Omori 2015 Abstract MiPschool London 2015

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Exploring the role of growth factor and mitochondrial dynamics on prostatic development.

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Omori A (2015)

Event: MiPschool London 2015

The prostatic epithelia consist primarily of basal and luminal cells that differentiate from embryonic urogenital sinus epithelia. Prostate tumors are believed to originate in the basal and luminal cells. However, factors that promote normal epithelial differentiation have not been well elucidated, particularly for bone morphogenetic protein (Bmp) signaling. Our data indicate that Bmp signaling increases during prostatic differentiation in the luminal epithelia. In vivo and in vitro analyses showed that Bmp signaling is a key factor for prostatic epithelial differentiation, possibly by controlling Nkx3.1. The Nkx3.1 gene is known as transcriptional factor and functioning for epithelial differentiation [1].

Recently it was discovered that mitochondrial dynamics, and Opa1 in particular, controls heart development [2], but whether it participates in normal prostatic development is unknown. Here, I will discuss preliminary results on the role of Opa1 in vivo in prostate development.


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Organism: Human  Tissue;cell: Genital 





Affiliations

Venetian Inst Mol Med, Univ Padova, Italy. -

References

  1. Omori A, Miyagawa S, Ogino Y, Harada M, Ishii K, Sugimura Y, Ogino H, Nakagata N, Yamada G (2014) Nonmyocytic androgen receptor regulates the sexually dimorphic development of the embryonic bulbocavernosus muscle. Endocrinology 155:2534-44.
  2. Kasahara A, Cipolat S, Chen Y, Dorn GW 2nd, Scorrano L (2013) Mitochondrial fusion directs cardiomyocyte differentiation via calcineurin and Notch signaling. Science. 342:734-7.