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Gerisch 2020 Dev Cell

From Bioblast
Publications in the MiPMap
Gerisch B, Tharyan RG, Mak J, Denzel SI, Popkes-van Oepen T, Henn N, Antebi A (2020) HLH-30/TFEB is a master regulator of reproductive quiescence. Dev Cell 53:316-29.

Β» PMID: 32302543

Gerisch B, Tharyan RG, Mak J, Denzel SI, Popkes-van Oepen T, Henn N, Antebi A (2020) Dev Cell

Abstract: All animals have evolved the ability to survive nutrient deprivation, and nutrient signaling pathways are conserved modulators of health and disease. In C. elegans, late-larval starvation provokes the adult reproductive diapause (ARD), a long-lived quiescent state that enables survival for months without food, yet underlying molecular mechanisms remain unknown. Here, we show that ARD is distinct from other forms of diapause, showing little requirement for canonical longevity pathways, autophagy, and fat metabolism. Instead it requires the HLH-30/TFEB transcription factor to promote the morphological and physiological remodeling involved in ARD entry, survival, and recovery, suggesting that HLH-30 is a master regulator of reproductive quiescence. HLH-30 transcriptome and genetic analyses reveal that Max-like HLH factors, AMP-kinase, mTOR, protein synthesis, and mitochondrial fusion are target processes that promote ARD longevity. ARD thus rewires metabolism to ensure long-term survival and may illuminate similar mechanisms acting in stem cell quiescence and long-term fasting.

Copyright Β© 2020 Elsevier Inc. All rights reserved. β€’ Keywords: TFEB, Adult reproductive diapause, Quiescence, Starvation β€’ Bioblast editor: Plangger M β€’ O2k-Network Lab: DE Cologne Antebi A


Labels: MiParea: Respiration, Developmental biology  Pathology: Aging;senescence 

Organism: Caenorhabditis elegans 

Preparation: Intact organism 



HRR: Oxygraph-2k 

2020-04