Gainutdinov 2022 BEC

From Bioblast

Bioenergetics Communications        
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Gnaiger 2020 BEC MitoPathways
Gnaiger Erich et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1.
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Bioenergetics Communications
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Gainutdinov T, Debska-Vielhaber G, Gizatullina Z, Vielhaber S, Orynbayeva Z, Gellerich FN (2022) Impaired Ca2+ signaling indicates disturbed mitochondrial function in fibroblasts from patients with sporadic and familial ALS. Bioenerg Commun 2022.18.

Β» Bioenerg Commun 2022.18. Open Access pdf
published online 2022-12-09

AGainutdinov Timur, Debska-Vielhaber Grazyna, Gizatullina Zemfira, Vielhaber Stefan, Orynbayeva Zulfiya, Gellerich Frank Norbert (2022) Bioenerg Commun

Abstract: BEC.png
Amyotrophic lateral sclerosis (ALS) is a progressive, devastating, neurodegenerative disorder affecting upper and lower motor neurons. Common mechanisms of ALS pathogenesis disturb cellular calcium homeostasis and cause mitochondrial dysfunction. Both influence mutually each other. As a result, chronic mitochondrial energy stress impairs cellular signaling and transport processes, leading to degeneration of motor neurons. We measured cytosolic Ca2+ in healthy and ALS fibroblasts. Mitochondrial calcium retention capacity in fibroblasts obtained from patients with sporadic (sALS) and familial (fALS) ALS differed between two subtypes and from healthy individuals. Changes of [Ca2+]cyt dynamics in ALS fibroblasts was partially rescued by treatment with antioxidants (Trolox and CoQ10). These results confirm a causative role of oxidative stress in mitochondrial dysfunction linked to ALS.
β€’ Keywords: ALS, CoQ10, cellular Ca2+ homeostasis, histamine, mitochondria, Trolox β€’ Bioblast editor: Tindle-Solomon L β€’ O2k-Network Lab: DE Bonn Kunz WS, DE Magdeburg Debska-Vielhaber G, DE Magdeburg Gellerich FN

ORCID: ORCID.png Gainutdinov Timur, ORCID.png Debska-Vielhaber Grazyna, ORCID.png Gizatullina Zemfira, ORCID.png Vielhaber Stefan, ORCID.png Orynbayeva Zulfiya, ORCID.png Gellerich Frank Norbert

MitoFit Preprint

Β» Gainutdinov 2022 MitoFit

Labels: MiParea: Patients  Pathology: Inherited, Neurodegenerative 

Organism: Human  Tissue;cell: Fibroblast  Preparation: Intact cells 

Regulation: Calcium 


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