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Kosenko 2010 Biology Bull

From Bioblast
Publications in the MiPMap
Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG (2010) The drug hypoxen: A new inhibitor of mitochondrial respiration and dehydrogenases. Biology Bull 37:346-50.

» PMID: 20799641

Kosenko EA, Abramova MB, Venediktova NI, Popova II, Kaminskii YG (2010) Biology Bull

Abstract: The effect of hypoxen on the oxygen consumption and activity of dehydrogenases in rat liver mitochondria has been studied. The addition of hypoxen to mitochondria caused a reduction of the rate of phosphorylating and uncoupling respiration. The minimal effective concentration of hypoxen was 15 μg/ml with succinate, 60 μg/ml with pyruvate or palmitoylcarnitine, and 120 μg/ml with glutamate as the substrates. The activities of malate, glutamate, and succinate dehydrogenases in mitochondria were significantly decreased by the effect of hypoxen. Keywords: Hypoxen (Oliphen, Moscow)


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Organism: Rat  Tissue;cell: Liver  Preparation: Isolated mitochondria 



HRR: Oxygraph-2k 

Pharmacology; Biotechnology