From Bioblast
HU Budapest Chinopoulos C
| O2k-Network Lab | Department of Medical Biochemistry Semmelweis University'Oroboros O2k-Training Centre'Power-O2k Network Cluster: HU Budapest Semmelweis Univ |
|---|---|
| Address | Tuzolto st. 37-47, 1094 |
| City | Budapest |
| State/Prov | |
| Country | Hungary |
| Weblink | |
| Contact | Chinopoulos Christos |
| Team | Pallag Gergely, Ravasz Dora, Bui David, Karnok Noemi |
| Team previous | Kiss Gergely, Konrad Csaba |
| Status | O2k-Training Centre O2k 2012- |
| Oroboros Events | IOC141, MitoEAGLE 2018 AT, MitoEAGLE 2018 LV, IOC127, MitoFit Workshop ATP 2017, IOC75, Bioblast 2012, IOC72, IOC66, IOC62 |
| Topics |
O2k-Publications
| Published | Reference | |
|---|---|---|
| Ravasz 2024 Sci Rep | 2024 | Ravasz D, Bui D, Nazarian S, Pallag G, Karnok N, Roberts J, Marzullo BP, Tennant DA, Greenwood B, Kitayev A, Hill C, Koml贸di T, Doerrier C, Cunatova K, Fernandez-Vizarra E, Gnaiger E, Kiebish Michael A, Raska A, Kolev K, Czumbel B, Narain NR, Seyfried TN, Chinopoulos C (2024) Residual Complex I activity and amphidirectional Complex II operation support glutamate catabolism through mtSLP in anoxia. Sci Rep 14:1729. https://doi.org/10.1038/s41598-024-51365-4 |
| Horvath 2022 Antioxidants (Basel) | 2022 | Horv谩th G, Sv谩b G, Koml贸di T, Ravasz D, Kacs贸 G, Doczi J, Chinopoulos C, Ambrus A, Tretter L (2022) Reverse and forward electron flow-induced H2O2 formation is decreased in 伪-ketoglutarate dehydrogenase (伪-KGDH) subunit (E2 or E3) heterozygote knock out animals. https://doi.org/10.3390/antiox11081487 |
| Pallag 2022 Int J Mol Sci | 2022 | Pallag G, Nazarian S, Ravasz D, Bui D, Koml贸di T, Doerrier C, Gnaiger E, Seyfried TN, Chinopoulos C (2022) Proline oxidation supports mitochondrial ATP production when Complex I is inhibited. https://doi.org/10.3390/ijms23095111 |
| Thoral 2021 Biol Lett | 2021 | Thoral E, Roussel D, Chinopoulos C, Teulier L, Salin K (2021) Low oxygen levels can help to prevent the detrimental effect of acute warming on mitochondrial efficiency in fish. Biol Lett 17:20200759. |
| Hierro-Yap 2021 J Biol Chem | 2021 | Hierro-Yap C, 艩ubrtov谩 K, Gahura O, Panicucci B, Dewar C, Chinopoulos C, Schnaufer A, Z铆kov谩 A (2021) Bioenergetic consequences of FoF1-ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei. J Biol Chem 296:100357. |
| Sarkadi 2020 Cancers (Basel) | 2020 | Sarkadi B, Meszaros K, Krencz I, Canu L, Krokker L, Zakarias S, Barna G, Sebestyen A, Papay J, Hujber Z, Butz H, Darvasi O, Igaz P, Doczi J, Luconi M, Chinopoulos C, Patocs A (2020) Glutaminases as a novel target for SDHB-associated pheochromocytomas/paragangliomas. Cancers (Basel) 12:E599. |
| Cornacchia 2019 Cell Stem Cell | 2019 | Cornacchia D, Zhang C, Zimmer B, Chung SY, Fan Y, Soliman MA, Tchieu J, Chambers SM, Shah H, Paull D, Konrad C, Vincendeau M, Noggle SA, Manfredi G, Finley LWS, Cross JR, Betel D, Studer L (2019) Lipid deprivation induces a stable, naive-to-primed intermediate state of pluripotency in human PSCs. Cell Stem Cell 25:120-36. |
| Stepanova 2019 Antioxid Redox Signal | 2019 | Stepanova Anna, Sosunov S, Niatsetskaya Z, Konrad Csaba, Starkov AA, Manfredi G, Wittig I, Ten V, Galkin A (2019) Redox-dependent loss of flavin by mitochondrial complex I in brain ischemia/reperfusion injury. Antioxid Redox Signal 31:608-22. |
| Salin 2018 Integr Comp Biol | 2018 | Salin K, Villasevil EM, Anderson GJ, Selman C, Chinopoulos C, Metcalfe NB (2018) The RCR and ATP/O indices can give contradictory messages about mitochondrial efficiency. Integr Comp Biol 58:486-94. |
| Stepanova 2018 J Neurochem | 2018 | Stepanova A, Konrad C, Manfredi G, Springett R, Ten V, Galkin A (2018) The dependence of brain mitochondria reactive oxygen species production on oxygen level is linear, except when inhibited by antimycin A. J Neurochem 148:731-45. |
| Stepanova 2018 J Cereb Blood Flow Metab | 2018 | Stepanova A, Konrad C, Guerrero-Castillo S, Manfredi G, Vannucci S, Arnold S, Galkin A (2018) Deactivation of mitochondrial complex I after hypoxia-ischemia in the immature brain. J Cereb Blood Flow Metab 39:1790-802. |
| Kahl 2018 Stroke | 2018 | Kahl A, Stepanova A, Konrad C, Anderson C, Manfredi G, Zhou P, Iadecola C, Galkin A (2018) Critical role of flavin and glutathione in complex I-mediated bioenergetic failure in brain ischemia/reperfusion injury. Stroke 49:1223-31. |
| Ravasz 2018 Biochim Biophys Acta | 2018 | Ravasz D, Kacso G, Fodor V, Horvath K, Adam-Vizi V, Chinopoulos C (2018) Reduction of 2-methoxy-1,4-naphtoquinone by mitochondrially-localized Nqo1 yielding NAD+ supports substrate-level phosphorylation during respiratory inhibition. Biochim Biophys Acta 1859:909-24. |
| Nemeth 2017 Thesis | 2017 | N茅meth B (2017) The effect of itaconic acid on mitochondrial substrate-level phosphorylation. PhD Thesis p84. |
| Stepanova 2017 J Cereb Blood Flow Metab | 2017 | Stepanova A, Kahl A, Konrad C, Ten V, Starkov AS, Galkin A (2017) Reverse electron transfer results in a loss of flavin from mitochondrial complex I: Potential mechanism for brain ischemia-reperfusion injury. J Cereb Blood Flow Metab 37:3649-58. |
| Ravasz 2017 Neurochem Int | 2017 | Ravasz D, Kacso G, Fodor V, Horvath K, Adam-Vizi V, Chinopoulos C (2017) Catabolism of GABA, succinic semialdehyde or gamma-hydroxybutyrate through the GABA shunt impair mitochondrial substrate-level phosphorylation. Neurochem Int 109:41-53. |
| Salin 2016 Physiol Rep | 2016 | Salin K, Villasevil EM, Auer SK, Anderson GJ, Selman C, Metcalfe NB, Chinopoulos C (2016) Simultaneous measurement of mitochondrial respiration and ATP production in tissue homogenates and calculation of effective P/O ratios. Physiol Rep 10.14814/phy2.13007. |
| Kacso 2016 Biochem J | 2016 | Kacso G, Ravasz D, Doczi J, N茅meth B, Madgar O, Saada A, Ilin P, Miller C, Ostergaard E, Iordanov I, Adams D, Vargedo Z, Araki M, Araki K, Nakahara M, Ito H, G谩l A, Moln谩r MJ, Nagy Z, Patocs A, Adam-Vizi V, Chinopoulos C (2016) Two transgenic mouse models for 尾-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations. Biochem J 473:3463-85. |
| Nemeth 2016 FASEB J | 2016 | N茅meth B, Doczi J, Csete D, Kacso G, Ravasz D, Adams D, Kiss G, Nagy AM, Horvath G, Tretter L, M贸csai A, Cs茅p谩nyi-K枚mi R, Iordanov I, Adam-Vizi V, Chinopoulos C (2016) Abolition of mitochondrial substrate-level phosphorylation by itaconic acid produced by LPS-induced Irg1 expression in cells of murine macrophage lineage. FASEB J 30:286-300. |
| Chinopoulos 2014 Methods Enzymol | 2014 | Chinopoulos C, Kiss G, Kawamata H, Starkov AA (2014) Measurement of ADP-ATP exchange in relation to mitochondrial transmembrane potential and oxygen consumption. Methods Enzymol 542:333-48. doi:10.1016/B978-0-12-416618-9.00017-0 |
| Kiss 2014 FASEB J | 2014 | Kiss G, Konrad C, Pour-Ghaz I, Mansour JJ, N茅meth B, Starkov AA, Adam-Vizi V, Chinopoulos C (2014) Diaphorases provide NAD+ in anoxia. FASEB J 28:1682-97. |
| Kiss 2013 FASEB J | 2013 | Kiss G, Konrad C, Doczi J, Starkov AA, Kawamata H, Manfredi G, Zhang SF, Gibson GE, Beal MF, Adam-Vizi V, Chinopoulos C (2013) The negative impact of alpha-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation. FASEB J 27:2392-406. |
| Konrad 2012 PLoS One | 2012 | Konrad C, Kiss G, Torocsik B, Adam-Vizi V, Chinopoulos C (2012) Absence of Ca2+-induced mitochondrial permeability transition but presence of bongkrekate-sensitive nucleotide exchange in C. crangon and P. serratus. PLoS One 7:e39839. |
| Chinopoulos 2011 Methods Mol Biol | 2011 | Chinopoulos C, Zhang SF, Thomas B, Ten V, Starkov AA (2011) Isolation and functional assessment of mitochondria from small amounts of mouse brain tissue. Methods Mol Biol 793:311-24. |
O2k-Abstracts
| Published | Reference | |
|---|---|---|
| Komlodi 2018b EBEC2018 | 2018 | Endogenous quinones sustain NADH oxidation by Complex I during anoxia, supporting substrate-level phosphorylation in mouse liver mitochondria. |
| Ravasz 2018 Abstract The evolving concept of mitochondria | 2018 | Vast pools of endogenous quinones sustain NADH oxidation by Complex I during anoxia, supporting substrate-level phosphorylation in mouse liver mitochondria. |
| Kiss 2012 Abstract Bioblast | 2012 | Kiss G, Konrad C, Doczi J, Starkov AA, Kawamata H, Manfredi G, Zhang SF, Gibson GE, Beal MF, Adam-Vizi V, Chinopoulos C (2012) The negative impact of alpha-ketoglutarate dehydrogenase complex deficiency on matrix substrate-level phosphorylation. Mitochondr Physiol Network 17.12. |
| Konrad 2012 Abstract Bioblast | 2012 | Konrad C, Kiss G, Torocsik B, Adam-Vizi V, Chinopoulos C (2012) Absence of Ca2+-induced mitochondrial permeability transition but presence of bongkrekate-sensitive nucleotide exchange in C. crangon and P. serratus. Mitochondr Physiol Network 17.12. |
Cooperation
Cooperation Semmelweis University Budapest and Medical University of Innsbruck (May 2011).
- Christos: Guest lecturer at IOC66 O2k-Fluorometry Workshop
NextGen-O2k
- Prof. Christos Chinopoulos is Key Opinion Leader (KOL) in the NextGen-O2k project.
Visiting scientist in the Oroboros O2k-Laboratory
Christos Chinopoulos : Visiting scientist at the Oroboros O2k-Laboratory from December 14 to December 22 2017
