Kaambre Tuuli

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Short-Term Scientific Missions

Management Committee

Members

COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping

Kaambre Tuuli

MitoPedia topics: EAGLE

COST: Member COST WG1: WG1 COST WG2: WG2

COST Mentor: Mentor

MC Member - Management Committee MitoEAGLE

Name	Kaambre Tuuli, PhD Head of Laboratory
Institution	Laboratory of Chemical Biology, Laboratory of National Institute of Chemical Physics and Biophysics, EE
Address	Akadeemia tee 23, 12618
City	Tallinn
State/Province
Country	Estonia
Email	[email protected]
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O2k-Network Lab	EE Tallinn Kaambre T

Bioenergetics Communications

Tuuli Kaambre is Associate Editor of the journal Bioenergetics Communications

Keywords: mitochondria, mitochondrial diseases, cancer metabolism, mitochondrial function, neurodegenerative diseases

Participated at

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Publications

	Published	Reference
Robledo-Cadena 2024 PLoS One	2024	Robledo-Cadena DX, Pacheco-Velázquez SC, Vargas-Navarro JL, Padilla-Flores JA, López-Marure R, Pérez-Torres I, Kaambre T, Moreno-Sánchez R, Rodríguez-Enríquez S (2024) Synergistic celecoxib and dimethyl-celecoxib combinations block cervix cancer growth through multiple mechanisms. PLoS One 19:e0308233. https://doi.org/10.1371/journal.pone.0308233
Tepp 2022 Biochem Biophys Rep	2022	Tepp K, Aid-Vanakova J, Puurand M, Timohhina N, Reinsalu L, Tein K, Plaas M, Shevchuk I, Terasmaa A, Kaambre T (2022) Wolframin deficiency is accompanied with metabolic inflexibility in rat striated muscles. Biochem Biophys Rep 30:101250.
Klepinina 2021 PLoS One	2021	Klepinina L, Klepinin A, Truu L, Chekulayev V, Vija H, Kuus K, Teino I, Pook M, Maimets T, Kaambre T (2021) Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLoS One 16:e0245348.
BEC 2020.1 doi10.26124bec2020-0001.v1	2020	Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1
Rebane-Klemm 2020 Cancers (Basel)	2020	Rebane-Klemm E, Truu L, Reinsalu L, Puurand M, Shevchuk I, Chekulayev V, Timohhina N, Tepp K, Bogovskaja J, Afanasjev V, Suurmaa K, Valvere V, Kaambre T (2020) Mitochondrial respiration in KRAS and BRAF mutated colorectal tumors and polyps. Cancers (Basel) 12:E815.
Tepp 2020 Biochim Biophys Acta Gen Subj	2020	Tepp K, Puurand M, Timohhina N, Aid-Vanakova J, Reile I, Shevchuk I, Chekulayev V, Eimre M, Peet N, Kadaja L, Paju K, Kaambre T (2020) Adaptation of striated muscles to Wolframin deficiency in mice: Alterations in cellular bioenergetics. Biochim Biophys Acta Gen Subj 1864:129523.
Puurand 2019 Cells	2019	Puurand M, Tepp K, Timohhina N, Aid J, Shevchuk I, Chekulayev V, Kaambre T (2019) Tubulin βII and βIII isoforms as the regulators of VDAC channel permeability in health and disease. Cells 8:E239.
Chabi 2019 MitoFit Preprint Arch EA	2019	Chabi Béatrice, Ost M, Gama-Perez P, Dahdah N, Lemieux H, Holody CD, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Pesta D, Calabria E, Casado M, Fernandez-Ortiz M, Acuña-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wüst R, Dayanidhi S, Gnaiger E, Doerrier C, Garcia-Roves PM (2019) Generating reference values on mitochondrial respiration in permeabilized muscle fibers. https://doi.org/10.26124/mitofit:ea19.MitoEAGLE.0001
Makrecka-Kuka 2019 Acta Physiol (Oxf)	2019	Makrecka-Kuka M, Liepinsh E, Murray AJ, Lemieux H, Dambrova M, Tepp K, Puurand M, Käämbre T, Han WH, de Goede P, O'Brien KA, Turan B, Tuncay E, Olgar Y, Rolo AP, Palmeira CM, Boardman NT, Wüst RCI, Larsen TS (2019) Altered mitochondrial metabolism in the insulin-resistant heart. Acta Physiol (Oxf) 228:e13430.
Puurand 2018 Int J Mol Sci	2018	Puurand M, Tepp K, Klepinin A, Klepinina L, Shevchuk I, Kaambre T (2018) Intracellular energy-transfer networks and high-resolution respirometry: a convenient approach for studying their function. Int J Mol Sci 19:e2933.
Klepinin 2018 J Bioenerg Biomembr	2018	Klepinin A, Ounpuu L, Mado K, Truu L, Chekulayev V, Puurand M, Shevchuk I, Tepp K, Planken A, Kaambre T (2018) The complexity of mitochondrial outer membrane permeability and VDAC regulation by associated proteins. J Bioenerg Biomembr 50:339-54.
Koit 2018 US Patent	2018	Koit A, Kaambre T (2018) Method for selecting patients responsive for cancer treatments. US Patent US20180017547A1.
Ounpuu 2017 Biochim Biophys Acta	2017	Ounpuu L, Klepinin A, Pook M, Teino I, Peet N, Paju K, Tepp K, Chekulayev V, Shevchuk I, Koks S, Maimets T, Kaambre T (2017) 2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells. Biochim Biophys Acta 1861:2146-54.
Koit 2017 Oxid Med Cell Longev	2017	Koit A, Shevchuk I, Ounpuu L, Klepinin A, Chekulayev V, Timohhina N, Tepp K, Puurand M,Truu L, Heck K, Valvere V, Guzun R, Kaambre T (2017) Mitochondrial respiration in human colorectal and breast cancer clinical material is regulated differently. Oxid Med Cell Longev 2017:1372640.
Tepp 2017 Mol Cell Biochem	2017	Tepp K, Puurand M, Timohhina N, Adamson J, Klepinin A, Truu L, Shevchuk I, Chekulayev V, Kaambre T (2017) Changes in the mitochondrial function and in the efficiency of energy transfer pathways during cardiomyocyte aging. Mol Cell Biochem 432:141-58.
Klepinin 2016 J Bioenerg Biomembr	2016	Klepinin A, Ounpuu L, Guzun R, Chekulayev V, Timohhina N, Tepp K, Shevchuk I, Schlattner U, Kaambre T (2016) Simple oxygraphic analysis for the presence of adenylate kinase 1 and 2 in normal and tumor cells. J Bioenerg Biomembr 48:531-48.
Bagur 2016 Biochim Biophys Acta	2016	Bagur R, Tanguy S, Foriel S, Grichine A, Sanchez C, Pernet-Gallay K, Kaambre T, Kuznetsov AV, Usson Y, Boucher F, Guzun R (2016) The impact of cardiac ischemia/reperfusion on the mitochondria-cytoskeleton interactions. Biochim Biophys Acta 1862:1159-71.
Guzun 2015 Acta Physiol (Oxf)	2015	Guzun R, Kaambre T, Bagur R, Grichine A, Usson Y, Varikmaa M, Anmann T, Tepp K, Timohhina N, Shevchuk I, Chekulayev V, Boucher F, Dos Santos P, Schlattner U, Wallimann T, Kuznetsov AV, Dzeja P, Aliev M, Saks V (2015) Modular organization of cardiac energy metabolism:energy conversion, transfer and feedback regulation. Acta Physiol (Oxf) 213:84-106.
Chekulayev 2015 Biochem Biophys Rep	2015	Chekulayev V, Mado K, Shevchuk I, Koit A, Kaldma A, Klepinin A, Timohhina N, Tepp K, Kandashvili M, Ounpuu L, Heck K, Truu L, Planken A, Valvere V, Kaambre T (2015) Metabolic remodeling in human colorectal cancer and surrounding tissues: alterations in regulation of mitochondrial respiration and metabolic fluxes. Biochem Biophys Rep 4:111-25.
Anmann 2014 Biochim Biophys Acta	2014	Anmann T, Varikmaa M, Timohhina N, Tepp K, Shevchuk I, Chekulayev V, Saks V, Kaambre T (2014) Formation of highly organized intracellular structure and energy metabolism in cardiac muscle cells during postnatal development of rat heart. Biochim Biophys Acta 1837:1350-61.
Kaldma 2014 Int J Biochem Cell Biol	2014	Kaldma A, Klepinin A, Chekulayev V, Mado K, Shevchuk I, Timohhina N, Tepp K, Kandashvili M, Varikmaa M, Koit A, Planken M, Heck K, Truu L, Planken A, Valvere V, Rebane E, Kaambre T (2014) An in situ study of bioenergetic properties of human colorectal cancer: The regulation of mitochondrial respiration and distribution of flux control among the components of ATP synthasome. Int J Biochem Cell Biol 55C:171-86.
Varikmaa 2014 Biochim Biophys Acta	2014	Varikmaa M, Bagur R, Kaambre T, Grichine A, Timohhina N, Tepp K, Shevchuk I, Chekulayev V, Metsis M, Boucher F, Saks V, Kuznetsov AV, Guzun R (2014) Role of mitochondria-cytoskeleton interactions in respiration regulation and mitochondrial organization in striated muscles. Biochim Biophys Acta 1837:232-45.
Klepinin 2014 J Bioenerg Biomembr	2014	Klepinin A, Chekulayev V, Timohhina N, Shevchuk I, Tepp K, Kaldma A, Koit A, Saks V, Kaambre T (2014) Comparative analysis of some aspects of mitochondrial metabolism in differentiated and undifferentiated neuroblastoma cells. J Bioenerg Biomembr 46:17-31.
Varikmaa 2013 J Bioenerg Biomembr	2013	Varikmaa M, Guzun R, Grichine A, Gonzalez-Granillo M, Usson Y, Boucher F, Kaambre T, Saks V (2013) Matters of the heart in bioenergetics: mitochondrial fusion into continuous reticulum is not needed for maximal respiratory activity. J Bioenerg Biomembr 45:319-31.
Kaambre 2013 Front Physiol	2013	Kaambre T, Chekulayev V, Shevchuk I, Tepp K, Timohhina N, Varikmaa M, Bagur R, Klepinin A, Anmann T, Koit A, Kaldma A, Guzun R, Valvere V, Saks V (2013) Metabolic control analysis of respiration in human cancer tissue. Front Physiol 4:151.
Guzun 2012 Biochim Biophys Acta	2012	Guzun R, Gonzalez-Granillo M, Karu-Varikmaa M, Grichine A, Usson Y, Kaambre T, Guerrero-Roesch K, Kuznetsov A, Schlattner U, Saks V (2012) Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial Interactosome. Biochim Biophys Acta 1818:1545-54.
Kuznetsov 2012 Biochem J	2012	Kuznetsov AV, Guzun R, Boucher F, Bagur R, Kaambre T, Saks V (2012) Mysterious Ca²⁺-independent muscular contraction: déjà vu. Biochem J 445:333-6.
Kaambre 2012 J Bioenerg Biomembr	2012	Kaambre T, Chekulayev V, Shevchuk I, Karu-Varikmaa M, Timohhina N, Tepp K, Bogovskaja J, Kütner R, Valvere V, Saks V (2012) Metabolic control analysis of cellular respiration in situ in intraoperational samples of human breast cancer. J Bioenerg Biomembr 44:539-58.
Gonzalez-Granillo 2012 J Mol Cell Cardiol	2012	Gonzalez-Granillo M, Grichine A, Guzun R, Usson Y, Tepp K, Chekulayev V, Shevchuk I, Karu-Varikmaa M, Kuznetsov AV, Grimm M, Saks V, Kaambre T (2012) Studies of the role of tubulin beta II isotype in regulation of mitochondrial respiration in intracellular energetic units in cardiac cells. J Mol Cell Cardiol 52:437-47.
Tepp 2011 Biochim Biophys Acta	2011	Tepp K, Shevchuk I, Chekulayev V, Timohhina N, Kuznetsov AV, Guzun R, Saks V, Kaambre T (2011) High efficiency of energy flux controls within mitochondrial interactosome in cardiac intracellular energetic units. Biochim Biophys Acta 1807: 1549-1561.
Guzun 2011 Biochim Biophys Acta	2011	Guzun R, Karu-Varikmaa M, Gonzalez-Granillo M, Kuznetsov AV, Michel L, Cottet-Rousselle C, Saaremäe M, Kaambre T, Metsis M, Grimm M, Auffray C, Saks V (2011) Mitochondria–cytoskeleton interaction: Distribution of β-tubulins in cardiomyocytes and HL-1 cells. Biochim Biophys Acta 1807:458-69.
Guerrero 2010 Mol Cell Biochem	2010	Guerrero K, Monge C, Brückner A, Puurand U, Kadaja L, Käämbre T, Seppet E, Saks V (2010) Study of possible interactions of tubulin, microtubular network, and STOP protein with mitochondria in muscle cells. Mol Cell Biochem 337:239-49.
Guzun 2009 Biochim Biophys Acta	2009	Guzun R, Timohhina N, Tepp K, Monge C, Kaambre T, Sikk P, Kuznetsov AV, Pison C, Saks V (2009) Regulation of respiration controlled by mitochondrial creatine kinase in permeabilized cardiac cells in situ. Importance of system level properties. Biochim Biophys Acta 1787:1089-105.
Timohhina 2009 J Bioenerg Biomembr	2009	Timohhina N, Guzun R, Tepp K, Monge C, Varikmaa M, Vija H, Sikk P, Kaambre T, Sackett D, Saks V (2009) Direct measurement of energy fluxes from mitochondria into cytoplasm in permeabilized cardiac cells in situ: some evidence for mitochondrial interactosome. J Bioenerg Biomembr 41:259-75.
Monge 2009 Can J Physiol Pharmacol 87:318-326.	2009	Monge C, Beraud N, Tepp K, Pelloux S, Chahboun S, Kaambre T, Kadaja L, Roosimaa M, Piirsoo A, Tourneur Y, Kuznetsov AV, Saks V, Seppet E (2009) Comparative analysis of the bioenergetics of adult cardiomyocytes and nonbeating HL-1 cells: respiratory chain activities, glycolytic enzyme profiles, and metabolic fluxes. Can J Physiol Pharmacol 87:318-26.
Anmann 2005 FEBS J	2005	Anmann T, Eimre M, Kuznetsov AV, Andrienko T, Kaambre T, Sikk P, Seppet E, Tiivel T, Vendelin M, Seppet EK, Saks VA (2005) Calcium-induced contraction of sarcomeres changes the regulation of mitochondrial respiration in permeabilized cardiac cells. FEBS J 272:3145-61.
Saks 2003 Biophys J	2003	Saks V, Kuznetsov A, Andrienko T, Usson Y, Appaix F, Guerrero K, Kaambre T, Sikk P, Lemba M, Vendelin M (2003) Heterogeneity of ADP diffusion and regulation of respiration in cardiac cells. Biophys J 84:3436-56.
Appaix 2003 Exp Physiol	2003	Appaix F, Kuznetsov AV, Usson Y, Kay L, Andrienko T, Olivares J, Kaambre T, Sikk P, Margreiter R, Saks V (2003) Possible role of cytoskeleton in intracellular arrangement and regulation of mitochondria. Exp Physiol 88:175-90.
Andrienko 2003 J Exp Biol	2003	Andrienko T, Kuznetsov AV, Kaambre T, Usson Y, Orosco A, Appaix F, Tiivel T, Sikk P, Vendelin M, Margreiter R, Saks VA (2003) Metabolic consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cells. J Exp Biol 206:2059-72.
Appaix 2002 Biochim Biophys Acta	2002	Appaix F, Guerrero K, Rampal D, Izikki M, Kaambre T, Sikk P, Brdiczka D, Riva-Lavieille C, Olivares J, Longuet M, Antonsson B, Saks VA (2002) Bax and heart mitochondria: uncoupling and inhibition of respiration without permeability transition. Biochim Biophys Acta 1556:155-67.
Seppet 2001 Biochim Biophys Acta	2001	Seppet EK, Kaambre T, Sikk P, Tiivel T, Vija H, Tonkonogi M, Sahlin K, Kay L, Appaix F, Braun U, Eimre M, Saks VA (2001) Functional complexes of mitochondria with Ca,Mg ATPases of myofibrils and sarcoplasmic reticulum in muscle cells. Biochim Biophys Acta 1504:379-95.
Saks 2001 Biochem J	2001	Saks VA, Kaambre T, Sikk P, Eimre M, Orlova E, Paju K, Piirsoo A, Appaix F, Kay L, Regitz-Zagrosek V, Fleck E, Seppet E (2001) Intracellular energetic units in red muscle cells. Biochem J 356:643-57.
Kay 1997 Biochim Biophys Acta	1997	Kay L, Li Z, Mericskay M, Olivares J, Tranqui L, Fontaine E, Tiivel T, Sikk P, Kaambre T, Samuel JL Rappaport L, Usson Y, Leverve X, Paulin D, Saks VA (1997) Study of regulation of mitochondrial respiration in vivo. An analysis of influence of ADP diffusion and possible role of cytoskeleton. Biochim Biophys Acta 1322:41-59.

Abstracts

	Published	Reference
Kaambre Tuuli 2022 Bioblast2022	2022	Bioblast 2022 participant.
Doerrier 2020 PaduaMuscleDays Poster	2020	Doerrier C, Gama-Perez P, Chabi B, Ost M, Distefano G, Pesta D, Dahdah N, Lemieux H, Holody C, Carpenter RG, Tepp K, Puurand M, Kaambre T, Dubouchaud H, Cortade F, Calabria E, Casado M, Fernandez-Ortiz M, Acuna-Castroviejo D, Villena JA, Grefte S, Keijer J, O'Brien K, Sowton A, Murray AJ, Campbell MD, Marcinek DJ, Nollet E, Wuest R, Dayanidhi S, Soendergaard SD, Chroeis KM, Gonzalez-Franquesa A, Goodpaster BH, Coen PM, Larsen S, Gnaiger E, Garcia-Roves PM (2020) Commitment to reproducibility in mitochondrial respiration studies with permeabilized muscle fibers. PaduaMuscleDays.
Chabi 2019 MiP2019	2019	Generating reference values on mitochondrial respiration in permeabilized muscle fibers.
Timohhina 2019 MiP2019	2019	Metabolic effects of mitochondria-targeted antioxidant peptides in colorectal cancer cells.
Aid-Vanakova 2019 MiP2019	2019	Adaptation of muscle OXPHOS in developing glucose intolerance - Wfs1 mice model.
Kaambre 2019 MiP2019	2019	No abstract, Co-autor of Timohhina 2019 MiP2019 and Aid-Vanakova 2019 MiP2019.
Garcia-Roves 2019 MiPschool Coimbra	2019	Generating reference values on mitochondrial respiration in permeabilized muscle fibers.
Puurand 2018 MiPschool Tromso E2	2018	Intracellular energy-transfer networks in health and disease – the results of oxygraphic studies.
Garcia-Roves 2018 MiP2018b	2018	Generating mitochondrial respirometry reference values from permeabilized mouse soleus muscle fibers. Working Group 2 report. Garcia-Roves_Presentation
Kaambre 2018 MiP2018	2018	No abstract.
Ounpuu 2018 MiP2018	2018	Metabolic plasticity of cancer stem-like cells.
Kaambre 2017 MiP2017	2017	No abstract.
Truu 2017 MiP2017	2017	Bioenergetic comparison of human colorectal and breast cancer clinical patients.
Puurand 2017 MiP2017	2017	Cellular phosphotransfer networks as a target of bioenergetic research – methods of oxygraphic study.
Ounpuu 2017 MiP2017	2017	The role of dietary fibers in the energy metabolism of human colon cancer cells.
Klepinin 2017 MiP2017	2017	Novel method to study the role of the adenylate kinase network in health and disease.
Truu 2017 Abstract IOC122	2017	Bioenergetics of colorectal cancer.
Tepp 2015 Abstract MiP2015	2015	Changes in energy transfer regulation during development and aging.
Shevchuk 2015 Abstract MiP2015	2015	Analysis of energy fluxes in colorectal cancer saponin skinned tissues and Caco-2 cells.
Kaambre 2015 Abstract MiP2015	2015	Quantitative characterization of respiratory parameters of human colorectal and breast cancer clinical material.
Kandashvili 2014 Abstract MiP2014	2014	Regulation of energy metabolism in human colorectal cancer cells in situ.
Maedo 2014 Abstract IOC 2014-04 Schroecken	2014	Maedo K, Kaldma A, Planken A, Klepinin A, Chekulayev V, Varikmaa M, Tepp K, Chevchuk I, Kaambre T (2014) Regulation of mitochondrial respiration in human colorectal cancer cells in situ: the possible role of beta-tubulins. Mitochondr Physiol Network 19.02.
Tepp 2013 Abstract MiP2013	2013	Tepp K, Anmann T, Varikmaa M, Timohhina N, Shevchuk I, Chekulayev V, Saks V, Kaambre T (2013) Bioenergetic aspects of postnatal development of cardiac cells: Formation of structure-function relationship. Mitochondr Physiol Network 18.08.