Parey 2020 Curr Opin Struct Biol

Parey K, Wirth C, Vonck J, Zickermann V (2020) Respiratory complex I - structure, mechanism and evolution. https://doi.org/10.1016/j.sbi.2020.01.004

» Curr Opin Struct Biol 63:1-9. PMID: 32058886

Parey Kristian, Wirth Christophe, Vonck Janet, Zickermann Volker (2020) Curr Opin Struct Biol

Abstract: Respiratory complex I is an intricate multi-subunit membrane protein with a central function in aerobic energy metabolism. During the last years, structures of mitochondrial complex I and respiratory supercomplexes were determined by cryo-EM at increasing resolution. Structural and computational studies have shed light on the dynamics of proton translocation pathways, the interaction of complex I with lipids and the unusual access pathway of ubiquinone to the active site. Recent advances in understanding complex I function include characterization of specific conformational changes that are critical for proton pumping. Cryo-EM structures of the NADH dehydrogenase-like (NDH) complex of photosynthesis and a bacterial membrane bound hydrogenase (MBH) have provided a broader perspective on the complex I superfamily.

• Bioblast editor: Plangger M

Labels: MiParea: mt-Structure;fission;fusion 

Enzyme: Complex I