Goodpaster 2016 Abstract MitoFit Science Camp 2016

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The molecular transducers of physical activity consortium (MoTrPAC) and MitoEAGLE: exercise effects on mitochondria.

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Goodpaster BH (2016)

Event: MitoFit Science Camp 2016 Kuehtai AT

The MoTrPAC is a new initiative funded by the U.S. National Institutes of Health to investigate the biological molecules in response to acute and chronic exercise, and to relate these changes to the benefits of physical activity. This molecular map will contain the many molecular signals that transmit the health effects of physical activity, and indicate how they are altered by age, sex, and fitness level. Clinical centers across the U.S. will obtain skeletal muscle, adipose tissue and blood specimens in ~2,500 healthy human subjects before and after bouts of acute exercise and following an exercise training program, and in a smaller number of non-exercise control subjects and in highly-trained athletes. Although not likely to be included in the primary analyses of blood and tissue specimens, mitochondria was a featured topic of importance during the NIH-convened working group webinars and discussions that helped guide the MoTrPAC [1]. We will propose an ancillary study to investigate the effects of exercise on mitochondrial genetics, energetics, dynamics, e.g., fusion, fission, mitophagy, epigenomics, oxidative stress and redox biology in skeletal muscle, adipose tissue and peripheral blood cells. This project within the MoTrPAC could synergize with MitoEAGLE to provide novel insights about the role of mitochondria and exercise in human health.


O2k-Network Lab: US FL Orlando Goodpaster BH


Labels: MiParea: Exercise physiology;nutrition;life style 


Organism: Human  Tissue;cell: Skeletal muscle, Blood cells, Fat 




Event: D3  MitoFit Science Camp 2016 

Affiliations

Translational Research Inst Metabolism Diabetes, Florida Hospital, Orlando, FL, USA. - [email protected]

References

  1. Neufer PD, Bamman MM, Muoio DM, Bouchard , Cooper DM, Goodpaster BH, Booth FW, Kohrt WM, Gerszten RE, Mattson MP, Hepple RT, Kraus WE, Reid MB, Bodine SC, Jakicic JM, Fleg JL, Williams JP, Joseph L, Evans M, Maruvada P, Rodgers M, Roary M, Boyce AT, Drugan JK, Koenig JI, Ingraham RH, Krotoski D, Garcia-Cazarin M, McGowan JA, Laughlin MR (2015) Understanding the cellular and molecular mechanisms of physical activity-induced health benefits. Cell Metab 22:4-11. »Bioblast Link