Harmonization

high-resolution terminology - matching measurements at high-resolution

Harmonization

Description

Harmonization is the process of minimizing redundant or conflicting standards which may have evolved independently. To obtain a common basis in reaching a defined objective, critical requirements are identified that need to be retained.

Harmonization of some terms in mitochondrial physiology links separate 'subcultures' in publication. Ambiguities are pointed out for clarification of concepts. A platform-independent terminology is preferred. See also Table 2. Harmonization of terminology on respiratory states.

Table 1. Some platform-independent and platform-specific or outdated terms in mitochondrial physiology

Symbol	Platform-independent terms	Platform-specific or outdated terms
ce	living cells	intact cells
R	ROUTINE respiration, in ROUTINE state	basal respiration, in basal state
P	OXPHOS capacity, in OXPHOS state of mt-preparations	State 3
L	LEAK respiration	proton leak; State 4
E	ET capacity, electron transfer capacity	maximum respiration; State 3u
L/E	L/E coupling-control ratio	1/UCR = L/E (ambiguous)
L/P	L/P coupling-control ratio	1/RCR = L/P
R/E	R/E control ratio	1/UCR = E/R
R-L	R-L net ROUTINE capacity, net ROUTINE respiration	ATP production, ATP-linked respiration
E-R	E-R reserve capacity	spare capacity
Rox	residual oxygen consumption, in ROX state	nonmitochondrial respiration; State 2

MitoPedia O2k and high-resolution respirometry: Oroboros QM