Palmeira 2017 MiP2017
central role in energy metabolism, as well as other essential cellular processes, such as calcium homeostasis, redox state, differentiation and signaling, and overall cell viability. Therefore, loss of mitochondrial function and/or structure, ranging from major mitochondrial defects to subtle alterations, is closely related with the development of human pathologies such as diabetes, cancer, inflammation, aging and infections. The number of mitochondria present in each cell greatly depends upon their metabolic requirements, and may range from hundreds to thousands. As such, the adaptive character of mitochondria is essential to dynamically adjust mitochondrial mass, size and function not only during normal conditions but especially in response to different cellular stresses. Indeed, physiological stimuli can activate signaling pathways that coordinate the communication between the nuclear and mitochondrial genomes to produce efficient mitochondria, and adjust to changing requirements for oxidative metabolism. Thus, an intense cross talk with the nucleus provides mitochondria with nuclear-encoded proteins as well as noncoding RNAs that are required for mitochondrial homeostasis and function. Pharmacological or alternative therapies offer promising approaches that can modulate the activity of this integrated system, leading to the maintenance of mitochondrial content and function, and ultimately prevention of cellular dysfunction.
• Bioblast editor: Kandolf G
Labels: MiParea: mt-Biogenesis;mt-density
- Dept Life Sciences, Univ Coimbra and Center Neurosciences Cell Biology, Univ Coimbra, Portugal. - [email protected]