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Galemou Yoga 2020 Biochim Biophys Acta Bioenerg

From Bioblast
Publications in the MiPMap
Galemou Yoga E, Angerer H, Parey K, Zickermann V (2020) Respiratory complex I - Mechanistic insights and advances in structure determination. https://doi.org/10.1016/j.bbabio.2020.148153

Β» Biochim Biophys Acta Bioenerg 1861:148153. PMID: 31935361 Open Access

Galemou Yoga Etienne, Angerer Heike, Parey Kristian, Zickermann Volker (2020) Biochim Biophys Acta Bioenerg

Abstract: Complex I is the largest and most intricate redox-driven proton pump of the respiratory chain. The structure of bacterial and mitochondrial complex I has been determined by X-ray crystallography and cryo-EM at increasing resolution. The recent cryo-EM structures of the complex I-like NDH complex and membrane bound hydrogenase open a new and more comprehensive perspective on the complex I superfamily. Functional studies and molecular modeling approaches have greatly advanced our understanding of the catalytic cycle of complex I. However, the molecular mechanism by which energy is extracted from the redox reaction and utilized to drive proton translocation is unresolved and a matter of ongoing debate. Here, we review progress in structure determination and functional characterization of complex I and discuss current mechanistic models. β€’ Keywords: Membrane bound hydrogenase, Mitochondria, NADH:Ubiquinone oxidoreductase, Oxidative phosphorylation, Redox-linked proton translocation, Respiratory chain β€’ Bioblast editor: Plangger M


Labels: MiParea: mt-Structure;fission;fusion 



Enzyme: Complex I