Gnaiger 2015 Abstract DrugDiscovery conference 2015
|A lifestyle drug for mitochondrial fitness – from respiratory mitochondrial diagnosis to therapy.
Gnaiger E (2015)
Mitochondrial dysfunction contributing to the etiology of preventable metabolic diseases is subject of intensive research with world-wide health implications. These investigations gained depth and scope by technological advances for diagnosis by comprehensive OXPHOS analysis using high-resolution respirometry. Fundamental questions of a causal relationship, however, between compromised mitochondrial function and disease remain to be resolved to optimize prevention and treatment.
Post-industrial societies are characterized by a high-energy input lifestyle with diminished physical activity and high incidence of non-transmittable diseases, in comparison to human populations where physical work is essentially important for sustaining life and in which degenerative diseases (T2 diabetes, various cancers, Alzheimer's) are essentially absent. Oxidative phosphorylation capacity (OXPHOS) is maintained high by a life style involving endurance and strength exercise. Depending on group selection in cross-sectional studies, OXPHOS declines from 20-30 years, or is independent of age up to 80 years. Independent of age at a BMI >30, a threshold of declining OXPHOS capacity is reached in human V. lateralis characteristic of a low-grade inflammatory state (‘mitochondrial fever’). Onset of degenerative diseases (T2 diabetes, neuromuscular degeneration, various cancers) and mitochondrial fever interact in an amplification loop progressing slowly with age, such that cause and effect of mitochondrial dysfunction cannot be distinguished. Diminished antioxidant capacity at low mitochondrial density is an important biomarker.
For implementing a life style supporting mitochondrial competence and preventing degenerative diseases in modern societies, we need (1) extended research programmes focused on the causative link between mitochondrial competence and effective prevention of degenerative diseases, (2) educational programmes on mitochondrial physiology targeted at general practitioners, teachers and the society at large, (3) cooperation of health care and insurance organizations to support preventive life style activities, and (4) do not miss any opportunity in taking the lead in living the mtLife Style Drug: mtLSD.
Contribution to K-Regio project MitoFit.
• Keywords: BMI
Labels: MiParea: Respiration, Exercise physiology;nutrition;life style, mt-Medicine, mt-Awareness
Coupling state: OXPHOS
1-Swarovski Research Lab, Dept Visceral, Transplant Thoracic Surgery, Medical Univ Innsbruck; 2-Oroboros Instruments, Innsbruck, Austria. - [email protected]