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Gnaiger 2000 Transplant Proc

From Bioblast
Publications in the MiPMap
Gnaiger E, Kuznetsov AV, Königsrainer A, Margreiter R (2000) Autooxidation of glutathione in organ preservation solutions. Transplant Proc 32:14.

» PMID: 10700947

Gnaiger Erich, Kuznetsov AV, Koenigsrainer A, Margreiter R (2000) Transplant Proc

Abstract: AUTOOXIDATION reactions of highly reduced organic compounds are a source of reactive oxygen species that contribute to ischemia/reperfusion injury. Antioxidants such as reduced glutathione (GSH; g-glutamylcysteinylglycine) are added to organ preservation solutions to reduce oxidative stress.1,2 GSH is unstable, however, in University of Wisconsin (UW) solution in the presence of oxygen.3 To our knowledge, no reports are available on the stability of GSH in other organ preservation solutions, such as histidine-tryptophan-ketoglutarate (HTK) or Celsior solution. The present study reports for the first time a quantitative comparison of autooxidation of GSH in a variety of established preservation solutions, demonstrating in particular the high stability of GSH in HTK solution.

O2k-Network Lab: AT Innsbruck Gnaiger E, AT Innsbruck Oroboros

Labels: MiParea: Pharmacology;toxicology 

Stress:Ischemia-reperfusion, Oxidative stress;RONS 

Preparation: Oxidase;biochemical oxidation 

Regulation: Oxygen kinetics, pH, Substrate, Temperature 

HRR: Oxygraph-2k