 | 2013 | Amoêdo ND, Rodrigues MF, Pereira S, Melo F, Jasiulionis M, Galina A, Rumjanek FD(2013) Comparative biochemistry of tumorigenesis: role of mitochondria in the metastatic process. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S ROX | Permeabilized cells Enzyme Intact cells | Mouse | Endothelial;epithelial;mesothelial cell Other cell lines |
| Slinde 2013 Abstract MiP2013 | 2013 | Slinde E, Egelandsdal B, Olsen RE (2013) Respiration of tissue and mitochondria from Atlantic salmon (Salmo salar, L) liver, muscle, heart, brain and blood. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N ROX | Permeabilized tissue Isolated mitochondria | Other mammals Fishes | Heart Liver Blood cells |
| Oliveira MF 2013 Abstract MiP2013 | 2013 | Oliveira MF (2013) Comparative mitochondrial physiology in blood feeding insect vectors and parasites. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | F N S Gp CIV ROX | Intact organism Intact organ Permeabilized cells Permeabilized tissue Homogenate Intact cells | Human Drosophila Hexapods Other invertebrates | Skeletal muscle Neuroblastoma |
| Garcia-Roves 2013 Abstract MiP2013 | 2013 | Garcia-Roves PM, Gonzalez-Franquesa A, Martinez-Navarro L, Fernandez-Ruiz R (2013) Metabolic flexibility before and after lifestyle intervention in a diet-induced type 2 diabetes animal model. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S CIV NS | Permeabilized cells Permeabilized tissue Homogenate | Mouse | Skeletal muscle Nervous system Liver Islet cell;pancreas;thymus Fat |
| Krumschnabel 2013 Abstract MiP2013 | 2013 | Krumschnabel G, Eigentler A, Fontana-Ayoub M, Draxl A, Fasching M, Gnaiger E (2013) Tissue homogenates for respiratory OXPHOS analysis in comparative mitochondrial physiology: mouse and trout – heart and liver. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S NS ROX | Homogenate | Mouse Fishes | Heart Nervous system Liver |
| Calzia 2013 Abstract MiP2013 | 2013 | Calzia E, Wagner K, Wagner F, Groeger M, Matallo J, McCook O, Wachter U, Vogt J, Radermacher P (2013) Studying mitochondrial effects of sulfide. Does the species matter? Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | Pig Mouse | Liver | ||
| Votion 2013 Abstract MiP2013 | 2013 | Votion DM, Mouithys-Mickalad A, Ceusters Justine D, Lemieux H, Tosi I, Franck T, Art T, Niesten A, Serteyn D (2013) The challenge of understanding myopathies in horses using permeabilized muscle cells. Mitochondr Physiol Network 18.08. | OXPHOS ET | F N S NS ROX | Permeabilized tissue | Horse | Skeletal muscle |
| Camacho-Pereira 2013 Abstract IOC75 | 2013 | Camacho-Pereira J (2013) CD38 as a regulator of mitochondrial function. Mitochondr Physiol Network 18.03. | LEAK ROUTINE OXPHOS ET | N S NS | Intact cells Permeabilized cells Isolated mitochondria | Mouse | Liver HEK Macrophage-derived |
| Pichaud 2013 Abstract MiP2013 | 2013 | Pichaud N, Blier PU(2013) Importance of mitochondrial haplotypes in the expression of metabolic phenotypes under different conditions. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S Gp CIV NS ROX | Permeabilized tissue | Drosophila Hexapods | Skeletal muscle |
| Jezek 2013 Abstract MiP2013 | 2013 | Ježek P, Ježek J, Zelenka J, Dlasková A, Jabůrek M (2013) Antioxidant synergy of mitochondrial uncoupling protein UCP2 and phospholipase iPLA2γ. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S ROX | Isolated mitochondria Intact cells | Mouse | Lung;gill Islet cell;pancreas;thymus |
| Pecina 2013 Abstract MiP2013 | 2013 | Pecina P, Houšťková H, Mráček T, Pecinová A, Nůsková H, Tesařová M, Hansíková H, Janota J, Zeman J, Houštěk J (2013) The use of lymphocytes for diagnostics of mitochondrial oxidative phosphorylation disorders. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S Gp NS Other combinations ROX | Permeabilized cells Homogenate | Human | Blood cells Lymphocyte |
| Chicco 2013 Abstract MiP2013 | 2013 | Chicco AJ, Le CH, Schlater A, Kanatous S (2013) Comparative muscle mitochondrial physiology of the northern elephant seal. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | F N Other combinations | Permeabilized tissue | Human Other mammals | Skeletal muscle |
| Zelenka J 2013 Abstract MiP2013 | 2013 | Zelenka J, Alan L, Jezek P(2013) Response of cancer cells to mitochondrial DNA damage. Mitochondr Physiol Network 18.08. | ROUTINE ET | Other cell lines | |||
| Gnaiger 2013 Abstract MiP2013 | 2013 | Gnaiger E, Søndergaard H, Munch-Andersen T, Damsgaard R, Hagen C, Díez-Sánchez C, Ara I, Wright-Paradis C, Schrauwen P, Hesselink M, Calbet J, Christiansen M, Helge JW, Saltin B, Boushel R (2013) Biochemical coupling efficiency in permeabilized fibers from arm and leg muscle in Inuit versus Caucasians: A functional test of the uncoupling hypothesis in Greenland. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | F N S NS | Permeabilized tissue | Human | Skeletal muscle |
| Rodrigues 2013 Abstract MiP2013 | 2013 | Rodrigues MF, Amoedo ND, Rumjanek FD (2013) Studies of bioenergetics alterations in breast cancer lines induced by histone desacetylase inhibitors. Mitochondr Physiol Network 18.08. | LEAK ROUTINE ET | ROX | Intact cells | Genital | |
| Hand 2013 Abstract MiP2013 | 2013 | Hand SC, Patil Y (2013) Defense against ATP depletion during the energy-limited state of diapause. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | N S | Intact organism Homogenate Isolated mitochondria Enzyme | Artemia Crustaceans | |
| Garcia-Souza 2013 Abstract IOC80 | 2013 | Garcia-Souza LF (2013) Thrombin trigger mitochondrial functional remodeling in human platelets. Mitochondr Physiol Network 18.09. | LEAK ROUTINE ET | Intact cells | Human | Blood cells | |
| Dzialowski 2013 Abstract MiP2013 | 2013 | Dzialowski EM, Ream S, Duquaine A, Sirsat TS, Goy Sirsat SK (2013) Mitochondrial function and the development of endothermy in the precocial Pekin duck (Anas pekin). Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | F N S NS | Intact organism Permeabilized tissue | Birds | Skeletal muscle |
| Cavalcanti de Albuquerque 2013 Abstract MiP2013 | 2013 | Cavalcanti de Albuquerque JP, Salvador IC, Martins EG, Jardim-Messeder D; Werneck de Castro JPS; Carvalho DP; Galina A (2013) Skeletal muscle mitochondrial function in ovariectomized rats: A time course study and the role of estrogen replacement. Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | F N S Gp NS ROX | Intact organism Permeabilized tissue | Rat | Skeletal muscle |
| Hendricks 2013 Abstract MiP2013 | 2013 | Hendricks E, Nathan BP, Menze MA (2013) Bioenergetics of permeabilized and intact nerve cell terminals from ApoE deficient and wild type mice. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S NS | Intact cells Permeabilized cells Isolated mitochondria | Mouse | Nervous system |
| Salin 2013 Abstract MiP2013 | 2013 | Salin K, Luquet E, Rey B, Roussel D, Voituron Y (2013) Mitochondrial functioning, a proximate mechanism underlying the pace-of- life? Mitochondr Physiol Network 18.08. | LEAK OXPHOS ET | S CIV | Isolated mitochondria Enzyme Oxidase;biochemical oxidation | Other mammals Amphibians | Liver |
| Christen 2013 Abstract MiP2013 | 2013 | Christen F, Desrosiers V, Blier PU (2013) Thermal sensitivity of mitochondria from arctic charr heart: Mitochondrial respiration and ROS production. Mitochondr Physiol Network 18.08. | OXPHOS ET | N S CIV NS ROX | Isolated mitochondria | Other mammals Fishes | Heart |
| Laner 2013 ASMRM | 2013 | Laner V, Gradl P, Eigentler A, Fontana-Ayoub M, Fasching M, Gnaiger E (2013) The Oroboros O2k for high-resolution respirometry and O2k-Fluorometry: a new quality in OXPHOS analysis. ASMRM2013. | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
| Hickey 2013 Abstract MiP2013 | 2013 | Hickey AJ, Iftikar FI, MacDonald J, Baker D (2013) Mitochondria in a changing climate? The role of mitochondrial in hyperthermic heart failure in different fish species. Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S CIV NS | Permeabilized tissue | Other mammals Fishes | Heart |
| Galina 2013 Abstract MiP2013 | 2013 | Galina A, Messeder DJM, Camacho-Pereira J, Pereira da Silva AP, Rodrigues-Ferreira C (2013) Effects of antitumor alkylating agent 3-bromopyruvate on energy transducing pathways in hepatoma HepG2, liver mitochondria and SERCA: Is there any role for mitochondrial hexokinase activity? Mitochondr Physiol Network 18.08. | LEAK ROUTINE OXPHOS ET | N S | Permeabilized cells Isolated mitochondria Enzyme Intact cells | Rat | Skeletal muscle Nervous system Liver Other cell lines |
| Doerrier 2012 Abstract Bioblast | 2012 | Doerrier C, Garcia JA, Escames G, Acuna-Castroviejo D (2012) Treatment with melatonin prevents myocardial mitochondrial dysfunction in experimental sepsis in mice. Mitochondr Physiol Network 17.12. | LEAK OXPHOS ET | N S NS | Permeabilized tissue | Mouse | Heart |
| Rodrigues 2012 Abstract IOC72 | 2012 | Rodrigues MF, Amoedo ND, Rumjanek FD (2012) Studies of bioenergetics alterations in breast cancer lines induced by sodium butyrate. Mitochondr Physiol Network 17.13. | LEAK ROUTINE ET | ||||
| Horscroft 2012 Abstract IOC72 | 2012 | Horscroft JA, Kotwica AO, Ashmore T, Colleoni F, Morash AJ, Gilbert E, Gnaiger E, Martin DS, Murray AJ (2012) Mitochondrial function at altitude in lowland Europeans and highland Sherpas. Mitochondr Physiol Network 17.13. | LEAK OXPHOS ET | N NS | Human | Skeletal muscle | |
| Hand 2012 Abstract Bioblast | 2012 | Patil Y, Gnaiger E, Hand SC (2012) Respiration in embryo lysates reveals diminished Complex I activity and inhibition of the phosphorylation system during diapause in Artemia franciscana. Mitochondr Physiol Network 17.12. | OXPHOS ET | N S NS | Homogenate | Artemia Crustaceans | |
| Horvath 2012 Abstract Bioblast | 2012 | Horvath G, Eigentler A, Gnaiger E, Tretter L (2012) Respiratory substrate effects on mitochondrial membrane potential - experiments with mouse cardiac muscle homogenate. Mitochondr Physiol Network 17.12. | LEAK OXPHOS ET | N S NS | Homogenate | Mouse | Heart |
| Kamath 2012 Abstract IOC72 | 2012 | Kamath VG, Lizenby ZJ, Adusumilli VRKR, Hsiung CH, McKee EE (2012) Measuring mitochondrial OXPHOS as a nucleoside reverse transcriptase inhibitor induced cardiac toxicity endpoint. Mitochondr Physiol Network 17.13. | LEAK OXPHOS ET | Isolated mitochondria | Rat | ||
| Labieniec-Watala 2012 Abstract Bioblast | 2012 | Labieniec-Watala M, Siewiera K, Watala C (2012) Seasonal fluctuations affect the physiology of laboratory animals – facts and artifacts from the perspective of heart mitochondrial respiratory response to tested compounds. Mitochondr Physiol Network 17.12. | LEAK OXPHOS ET | N S NS | Homogenate Isolated mitochondria | Mouse Rat | Heart Liver Fibroblast |
| Amoedo 2012 Abstract Bioblast | 2012 | Amoedo ND, Rodrigues MF, Pereira SAS, Melo FH, Jasiulionis MG, Galina A, Rumjanek FD (2012) Mitochondrial function and bioenergetics during malignant transformation and metastasis. Mitochondr Physiol Network 17.12. | LEAK ROUTINE OXPHOS ET | S | Intact cells | Mouse | Other cell lines |
| Le 2012 Abstract Bioblast | 2012 | Le CH, Hocker AD, Dreyer HC, Roach RC, Gnaiger E, Chicco AJ (2012) Two-week acclimatization to 5200m markedly alters substrate utilization and increases OXPHOS efficiency, with no effect on respiratory capacity in skeletal muscle mitochondria. Mitochondr Physiol Network 17.12. | OXPHOS ET | N S | Permeabilized tissue | Human | Skeletal muscle |
| Albertini 2012 Abstract Bioblast | 2012 | Albertini E, Koziel R, Duerr A, Neuhaus M, Jansen-Duerr P (2012) Cystathionine beta synthase modulates senescence of human endothelial cells. Mitochondr Physiol Network 17.12. | LEAK ROUTINE ET | Intact cells | Endothelial;epithelial;mesothelial cell HUVEC | ||
| Watala 2012 Abstract Bioblast | 2012 | Watala C, Przygodzki T, Siewiera K, Kassassir H, Talar M, Labieniec-Watala M (2012) Oxygen consumption in resting and activated blood platelets: platelet mitochondria and cyclooxygenases as compounding targets for high-resolution respirometry. Mitochondr Physiol Network 17.12. | ROUTINE ET | NS ROX | Isolated mitochondria Enzyme Intact cells | Human Rat | Endothelial;epithelial;mesothelial cell Blood cells Platelet |
| Jacobs 2012 Abstract Bioblast | 2012 | Jacobs R, Lundby C (2012) Mitochondria express enhanced quality as well as quantity in parallel with aerobic fitness across recreationally active individuals up to elite athletes. Mitochondr Physiol Network 17.12. | LEAK OXPHOS ET | F N S NS | Permeabilized cells | Human | Skeletal muscle |
| Towheed 2012 Abstract IOC72 | 2012 | Towheed A (2012) Elucidating pathogenesis of ATP synthase dysfunction in a Drosophila model of mitochondrial encephalomyopathy. Mitochondr Physiol Network 17.13. | LEAK ROUTINE OXPHOS ET | N S NS | Intact organism Permeabilized tissue | Drosophila Hexapods | |
| Pesta 2011Abstract Mitochondrial Medicine-Training | 2011 | Pesta D, Hoppel F, Macek C, Messner H, Faulhaber M, Kobel C, Parson W, Burtscher M, Schocke M, Gnaiger E (2011) Mitochondrial improvements after strength, endurance, and intermittend hypoxic training in sedentary humans. A respiratory study on permeabilized muscle fibers. Abstract Mitochondrial Medicine Chicago. | LEAK OXPHOS ET | F N S NS ROX | Permeabilized tissue | Human | Skeletal muscle |
| Sumbalova 2011 Abstract Mitochondrial Medicine | 2011 | Sumbalova Z, Fasching M, Gnaiger E (2011) Substrate control in mitochondrial respiration and regulation of mitochondrial membrane potential. Abstract Mitochondrial Medicine Chicago. | LEAK OXPHOS ET | N S NS | Homogenate Isolated mitochondria | Mouse | Nervous system |
| Pesta 2010 MiP Abstract | 2010 | Pesta D, Faulhaber M, Burtscher M, Gnaiger E, Schocke M (2010) Investigation of muscle metabolism of the M. quadriceps via 31P MRS and high-resolution respirometry in connection with 10 weeks of strength and endurance training in normoxia and hypoxia. MiP2010. | LEAK OXPHOS ET | F N S NS | Human | ||
| Matallo MiP2010 | 2010 | Matallo J, Reich V, Calzia E, Radermacher P, Groeger M (2010) Interactions between sulfide and mitochondrial respiration in cultured murine alveolar macrophage. Abstract. MiP2010. | OXPHOS ET | N S | Permeabilized cells | Lung;gill Macrophage-derived | |
| Amoedo 2010 Abstract MiP2010 | 2010 | Amoêdo ND, Rodrigues MF, Pezutto P, Lourenço MVC, Madeiro da Costa RF, Oliveira MF, Galina A, Rumjanek FD, El-Bacha T (2010) Metabolic reprogramming of lung cancer cell induced by sodium butyrate: Studies on mitochondrial physiology and bioenergetics. Mitochondr Physiol Network 15.06. | OXPHOS ET | Intact cells | Human | Endothelial;epithelial;mesothelial cell Fibroblast | |
| Gnaiger 2005 Abstract MiP2005 | 2005 | Gnaiger Erich, Wright-Paradis C, Sondergaard H, Lundby C, Calbet Jose AL, Saltin Bengt, Helge J, Boushel R (2005) High-resolution respirometry in small biopsies of human muscle: correlations with body mass index and age. MiP2005. | OXPHOS ET | F N CIV NS | Permeabilized tissue | Human | Skeletal muscle |
| Bioblast link | Reference | Year |
|---|---|---|
| Gnaiger 2020 BEC MitoPathways | Gnaiger E (2020) Mitochondrial pathways and respiratory control. An introduction to OXPHOS analysis. 5th ed. https://doi.org/10.26124/bec:2020-0002 | BEC 2020.2 |
| BEC 2020.1 doi10.26124bec2020-0001.v1 | Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. https://doi.org/10.26124/bec:2020-0001.v1 | BEC 2020.1 |
MitoPedia concepts:
MiP concept,
Respiratory state,
Recommended
MitoPedia methods:
Respirometry
MitoPedia topics:
Uncoupler,
EAGLE
Labels:
Coupling state: ET
HRR: Theory
