Heimler 2022 MitoFit

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Heimler 2022 MitoFit

Publications in the MiPMap
Heimler SR, Phang HJ, Bergstrom J, Mahapatra G, Dozier S, Gnaiger E, Molina AJA (2022). Platelet bioenergetics are associated with resting metabolic rate and exercise capacity in older women. MitoFit Preprints 2022.7. https://doi.org/10.26124/mitofit:2022-0007


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Platelet bioenergetics associated with resting metabolic rate and exercise capacity in older women

Heimler Stephanie R, Phang Howard J, Bergstrom Jaclyn, Mahapatra Gargi, Dozier Stephen, Gnaiger Erich, Molina Anthony JA (2022-04-12) MitoFit Prep

Abstract: This study investigates relationships between platelet mitochondrial bioenergetics and resting metabolic rate (RMR), body composition, and exercise fitness in women over 60 years of age. We report positive correlations between peak respiratory exchange ratio (RER) and RMR with five measures of platelet respiration, supporting the premise that blood cells can be utilized to report on mitochondrial function associated with physical health and fitness. Identifying mechanisms associated with physical performance among older adults supports the development of reliable biomarkers of healthy aging and can advance the development of efficacious interventions.

Keywords: platelets, resting metabolic rate RMR, cardiopulmonary exercise testing, OXPHOS capacity P, electron transfer capacity E, inverted regression analysis Bioblast editor: Tindle-Solomon L O2k-Network Lab: AT Innsbruck Oroboros, US CA San Diego Molina AJA, US NC Winston-Salem Molina AJA

ORCID: ORCID.png Heimler Stephanie R, ORCID.png Phang Howard J, ORCID.png Mahapatra Gargi,ORCID.png Gnaiger Erich, ORCID.png Molina Anthony JA

Data availability

Original files are available Open Access at Zenodo repository: DOI 10.5281/zenodo.6452014

Labels: MiParea: Respiration, Exercise physiology;nutrition;life style 

Organism: Human  Tissue;cell: Blood cells  Preparation: Permeabilized cells 

Coupling state: OXPHOS, ET  Pathway: F, N, S, Gp, ROX  HRR: Oxygraph-2k 

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