Nozickova Katerina

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COST Action CA15203 (2016-2021): MitoEAGLE
Evolution-Age-Gender-Lifestyle-Environment: mitochondrial fitness mapping

Nozickova Katerina

MitoPedia topics: EAGLE

COST: Member

COST WG3: WG3

Name	Nozickova Katerina,
Institution	Institute of Physiology, Faculty of Medicine in Hradec Kralove, Charles University in Prague, CZ
Address	Simkova 870, 500 38
City	Hradec Kralove
State/Province
Country	Czech Republic
Email	[email protected]
Weblink
O2k-Network Lab	CZ Hradec Kralove Cervinkova Z

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Publications

	Published	Reference
Stankova 2020 Int J Mol Sci	2020	Staňková P, Kučera O, Peterová E, Lotková H, Maseko TE, Nožičková K, Červinková Z (2020) Adaptation of mitochondrial substrate flux in a mouse model of nonalcoholic fatty liver disease. Int J Mol Sci 21:E1101.
BEC 2020.1 doi10.26124bec2020-0001.v1	2020	Gnaiger E et al ― MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenerg Commun 2020.1. https://doi.org/10.26124/bec:2020-0001.v1

Abstracts

	Published	Reference
Stankova 2018 MiP2018	2018	Impact of western diet on energy metabolism in mouse liver.
Sobotka 2017 Abstract MITOEAGLE Barcelona	2017	The effect of 24 weeks of high-fat and high-cholesterol diet on rat liver mitochondria. Sobotka_Presentation
Nozickova 2017 MiPschool Obergurgl	2017	Sulfite oxidase.
Nozickova 2017 MiP2017	2017	The early adaptation of rat liver mitochondria to high fat diet.
Sobotka 2017 MiP2017	2017	Metabolic changes in rat liver mitochondria during the development of liver steatosis.
Sobotka 2016 Abstract IOC116	2016	Sobotka O, Kucera Otto, Stankova P, Endlicher R, Nozickova K, Banni A, Cervinkova Z (2016) Mitochondrial respiration in fatty liver. Mitochondr Physiol Network 21.11

MitoEAGLE Short-Term Scientific Mission

- - - STSM Grant Period 2

Work Plan summary

I aim and motivation Obviously my aim is to understand mitochondrial physiology. I am member of scientific group concerned with hepatocytes, especially their metabolism. Measuring utilization of oxygen by hepatic mitochondria is a great way how to observe metabolic changes caused by different conditions, in my case NAFLD (non-alcoholic fatty liver disease) caused by high fat diet. This disease is wide spread at USA and Europe and the number of affected patients is increasing. The pathophysiology of NAFLD has not been sufficiently explained yet. I hope, that characterization of respiratory changes in NAFLD mitochondria will be supportive to elucidation and curing NAFLD.

As far as I am student of medicine and hopefully I will become a doctor, I find knowledge of mitochondrial physiology very beneficial for my further specialization. II. Proposed contribution As I mentioned, I am concerned in changes of mitochondrial respiration caused by NAFLD (non-alcoholic fatty liver disease), I would like to extend my knowledge about mitochondrial physiology. MitoEAGLE project is a great opportunity to get deeper into a topic and also get other points of views. III. Techniques The instrument I am interested in is an Oroboros instrument. I hope that during the meeting I will find further ways of usage and also its limitation. The most important I find discussion about interpretation of results obtained during measurements. Last but not least MitoEAGLE project is also focused on proper terminology usage, very important for understanding and sharing outcomes and theories. IV. Planning I would like to extend the project I am participating now. Our recent outcomes show, that long time high fat diet, leading to NAFLD, significantly decreases ETS capacity (electron transfer system capacity). Some studies shown, that some disturbances at respiratory chain might lead to mitochondrial proliferation. I would like to investigate this possibility and its further impact on development of NAFLD. According to my next carrier steps, I hope I will finish my medicine studies in two years and become a doctor specialized in diseases of metabolism. After finishing my MD degree I would like to continue my research as a Ph.D. program student.

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