Cookies help us deliver our services. By using our services, you agree to our use of cookies. More information

Okada 2021 Front Physiol

From Bioblast
Publications in the MiPMap
Okada Y, Paton JFR, López-Barneo J, Wilson RJA, Marina N, Pokorski M (2021) Editorial: Hypoxia and cardiorespiratory control.

» Front Physiol 12:820815. Open Access

Okada Y, Paton JFR, López-Barneo J, Wilson RJA, Marina N and Pokorski M (2021) Front Physiol

Abstract: To maintain adequate oxygen levels in the body, which is essential for a healthy life, the respiratory and cardiovascular systems play vitally important roles. When the oxygen content is insufficient, i.e., when hypoxia is loaded, respiratory and cardiovascular systems respond to restore, compensate, or adapt to hypoxia, e.g., by increasing ventilation and blood flow to maintain oxygen transport to vital organs. Traditionally, it has been thought that hypoxia is detected solely by carotid and aortic bodies, i.e., by peripheral chemoreceptors, and information from the peripheral chemoreceptors is transmitted to respiratory and cardiovascular centers in the brainstem whose respiratory and cardiovascular neural outputs are regulated. However, recent progress in neurophysiology has clarified that there are hypoxia-sensors not only in the periphery but also in the central nervous system. Hypoxia also affects the vascular system causing atherosclerosis and pulmonary hypertension and impairs blood glucose regulation that also facilitates atherosclerosis. The effects of hypoxia on vital organs and tissues vary depending on the modality of hypoxia exposure, i.e., acute, chronically sustained, or intermittent hypoxia. Although these issues have been vigorously investigated, the underlying mechanisms are yet to be unraveled. Likewise, long-range consequences for organ and tissue functions affected by hypoxia have not been fully elucidated. In the article collection of this Research Topic, a series of studies report the latest and most notable pathophysiological findings that are categorized into four areas: respiratory control, glucose metabolism, pulmonary hypertension, and sympathetic nervous system activation. The articles attempt to clarify many of the unsolved issues summarized below.

Bioblast editor: Gnaiger E

Labels: MiParea: Respiration 

Stress:Hypoxia  Organism: Human  Tissue;cell: Nervous system  Preparation: Intact organism