Gama Perez 2023 MiP2023

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Gama Perez 2023 MiP2023

Gama Perez Pau
Impact of obesity on white adipose tissue plasticity: addressing depot-specific responses

Link: MiP2023 Obergurgl AT

Gama Perez Pau (2023)

Event: MiP2023 Obergurgl AT

Authors: Gama Perez Pau

Chronic overfeeding has a profound metabolic impact on multiple tissues. Consequently, unraveling the differential adaptations in each of them is fundamental to understand the progression of obesity-related comorbidities. In our laboratory we have tackled this issue in a model of obesity and weight loss induced by a combined nutritional and exercise intervention. This model has enabled us to identify visceral adipose tissue as the most vulnerable organ to such stress, not only by the magnitude of changes observed in the obese state but most importantly, because of the permanent alterations we observe even after the restoration of adequate weight and metabolic health. Whether this fingerprint is a distinctive trait of the visceral fat or it is affecting other depots is still unsolved, although the recognized developmental, morphological as well as functional differences among fat depots might drive a differential response. To this end, we aim to explore the subcutaneous adipose tissue behavior in our model, characterizing those significant indicators of vulnerability already identified in the visceral depot. These include linear regression models to correlate tissue mass and body weight, histological and immunohistochemical analysis to characterize the morphological remodeling of the tissue, the assessment of transcriptional changes in both tissues, as well as the impact on mitochondria through the evaluation of OXPHOS capacities and the quantification of mitochondrial DNA. This comparative analysis suggests that unlike visceral fat, the detrimental impact of chronic overfeeding is blunted in subcutaneous adipose tissue, with no apparent consequences on its metabolic plasticity. Among the important points to consider, these findings could represent a relevant concern for the study of obesity-related pathophysiology in humans since, thus far, most longitudinal studies exploring adipose tissue responses to weight fluctuations have been addressed in subcutaneous biopsies due to ethical constrains.


β€’ O2k-Network Lab: ES Barcelona Garcia-Roves PM


Affiliations

Gama-Perez Pau
Department of Physiological Science, University of Barcelona, Barcelona, Spain
Biomedical Epigenomics Group, IDIBAPS, Barcelona, Spain
Corresponding author: [email protected]

Labels: MiParea: Exercise physiology;nutrition;life style  Pathology: Obesity 


Tissue;cell: Fat 




Event: Oral 


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