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Mahapatra 2023 MiP2023

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MiPschool 2023

Mahapatra 2023 MiP2023

Mahapatra Gargi
Platelet bioenergetics reveals distinct systemic bioenergetic capacities associated with insulin sensitivity in older adults.

Link: MiP2023 Obergurgl AT

Mahapatra Gargi (2023)

Event: MiP2023 Obergurgl AT

Authors: Mahapatra Gargi, Gao Zhengrong, Bateman James R III, Lockhart Samuel Neal, Bergstrom Jaclyn, Craft Suzanne, Molina Anthony JA

Impaired glucose tolerance (IGT), including prediabetes and diabetes, increases risk of developing age related disorders, including Alzheimer’s disease (AD). We analyzed mitochondrial bioenergetics in platelets collected from 208 adults, 55 years and older, with or without insulin sensitivities (112 normoglycemics (NG), 96 IGTs). Platelets from IGT participants exhibited unique bioenergetic profiles exemplified by higher mitochondrial respiration than NG. IGT platelets exhibited higher glucose-dependent maximal (Max) and spare respiratory (SRC) capacities compared to NG, and higher fatty acid oxidation-dependent maximal coupled (MaxOXPHOS) and uncoupled (MaxETS) respiration compared to NG. Correlating bioenergetics from all 208 participants combined with glucose measures (OGTT_120, OGTT_AUC, and HbA1c) revealed significant positive associations. Most associations were unaltered with age, sex, and BMI adjustments. Further separating NG and IGT participants and correlating platelet respiration with glucose measures revealed distinct trends in NG versus IGT group. In NG, previously observed associations remained intact, and new significant positive associations emerged between platelet bioenergetics and HbA1c. Associations in IGT group were overall negative. Identifying systemic mitochondrial mechanisms that associate with glucose intolerance in older adults will help in monitoring pathological progression of AD in relation to comorbidities such as insulin sensitivity, and supports the development of minimally invasive biomarkers of AD.

  1. Mahapatra G, Gao, Bateman JR III, Lockhart SN, Bergstrom J, DeWitt AR, Piloso JE, Kramer PA, Gonzalez-Armenta JL, Amick A, Casanova R, Craft S, Molina AJA (2022) Blood-Based Bioenergetic Profiling Reveals Differences in Mitochondrial Function Associated with Cognitive Performance and Alzheimer’s Disease Alzheimer's & Dementia 2022.

Keywords: platelets, glucose tolerance, mitochondrial bioenergetics, maximal respiration, fatty acid oxidation

O2k-Network Lab: US CA San Diego Molina AJA


Table 1. Platelet bioenergetics

Affiliations and acknowledgements

Mahapatra Gargi1, Gao Zhengrong1, Bateman James R III1,2, LockhartSamuel Neal 1, Bergstrom Jaclyn3, Craft Suzanne1, Molina Anthony JA3
  1. Section on Gerontology and Geriatrics, Sticht Center for Healthy Aging and Alzheimer's Prevention, Department of Internal Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA
  2. Department of Neurology, Wake Forest Baptist Medical Center, Winston-Salem, NC, USA
  3. Division of Geriatrics, Gerontology, and Palliative Care; Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA, USA
Corresponding author: [email protected]
Funding: NIH grant, R01 AG054523, WF ADRC; P30AG049638


Event: E2