Hebert-Chatelain 2019b MiP2019

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Etienne Herbert Chatelain
Mitochondria get stoned by cannabinoid receptors.

Link: MiP2019

Hebert-Chatelain E (2019)

Event: MiP2019

COST Action MitoEAGLE

Cannabinoid receptors (CB1) are powerful regulators of brain physiology and cognition. These inhibitors of synaptic transmission are activated by exo-cannabinoids (such as the psychoactive THC from Cannabis sativa) and endocannabinoids (that are produced directly in human cells). As other G protein-coupled receptors, CB1 are classically seen as plasma membrane proteins ideally located to convert extracellular stimuli into intracellular responses. Recent evidence however demonstrated important roles for intracellular CB1 in higher brain functions. Notably, CB1 receptors are functionally present in mitochondrial membranes (mtCB1) in different types of brain cells. Activation of mtCB1 slows down complex I activity, oxygen consumption and mitochondrial trafficking in several cell types. The impact of mtCB1 activation on higher brain functions appears however cell type- and brain region- specific. Although it is well known that chronic mitochondrial dysfunctions can lead to neurodegenerative diseases, these novel findings highlight the role of acute modulation of cell type-specific mitochondrial activity in brain physiology and behavior.


Bioblast editor: Plangger M, Tindle-Solomon L


Labels: MiParea: mt-Membrane, Pharmacology;toxicology 


Tissue;cell: Nervous system 





Affiliations

Canada Research Chair Mitochondrial Signaling Physiopathology, Univ Moncton, Canada