From Bioblast

CA22169 - EUropean network to tackle METAbolic alterations in HEART failure (EU-METAHEART)

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CA22169 - EUropean network to tackle METAbolic alterations in HEART failure (EU-METAHEART)

  • MoU: 079/23
  • CSO Approval date: 2023-05-12
  • Duration: 48 months
  • Start: 2023-10-18



The COST Action β€œEUropean network to tackle METAbolic alterations in HEART failure” (EU-METAHEART) will bring together excellent researchers from Europe to contribute a broad spectrum of scientific expertise, cutting-edge technologies, scientific exchange and education to foster breakthrough science that moves the field forward towards improving the treatment of patients with heart failure. By sharing diverse expertise that cover not only conventional analyses of metabolism and mitochondrial function, but also omics-based approaches towards genetics, epigenetics and metabolism and in particular, integrated assessment of excitation-contraction coupling with mitochondrial redox control and energetics, as well as advanced in vivo imaging technologies, the novelty of this COST Action is that it will allow to develop a comprehensive and cutting-edge approach towards deeper understanding of metabolic dysfunction in HF. We have identified four scientific key areas to which metabolic or mitochondrial dysfunction are central, which will be addressed by four working groups (WGs):
1) Impact of metabolic disorders on substrate and intermediary metabolism in cardiac myocytes
2) Metabolic aspects of vascular dysfunction
3) Immunometabolism: how metabolic alterations control inflammation and vice versa
4) Mechano-energetic uncoupling and mitochondrial redox alterations
These research areas are tightly intertwined and can hardly be investigated in isolation (from each other). Therefore, EU-METAHEART will employ an integrative approach to bring all these research fields under one umbrella. The working groups focus on their respective four topics, but benefit from the expertise in the respective other WGs to overcome scientific and methodological boundaries and rapidly move the field forward towards drug development.



Management Committee

See the list of the Management Committee here.

Oroboros project involvement

Dr. Erich Gnaiger, CEO of Oroboros Instruments GmbH, is a member of the Management Committee of the CA22169 - EUropean network to tackle METAbolic alterations in HEART failure (EU-METAHEART).


EU-METAHEART Conference Wuerzburg DE2024-09-12
COST Action
Wuerzburg, DE, 2024 Sep 12-13. COST-Action EU-METAHEART Conference 2024.
IOC165 Wuerzburg DE2024-09-09
Wuerzburg DE, 2024 Sep 09 - Sep 11. COST-Action EU-METAHEART Training School, IOC165.
EU-METAHEART MC2 Meeting 2024 Antalya TR2024-03-18
COST Action
Antalya TR, 2024 Mar 18-21. EU-METAHEART MC2 Meeting
EU-METAHEART Kick-off meeting Brussels BE2023-10-18
COST Action
Brussels BE, 2023 October 18. EU-METAHEART Kick-off meeting - first MC meeting for COST Action project.


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Funded by the European Union.

COST (European Cooperation in Science and Technology) is a funding agency for research and innovation networks. Our Actions help connect research initiatives across Europe and enable scientists to grow their ideas by sharing them with their peers. This boosts their research, career, and innovation. -

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