Oxoglutarate dehydrogenase

From Bioblast

high-resolution terminology - matching measurements at high-resolution

Oxoglutarate dehydrogenase


Oxoglutarate dehydrogenase (Ξ±-ketoglutarate dehydrogenase) is a highly regulated enzyme of the tricarboxylic acid cycle. It catalyses the conversion of oxoglutarate (alpha-ketoglutarate) to succinyl-CoA, reduces NAD+ to NADH and thus links to Complex I in the Electron transfer-pathway. OgDH is activated by low Ca2+ (<20 Β΅M) but inactivated by high Ca2+ (>100 Β΅M). OgDH is an important source of ROS.

Abbreviation: OgDH

Reference: Tretter 2005 Philos Trans R Soc Lond B Biol Sci

MitoPedia topics: Enzyme 

The oxoglutarate dehydrogenase complex consists of the oxoglutarate dehydrogenase, dihydrolipoyl succinyltransferase (DLST) and dihydrolipoyl dehydrogenase (DLD).
The reaction catalyzed by OgDH is:
Oxoglutarate (Ξ±-ketoglutarate) + NAD+ + CoA β†’ Succinyl CoA + CO2 + NADH + H+
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