Khmil 2016 International Symposium Mitochondrial Motility

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Khmil NV, Mosencov AA, Ovsyannikova TN, Dyachenko VD, Goncharenko MS, Kolomytkin OV, Mironova GD (2016) Influence of oranoselenium compounds on functioning of rat liver mitochondria. International Symposium Mitochondrial Motility 96-100.

Khmil NV, Mosencov AA, Ovsyannikova TN, Dyachenko VD, Goncharenko MS, Kolomytkin OV, Mironova GD (2016) International Symposium Mitochondrial Motility

Abstract: It has been determined that 80% of population in Russia lack selenium [1,2]. At the same time, the problem of diseases caused by deficit of selenium, and as a result the development of oxidative stress in patients, has been left unsettled. The data shows that various organoselenium compounds are able to demonstrate antitoxic, antibacterial, antioxidant, anantiviral, antiarrhythmic and fungicidal activity. During the past few years, a number of laboratories have synthesized the organic forms of selenium with the purpose of preventing deficit of selenium and other diseases. In the recent decade, several selenium-containing compounds have been synthesized at the Taras Shevchenko Luhansk National University [3–5]. It has been shown that some of them can be of strong antioxidant effect [6,7]. It is known that the positive effect of antioxidants is achieved through their ability to remove excessive peroxide: up to 85–90% of peroxide are formed in the electron transport chain of mitochondrion. Thereby, the relationship study between the structure and biological activity of these compounds and their influence on energy and oxidative metabolism in the mitochondria undoubtedly is of interest. Thus, the aim of this work was to study and compare the influence of six different selenium-containing newly synthesized compounds on respiratory and phosphorylation parameters, as well as on the concentration of peroxide lipids in liver mitochondria of rats.

β€’ Bioblast editor: Kandolf G β€’ O2k-Network Lab: RU Pushchino Mironova GD

Labels: MiParea: Respiration, Exercise physiology;nutrition;life style, Pharmacology;toxicology 

Stress:Oxidative stress;RONS  Organism: Rat  Tissue;cell: Liver 

Coupling state: OXPHOS  Pathway: NS  HRR: Oxygraph-2k 


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