Lundby 2013 Abstract MiP2013
|Lundby C, Bonne T, Flück D, Jacobs R, Meinild AK, Lundby S, Robach P (2013) The effects of hypoxic training on aerobic performance in normoxia and moderate hypoxia: a randomized, double blind, placebo controlled study. Mitochondr Physiol Network 18.08.|
Event: MiPNet18.08 MiP2013
The effects of hypoxic training on exercise performance remain controversial. To test the hypotheses that (i) hypoxic training possesses ergogenic effects at sea-level and altitude, and (ii) the benefits are primarily mediated by improved mitochondrial function of skeletal muscle, we determined aerobic performance (incremental test to exhaustion and time trial) in moderately-trained subjects undergoing six weeks of endurance training (3-4 times/week, 60 min/session) in normoxia (placebo, N=8) or normobaric hypoxia (FIO2=0.15; N=9) using a double blinded and randomized design . Exercise tests were performed in normoxia and acute hypoxia (FIO2=0.15). Mitochondrial oxidative capacity and efficiency were quantified from skeletal muscle biopsies. Total hemoglobin mass (Hbmass) was measured by carbon-monoxide rebreathing. Neither maximal capacity of oxidative phosphorylation nor mitochondrial efficiency was altered by training or hypoxia. Hypoxic training increased Hbmass more than placebo (8.4 vs 3.3%, P=0.03). In normoxia, hypoxic training had no additive effect on maximal oxygen uptake (VO2max), time trial performance or cycling efficiency. In acute hypoxia, hypoxic training conferred no advantage on VO2max, but improved cycling efficiency, and tended to enhance time trial performance (52 vs 32%, P=0.09). Our data suggest that training in hypoxia possesses no ergogenic effect at sea level, but may confer some advantage for endurance performance at moderate altitude, possibly through Hbmass expansion.
Labels: MiParea: Respiration, Exercise physiology;nutrition;life style
Stress:Ischemia-reperfusion Organism: Human Tissue;cell: Skeletal muscle Preparation: Permeabilized tissue
Coupling state: OXPHOS
Zurich Center for Integrative Human Physiology (ZIHP), Institute of Physiology, University of Zurich, Switzerland. - Email: [email protected]